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中华医学杂志(英文版) 1988年第11期101卷 840-840页

作者： Chen Tu-Xing Sun Hong-xun Kiwamu Oktia tadayoshi takemoto Department of Internal Medicine First Affiliated Hospital of Nanjing Medical College Nanjing Yamaguchi University School of Medicine Japan

The effects of epidermal growth factor (EGF), glucagon and insulin on the DNA synthesis of hepatocytes after experimental hepatocellular necrosis in rats were studied in vivo with the monoclonal anti-bromodeoxyuridine antibody technique. The results showed that EGF could substantially stimulate the DNA synthesis of the damaged liver cells induced by CCI4. When EGF was administered in combination with glucagon and insulin, they could result in a dramatic increase in the DNA synthesis. In con- trast to primary culture of hepatocytes and cells after partial hepatectomy, glucagon could also stimulate the regeneration of damaged liver cells. Insulin, when used alone, did not show apparent effect on hepatic regeneration. It is suggested that EGF and EGF-glucagon-insulin therapy may be useful in the treatment of acute hepatic failure.

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Correlations between IMC thickness and three factors in Sn-3Ag-0.5Cu alloy system

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中国有色金属学会会刊：英文版 2007年第4期17卷 686-690页

作者：孟工戈 T. takemoto H. Nishikawa College of Materials Science and Engineering Harbin University of Science and Technology Joining and Welding Research Institute Osaka UniversityIbalaki Osaka 567-0047 Japan

The effects of Ni content, soldering temperature and time on the IMC thickness in Sn-3Ag-0.5Cu and Sn-3Ag-0.5Cu-0.2Co alloys were researched using uniform design method and computer programs. For each alloy, the factors were divided into three levels in the experiment. Two correlative equations are given by regression. They indicate that the effects of three factors on the function are in the mutual and quadratic forms. And the analysis of variance shows the equations are sound and meaningful. Using the equations, it is easy to search, predict and control the IMC thickness. The existence of element Co accelerates the crystallization and growing up of IMC.

关键词：锡银铜合金无铅焊料金属间化合物厚度均匀设计

Effect of elements Ni and Co on morphology and type of IMC at Sn-3Ag-0.5Cu solder joint interface

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Journal of Harbin Institute of Technology(New Series) 2009年第5期16卷 648-651页

作者：孟工戈 takemoto Tadashi NISHIKAWA Hiroshi School of Material Science & Engineering Harbin University of Science and Technology Joining and Welding Research Institute Osaka University

The intermetallic compound (IMC) is hard and brittle,and its forming and growth at soldering joint interface is an important issue in joint *** data obtained by digital optical electronic microscope indicate that the addition of element Co changes the IMC morphology from ball-like and bar-like to distinct and sharp in crest lines and *** addition of elements Ni and Co in Sn-3Ag-0.5Cu solder promotes the nucleation and makes the IMC size *** electron probe microanalysis (EPMA) determines the chemical compositions and confirms that the IMC is changed into the (Cu,Co,Ni)6Sn5+(Cu,Co,Ni)3Sn4 mixed type from the type of Cu6Sn5 with the elements Ni and Co in the solder.

关键词： Sn-3Ag-0. 5Cu solder IMC Ni/Co morphology type

Comparative assessment of primary and secondary infection risks in a norovirus outbreak using a household model simulation

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Journal of Environmental Sciences 2016年第12期28卷 13-20页

作者： Fuminari Miura Toru Watanabe Kozo Watanabe Kazuhiko takemoto Kensuke Fukushi Department of Urban Engineering Graduate School of Engineering the University of Tokyo Department of Food Life and Environmental Sciences Faculty of Agriculture Yamagata University Department of Civil and Environmental Engineering Ehime University Institute for the Advanced Study of Sustainability the United Nations University Todai Institutes for Advanced Study(TODIAS) Integrated Research System for Sustainability Science(IR3S) The University of Tokyo

Diarrheal diseases can be transmitted via both primary infection due to exposures to contaminated materials from the environment and secondary infection due to person- to-person contacts. Usually, the importance of secondary infection is empirically assessed by fitting mathematical models to the epidemic curves. However, these empirical models may not be applicable to other epidemic cases because they are developed only for the target epidemics and they don＇t consider the detail routes of infection. In our previous study, we developed a theoretical model taking into account the various routes of infection that commonly occur in households （e.g., shaking hands, food handling, and changing diapers）. This model was made flexible and applicable to any epidemics by means of adjusting model parameters. In this study, we proposed a new index ＂Vulnerability indicator to secondary infection （VISI）＂, which expressed a ratio of secondary infection to primary infection risks and calculated this index in a simulated norouirus （NOV） epidemic that involved I0,000 households. The results demonstrated that households composed of more than three members including infant（s） had much higher levels of VlSl （5-45） than two-member-households with VlSI （0.1-4）. These results concluded that the infants were likely to be a hub of secondary infections in highly dense families and therefore careful handling of diapers was deemed indispensible in such families to effectively control the secondary infections.

