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Current trends in perioperative treatment of resectable gastric cancer

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World Journal of Gastrointestinal Surgery 2023年第3期15卷 323-337页

作者： İbrahim y.ldız Leyla Özer Elif Şenocak taşçı İbrahim Vedat Bayoglu Erman Aytac Department of medical Oncology Acıbadem MAA Universityİstanbul 34567Turkey Department of medical Oncology Acıbadem Universityİstanbul 34567Turkey Department of medical Oncology Marmara Universityİstanbul 12345Turkey Department of Surgery Acibadem University School of MedicineIstanbul 34567Turkey

In the last few decades,the treatment strategy for locally advanced resectable gastric cancer(GC)has shifted to a multimodal approach,which potentially decreases recurrence risk and improves survival *** therapy leads to downstaging,increased curative resection rates,and prolonged disease-free and overall survival,by preventing micrometastases in patients with resectable *** of neoadjuvant therapy provides information about tumor biology and in vivo sensitivity.A consensus regarding the therapeutic approach for non-metastatic GC does not exist,and many clinical trials aim to clarify this *** in precision medicine and the role of immunotherapy have been the focus of research in GC ***,the current status and possible future developments of perioperative therapy for locally advanced resectable GC are reviewed,based on the most recent randomized clinical trials.

关键词： Perioperative treatment Immunotherapy Neoadjuvant Chemotherapy Gastric cancer Adjuvant

Does glioblastoma cyst fluid promote sciatic nerve regeneration?

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Neural regeneration research 2015年第10期10卷 1643-1649页

作者： rafet ?zay Abit Akta? mevlüt ?zgür ta?kap?l?o?lu Bora Gürer Bülent Erdo?an yusuf ?ükrü ?a?lar Department of Neurosurgery Diskapi Y?ld?r?m Beyaz?t Educational and Research Hospital Department of Histology and Embryology Faculty of Veterinary Medicine Istanbul University Department of Neurosurgery School of Medicine Uluda? University Fatih Sultan mehmet Education and research Hospital Department of Neurosurgery School of Medicine Fatih University Department of Neurosurgery School of Medicine Ankara University

Glioblastoma cyst fluid contains growth factors and extracellular matrix proteins which are known as neurotrophic and neurite-promoting agents. Therefore, we hypothesized that glioblastoma cyst fluid can promote the regeneration of injured peripheral nerves. To validate this hypothesis, we transected rat sciatic nerve, performed epineural anastomosis, and wrapped the injured sciatic nerve with glioblastoma cyst fluid- or saline-soaked gelatin sponges. Neurological function and histomorphological examinations showed that compared with the rats receiving local saline treatment, those receiving local glioblastoma cyst fluid treatment had better sciatic nerve function, fewer scars, greater axon area, counts and diameter as well as fiber diameter. These findings suggest that glioblastoma cyst fluid can promote the regeneration of injured sciatic nerve and has the potential for future clinical application in patients with peripheral nerve injury.

关键词： nerve regeneration peripheral nerve injury sciatic nerve injury cyst fluid glioblastoma growth factors neural regeneration

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葡萄枝屑栽培平菇的产量及营养成分效应研究

河南农业科学 2017年第6期46卷 93-97页

作者：忻龙祚金亚征常美花吴伟刚塔秀成王激清河北北方学院园艺系河北张家口075400

为解决平菇栽培原料供应价格飙升、供应紧张的现状,以平菇为试材,在平菇栽培培养料中按不同比例添加葡萄枝屑(0、30%、50%、70%),研究葡萄枝屑对平菇菌丝体生长、子实体产量及子实体营养成分的影响。先将葡萄枝屑、玉米芯、土霉素药渣... 详细信息

为解决平菇栽培原料供应价格飙升、供应紧张的现状,以平菇为试材,在平菇栽培培养料中按不同比例添加葡萄枝屑(0、30%、50%、70%),研究葡萄枝屑对平菇菌丝体生长、子实体产量及子实体营养成分的影响。先将葡萄枝屑、玉米芯、土霉素药渣等原料按不同比例浸泡混匀,装袋培养灰色平菇栽培种,采用柱前衍生反相高效液相色谱法测定平菇子实体氨基酸含量,按照国家标准测定方法测定平菇中微量元素含量。结果表明:添加适宜比例葡萄枝屑栽培平菇,菌丝体长势强,生长速率高,菌丝洁白、粗壮、紧密;添加葡萄枝屑可显著提高平菇产量,其中以添加50%葡萄枝屑的平菇产量最高(324.0 g/袋),且加入葡萄枝屑3个处理的生物学效率为90.3%~99.7%;添加葡萄枝屑可提高平菇子实体中铁、锌、硼等微量元素的含量;4个基质配方栽培的平菇基本能满足人体对必需氨基酸的搭配需求,且添加葡萄枝屑栽培的平菇赖氨酸含量显著高于不添加葡萄枝屑的对照。因此,加入葡萄枝屑可提高平菇的产量及微量元素含量,满足人体对必需氨基酸的需求。

