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China & The World Cultural Exchange 2024年第3期 24-27页

作者： Wang tiantian 不详

Longquan celadon is deeply meaningful in history and possesses multiple attributes including aesthetics,practicality,science,and cultural exchange,offering unique advantages in empowering traditional cultural dissemin... 详细信息

关键词： beautiful offering connecting

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羊水栓塞术后腹壁血肿3例临床分析

中国临床医学 2007年第5期14卷 713-714页

作者：汪萍苏悦周甜甜扬州大学医学院附属医院妇产科江苏扬州225001

羊水栓塞是一种少见但凶险的产科并发症,临床表现主要是迅速出现心肺功能衰竭,凝血功能障碍及急性肾功能衰竭.治疗中常需剖宫产终止妊娠,或因难治性子宫出血而需切除子宫.我院3例羊水栓塞进腹手术后发生腹壁血肿,本文对其致病因素及防... 详细信息

羊水栓塞是一种少见但凶险的产科并发症,临床表现主要是迅速出现心肺功能衰竭,凝血功能障碍及急性肾功能衰竭.治疗中常需剖宫产终止妊娠,或因难治性子宫出血而需切除子宫.我院3例羊水栓塞进腹手术后发生腹壁血肿,本文对其致病因素及防治进行探讨.

关键词：羊水栓塞腹壁血肿临床分析栓塞术后心肺功能衰竭凝血功能障碍产科并发症肾功能衰竭

微课在高校音乐专业教学中的功能性应用:从教学任务谈起

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齐鲁艺苑（山东艺术学院学报） 2020年第3期 116-122页

作者：周甜甜烟台大学音乐与舞蹈学院山东烟台264005

使用文献资料法梳理微课的起源与发展,并界定微课的概念--微课是为实现教学目的、完成教学任务所采用的借助信息技术进行片段学习的数字资源及其教学方式的统称。在高等学校音乐专业的教学中使用微课,有助于音乐教学目的的达成和任务的... 详细信息

使用文献资料法梳理微课的起源与发展,并界定微课的概念--微课是为实现教学目的、完成教学任务所采用的借助信息技术进行片段学习的数字资源及其教学方式的统称。在高等学校音乐专业的教学中使用微课,有助于音乐教学目的的达成和任务的完成,微课主要通过改变音乐知识传授方式、促进音乐技能习得、强化音乐能力发展和完善音乐个性(风格)等方式发挥作用。

关键词：微课高校音乐专业教学

Chemotactic nanomotor for multimodal combined therapy of glioblastoma

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Science China Chemistry 2024年第4期67卷 1277-1288页

作者： Ting Li Lin Chen Yunxin Xue Xiangyu Xiao Wenjun Dai Kaiyuan Tan tiantian Chen Yingfang Tao Chun Mao Jian Shen Mimi Wan National and Local Joint Engineering Research Center of Biomedical Functional Materials School of Chemistry and Materials ScienceNanjing Normal UniversityNanjing 210023China

Glioblastoma(GBM) is the most aggressive malignant brain tumor. Due to the infiltration and heterogeneity of GBM, the obstruction of the blood-brain barrier(BBB) and the unique immunosuppressive mechanism, it is hard to achieve significant effects of GBM treatment. Here, a kind of chemotactic nanomotor that loaded with glucose oxidase(GOx) and carboxylated cisplatin(Pt(IV)) prodrug on the L-arginine-derived polymer is proposed. The nanomotors are driven by catalysis of glucose decomposition and the positive chemotaxis towards the GBM microenvironment where inducible nitric oxide synthase and reactive oxygen species are highly expressed. This facilitates the BBB crossing and GBM targeting of the nanomotors. In addition, the released nitric oxide(NO) during propulsion as well as the loaded GOx and Pt(IV) can exert combined NO/starvation/chemotherapy. Meanwhile, it is able to induce and enhance the immune response through multiple pathways, thus better coping with the complexities of GBM treatment.

关键词： chemotaxis combined therapy glioblastoma nanomotors

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基于生物芯片检测大骨节病相关基因的甲基化

中华地方病学杂志 2017年第3期36卷 196-200页

作者：周天天史晓薇郭雄西安交通大学医学院公共卫生学院地方病研究所卫计委微量元素与地方病研究重点实验室西安710061 西安交通大学医学院第一附属医院儿科西安710061

目的采用基因芯片技术筛选大骨节病DNA差异甲基化位点和基因，探讨DNA甲基化与大骨节病发病机制的关系。方法收集12例大骨节病患者（病例组）、12例健康人（对照组）外周血血样，提取血液DNA，利用450K芯片技术检测病例组和对照组DNA的... 详细信息

