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CA19-9 level determines therapeutic modality in pancreatic cancer patients with para-aortic lymph node metastasis

Hepatobiliary & Pancreatic Diseases International 2018年第1期17卷 75-80页

作者： tadafumi asaoka Atsushi Miyamoto Sakae Maeda Naoki Hama Masanori Tsujie Masataka Ikeda Mitsugu Sekimoto Shoji Nakamori Department of Surgery National Hospital Organization Osaka National Hospital

Background: In general, para-aortic lymph node(LN16) metastasis has been considered as a contraindication for pancreatic resection. However, some pancreatic cancer patients with LN16 metastasis have been reported to survive for longer than expected after pancreatectomy. The purpose of this study was to determine whether pancreatic cancer patients with LN16 metastasis might benefit from ***: We retrospectively reviewed 201 consecutive patients with invasive pancreatic ductal adenocarcinoma who underwent surgery at Osaka National Hospital between April 2003 and December *** patients included 22 patients with LN16 metastasis who underwent an extended lymphadenectomy and 25 patients who underwent a palliative surgical biliary and gastric bypass. The clinicopathological data and outcomes were evaluated using univariate and multivariate ***: The overall survival of the patients with LN16 metastasis was poorer than that of the LN16-negative patients(P = 0.0014). An overall survival analysis of the LN16-positive patients stratified according to the preoperative CA19-9 level showed a significant difference between patients with a low preoperative CA19-9 level(≤360 U/mL) and those with a high preoperative CA19-9 level(>360 U/mL)(P = 0.0301). No significant difference in overall survival of patients was observed between those with LN16 positivity and those who underwent bypass surgery. However, the overall survival of the LN16-positive patients with a CA19-9 level ≤360 U/mL(n = 11) was significantly higher than that of those who underwent bypass surgery(P = 0.0452).Conclusion: Surgical resection and extended lymphadenectomy remains an option for pancreatic cancer patients with LN16-positivity whose CA19-9 level is ≤360 U/mL.

关键词： Pancreatic cancer CA19-9 Para-aortic lymph node

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Throughfall and stemflow chemical dynamics of Satoyama, a traditional secondary forest system under threat in Japan

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Journal of Forestry Research 2022年第3期33卷 813-826页

作者： Satoshi asaoka Fuyuhiko Sumikawa Yoshifumi Watanabe Waqar Azeem Jadoon Masaki Ohno Nobumichi Shutoh Yuki Wakamatsu Lawrence M.Liao Akane Kanazawa Yuka Sato Natsumi Fujiwara Graduate School of Integrated Sciences for Life Hiroshima University1-4-4 KagamiyamaHigashi-Hiroshima739-8528Japan Research Center for Inland Seas Kobe University5-1-1 FukaeminamiHigashinadaKobe658-0022Japan Naragakuen Senior High School 430 YamadaYamatokoriyamaNara639-1093Japan Department of Environmental Sciences Faculty of Natural and Computational SciencesHazara UniversityDhodiaMansehra21130Khyber PakhtunkhwaPakistan Niigata University of Pharmacy and Applied Life Sciences 265-1 HigashijimaAkihaNiigata956-8603Japan Faculty of Science and Engineering Kindai University3-4-1 KowakaeHigashi-OsakaOsaka577-8502Japan Department of Maritime Science and Technology Japan Coast Guard Academy5 WakabaKureHiroshima737-8512Japan

The term 'Satoyama' refers to traditional and unique secondary forests in Japan that occupy intermediate zones between villages ('sato') and hills or mountains ('yama'). Satoyama landscapes help sustain ecosystem services and the diversity of secondary natural environments. As Japan relies more heavily on foreign timber imports, the traditional role of Satoyama in providing forest products has diminished, and this has led to their abandonment and poor management. The chemical behavior of cations, anions, and dissolved organic matter in throughfall and stemflow from one such threatened Satoyama system in central Japan was investigated. From autumn to winter, the atmospheric deposition of sulfates and nitrates was 2.5–6.0 times higher compared to the amounts in summer due to the intrusion of air masses from the Asian continent. The dissolved organic matter in the throughfall and stemflow was composed mainly of humic substances and protein derivatives. The deposition fluxes of dissolved organic carbon from throughfall (7.31–10.1 g m^(−2) a^(−1)) and stemflow (1.79–3.84 g m^(−2) a^(−1)) in this study were within ranges seen in temperate forests in previous studies. The deposition flux of sulfates was low compared to that in other forest types because canopy interaction was lower, suggesting higher canopy openness than in primary forests. If a shift from a mixed species Satoyama forest to a conifer-dominated forest occurs after the mass mortality of oak, the deposition flux of dissolved organic carbon and K^(+) might decrease by 33% and 62%, respectively, while NO_(3)^(−) might increase by 20%. In the near future, the degradation of Satoyama landscapes might change the levels of dissolved organic carbon and nitrogen loads, resulting in imbalances in river-ocean linkages affecting forested catchments and aquatic ecosystems in Japan.

