Subclinical synovitis detected by magnetic resonance imaging and ultrasonography following clinical remission in patients with rheumatoid arthritis:A retrospective study

作     者：Masao Nawata Kazuki Someya Takafumi Aritomi Masashi Funada Katsumi Nakamura Kazuyoshi Saito Yoshiya Tanaka Masao Nawata;Kazuki Someya;Takafumi Aritomi;Masashi Funada;Katsumi Nakamura;Kazuyoshi Saito;Yoshiya Tanaka

作者机构：Department of Clinical Immunology and RheumatologyTobata General HospitalKitakyushuJapan The First Department of Internal MedicineUniversity of Occupational and Environmental Health JapanKitakyushuJapan Department of RadiologyTobata General HospitalKitakyushuJapan 

出 版 物：《Rheumatology & Autoimmunity》 (风湿病与自身免疫（英文）)

年 卷 期：2021年第1卷第1期

页      面：9-17页

学科分类：1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 100214[医学-肿瘤学] 10[医学] 

基　　金：Eli Lilly Japan K.K 

主　　题：magnetic resonance imaging patient-reported outcome measures remission induction rheumatoid arthritis ultrasonography 

摘      要：Background:Subjective residual symptoms persist after clinical remission of rheumatoid arthritis(RA)in Japanese *** studies have examined the relationship between these symptoms and subclinical inflammation using high-sensitivity imaging(musculoskeletal ultrasound[MSUS]and magnetic resonance imaging[MRI]).We examined the relationship between subjective residual symptoms and imaging findings in patients with RA who achieved clinical ***:We enrolled 30 patients with *** primary endpoint was the patients subjective residual *** secondary endpoint was the relationship between the aforementioned symptoms and imaging ***:Despite a mean Simplified Disease Activity Index of 1.3,imaging evaluation revealed inflammatory *** the multivariate analysis,the Health Assessment Questionnaire Disability Index(HAQ-DI)and pain visual analog scale(VAS)scores were extracted as independent related factors of subjective residual *** stratified analysis according to HAQ-DI showed a significant difference in synovitis on MRI between patients with and without residual disability(12.0±8.7 vs.5.3±5.3,respectively;p=0.0192).However,MSUS scores showed no significant difference in these two *** addition,no significant differences were found in MSUS and MRI scores between patients with and without residual pain ***:Our findings demonstrated residual synovitis related to patientreported outcomes in patients with RA who achieved clinical *** particular,patients with an HAQ-DI score of0.25 even after achieving clinical remission should be further examined by MRI and/or MSUS for the evaluation of residual synovitis.