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Indigenous microbiota protects development of medication-related osteonecrosis induced by periapical disease in mice

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International Journal of Oral Science 2022年第2期14卷 156-163页

作者： Wen Du Mengyu Yang Terresa kim Sol kim Drake W.Williams Maryam Esmaeili Christine hong Ki-hyuk Shin Mo K.Kang No-hee Park Reuben h.kim State Key Laboratory of Oral Diseases&National Clinical Research Center for Oral Diseases&Department of Prosthodontics West China Hospital of StomatologySichuan UniversityChengduChina The Shapiro Family Laboratory of Viral Oncology and Aging Research Los AngelesUSA Section of Restorative Dentistry UCLA School of DentistryLos AngelesUSA Department of Orofacial Sciences UCSF School of DentistrySan FranciscoUSA UCLA Jonsson Comprehensive Cancer Center Los AngelesUSA David Geffen School of Medicine at UCLA Los AngelesUSA

Bacterial infection is a common finding in patients,who develop medication-related osteonecrosis of the jaw(MRONJ)by the longterm and/or high-dose use of anti-resorptive agents such as bisphosphonate(BPs).however,pathological role of bacteria in MRONJ development at the early stage remains ***,we demonstrated that commensal microbiota protects against MRONJ development in the pulp-exposed periapical periodontitis mouse model.C57/BL6 female mice were treated with intragastric broadspectrum antibiotics for 1 *** acid(ZOL)through intravenous injection and antibiotics in drinking water were administered for throughout the *** was exposed on the left maxillary first molar,then the mice were left for 5 weeks after which bilateral maxillary first molar was extracted and mice were left for additional 3 weeks to *** mice were harvested,and cecum,maxilla,and femurs were *** development was assessed usingμCT and histologic *** antibiotic was treated in mice,these mice had no weight changes,but developed significantly enlarged ceca compared to the control group(CTL mice).Periapical bone resorption prior to the tooth extraction was similarly prevented when treated with antibiotics,which was confirmed by decreased osteoclasts and *** treatment with pulp exposure significantly increased bone necrosis as determined by empty lacunae and necrotic bone ***,antibiotics treatment could further exacerbate bone necrosis,with increased osteoclast *** findings suggest that the commensal microbiome may play protective role,rather than pathological role,in the early stages of MRONJ development.

关键词： protective finding antibiotics

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A Cu-Pd alloy catalyst with partial phase separation for the electrochemical CO_(2) reduction reaction

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Journal of Energy Chemistry 2024年第6期93卷 8-15,I0001页

作者： Gyeong ho han Jung Yong Seo Minji Kang Myung-gi Seo Youngheon Choi Soo Young kim Sang hyun Ahn School of Chemical Engineering and Material Science Chung-Ang UniversitySeoul 06974Republic of Korea Lotte Chemical Institute of Technology Daejeon 34110Republic of Korea Department of Materials Science and Engineering Korea UniversitySeoul 02841Republic of Korea

Cu catalysts can convert CO_(2) through an electrochemical reduction reaction into a variety of useful carbon-based ***,this capability provides an obstacle to increasing the selectivity for a single ***,we report a simple fabrication method for a Cu-Pd alloy catalyst for use in a membrane electrode assembly(MEA)-based CO_(2) electrolyzer for the electrochemical CO_(2) reduction reaction(ECRR)with high selectivity for CO *** the composition of the Cu-Pd alloy catalyst was fabricated at 6:4,the selectivity for CO increased and the production of multi-carbon compounds and hydrogen is *** a Cu-Pd alloy catalyst with 6:4 ratio as the cathode of the MEAbased CO_(2) electrolyzer showed a CO faradaic efficiency of 92.8%at 2.4 V_(cell).We assumed that these results contributed from the crystal planes on the surface of the Cu-Pd *** phases of the Cu-Pd alloy catalyst were partially separated through annealing to fabricate a catalyst with high selectivity for CO at low voltage and C_(2)h_4 at high *** results of CO-stripping testing confirmed that when Cu partially separates from the lattice of the Cu-Pd alloy,the desorption of~*CO is suppressed,suggesting that C-C coupling reaction is favored.

