Does glioblastoma cyst fluid promote sciatic nerve regeneration?

作     者：Rafet ?zay Abit Akta? Mevlüt ?zgür Ta?kap?l?o?lu Bora Gürer Bülent Erdo?an Yusuf ?ükrü ?a?lar 

作者机构：Department of Neurosurgery Diskapi Y?ld?r?m Beyaz?t Educational and Research Hospital Department of Histology and Embryology Faculty of Veterinary Medicine Istanbul University Department of Neurosurgery School of Medicine Uluda? University Fatih Sultan Mehmet Education and Research Hospital Department of Neurosurgery School of Medicine Fatih University Department of Neurosurgery School of Medicine Ankara University 

出 版 物：《Neural Regeneration Research》 (中国神经再生研究（英文版）)

年 卷 期：2015年第10卷第10期

页      面：1643-1649页

核心收录：

学科分类：0710[理学-生物学] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 100214[医学-肿瘤学] 10[医学] 

主　　题：nerve regeneration peripheral nerve injury sciatic nerve injury cyst fluid glioblastoma growth factors neural regeneration 

摘      要：Glioblastoma cyst fluid contains growth factors and extracellular matrix proteins which are known as neurotrophic and neurite-promoting agents. Therefore, we hypothesized that glioblastoma cyst fluid can promote the regeneration of injured peripheral nerves. To validate this hypothesis, we transected rat sciatic nerve, performed epineural anastomosis, and wrapped the injured sciatic nerve with glioblastoma cyst fluid- or saline-soaked gelatin sponges. Neurological function and histomorphological examinations showed that compared with the rats receiving local saline treatment, those receiving local glioblastoma cyst fluid treatment had better sciatic nerve function, fewer scars, greater axon area, counts and diameter as well as fiber diameter. These findings suggest that glioblastoma cyst fluid can promote the regeneration of injured sciatic nerve and has the potential for future clinical application in patients with peripheral nerve injury.