关键词：葡萄枝屑平菇菌丝体产量微量元素氨基酸

河北滦平球状闪长岩岩石地球化学特征与源区性质探讨

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地球化学 2004年第6期33卷 593-601页

作者：马芳穆治国刘玉琳 r.J.Fleck 南京大学地球科学系成矿作用机制研究国家重点实验室北京大学地球与空间科学学院 U.S.Geological Survey 345 middle field rd. Ms937Menlo ParkCA945025American

滦平球状闪长岩体具有特殊的地球化学性质,其中最显著的岩石化学特征表现为高度富Al2O3(21.58%～26.80%)而相对贫K2O(0.35%～1.87%)。地球化学方面以异常高的Sr含量和较高的Ba含量、极低的稀土元素总量、明显的Eu正异常为特征而明显不同... 详细信息

滦平球状闪长岩体具有特殊的地球化学性质,其中最显著的岩石化学特征表现为高度富Al2O3(21.58%～26.80%)而相对贫K2O(0.35%～1.87%)。地球化学方面以异常高的Sr含量和较高的Ba含量、极低的稀土元素总量、明显的Eu正异常为特征而明显不同于SiO2含量类似的其他钙碱性岩类。此外,该球状闪长岩体还表现为贫Nb、ta、Zr、Hf、y等高场强元素和Th、U、rb等强不相容元素,较强的轻重稀土元素分馏程度,岩石地球化学的总体特征可与埃达克岩相对比,但其Eu正异常和Sr正异常更为明显。岩体中球体的Sr同位素初始值为0.70533～0.70537,核部斜长角闪岩捕虏体和壳层的εNd(t)有明显的差别,分别为-12.6和-17.7,Nd同位素地壳保留年龄分别为2.11Ga和2.64Ga,表明它们来自古老地壳的不同层位。滦平球状闪长质岩浆可能是由新太古代亏损型拉斑玄武质斜长角闪岩选择性部分熔融(主要是斜长石)形成的高Al2O3岩浆,它们在上升过程中捕获了古元古代的斜长角闪岩。

关键词：地球化学亏损型拉斑玄武质岩石选择性部分熔融滦平岩体河北省

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抗乙酰胆碱受体单链抗体的纯化

延边大学医学学报 2004年第2期27卷 79-83页

作者：杨康鹃孟繁平 de Baets m. 延边大学医学院细胞生物学与医学遗传学教研室吉林延吉133000 延边大学医学院微生物学与免疫学教研室吉林延吉133000 荷兰马斯特里赫特大学医学院神经学系

[目的 ]纯化抗乙酰胆碱受体单链抗体 ,为测定其特异性准备材料 .[方法 ]将大肠杆菌表达的单链抗体 (含有 6xHis及c myc标记肽 )经Ni nitrilotriaceticacid(Ni Nta)纯化 ,以十二烷基硫酸钠聚丙烯酰胺凝胶电泳和应用鼠抗c myc单克隆抗... 详细信息

[目的 ]纯化抗乙酰胆碱受体单链抗体 ,为测定其特异性准备材料 .[方法 ]将大肠杆菌表达的单链抗体 (含有 6xHis及c myc标记肽 )经Ni nitrilotriaceticacid(Ni Nta)纯化 ,以十二烷基硫酸钠聚丙烯酰胺凝胶电泳和应用鼠抗c myc单克隆抗体的免疫印迹试验鉴定纯化产物 ,并根据吸光度值测定表达产物的含量 .[结果 ]在纯化产物中发现大小约为 36KD的单链抗体 ,杂质蛋白带较少 ,表达量约为30 μg/L .[结论 ]用Ni Nta纯化带有 6xHis标记肽的单链抗体的方法简单、纯度高 ,以大肠杆菌表达抗乙酰胆碱受体单链抗体时产量低 .

关键词：抗体受体胆碱能纯化