关键词： Norovirus Quantitative microbial riskassessment Secondary infection

Metallic Contaminant Detection using a High-Temperature Superconducting Quantum Interference Devices Gradiometer

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Chinese Physics Letters 2010年第8期27卷 253-255页

作者： Saburo Tanaka Tomohiro Akai Makoto takemoto Yoshimi Hatsukade Takeyoshi Ohtani Yoshio Ikeda Shuichi Suzuki Toyohashi University of Technology 1-1 Hibarigaoka Tempaku-cho Toyohashi Aichi 441-8580 Japan Advance Food Technology Co. Ltd. Toyohashi Aichi 441-8113 Japan

We develop magnetic metallic contaminant detectors using high-temperature superconducting quantum interference devices （HTS-SQUIDs） for industrial products. Finding ultra-small metallic contaminants is an important issue for manufacturers producing commercial products such as lithium ion batteries. If such contaminants cause damages, the manufacturer of the product suffers a big financial loss due to having to recall the faulty products. Previously, we described a system for finding such ultra-smafi particles in food. In this study, we describe further developments of the system, for the reduction of the effect of the remnant field of the products, and we test the parallel magnetization of the products to generate the remnant field only at both ends of the products. In addition, we use an SQUID gradiometer in place of the magnetometer to reduce the edge effect by measuring the magnetic field gradient. We test the performances of the system and find that tiny iron particles as small as 50 × 50 μm^2 on the electrode of a lithium ion battery could be clearly detected. This detection level is difficult to achieve when using other methods.

关键词： HIGH temperature superconductors SUPERCONDUCTING quantum interference devices PHYSICAL measurements INDUSTRIAL goods LITHIUM-ion batteries MAGNETIZATION PERFORMANCE evaluation

Prediction of flare-ups of ulcerative colitis using quantitative immunochemical fecal occult blood test

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World Journal of Gastroenterology 2010年第9期16卷 1110-1114页

作者： Motoaki Kuriyama Jun Kato Koji takemoto Sakiko Hiraoka Hiroyuki Okada Kazuhide Yamamoto Department of Gastroenterology and Hepatology Okayama University Graduate School of MedicineDentistryand Pharmaceutical Sciences

AIM:To examine the feasibility of predicting the flareup of ulcerative colitis (UC) before symptoms emerge using the immunochemical fecal occult blood test (IFOBT).METHODS:We prospectively measured fecal hemoglobin concentrations in 78 UC patients using the I-FOBT every 1 or 2 ***:During a 20 mo-period,823 fecal samples from 78 patients were *** median concentration of fecal hemoglobin was 41 ng/mL (range:0-392 500 ng/mL).There were three types of patients with regard to the correlation between I-FOBT and patient symptoms;the synchronous transition type with symptoms (44 patients),the unrelated type withsymptoms (19 patients),and the flare-up predictive type (15 patients).In patients with the flare-up predictive type,the values of I-FOBT were generally low during the study period with stable *** to four weeks before the flare-up of symptoms,the I-FOBT values were ***,in these patients,I-FOBT could predict the flare-up before symptoms ***:Flare-up could be predicted by I-FOBT in approximately 20% of UC *** results warrant periodical I-FOBT in UC patients.

关键词： Flare-ups Immunochemical fecal occult blood test Inflammatory bowel disease Prediction Ulcerative colitis

Isolated neutropenia caused by copper deficiency due to jejunal feeding and excessive zinc intake:A case report

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World Journal of Clinical Cases 2021年第29期9卷 8825-8830页

