Epigenetic Regulation of Serotonin Transporter in Psychiatric Disorders

作     者：Hiroko Sugawara Miki Bundo Jun Ishigooka Kazuya Iwamoto Tadafumi Kato 

作者机构：Laboratory for Molecular Dynamics of Mental DisordersRIKEN Brain Science Institute2-1 HirosawaWakoSaitama 351-0198Japan Department of PsychiatryTokyo Women's Medical UniversityTokyo 162-8666Japan Department of Molecular PsychiatryGraduate School of MedicineUniversity of TokyoTokyo 113-8655Japan Department of Psychiatry.Tokyo Women's Medical UniversityTokyo 162-8666Japan 

出 版 物：《Journal of Genetics and Genomics》 (遗传学报（英文版）)

年 卷 期：2013年第40卷第7期

页      面：325-329页

核心收录：

学科分类：1002[医学-临床医学] 100205[医学-精神病与精神卫生学] 10[医学] 

主　　题：SLC Epigenetic Regulation of Serotonin Transporter in Psychiatric Disorders 

摘      要：SLC6A4 （solute carrier family 6, member 4） gene encodes a serotonin transporter （5-hydroxytryptamine transporter, HTT）, which transports synaptic serotonin into presynaptic terminal. SLC6A4 is known to be the target of antidepressants such as selective serotonin reuptake inhibitors （SSRIs）. Inhibition of HTT increases synaptic serotonin concentration and thereby exerts antidepressant efficacy. A large number of genetic studies suggest the contribution of genetic variations of SLC6A4 to various psychiatric disorders. The most studied genetic variation, HTT-linked polymorphic region （HTTLPR）,