On the evolutionary trail of MagRs

作     者：Jing Zhang Yafei Chang Peng Zhang Yanqi Zhang Mengke Wei Chenyang Han Shun Wang Hui-Meng Lu Tiantian Cai Can Xie Jing Zhang;Yafei Chang;Peng Zhang;Yanqi Zhang;Mengke Wei;Chenyang Han;Shun Wang;Hui-Meng Lu;Tiantian Cai;Can Xie

作者机构：High Magnetic Field LaboratoryHefei Institutes of Physical ScienceChinese Academy of SciencesScience IslandHefeiAnhui 230031China Science Island Branch of Graduate SchoolUniversity of Science and Technology of ChinaHefeiAnhui 230036China Institutes of Physical Science and Information TechnologyAnhui UniversityHefeiAnhui 230039China School of Life SciencesKey Laboratory for Space Bioscience and BiotechnologyNorthwestern Polytechnical UniversityXi’anShaanxi 710072China Institute of Quantum SensingZhejiang UniversityHangzhouZhejiang 310027China 

出 版 物：《Zoological Research》 (动物学研究（英文）)

年 卷 期：2024年第45卷第4期

页      面：821-830页

核心收录：

学科分类：0710[理学-生物学] 07[理学] 09[农学] 

基　　金：National Natural Science Foundation of China(31640001 and T2350005 to C.X.) Ministry of Science and Technology of China(2021ZD0140300 to C.X.) Presidential Foundation of Hefei Institutes of Physical Science,Chinese Academy of Sciences(Y96XC11131,E26CCG27,and E26CCD15 to C.X.,E36CWGBR24B and E36CZG14132 to T.C.) 

主　　题：Magnetoreception Magnetoreceptor(MagR) Iron-sulfur cluster Stability Evolutionary biochemistry 

摘      要：Magnetic sense,or termed magnetoreception,has evolved in a broad range of taxa within the animal kingdom to facilitate orientation and ***,highly conserved A-type iron-sulfur proteins,are widely distributed across all phyla and play essential roles in both magnetoreception and iron-sulfur cluster ***,the evolutionary origins and functional diversification of MagRs from their prokaryotic ancestor remain *** this study,MagR sequences from 131 species,ranging from bacteria to humans,were selected for analysis,with 23 representative sequences covering species from prokaryotes to Mollusca,Arthropoda,Osteichthyes,Reptilia,Aves,and mammals chosen for protein expression and *** studies revealed a gradual increase in total iron content in MagRs during *** types of MagRs were identified,each with distinct iron and/or iron-sulfur cluster binding capacity and protein stability,indicating continuous expansion of the functional roles of MagRs during speciation and *** evolutionary biochemical study provides valuable insights into how evolution shapes the physical and chemical properties of biological molecules such as MagRs and how these properties influence the evolutionary trajectories of MagRs.