关键词： Atmospheric deposition Dissolved organic matter Humic substance Mass mortality Oak trees Sustainable development goals

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Surface properties of nitrogen-ion-implanted TiNi shape memory alloy

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Journal of University of Science and Technology Beijing 2006年第2期13卷 154-157页

作者： Chongyan Leng Teruo asaoka Rong Zhou School of Materials and Metallurgical Engineering Kunming University of Science and Technology Kunming 650093 China Department of Intelligent and Mechanical Engineering Tokyo Denki University Hatoyama Hiki-Gun Saitama 350-0394 Japan School of Mechanical Engineering Kunming University of Science and Technology Kunming 650093 China

X-ray diffraction （XRD）, auger electron spectroscopy （AES）, and X-ray photoelectron spectroscopy （XPS） were used to characterize the surface properties of the N^ ＋-ion-implanted TiNi alloy. There is a high nitrogen content region at the outermost surface of the N^＋-ion-implanted TiNi alloy. The detected nitrogen exists mainly in the form of TiN. Small amounts of Ti305 and TiO2 also exist on the surface of the N^＋-ion-implanted TiNi sample. The modified layer of the N^＋-ion-implanted sample can work as an obstacle layer of the nickel＇s dissolution, which obstructs Ni dissolving from the TiNi surface effectively.

关键词： shape memory alloys TiNi surface properties

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Resin Catalyst Hybrids

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复旦学报（自然科学版） 2005年第5期44卷 644-645页

作者： S. asaoka Faculty of Environmental Engineering The University of KitakyushuKitakyushu 808-0135 Japan

1Introduction: What are resin catalyst hybrids?There are typically two types of resin catalyst. One is acidic resin which representative is polystyrene sulfonic acid. The other is basic resin which is availed as metal complex support. The objective items of this study on resin catalyst are consisting of pellet hybrid, equilibrium hybrid and function hybrid of acid and base,as shown in Fig. 1[1-5]

关键词：树脂催化剂混合物磺酸基

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Epigenetic Regulation of Serotonin Transporter in Psychiatric Disorders

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Journal of Genetics and Genomics 2013年第7期40卷 325-329页

作者： Hiroko Sugawara Miki Bundo Jun Ishigooka Kazuya Iwamoto tadafumi Kato Laboratory for Molecular Dynamics of Mental Disorders RIKEN Brain Science Institute2-1 HirosawaWakoSaitama 351-0198Japan Department of Psychiatry Tokyo Women's Medical UniversityTokyo 162-8666Japan Department of Molecular Psychiatry Graduate School of MedicineUniversity of TokyoTokyo 113-8655Japan Department of Psychiatry.Tokyo Women's Medical University Tokyo 162-8666Japan

SLC6A4 （solute carrier family 6, member 4） gene encodes a serotonin transporter （5-hydroxytryptamine transporter, HTT）, which transports synaptic serotonin into presynaptic terminal. SLC6A4 is known to be the target of antidepressants such as selective serotonin reuptake inhibitors （SSRIs）. Inhibition of HTT increases synaptic serotonin concentration and thereby exerts antidepressant efficacy. A large number of genetic studies suggest the contribution of genetic variations of SLC6A4 to various psychiatric disorders. The most studied genetic variation, HTT-linked polymorphic region （HTTLPR）,

关键词： SLC Epigenetic Regulation of Serotonin Transporter in Psychiatric Disorders

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二氧化铈纳米晶的晶面调控机制及催化性能研究

二氧化铈纳米晶的晶面调控机制及催化性能研究

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第十四届中国包头·稀土产业论坛、中国稀土学会2022学术年会

作者：郝晓东徐阳许并社 tadafumi Adschiri Yuichi Ikuhara

二氧化铈（CeO）,作为一种十分重要的稀土氧化物材料,在催化、固态燃料电池、生物等领域都有着十分广泛的应用前景。我国的稀土资源储量非常丰富,占世界总储量的80%,其中铈在地壳中的丰富度占居25位。我国的CeO产品的贸易量虽然很大,可... 详细信息