关键词： Cu-Pd catalyst Electrodeposition Electrochemical carbon dioxide reduction Partial phase separation Membrane electrode assembly-based electrolyzer

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Glucose-mediated mitochondrial reprogramming by cholesterol export at TM4SF5-enriched mitochondria-lysosome contact sites

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Cancer Communications 2024年第1期44卷 47-75页

作者： Ji Eon kim So-Young Park Chulhwan Kwak Yoonji Lee Dae-Geun Song Jae Woo Jung haesong Lee Eun-Ae Shin Yangie Pinanga Kyung-hee Pyo Eun hae Lee Wonsik kim Soyeon kim Chang-Duck Jun Jeanho Yun Sun Choi hyun-Woo Rhee Kwang-hyeon Liu Jung Weon Lee Department of Pharmacy College of PharmacySeoul National UniversitySeoulRepublic of Korea Research Institute of Pharmaceutical Sciences College of PharmacySeoul National UniversitySeoulRepublic of Korea BK21 FOUR Community-Based Intelligent Novel Drug Discovery Education Unit College of Pharmacy and Research Institute of Pharmaceutical SciencesKyungpook National UniversityDaeguRepublic of Korea Department of Chemistry Seoul National UniversitySeoulRepublic of Korea College of Pharmacy Chung-Ang UniversitySeoulRepublic of Korea Natural Product Informatics Research Center Korea Institute of Science and Technology(KIST)Gangneung-siGangwon-doRepublic of Korea School of Life Sciences Gwangju Institute of Science and Technology(GIST)GwangjuRepublic of Korea Department of Biochemistry College of MedicineDong-A UniversityBusanRepublic of Korea Global AI Drug Discovery Center College of Pharmacy and Graduate School of Pharmaceutical SciencesEwha Womans UniversitySeoulRepublic of Korea Interdisciplinary Program in Genetic Engineering Seoul National UniversitySeoulRepublic of Korea

Background:Transmembrane 4 L six family member 5(TM4SF5)translocates subcellularly and functions metabolically,although it is unclear how intracellu-lar TM4SF5 translocation is linked to metabolic *** is thus of interests to understand how the traffic dynamics of TM4SF5 to subcellular endosomal membranes are correlated to regulatory roles of ***:here,we explored the metabolic significance of TM4SF5 localization at mitochondria-lysosome contact sites(MLCSs),using in vitro cells and in vivo animal systems,via approaches by immunofluorescence,proximity labelling based proteomics analysis,organelle reconstitution ***:Upon extracellular glucose repletion following depletion,TM4SF5 became enriched at MLCSs via an interaction between mitochondrial FK506-binding protein 8(FKBP8)and lysosomal *** labeling showed molecular clustering of phospho-dynamic-related protein I(DRP1)and certain mitophagy receptors at TM4SF5-enriched MLCSs,leading to mitochondrial fis-sion and ***4SF5 bound NPC intracellular cholesterol transporter 1(NPC1)and free cholesterol,and mediated export of lysosomal cholesterol to mitochondria,leading to impaired oxidative phosphorylation but intact tri-carboxylic acid(TCA)cycle andβ-*** mouse models,hepatocyte Tm4sf5 promoted mitophagy and cholesterol transport to mitochondria,both with positive relations to liver ***:Our findings suggested that TM4SF5-enriched MLCSs regu-late glucose catabolism by facilitating cholesterol export for mitochondrial reprogramming,presumably while hepatocellular carcinogenesis,recapitulating aspects for hepatocellular carcinoma metabolism with mitochondrial repro-gramming to support biomolecule synthesis in addition to glycolytic energetics.

关键词： cholesterol fluorescent imaging glucose catabolism hepatocellular carcinogenesis mem-brane contact sites mitochondria function mitophagy oxidative phosphorylation protein-protein interaction tetraspanin

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Low temperature-mediated repression and far-red light-mediated induction determine morning FLOWERING LOCUS T expression levels

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Journal of Integrative Plant Biology 2024年第1期66卷 103-120页

作者： hayeon kim hye Won Kang Dae Yeon hwang Nayoung Lee Akane Kubota takato Imaizumi Young hun Song Department of Agricultural Biotechnology Seoul National UniversitySeoul 08826Korea Department of Biology Ajou UniversitySuwon 16499Korea Plant Genomics and Breeding Institute Seoul National UniversitySeoul 08826Korea Graduate School of Science and Technology Nara Institute of Science and TechnologyIkomaNara 630‐0192Japan Department of Biology University of WashingtonSeattleWA 98195USA Institute of Agricultural Life Sciences Seoul National UniversitySeoul 08826Korea