作者： Hiromitsu Ohmori Hiroko Kodama Masahiko takemoto Masami Yamasaki Tomio Matsumoto Masao Kumode Takafumi Miyachi Ryo Sumimoto Department of Pediatrics National Hospital Organization Yanai Medical CenterYanai 742-1352YamaguchiJapan Doctoral Program in Health and Dietetics Graduate School of Health SciencesTeikyo Heisei UniversityToshima-ku 170-8445TokyoJapan Department of Surgery National Hospital Organization Yanai Medical CenterYanai 742-1352YamaguchiJapan Department of Neurology National Hospital Organization Yanai Medical CenterYanai 742-1352YamaguchiJapan Department of Pediatrics Biwako Gakuen Kusatsu Medical and Welfare Center for Children and Persons with Severe Motor and Intellectual DisabilitiesKusatsu 525-0034ShigaJapan

BACKGROUND Percutaneous endoscopic gastrostomy with jejunal extension(PEG-J)is often used to treat patients with neurological impairment and difficulty in ***,these patients often develop copper *** report describes a case of isolated neutropenia,which is a rare manifestation of copper *** SUMMARY Our patient was a 19-year-old boy with neurological impairment and gastroesophageal *** received PEG-J feeding,including an enteral supplement containing copper and ***,as his serum zinc level was low(53μg/dL)at the age of 19 years and 2 mo,we changed to a zinc-rich supplement containing 22 mg/d of zinc and 1.0 mg/d of *** supplement comprised a mixture of isocal 1.0 junior(5 packs/d),Tezon[2 packs(250 mL)/d],and cocoa *** months later,he had neutropenia(606/mm^(3))with a serum copper level of 16μg/*** were no other manifestations of copper deficiency,including *** deficiency and neutropenia both improved following the administration of cocoa powder and *** In patients receiving long-term PEG-J feeds,white blood cell counts,hemoglobin,and serum levels of copper and zinc should be regularly monitored.

关键词： Percutaneous endoscopic gastrostomy with jejunal extension feeding Neutropenia Copper Zinc Deficiency Case report

The foraging behavior of Japanese macaques Macaca fuscata in a forested enclosure: Effects of nutrient composition,energy and its seasonal variation on the consumption of natural plant foods

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Current Zoology 2010年第2期56卷 198-208页

作者： M.Firoj JAMAN Michael A.HUFFMAN Hiroyuki takemoto Primate Research Institute Kyoto University Department of Zoology University of Dhaka

In the wild, primate foraging behaviors are related to the diversity and nutritional properties of food, which are affected by seasonal variation. The goal of environmental enrichment is to stimulate captive animals to exhibit similar foraging behavior of their wild counterparts, e.g. to extend foraging time. We conducted a 12-month study on the foraging behavior of Japanese macaques in a semi-naturally forested enclosure to understand how they use both provisioned foods and naturally available plant foods and what are the nutritional criteria of their consumption of natural plants. We recorded time spent feeding on provisioned and natural plant foods and collected the plant parts ingested of their major plant food species monthly, when available. We conducted nutritional analysis （crude protein, crude lipid, neutral detergent fiber-‘NDF＇, ash） and calculated total non-structural carbohydrate - ‘TNC＇ and total energy of those food items. Monkeys spent 47% of their feeding time foraging on natural plant species. The consumption of plant parts varied significantly across seasons. We found that leaf items were consumed in months when crude protein, crude protein-to-NDF ratio, TNC and total energy were significantly higher and NDF was significantly lower, fruit/nut items in months when crude protein and TNC were significantly higher and crude lipid content was significantly lower, and bark items in months when TNC and total energy were higher and crude lipid content was lower. This preliminary investigation showed that the forested enclosure allowed troop members to more fully express their species typical flexible behavior by challenging them to adjust their foraging behavior to seasonal changes of plant item diversity and nutritional content, also providing the possibility for individuals to nutritionally enhance their diet .

关键词： Nutrition Food consumption Semi-natural vegetation Provisioned foods Captive primates Enrichment

Genetic Characterization of Streptococcus pyogenes emm89 Strains Isolated in Japan From 2011 to 2019

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Infectious Microbes & Diseases 2020年第4期2卷 160-166页