二氧化铈（CeO）,作为一种十分重要的稀土氧化物材料,在催化、固态燃料电池、生物等领域都有着十分广泛的应用前景。我国的稀土资源储量非常丰富,占世界总储量的80%,其中铈在地壳中的丰富度占居25位。我国的CeO产品的贸易量虽然很大,可是产品的质量和精度却一直没有得到明显的提升,价格比较低廉。纳米CeO的优势主要体现在:颗粒尺寸较小、表面原子配位不全、内部Ce离子价态的变化等因素使其表面活性增强;并且随着颗粒尺寸的减小,会形成凹凸不平的原子台阶,进一步增加反应接触面积,表现出更加优异的反应活性。因此,通过合理改变合成工艺,精确设计与调控具备特定形貌、暴露晶面、晶粒尺寸的高活性CeO至关重要。基于此,我们采用的超临界水热合成方法,合成单分散的立方CeO纳米晶,并系统改变表面修饰条件,合成不同暴露面、晶粒尺寸的CeO纳米晶,并结合先进的球差校正扫描透射电子显微镜（AC-STEM）及电子能量损失谱（EELS）多种分析手段对不同晶面进行深入分析,探究纳米晶的生长机理[1,2]。与此同时,我们定量地研究了纳米晶中Ce离子化学价态的分布规律,结合第一性原理计算深入讨论了纳米尺寸效应、掺杂元素、晶格结构和离子化学价态之间的相互关系[3,4]。此外,通过其他活性元素掺杂复合,进一步探讨CeO纳米晶的催化性[5]。本研究聚焦CeO纳米晶,深入讨论CeO纳米晶的晶面演变机制,并对不同暴露晶面的CeO纳米晶的离子价态、表面化学、原子结构等物理化学性质进行探讨,为进一步设计与合成高活性和高质量的CeO纳米晶提供可靠的理论依据和实验数据。

关键词： CeO2纳米晶可控生长晶面调控 Ce离子价态催化性能

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Corticotropin-releasing factor secretion from dendritic cells stimulated by commensal bacteria

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World Journal of Gastroenterology 2011年第35期17卷 4017-4022页

作者： Mariko Hojo Toshifumi Ohkusa Harumi Tomeoku Shigeo Koido Daisuke asaoka Akihito Nagahara Sumio Watanabe Department of Gastroenterology Juntendo University School of MedicineTokyo 113-8421Japan Department of Gastroenterology and Hepatology The Jikei University Kashiwa HospitalChiba 277-8567Japan

AIM:To study the production and secretion of corticotropin-releasing factor (CRF) by dendritic cells and the influence of commensal ***:JAWSⅡ cells (ATCC CRL-11904),a mouse dendritic cell line,were seeded into 24-well culture plates and grown for 3 *** bacterial strains of Clostridium clostrodiiforme (JCM1291),Bacteroides vulgatus (***) (JCM5856),Escherichia coli (JCM1649),or Fusobacterium varium (***) (ATCC8501) were added to the cells except for the control well,and incubated for 2 *** incubation,we performed enzyme-linked immunosorbent assay for the cultured medium and reverse transcription polymerase chain reaction for the dendritic cells,and compared these values with ***:The level of CRF secretion by control dendritic cells was 40.4±6.2 pg/*** CRF levels for cells incubated with *** and *** were significantly higher than that of the control (P<0.0001).CRF mRNA was present in the control sample without bacteria,and CRF mRNA levels in all samples treated with bacteria were above that of the control *** caused the greatest increase in CRF mRNA ***:Our results suggest that dendritic cells produce CRF,a process augmented by commensal bacteria.

关键词：促肾上腺皮质激素释放因子树突状细胞共生细菌细胞分泌慢性肾功能衰竭逆转录聚合酶链反应酶联免疫吸附试验 mRNA水平

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Evaluation of rebound tonometer iCare IC200 as compared with IcarePRO and Goldmann applanation tonometer in patients with glaucoma

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Eye and Vision 2021年第1期8卷 244-252页

作者： Shunsuke Nakakura Ryo asaoka Etsuko Terao Yuki Nagata Yasuko Fukuma Satomi Oogi Miku Shiraishi Yoshiaki Kiuchi Department of Ophthalmology Saneikai Tsukazaki Hospital68-1 Aboshi WakuHimeji 671-1227Japan Department of Ophthalmology Seirei Hamamatsu General HospitalHamamatsuShizuokaJapan Seirei Christopher University HamamatsuShizuokaJapan Department of Ophthalmology and Visual Sciences Graduate School of Biomedical SciencesHiroshima UniversityHiroshimaJapan

