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Gut microbiome:A revolution in typeⅡdiabetes mellitus

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World Journal of Diabetes 2024年第9期15卷 1874-1888页

作者： Madhan Jeyaraman tejaswin Mariappan Naveen Jeyaraman Sathish Muthu swaminathan Ramasubramanian Gabriel Silva Santos Lucas Furtado da Fonseca JoséFábio Lana Department of Orthopaedics ACS Medical College and HospitalDr MGR Educational and Research InstituteChennai 600077Tamil NaduIndia Department of Orthopaedics Brazilian Institute of Regenerative MedicineIndaiatuba 13334-170São PauloBrazil Department of Orthopaedics Orthopaedic Research GroupCoimbatore 641045Tamil NaduIndia Department of Community Medicine Government Stanley Medical College and HospitalChennai 600001Tamil NaduIndia Department of Orthopaedics Government Medical CollegeKarur 639004Tamil NaduIndia Department of Biotechnology Faculty of EngineeringKarpagam Academy of Higher EducationCoimbatore 641021Tamil NaduIndia Department of Orthopaedics Government Medical CollegeOmandurar Government EstateChennai 600002Tamil NaduIndia

typeⅡdiabetes mellitus(t2DM)has experienced a dramatic increase globally across countries of various income levels over the past three *** persistent prevalence of t2DM is attributed to a complex interplay of genetic and environmental *** numerous pharmaceutical therapies have been developed,there remains an urgent need for innovative treatment approaches that offer effectiveness without significant adverse *** this context,the exploration of the gut microbiome presents a promising *** has increasingly shown that the gut microbiome of individuals with t2DM exhibits distinct differences compared to healthy individuals,suggesting its potential role in the disease’s pathogenesis and *** emerging field offers diverse applications,particularly in modifying the gut environment through the administration of prebiotics,probiotics,and fecal microbiome *** interventions aim to restore a healthy microbiome balance,which could potentially alleviate or even reverse the metabolic dysfunctions associated with *** current results from clinical trials have not yet shown dramatic effects on diabetes management,the groundwork has been laid for deeper *** and future clinical trials are critical to advancing our understanding of the microbiome’s impact on *** further elucidating the mechanisms through which microbiome alterations influence insulin resistance and glucose metabolism,researchers can develop more targeted *** potential to harness the gut microbiome in developing new therapeutic strategies offers a compelling prospect to transform the treatment landscape of t2DM,potentially reducing the disease’s burden significantly with approaches that are less reliant on traditional pharmaceuticals and more focused on holistic,systemic health improvements.

关键词： typeⅡdiabetes Gut microbiome Probiotics Prebiotics Fecal microbiota transplantation

Biodegradation of mixture of VOC's in a biofilter

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Journal of Environmental Sciences 2004年第1期16卷 30-33页

作者： D.Arulneyam t. swaminathan Biotechnology Research Centre Department of Chemical EngineeringIndian Institute of TechnologyBiotechnology Research CentreDepartment of Chemical EngineeringIndian Institute of Technology Madras Chennai 600 036 IndiaMadras Chennai 600 036 India

Volatile organic compounds(VOC's) in air have become major concern in recent years. Biodegradation of a mixture of ethanol and methanol vapor was evaluated in a laboratory biofilter with a bed of compost and polystyrene particles using an acclimated mixed culture. the continuous performance of the biofilter was studied with different proportion of ethanol and methanol at different initial concentration and flow rates. the result showed significant removal for both ethanol and methanol, which were composition dependent. the presence of either compound in the mixture inhibited the biodegradation of the other.

关键词： biofilter methanol ethanol elimination capacity upset loading VOCs biodegradation

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Photoelectrochemical behaviour of Cdln2S4 films deposited by pulse electrodeposition using non-aqueous electrolyte

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Frontiers of Materials Science 2013年第4期7卷 379-386页

作者： Chockalingam JAYANtHI swaminathan DHANAPANDIAN Kollegal Ramakrishna MURALI Department of Physics Government Arts College Dharmapud 636705 Tamilnadu India Department of Physics Annamalai University Annamalainagar 608002 Tamilnadu India Electrochemical Materials Science Division. Central Electrochemical Research Institute. Karaikudi 630006 Tamilnadu. India

Cdln2S4 films were deposited by the pulse electrodeposition technique on tin oxide-coated glass substrates, at different duty cycles in the range of 6%-50%. the deposition potential was -0.7 V vs, saturated calomel electrode （SCE） using non-aqueous di（ethylene glycol） electrolyte, XRD analysis of the films indicated polycrystalline nature. Grain size, strain and dislocation density were evaluated from the XRD data, EDX analysis of the surface composition confirms the formation of stoichiometric Cdln2S4 films, Optical studies show a direct band-gap values in the range of 2.14-2.23 eV for the films deposited at different duty cycles. Room temperature resistivity of the films was in the range of 40-21 *** with the increase of duty cycle. Photoelectrochemical （PEC） solar cells constructed with the films deposited at 50% duty cycle and post-heat-treated at 500~C indicated open circuit voltage （Voc） of 0.595 V, short circuit current density （Jsc） of 6.20 ***-2, fill factor （if） of 0.61, efficiency （t/） of 3.75%, series resistance （Rs） of 4Q and shunt resistance （Rsh） of 2.50kQ. Making use of the advantages of pulse electrodeposition it can be used to deposit nanocrystalline films which can be employed in optoelectronic and photovoltaic devices.

