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Serum metabolome profiles characterized by patients with hepatocellular carcinoma associated with hepatitis B and C

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World Journal of Gastroenterology 2016年第27期22卷 6224-6234页

作者： takafumi saito Masahiro Sugimoto Kazuo Okumoto Hiroaki Haga Tomohiro Katsumi Kei Mizuno Taketo Nishina Sonoko Sato Kaori Igarashi Hiroko Maki Masaru Tomita Yoshiyuki Ueno Tomoyoshi Soga Department of Gastroenterology Yamagata University School of Medicine Institute for Advanced Biosciences Keio University

AIM: To clarify the characteristics of metabolite profiles in virus-related hepatocellular carcinoma (HCC) patients using serum metabolome ***: The serum levels of low-molecular-weight metabolites in 68 patients with HCC were quantified using capillary electrophoresis chromatography and mass spectrometry. Thirty and 38 of the patients suffered from hepatitis B virus-related HCC (HCC-B) and hepatitis C virus-related HCC (HCC-C), ***: The main metabolites characteristic of HCC were those associated with glutathione metabolism, notably 13 γ-glutamyl peptides, which are by-products of glutathione induction. Two major profiles, i.e., concentration patterns, of metabolites were identified in HCC patients, and these were classified into two groups: an HCC-B group and an HCC-C group including some of the HCC-B cases. The receiver operating characteristic curve for the multiple logistic regression model discriminating HCC-B from HCC-C incorporating the concentrations of glutamic acid, methionine and γ-glutamyl-glycine-glycine showed a highly significant area under the curve value of 0.94 (95%CI: 0.89-1.0, P < 0.0001).CONCLUSION: The serum levels of γ-glutamyl peptides, as well as their concentration patterns, contribute to the development of potential biomarkers for virus-related HCC. The difference in metabolite profiles between HCC-B and HCC-C may reflect the respective metabolic reactions that underlie the different pathogeneses of these two types of HCC.

关键词： Metabolome Hepatocellular carcinoma γ -glutamyl peptides Glutathione Oxidative stress

Pancreatic hyperechogenicity associated with hypoadiponectinemia and insulin resistance: A Japanese population study

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World Journal of Hepatology 2016年第33期8卷 1452-1458页

作者： Naohiko Makino Nakao Shirahata Teiichiro Honda Yoshiaki Ando Akiko Matsuda Yushi Ikeda Miho Ito Yuko Nishise takafumi saito Yoshiyuki Ueno Sumio Kawata Department of Gastroenterology Faculty of MedicineYamagata University Department of Internal Medicine Hyogo Prefectural Nishinomiya Hospital

AIMTo examine the relationship between pancreatic hyperechogenicity and risk factors for metabolic syndrome. METHODSA general population-based survey of lifestyle-related diseases was conducted from 2005 to 2006 in Japan. The study involved 551 participants older than 40 year of age. Data for 472 non-diabetic adults were included in the analysis. The measures included the demographic factors, blood parameters, results of a 75 g oral glucose tolerance test, and abdominal ultrasonography. The echogenicity of the pancreas and liver was compared, and then the subjects were separated into two groups: cases with pancreatic hyperechogenicity (n = 208) and cases without (controls, n = 264). The differences between both groups were compared using an unpaired t-test or Fisher’s exact test. Multiple logistic regression analysis was used to determine the relationship between the pancreatic hyperechogenicity and clinical and biochemical parameters. RESULTSSubjects with pancreatic hyperechogenicity had decreased serum adiponectin concentration compared to control subjects [8.9 (6.5, 12.8) vs 11.1 (7.8, 15.9), P P CONCLUSIONPancreatic hyperechogenicity is independently associated with increased BMI, insulin resistance, and hypoadiponectinemia in the general population.

关键词： Pancreatic hyperechogenicity Metabolic syndrome Obesity Adiponectin The Takahata study

Bone marrow cell-based regenerative therapy for liver cirrhosis

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World Journal of Methodology 2013年第4期3卷 65-69页

作者： takafumi saito Kyoko Tomita Hiroaki Haga Kazuo Okumoto Yoshiyuki Ueno Department of Gastroenterology Yamagata University School of MedicineYamagata 990-9585Japan

Bone marrow cells are capable of differentiation into liver ***,transplantation of bone marrow cells has considerable potential as a future therapy for regeneration of damaged liver *** bone marrow infusion therapy has been applied to patients with liver cirrhosis,and improvement of liver function parameters has been *** this review,we summarize clinical trials of regenerative therapy using bone marrow cells for advanced liver diseases including cirrhosis,as well as topics pertaining to basic in vitro or in vivo approaches in order to outline the essentials of this novel treatment modality.