目的采用基因芯片技术筛选大骨节病DNA差异甲基化位点和基因，探讨DNA甲基化与大骨节病发病机制的关系。方法收集12例大骨节病患者（病例组）、12例健康人（对照组）外周血血样，提取血液DNA，利用450K芯片技术检测病例组和对照组DNA的差异甲基化情况，并进行对照分析，按校正后P值和甲基化差异分值结合GenomeStudio软件筛选差异甲基化基因及位点，对筛选出的差异甲基化基因进一步采用亚硫酸氢钠处理后测序法（BSP）进行验证。结果共分析484948个位点，病例组和对照组差异显著的位点共93个，其中高甲基化位点34个．低甲基化位点59个。位点所对应的基因共50个，43个基因无文献报道。聚类分析结果显示，在免疫反应、抗原处理、磷和磷酸代谢及磷酸化作用、金属离子结合等过程中存在大量甲基化差异基因。利用BSP法验证，人类白细胞抗原（HIA）-DRB1基因在病例组与对照组间的甲基化率（48％比70％）无显著性差异（x^2=3．688，P〉0．05）。结论大骨节病人群外周血DNA存在不同于正常人群的高或低差异甲基化位点，BSP验证HLA—DRB1基因位点与甲基化芯片结果未发现显著性差异。

关键词：大骨节病 DNA甲基化基因芯片

High performance wide bandgap perovskite solar cell with low V_(OC) deficit less than 0.4 V

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Journal of Energy Chemistry 2024年第4期91卷 313-322页

作者： Haikuo Guo Fuhua Hou Xuli Ning Xiaoqi Ren Haoran Yang Rui Liu tiantian Li Chengjun Zhu Ying Zhao Wei Li Xiaodan Zhang School of Physical Science and Technology Key Laboratory of Semiconductor Photovoltaic Technology and Energy Materials at Universities of Inner Mongolia Autonomous RegionInner Mongolia UniversityHohhot 010021Inner MongoliaChina Institute of Photoelectronic Thin Film Devices and Technology of Nankai University Key Laboratory of Photoelectronic Thin Film Devices and Technology of TianjinSolar Energy Research Center of Nankai UniversityTianjin 300350China State Key Laboratory of Advanced Technology for Materials Synthesis and Processing Wuhan University of TechnologyWuhan 430000HubeiChina

Wide bandgap perovskite solar cells(PSCs)have attracted significant attention because they can be applied to the top cells of tandem solar ***,high open-circuit voltage(V_(OC))deficit(>0.4 V)result from poor crystallization and high non-radiative recombination losses become a serious limitation in the pursuit of high ***,the relevance between different Pbl_(2)proportions and performance parameters are revealed through analysis of surface morphology,residual stress,and *** increase of Pbl_(2)proportion promotes crystal growth and reduces the work function of the perovskite film surface and promotes the energy level alignment with the carrier transport layer,which decreased the V_(OC)***,residual PbI_(2)exacerbated the stress level of perovskite film,and the resulting lattice disorder deteriorated the photostability of the ***,after the synergistic passivation of residual PbI_(2)and PEAI,the V_(OC)achieves 1.266 V and V_(OC)deficit is less than 0.4 V,the record value in wide bandgap PSCs.

关键词： Pb management Perovskite solar cell Strain Wide bandgap Stability

两种氮浓度对轮叶黑藻(Hydrilla verticillata)腐解过程营养盐释放及附着生物膜内氮循环基因丰度的影响

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湖泊科学 2021年第3期33卷 749-760页

作者：刘敏张松贺张丽莎周甜甜刘远思河海大学环境学院南京210098

氨氮是地表水常见污染物,尤其在农业区域,氮类化肥的不合理施用会导致周边水体氮浓度迅速升高并保持较高水平.然而,当前对高氮水平下沉水植物腐败和附着氮循环微生物的影响尚不清楚.以轮叶黑藻(Hydrilla verticillata)为研究用沉水植物... 详细信息

氨氮是地表水常见污染物,尤其在农业区域,氮类化肥的不合理施用会导致周边水体氮浓度迅速升高并保持较高水平.然而,当前对高氮水平下沉水植物腐败和附着氮循环微生物的影响尚不清楚.以轮叶黑藻(Hydrilla verticillata)为研究用沉水植物,在实验室内模拟水体内8和16 mg/L氮浓度下轮叶黑藻腐解过程中营养盐释放及残体表面微生物氮循环功能基因丰度的变化.研究发现水体两种氮浓度下轮叶黑藻腐解过程中残体腐解及营养盐释放速率无显著差异;与对照相比,植物腐败初期水体内碳、磷浓度迅速增加,而溶解氧浓度及氧化还原电位迅速降低,随着时间的推移上述水质指标逐步恢复至初期状态(第146天);水体荧光溶解性有机质主要包括紫外类富里酸、可见类富里酸、色氨酸类蛋白质和酪氨酸类蛋白质等类型.在5个氮循环相关基因中,氮负荷增加对轮叶黑藻残体生物膜内amo A、napA和narG的丰度有显著影响.冗余分析表明氮循环基因丰度受水体总氮浓度的影响较小,与植物总有机碳含量和水体化学需氧量及溶解氧浓度存在相关性.研究结果表明虽然当前氮水平对植物腐败过程影响不大、对氮循环基因丰度有一定影响,但是对该水生植被(尤其是植物腐败初期)和农业退水排放的管理仍需加强,以降低其对水体的影响.