作者： Yujiro Hirose Masaya Yamaguchi Norihiko takemoto Tohru Miyoshi-Akiyama Tomoko Sumitomo Masanobu Nakata tadayoshi Ikebe Tomoki Hanada Takahiro Yamaguchi Ryuji Kawahara Rumi Okuno Hitoshi Otsuka Yuko Matsumoto Yuji Terashima Yu Kazawa Noriko Nakanishi Kaoru Uchida Yumi Akiyama Kaori Iwabuchi Chikara Nakagawa Kazunari Yamamoto Victor Nizet Shigetada Kawabata Department of Oral and Molecular Microbiology Osaka University Graduate School of DentistrySuitaOsakaJapan Department of Pediatrics University of California at San Diego School of MedicineLa JollaCAUSA Department of Infectious Diseases Research InstituteNational Center for Global Health and MedicineTokyoJapan Department of Oral Microbiology Kagoshima University Graduate School of Medical and Dental SciencesKagoshimaJapan Department of Bacteriology I National Institute of Infectious DiseasesTokyoJapan Division of Microbiology Osaka Institute of Public HealthOsaka CityOsakaJapan Department of Microbiology Tokyo Metropolitan Institute of Public HealthTokyoJapan Department of Public Health Sciences Yamaguchi Prefectural Institute of Public Health and Environment Yamaguchi CityYamaguchiJapan Microbiological Testing and Research Division Yokohama City Institute of Public HealthYokohamaKanagawaJapan Department of Microbiology Fukushima Prefectural Institute of Public HealthFukushima CityFukushimaJapan Department of Infectious Diseases Kobe Institute of HealthKobeHyogoJapan Department of Bacteriology Toyama Institute of HealthImizuToyamaJapan Infectious Disease Research Division Hyogo Prefectural Institute of Public Health ScienceKakogawaHyogoJapan Department of Health Science Iwate Prefectural Research Institute for Environmental Sciences and Public HealthMoriokaIwateJapan Division of Microbiology Kyoto City Institute of Health and Environmental SciencesKyoto CityKyotoJapan Niigata City Institute of Public Health and the Environment Niigata CityNiigataJapan Skaggs School of Pharmaceutical Sciences University of California at San DiegoLa JollaCAUSA.

Invasive infection caused by Streptococcus pyogenes emm89 strains has been increasing in several countries linked to a recently emergent clade of emm89 strains,designated clade *** Japan,the features of emm89 *** strains,such as clade classification,remains *** this study,we collected emm89 strains isolated from both streptococcal toxic shock syndrome(STSS)(89 STSS isolates)and noninvasive infections(72 non-STSS isolates)in Japan from 2011 to 2019,and conducted wholegenome sequencing and comparative analysis,which resulted in classification of a large majority into clade 3 regardless of disease *** addition,invasive disease-associated factors were found among emm89 strains,including mutations of control of virulence sensor,and absence of the hylP1 gene encoding *** findings provide new insights into genetic features of emm89 strains.

关键词： clade 3 emm89 streptococcal toxic shock syndrome Streptococcus pyogenes

Vacuum Insulation and Achievement of 980 keV,185 A/m^2 H-Ion Beam Acceleration at JAEA for the ITER Neutral Beam Injector

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Plasma Science and Technology 2013年第2期15卷 179-183页

作者： Hiroyuki TOBARI Masaki TANIGUCHI Mieko KASHIWAGI Masayuki DAIRAKU Naotaka UMEDA Haruhiko YAMANAKA Kazuki TSUCHIDA Jumpei takemoto Kazuhiro WATANABE Takashi INOUE Keishi SAKAMOTO Japan Atomic Energy Agency (JAEA) Mukouyama 801-1 Naka Ibaraki 311-1093 Japan

Abstract Vacuum insulation of -1 MV is a common issue for the HV bushing and the accel- erator for the ITER neutral beam injector （NBI）. The HV bushing as an insulating feedthrough has a five-stage structure and each stage consists of double-layered insulators. To sustain -1 MV in vacuum, reduction of electric field at several triple points existing around the double-layered insulators is a critical issue. To reduce electric field simultaneously at these points, three types of stress ring have been developed. In a voltage holding test of a full-scale mockup equipped with these stress rings, 120% of rated voltage was sustained and the voltage holding capability required in ITER was verified. In the MeV accelerator, whose target is the acceleration of a H- ion beam of 1 MeV, 200 A/mS, the gap between the grid support was extended to suppress breakdowns triggered by electric field concentration at the edge and corner of the grid support. This modi- fication improved the voltage holding capability in vacuum, and the MeV accelerator succeeded in sustaining -1 MV stably, b-~rthermore, it appeared that the H- ions beam was deflected and a part of the beam was intercepted at the acceleration grid, This causes high heat load on the grids and breakdowns during beam acceleration. To suppress the direct interception, a new grid was designed with proper aperture displacement based on a three dimensional beam trajectory analysis, As a result, 980 keV, 185 A/ms H- ion beam acceleration has been demonstrated, which is close to the ITER requirement.

关键词： neutral beam injector (NBI) negative ion beam HV bushing vacuum insu-lation