关键词： Bone marrow Liver regeneration Cirrhosis Stem cell Transplantation

Automated crystal structure analysis based on blackbox optimisation

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npj Computational Materials 2020年第1期6卷 1022-1028页

作者： Yoshihiko Ozaki Yuta Suzuki takafumi Hawai Kotaro saito Masaki Onishi Kanta Ono Artificial Intelligence Research Center(AIRC) National Institute of Advanced Industrial Science and Technology(AIST)TokyoJapan GREE Inc.TokyoJapan Institute of Materials Structure Science(IMSS) High Energy Accelerator Research Organization(KEK)IbarakiJapan SOKENDAI(The Graduate University for Advanced Studies) IbarakiJapan Paul Scherrer Institute VilligenSwitzerland Medley IncTokyoJapan

In the present study,we show that time-consuming manual tuning of parameters in the Rietveld method,one of the most frequently used crystal structure analysis methods in materials science,can be automated by considering the entire trial-and-error process as a blackbox optimisation *** automation is successfully achieved using Bayesian optimisation,which outperforms both a human expert and an expert-system type automation despite the absence of *** approach stabilises the analysis quality by eliminating human-origin variance and bias,and can be applied to various analysis methods in other areas which also suffer from similar tiresome and unsystematic manual tuning of extrinsic parameters and human-origin variance and bias.

关键词： analysis black structure

Effectiveness of microwave endometrial ablation combined with hysteroscopic transcervical resection in treating submucous uterine myomas

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World Journal of Clinical Cases 2022年第36期10卷 13200-13207页

作者： Toshiyuki Kakinuma Kaoru Kakinuma Ayano Shimizu Ayaka Kaneko Masataka Kagimoto takafumi Okusa Eri Suizu Koyomi saito Yoshio Matsuda Kaoru Yanagida Nobuhiro Takeshima Michitaka Ohwada Department of Obstetrics and Gynecology International University of Health and Welfare HospitalNasushiobara 329-2763Japan

BACKGROUND Hypermenorrhea is characterized by excessive menstrual bleeding that causes severe anemia and interferes with everyday *** condition can restrict women’s social activities and decrease their quality of *** endometrial ablation(MEA)using a 2.45-GHz energy source is a minimally invasive alternative to conventional hysterectomy for treating hypermenorrhea that is resistant to conservative treatment,triggered by systemic disease or medications,or caused by uterine myomas and *** popularity of MEA has increased *** MEA can safely and effectively treat submucous myomas,some patients may still experience recurrent hypermenorrhea postoperatively and may require additional *** To investigate the efficacy of MEA combined with transcervical resection(TCR).METHODS Participants underwent cervical and endometrial *** resonance imaging and hysteroscopy were performed to evaluate the size and location of the *** was performed before MEA using a *** was performed using transabdominal *** variables included operation time,number of ablation cycles,length of hospital stay,and visual analog scale cores for hypermenorrhea,dysmenorrhea,and treatment satisfaction at 3 and 6 mo *** postoperative incidence of amenorrhea,changes in hemoglobin concentrations,and MEA-related complications were *** A total of 34 women underwent a combination of MEA and TCR during the study *** patients were excluded from the study as their histopathological tests identified uterine malignancies(uterine sarcoma and endometrial cancer).The 32 eligible women(6 nulliparous,26 multiparous)had a mean age of 45.2±4.3 years(range:36–52 years).Patients reported very severe hypermenorrhea(10/10 points on the visual analog scale)before the ***,after the procedure,the hypermenorrhea scores decreased to 1.2±1.3 and 0.9±1.3 at 3 and 6 mo,respectively(P<0.001)

关键词： Dysmenorrhea Endometrial ablation techniques Menorrhagia Microwaves Myoma Uterus

Subclinical synovitis detected by magnetic resonance imaging and ultrasonography following clinical remission in patients with rheumatoid arthritis:A retrospective study

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Rheumatology & Autoimmunity 2021年第1期1卷 9-17页

作者： Masao Nawata Kazuki Someya takafumi Aritomi Masashi Funada Katsumi Nakamura Kazuyoshi saito Yoshiya Tanaka Department of Clinical Immunology and Rheumatology Tobata General HospitalKitakyushuJapan The First Department of Internal Medicine University of Occupational and Environmental Health JapanKitakyushuJapan Department of Radiology Tobata General HospitalKitakyushuJapan

Background:Subjective residual symptoms persist after clinical remission of rheumatoid arthritis(RA)in Japanese *** studies have examined the relationship between these symptoms and subclinical inflammation using high-sensitivity imaging(musculoskeletal ultrasound[MSUS]and magnetic resonance imaging[MRI]).We examined the relationship between subjective residual symptoms and imaging findings in patients with RA who achieved clinical ***:We enrolled 30 patients with *** primary endpoint was the patients'subjective residual *** secondary endpoint was the relationship between the aforementioned symptoms and imaging ***:Despite a mean Simplified Disease Activity Index of 1.3,imaging evaluation revealed inflammatory *** the multivariate analysis,the Health Assessment Questionnaire Disability Index(HAQ-DI)and pain visual analog scale(VAS)scores were extracted as independent related factors of subjective residual *** stratified analysis according to HAQ-DI showed a significant difference in synovitis on MRI between patients with and without residual disability(12.0±8.7 vs.5.3±5.3,respectively;p=0.0192).However,MSUS scores showed no significant difference in these two *** addition,no significant differences were found in MSUS and MRI scores between patients with and without residual pain ***:Our findings demonstrated residual synovitis related to patientreported outcomes in patients with RA who achieved clinical *** particular,patients with an HAQ-DI score of>0.25 even after achieving clinical remission should be further examined by MRI and/or MSUS for the evaluation of residual synovitis.