In order to flower in the appropriate season,plants monitor light and temperature changes and alter downstream pathways that regulate florigen genes such as Arabidopsis(Arabidopsis thaliana)FLOWERING LOCUS T(FT).In Arabidopsis,FT messenger RNA levels peak in the morning and evening under natural long-day conditions(LDs).however,the regulatory mechanisms governing morning FT induction remain poorly *** morning FT peak is absent in typical laboratory LDs characterized by high red:far-red light(R:FR)ratios and constant ***,we demonstrate that ZEITLUPE(ZTL)interacts with the FT repressors TARGET OF EATs(TOEs),thereby repressing morning FT expression in natural *** LDs with simulated sunlight(R:FR=1.0)and daily temperature cycles,which are natural LD-mimicking environmental conditions,FT transcript levels in the ztl mutant were high specifically in the morning,a pattern that was mirrored in the toe1 toe2 double *** night-to-morning temperatures increased the inhibitory effect of ZTL on morning FT expression by increasing ZTL protein levels early in the ***-red light counteracted ZTL activity by decreasing its abundance(possibly via phytochrome A(phyA))while increasing GIGANTEA(GI)levels and negatively affecting the formation of the ZTL-GI complex in the ***,the phyA-mediated high-irradiance response and GI play pivotal roles in morning FT *** findings suggest that the delicate balance between low temperature-mediated ZTL activity and the far-red light-mediated functions of phyA and GI offers plants flexibility in fine-tuning their flowering time by controlling FT expression in the morning.

关键词： far-red light FLOWERING LOCUS T flowering time GIGANTEA low night-to-morning temperature natural long days phytochrome A red to far-red ratio ZEITLUPE

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What Causes the Springtime Tropospheric Ozone Maximum over Northeast Asia?

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Advances in Atmospheric Sciences 2010年第3期27卷 543-551页

作者： Jae h.kim hyunjin LEE Department of Atmospheric Science Pusan National University

Scientists have long debated the relative importance of tropospheric photochemical production versus stratospheric influx as causes of the springtime tropospheric ozone maximum over northern mid-latitudes. This paper investigates whether or not stratospheric intrusion and photochemistry play a significant role in the springtime ozone maximum over Northeast Asia, where ozone measurements are sparse. We examine how tropospheric ozone seasonalities over Naha （26°N, 128°E）, Kagoshima （31°N, 131°E）, and Pohang （36°N, 129°E）, which are located on the same meridional line, are related to the timing and location of the jet stream. The ozone seasonality shows a gradual increase from January to the maximum ozone month, which corresponds to April at Naha, May at Kagoshima, and June at Pohang. In order to examine the occurrence of stratospheric intrusion, we analyze a correlation between jet stream activity and tropospheric ozone seasonality. From these analyses, we did not find any favorable evidence supporting the hypothesis that the springtime enhancement may result from stratospheric intrusion. According to trajectory analysis for vertical and horizontal origins of the airmass, a gradual increasing tendency in ozone amounts from January until the onset of monsoon was similar to the increasing ozone formation tendency from winter to spring over China's Mainland, which has been observed during the build-up of tropospheric ozone over Central Europe in the winter-spring transition period due to photochemistry. Overall, the analyses suggest that photochemistry is the most important contributor to observed ozone seasonality over Northeast Asia.

关键词： tropospheric ozone photochemistry, stratospheric intrusion, jet stream activity, trajectory

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CD200Rhigghh neutrophils with dysfunctional autophagy establish systemic immunosuppression by increasing regulatory T cells

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Cellular & Molecular Immunology 2024年第4期21卷 349-361页

作者： Ye Seon kim Yu Sun Jeong Geon ho Bae Ji hyeon Kang Mingyu Lee Brian A.Zabel Yoe-Sik Bae Department of Biological Sciences Sungkyunkwan UniversitySuwon16419Republic of Korea Department of health Science and Technology SAIHSTSungkyunkwan UniversitySeoul06351Republic of Korea Palo Alto Veterans Institute for Research Veterans Affairs HospitalPalo AltoCA94304USA

Distinct neutrophil populations arise during certain pathological *** generation of dysfunctional neutrophils during sepsis and their contribution to septicemia-related systemic immune suppression remain *** this study,using an experimental sepsis model that features immunosuppression,we identified a novel population of pathogenic CD200R^(high) neutrophils that are generated during the initial stages of sepsis and contribute to systemic immune suppression by enhancing regulatory T(T_(reg))*** to their CD200R^(low)counterparts,sepsis-generated CD200Rhigh neutrophils exhibit impaired autophagy and dysfunction,with reduced chemotactic migration,superoxide anion production,and TNF-α*** soluble CD200 blocks autophagy and neutrophil maturation in the bone marrow during experimental sepsis,and recombinant CD200 treatment in vitro can induce neutrophil dysfunction similar to that observed in CD200R^(high) *** administration of anα-CD200R antibody effectively reversed neutrophil dysfunction by enhancing autophagy and protecting against a secondary infection challenge,leading to increased *** analysis revealed that CD200R^(high) neutrophils expressed high levels of Igf1,which elicits the generation of Treg cells,while the administration of anα-CD200R antibody inhibited Treg cell generation in a secondary infection *** together,our findings revealed a novel CD200R^(high) neutrophil population that mediates the pathogenesis of sepsis-induced systemic immunosuppression by generating Treg cells.