关键词：沉水植物轮叶黑藻腐解营养盐氮循环微生物

Self-assembly multifunctional DNA tetrahedron for efficient elimination of antibiotic-resistant bacteria

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Aggregate

Aggregate 2024年第1期5卷 204-215页

作者： tiantian Wu Yu Fu Shuang Guo Yanqiang Shi Yuxin Zhang Zhijin Fan Bin Yang Baoquan Ding Yuhui Liao Molecular Diagnosis and Treatment Center for Infectious Diseases Dermatology HospitalSouthern Medical UniversityGuangzhouChina CAS Key Laboratory of Nanosystem and Hierarchical Fabrication CAS Center for Excellence in NanoscienceNational Center for Nanoscience and TechnologyBeijingChina Longgang District Central Hospital of Shenzhen ShenzhenChina

Antibiotic resistance is a major challenge in the clinical treatment of bacterial infectious ***,we constructed a multifunctional DNA nanoplatform as a versatile carrier for bacteria-specific delivery of clinical antibiotic ciprofloxacin(CIP)and classic nanoantibiotic silver nanoparticles(AgNP).In our rational design,CIP was efficiently loaded in the self-assembly double-bundle DNA tetrahedron through intercalation with DNA duplex,and single-strand DNA-modified AgNP was embedded in the cavity of the DNA tetrahedron through *** the site-specific assembly of targeting aptamer in the well-defined DNA tetrahedron,the bacteria-specific dual-antibiotic delivery system exhibited excellent combined bactericidal *** enhanced antibiotic accumulation through breaking the out membrane of bacteria,the antibiotic delivery system effectively inhibited biofilm formation and promoted the healing of infected wounds in *** DNAbased antibiotic delivery system provides a promising strategy for the treatment of antibiotic-resistant infections.

关键词： antibiotic resistance anti-infection therapy biofilm DNA nanotechnology targeted delivery

On the evolutionary trail of MagRs

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Zoological Research 2024年第4期45卷 821-830页

作者： Jing Zhang Yafei Chang Peng Zhang Yanqi Zhang Mengke Wei Chenyang Han Shun Wang Hui-Meng Lu tiantian Cai Can Xie High Magnetic Field Laboratory Hefei Institutes of Physical ScienceChinese Academy of SciencesScience IslandHefeiAnhui 230031China Science Island Branch of Graduate School University of Science and Technology of ChinaHefeiAnhui 230036China Institutes of Physical Science and Information Technology Anhui UniversityHefeiAnhui 230039China School of Life Sciences Key Laboratory for Space Bioscience and BiotechnologyNorthwestern Polytechnical UniversityXi’anShaanxi 710072China Institute of Quantum Sensing Zhejiang UniversityHangzhouZhejiang 310027China

Magnetic sense,or termed magnetoreception,has evolved in a broad range of taxa within the animal kingdom to facilitate orientation and ***,highly conserved A-type iron-sulfur proteins,are widely distributed across all phyla and play essential roles in both magnetoreception and iron-sulfur cluster ***,the evolutionary origins and functional diversification of MagRs from their prokaryotic ancestor remain *** this study,MagR sequences from 131 species,ranging from bacteria to humans,were selected for analysis,with 23 representative sequences covering species from prokaryotes to Mollusca,Arthropoda,Osteichthyes,Reptilia,Aves,and mammals chosen for protein expression and *** studies revealed a gradual increase in total iron content in MagRs during *** types of MagRs were identified,each with distinct iron and/or iron-sulfur cluster binding capacity and protein stability,indicating continuous expansion of the functional roles of MagRs during speciation and *** evolutionary biochemical study provides valuable insights into how evolution shapes the physical and chemical properties of biological molecules such as MagRs and how these properties influence the evolutionary trajectories of MagRs.

关键词： Magnetoreception Magnetoreceptor(MagR) Iron-sulfur cluster Stability Evolutionary biochemistry

Study on the Interactivity of Controlled and Automatic Information Processing in L2 Reading

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Sino-US English Teaching 2024年第7期21卷 314-321页

作者： DONG tiantian WANG Yong University of Shanghai for Science and Technology ShanghaiChina

L2 reading is not only an important channel for people to obtain information and knowledge,but also the main way for people to learn a foreign *** information processing can be divided into controlled processing and automatic *** information processing is a conscious and resource-intensive processing model,while automatic information processing is an unconscious and automatic processing *** study investigates the characteristics and interactivity of controlled and automatic information processing in L2 reading,and explores the roles of controlled and automatic information processing strategies in improving L2 reading *** findings are as follows:(a)controlled and automatic information processing is interactive in L2 reading;and(b)the uses of controlled and automatic information processing strategies are beneficial to the improvement of the reading ability of L2 *** study has important theoretical and practical value in improving the efficiency of L2 reading teaching and learning.

关键词： L2 reading controlled information processing automatic information processing interactivity