关键词： magnetic resonance imaging patient-reported outcome measures remission induction rheumatoid arthritis ultrasonography

Audio-Visual Biofeedback for Respiratory Motion Management: Comparison of the Reproducibility of Breath-Holding between Visual and Audio Guidance

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Journal of Modern Physics 2018年第13期9卷 2286-2294页

作者： Naoki Sano Masahide saito Hiroshi Onishi Kengo Kuriyama takafumi Komiyama Kan Marino Shinichi Aoki Masayuki Araya Department of Radiology University of Yamanashi Yamanashi Japan

Purpose: To compare the reproducibility of breath-holding and comfort between two biofeedback guidance methods (audio and visual) in a respiratory monitoring system. Method and Materials: An audio-feedback respiratory monitoring device, which was modified from a visual-feedback self-respiration monitoring system (Abches, APEX Medical Inc., Tokyo, Japan) previously developed by the authors’ group, was constructed. Twenty patients (13 men, 7 women;mean age, 68.5 years;range, 54 - 85 years) with tumors in the thorax or abdominal region were enrolled in the present study. Computed tomography images were acquired from all patients three times using the two (i.e., audio and visual) respiration monitoring devices. To evaluate the reproducibility of breath-holding, the distance between an anatomical landmark and the tumor position was measured. Furthermore, patients were asked which guidance method they preferred (visual or audio) for comfortable breath-holding. Results: The two guidance methods improved the reproducibility of breath-holding compared with free-breathing, and no significant overall differences between two methods were observed (the mean displacements of the landmark-tumor distance were 2.60 ±1.38 mm and 2.35 ±1.63 mm, for visual and audio guidance, respectively). In five patients, the magnitude of position displacement in the series of three computed tomography images under audio guidance was twice as large as the other under visual guidance. Audio guidance was preferred to visual guidance by 65% (13 of 20) of the patients. However, the reproducibility of breath-holding did not always correspond with patient preference. Conclusion: There were some individual differences in the reproducibility of the visual and audio guidance methods. More appropriate, individualized guidance methods for each patient would improve the reproducibility of breath-holding in respiratory motion management.

关键词： Respiratory Motion Management

Evaluation of Deformable Image Registration and Dose Accumulation Using Histogram Matching Algorithm between kVCT and MVCT with Helical Tomotherapy

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Journal of Modern Physics 2018年第13期9卷 2274-2285页

作者： Masahide saito Yuki Shibata Naoki Sano Kengo Kuriyama takafumi Komiyama Kan Marino Shinichi Aoki Hiroshi Onishi Department of Radiology University of Yamanashi Yamanashi Japan

Purpose: To evaluate the accuracy of deformable image registration (DIR) between the planning kVCT (pCT) and the daily MVCT combined with the histogram matching (HM) algorithm, and evaluate the deformable dose accumulation using a suggested method for adaptive radiotherapy with Helical Tomotharapy (HT). Methods: For five prostate cancer patients (76 Gy/38 Fr) treated with HT in our institution, seven MVCT series (a total of 35 series) acquired weekly were investigated. First, to minimize the effect of different HU values between pCT and MVCT, this image-processing method adjusts HU values between pCT and MVCT images by using image cumulative histograms of HU values, generating an HM-MVCT. Then, the DIR of the pCT to the HM-MVCT was performed, generating a deformed pCT. Finally, deformable dose accumulation was performed toward the pCT image. Results: The accuracy of DIR was significantly improved by using the HM algorithm, compared with non-HM method for several structures (p ±0.05, 0.83 ±0.06, and 0.90 ± 0.04 for the CTV, rectum, and bladder, respectively, while that of the HM method was 0.81 ±0.06, 0.81 ±0.04, and 0.92 ±0.06, respectively. For the deformable dose accumulation, some difference was observed between the two methods, particularly for the small calculated regions, such as rectum V60 and V70. Conclusion: Adapting the HM method can improve the accuracy of DIR. Furthermore, dose calculation using the deformed pCT using HM methods can be an effective tool for adaptive radiotherapy.

关键词： Radiotherapy Tomotherapy MVCT Histogram-Matching Deformable Image Registration