关键词： Sepsis Neutrophils CD200R Autophagy IGF-1 Regulatory T cells

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Biomimetic Fe_(7)S_(8)/Carbon electrocatalyst from[FeFe]-hydrogenase for improving ph-Universal electrocatalytic hydrogen production Special Collection:Aggregation-Induced Processes and Functions

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Aggregate 2024年第1期5卷 451-459页

作者： Dohun kim Subramani Surendran Sejin Im Jaehyoung Lim Kyoungsuk Jin Ki Tae Nam Uk Sim Department of Energy Science&Engineering Daegu Gyeongbuk Institute of Science&Technology(DGIST)DaeguRepublic of Korea hydrogen Energy Technology Laboratory Korea Institute of Energy Technology(KENTECH)NajuRepublic of Korea Department of Chemistry Korea UniversitySeoulRepublic of Korea Department of Materials Science and Engineering Seoul National UniversitySeoulRepublic of Korea

Efficient and cost-effective electrocatalysts that can operate across a wide range of ph conditions are essential for green hydrogen *** by biological systems,Fe_(7)S_(8)nanoparticles incorporated on polydopamine matrix electrocatalyst were synthesized by co-precipitation and annealing *** resulting Fe_(7)S_(8)/C electrocatalyst possesses a three-dimensional structure and exhibits enhanced electrocatalytic performance for hydrogen production across various ph ***,the Fe_(7)S_(8)/C electrocatalyst demonstrates exceptional activity,achieving low overpotentials of 90.6,45.9,and 107.4 mV in acidic,neutral,and alkaline environments,*** impedance spectroscopy reveals that Fe_(7)S_(8)/C exhibits the lowest charge transfer resistance under neutral conditions,indicating an improved proton-coupled electron transfer ***-wave electron paramagnetic resonance results confirm a change in the valence state of Fe from 3+to 1+during the hydrogen evolution reaction(hER).These findings closely resemble the behavior of natural[FeFe]-hydrogenase,known for its superior hydrogen production in neutral *** remarkable performance of our Fe_(7)S_(8)/C electrocatalyst opens up new possibilities for utilizing bioinspired materials as catalysts for the hER.

关键词： biomimetic electrocatalyst hydrogen production renewable energy

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Tungsten-based nanocatalysts with different structures for visible light responsive photocatalytic degradation of bisphenol A

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Journal of Environmental Sciences 2024年第5期139卷 569-588页

作者： hai Bang Truong Thi Thu Loan Doan Nguyen Tien hoang Nguyen Van Tam Minh.kim Nguyen Le Gia Trung Jin Seog Gwag Nguyen Tien Tran Optical Materials Research Group Science and Technology Advanced InstituteVan Lang UniversityHo Chi Minh CityViet Nam Faculty of Applied Technology School of TechnologyVan Lang UniversityHo Chi Minh CityViet Nam The University of Da Nang University of Science and Technology54 Nguyen Luong BangDa NangViet Nam The University of Da Nang University of Science and Education459 Ton Duc Thang St.Lien ChieuDa Nang 550000Viet Nam Institute of Veterinary Science and Technology 31ha zoneTrau QuyGia LamHa Noi 12400Viet Nam Department of Physics Yeungnam UniversityGyeongsanGyeongbuk 38541Republic of Korea Center for Advanced Chemistry Institute of Research and DevelopmentDuy Tan University03 Quang TrungDa Nang 550000Viet Nam Faculty of Natural Sciences Duy Tan University03 Quang TrungDa Nang 550000Viet Nam

Environmental pollution,such as water contamination,is a critical issue that must be absolutely ***,three different morphologies of tungsten-based photocatalysts(WO_(3)nanorods,WO_(3)/WS_(2)nanobricks,WO_(3)/WS_(2)nanorods)are made using a simple hydrothermal method by changing the solvents(h_(2)O,DMF,aqueous hCl solution).The as-prepared nanocatalysts have excellent thermal stability,large porosity,and high *** results show all materials have good photocatalytic activity in aqueous media,with WO_(3)/WS_(2)nanorods(NRs)having the best activity in the photodegradation of bisphenol A(BPA)under visible-light *** may originate from increased migration of charge carriers and effective prevention of electron–hole recombination in WO_(3)/WS_(2)NRs,whereby this photocatalyst is able to generate more reactive·Oh and·O_(2)^(–)species,leading to greater photocatalytic *** 99.6% of BPA is photodegraded within 60 min when using 1.5 g/L WO_(3)/WS_(2)NRs and 5.0 mg/L BPA at ph ***,the optimal conditions(ph,catalyst dosage,initial BPA concentration)for WO_(3)/WS_(2)NRs are also elaborately *** rod-like heterostructures are expressed as potential catalysts with excellent photostability,efficient reusability,and highly active effectivity in different types of *** particular,the removal efficiency of BPA by WO_(3)/WS_(2)NRs reduces by only 1.5% after five recycling runs and even reaches 89.1%in contaminated lake *** study provides promising insights for the nearly complete removal of BPA from wastewater or different water resources,which is advantageous to various applications in environmental remediation.