Background:This study investigated the agreement between a new rebound tonometer,IC200,and IcarePRO and Goldmann applanation tonometry(GAT).Methods:This was a prospective cross-sectional *** measured the intraocular pressure(IOP)in 145 eyes of 145 glaucoma patients in the sitting position using GAT,IcarePRO,and *** and IC200 measurements were also obtained in the supine ***200 measurement was performed using two modes:single six(IC200-single)and automatic(IC200-continuous)six-measurements ***:All tonometers provided high reproducibility in both positions(all intraclass correlation coefficients>0.90),although it was highest with GAT,followed by IC200-continuous and IC200-single and then *** the sitting position,the mean(±SD)IOPs of GAT,IcarePRO,IC200-single,and IC200-continuous were 14.5±2.9 mmHg,13.3±3.2 mmHg,11.6±3.2 mmHg,and 11.5±3.2 mmHg,*** measured with IcarePRO or IC200 were significantly lower than those with GAT,particularly in patients with low *** measured with all tonometers were significantly elevated in the supine position as compared with the sitting position,but this difference was significantly greater with IC200-single and IC200-continuous compared with *** elevation was significant in eyes without bleb versus those with bleb,but this finding was not observed when IOP was measured with *** IOPs of the single and continuous modes of IC200 were interchangeable in both ***:GAT,IcarePRO,and IC200 had sufficiently high reproducibility,but measurements with IcarePRO may not be accurate in the supine *** of IOP in the supine position,especially in eyes with bleb,was more sensitively captured with IC200 than with IcarePRO.

关键词： Glaucoma IC200 IcarePRO Rebound tonometer Goldmann applanation tonometer

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Characteristic pathological findings and effects of ecabet sodium in rat reflux esophagitis

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World Journal of Gastroenterology 2009年第28期15卷 3480-3485页

作者： Daisuke asaoka Akihito Nagahara Masako Oguro Yuko Izumi Akihiko Kurosawa Taro Osada Masato Kawabe Mariko Hojo Michiro Otaka Sumio Watanabe Department of Gastroenterology Juntendo University School of Medicine

AIM:To explore the pathological flndings in the entire esophagus in rats with reflux esophagitis, and the effects of ecabet sodium(ES).METHODS:A rat model of chronic acid reflux esophagitis was *** the treatment group, ES was administered after surgery(n = 16).No drug was administered postoperatively to the esophagitis group(n = 9).Shamoperated rats were used as a control group(n = 5).Rats were sacriflced on day 7 after the *** epithelial thickness and leukocyte inflltration were examined in the upper, middle and lower areas of the *** survival rate, incidence of esophageal ulcer, and mean surface area and number of esophageal ulcers were determined in the esophagitis and ES *** histology was assessed in all three ***:Leukocyte infiltration in the esophagitis group was 26.3 ± 22.0 in the middle esophagus and 8.2 ± 4.9 in the upper esophagus, which was signiflcantly greater than that in the controls(1.3 ± 1.1 and 1.4 ± 1.0, respectively)(P < 0.05).The thickness of the epithelium in the esophagitis group was 210.8 ± 47.7 μm in the lower esophagus and 204.2 ± 60.1 μm in the middle esophagus, which was significantlygreater than that in the controls(26.0 ± 5.5 and 21.0 ± 6.5 μm, respectively)(P < 0.05).The mean number of ulcers per animal in the ES group in the entire esophagus was 5.4 ± 2.5, which was signiflcantly less than that in the esophagitis group(9.0 ± 3.5)(P < 0.05).The epithelial thickness in the ES group was 97.5 ± 32.2 μm in the lower esophagus, which was decreased compared with that in the esophagitis group(210.8 ± 47.7 μm)(P < 0.05).CONCLUSION:Mucosal inflammation extended to the upper esophagus close to the *** study suggested that ES may have a useful defensive role in reflux esophagitis.

关键词：特征和食管大鼠病理钠

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Molecular Basis of Bipolar Disorder

Molecular Basis of Bipolar Disorder

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亚太地区国际脑研究研讨会

作者： Takaoki Kasahara tadafumi Kato Laboratory for Molecular Dynamics of Mental Disorders RIKEN Brain Science Institute Japan Laboratory for Molecular Dynamics of Mental Disorders RIKEN Brain Science Institute Japan

＜正＞ Bipolar disorder, previously known as manic depressive illness, affects approximately 0.8% of the population and causes severe psychosocial impairment. High concordance rate of bipolar disorder in monozygotic twins （approximately 70%） suggests the role of genetic factors in this *** energy metabolism in the brains of patients with bipolar disorder has been reported using phosphorus magnetic resonance spectroscopy （31P-MRS）. Some of the 31P-MRS findings in bipolar disorder, such as reduced phosphocreatine levels, were similar to those reported in patients with a mitochondrial disorder, i.e. mitochondrial myopathy, chronic

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