Prediction of flare-ups of ulcerative colitis using quantitative immunochemical fecal occult blood test

作     者：Motoaki Kuriyama Jun Kato Koji Takemoto Sakiko Hiraoka Hiroyuki Okada Kazuhide Yamamoto 

作者机构：Department of Gastroenterology and HepatologyOkayama University Graduate School of MedicineDentistryand Pharmaceutical Sciences 

出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)

年 卷 期：2010年第16卷第9期

页      面：1110-1114页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

主　　题：Flare-ups Immunochemical fecal occult blood test Inflammatory bowel disease Prediction Ulcerative colitis 

摘      要：AIM:To examine the feasibility of predicting the flareup of ulcerative colitis (UC) before symptoms emerge using the immunochemical fecal occult blood test (IFOBT).METHODS:We prospectively measured fecal hemoglobin concentrations in 78 UC patients using the I-FOBT every 1 or 2 ***:During a 20 mo-period,823 fecal samples from 78 patients were *** median concentration of fecal hemoglobin was 41 ng/mL (range:0-392 500 ng/mL).There were three types of patients with regard to the correlation between I-FOBT and patient symptoms;the synchronous transition type with symptoms (44 patients),the unrelated type withsymptoms (19 patients),and the flare-up predictive type (15 patients).In patients with the flare-up predictive type,the values of I-FOBT were generally low during the study period with stable *** to four weeks before the flare-up of symptoms,the I-FOBT values were ***,in these patients,I-FOBT could predict the flare-up before symptoms ***:Flare-up could be predicted by I-FOBT in approximately 20% of UC *** results warrant periodical I-FOBT in UC patients.