关键词： Photodegradation Bisphenol A Tungsten-based nanocatalyst Structure Nanorod

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Submicron Ag-coated Cu particles as filler in sintering paste: Suppression of Ag dewetting and improvement of sinterability by surface modification using stearic acid

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Transactions of Nonferrous Metals Society of China 2024年

作者： Yeongjung kim Yong-Sung Eom Kwang-Seong Choi Jong-hyun Lee Department of Materials Science and Engineering Seoul National University of Science and Technology 232 Gongneung-ro Low-Carbon Integration Tech Creative Research Section ETRI 218 Gajeong-ro Materials Research Institute for Future Convergence Seoul National University of Science and Technology 232 Gongneung-ro

Four types of submicron Ag-coated Cu particles with different Ag contents were prepared as sintering paste fillers， and the Ag contents of the particles were measured to be 10， 20， 30， and 40 wt%. Four types of particles （in order of increasing Ag content: A10， A20， A30， and A40） were surface-modified with stearic acid， to suppress the Ag shell dewetting and improve sinterability. The surface-modified particles were mixed with a polyol-based solvent to fabricate a resin-free paste. Subsequently， the pastes were screen-printed onto a slide glass and sintered at 250 ℃ in a nitrogen atmosphere for 1–10 min to form an electrode. The electrical resistivity of the sintered film as a function of sintering time was measured using a four-point probe. All the four surface-modified Cu@Ag particles with different Ag contents exhibited decreased electrical resistivity. Particularly， the largest difference in values after and before the surface modification was observed for A40 with the highest Ag content; the electrical resistivities of the initial and surface-modified particles were 1.51×10-4and 6.67×10-5Ω·cm， respectively， after sintering for 10 min. The findings of this study confirmed that the surface modification using stearic acid effectively suppressed the dewetting of the Ag shell and improved the sinterability of the submicron Cu@Ag particles.

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Stable operation of highly loaded pure Si-Fe anode under ambient pressure via carboxy silane-directed robust solid electrolyte interphase

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Journal of Energy Chemistry 2024年第7期94卷 568-576页

作者： Guntae Lim Dong Guk Kang hyeon Gyu Lee Yen hai Thi Tran Kihun An Junghyun Choi Kwang Chul Roh Do Youb kim Seung-Wan Song Department of Chemical Engineering&Applied Chemistry Chungnam National University Daejeon 34134Republic of Korea Energy Storage Materials Center Korea Institute of Ceramic Engineering&TechnologyJinju 52851Republic of Korea Advanced Energy Materials Research Center Korea Research Institute of Chemical TechnologyDaejeon 34114Republic of Korea

Incorporation of higher content Si anode material beyond 5 wt% to Li-ion batteries(LIBs)is challenging,owing to large volume change,swelling,and solid electrolyte interphase(SEI)instability ***,a strategy of diacetoxydimethylsilane(DAMS)additive-directed SEI stabilization is proposed for a stable operation of Si-0.33FeSi_(2)(named as Si-Fe)anode without graphite,which provides siloxane inorganics and organics enrichment that compensate insufficient passivation of fluoroethylene carbonate(FEC)additive and reduce a dependence on *** stable cycling performance of highly loaded(3.5 mA h cm^(-2))pure Si-Fe anode is achieved with 2 wt%DAMS combined with 9 wt%FEC additives under ambient pressure,yielding high capacity 1270 mA h g^(-1)at 0.5 C and significantly improved capacity retention of 81% after 100 cycles,whereas short circuit and rapid capacity fade occur with FEC only ***-directed robust SEI layer dramatically suppresses swelling and particles crossover through separator,and therefore prevents short circuit,demonstrating a possible operation of pure Si or Sidominant anodes in the next-generation high-energy-density and safe LIBs.

关键词： high-energy Li-ion battery Pure Si-Fe anode without graphite Silane additive SEI layer Suppressed swelling

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