关键词： thin film semiconductor Cdln2S4 photoelectrochemical (PEC) cell

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Damage mechanism identification in composites via machine learning and acoustic emission

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npj Computational Materials 2021年第1期7卷 852-866页

作者： C.Muir B.swaminathan A.S.Almansour K.Sevener C.Smith M.Presby J.D.Kiser t.M.Pollock S.Daly Materials Department University of California-Santa BarbaraSanta BarbaraCAUSA NASA Glenn Research Center ClevelandOHUSA Materials Scienceand Engineering Department University of Michigan-Ann ArborAnn ArborMIUSA Mechanical Engineering Department University of California-Santa BarbaraSanta BarbaraCAUSA

Damage mechanism identification has scientific and practical ramifications for the structural health monitoring,design,and application of composite *** advances in machine learning uncover pathways to identify the waveform-damage mechanism relationship in higher-dimensional spaces for a comprehensive understanding of damage *** review evaluates the state of the field,beginning with a physics-based understanding of acoustic emission waveform feature extraction,followed by a detailed overview of waveform clustering,labeling,and error analysis *** requirements for damage mechanism identification in any machine learning framework,including those currently in use,under development,and yet to be explored,are discussed.

关键词： composites composite mechanism

A machine learning framework for damage mechanism identification from acoustic emissions in unidirectional SiC/SiC composites

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npj Computational Materials 2021年第1期7卷 1326-1335页

作者： C.Muir B.swaminathan K.Fields A.S.Almansour K.Sevener C.Smith M.Presby J.D.Kiser t.M.Pollock S.Daly Materials University of California-Santa BarbaraSanta BarbaraCAUSA Mechanical Engineering University of California-Santa BarbaraSanta BarbaraCAUSA NASA Glenn Research Center ClevelandOHUSA Materials Science and Engineering University of Michigan-Ann ArborAnn ArborMIUSA

In this work,we demonstrate that damage mechanism identification from acoustic emission(AE)signals generated in minicomposites with elastically similar constituents is *** waveforms were generated by SiC/SiC ceramic matrix minicomposites(CMCs)loaded under uniaxial tension and recorded by four sensors(two models with each model placed at two ends).Signals were encoded with a modified partial power scheme and subsequently partitioned through spectral *** cracking and fiber failure were identified based on the frequency information contained in the AE event they produced,despite the similar constituent elastic properties of the matrix and ***,the resultant identification of AE events closely followed CMC damage chronology,wherein early matrix cracking is later followed by fiber breaks,even though the approach is fully domain-knowledge ***,the partitions were highly precise across both the model and location of the sensors,and the partitioning was *** presented approach is promising for CMCs and other composite systems with elastically similar constituents.

关键词： composites damage mechanism

帕里骨化醇单用以及联合成纤维细胞生长因子23受体抑制剂在慢性肾功能衰竭中的心脏保护作用:试验与临床研究

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中华高血压杂志(中英文) 2019年第11期 1098-1098页

作者： Czaya B Seeherunvong W Singh S Yanucil C Ruiz P Qui-roz Y Grabner A Katsoufis C swaminathan S Abitbol C Rodriguez-Iturbe B Faul C Freundlich M

在尿毒症动物的研究中发现,维生素D受体(vitamin D receptor,VDR)激动剂如帕里骨化醇(paricalcitol,Pc)可减轻心肌肥大,但目前在慢性肾脏病患者中尚未观察到该作用是否存在。成纤维细胞生长因子23(fibroblast growth factor 23,FGF23)... 详细信息

在尿毒症动物的研究中发现,维生素D受体(vitamin D receptor,VDR)激动剂如帕里骨化醇(paricalcitol,Pc)可减轻心肌肥大,但目前在慢性肾脏病患者中尚未观察到该作用是否存在。成纤维细胞生长因子23(fibroblast growth factor 23,FGF23)水平升高可激活心肌钙调神经磷酸酶/活化t细胞核因子(nuclear factor of activated t cell,NFAt)信号通路,引起心肌肥厚,可能对抗VDR激动剂治疗的心肌保护

关键词：成纤维细胞生长因子骨化醇心脏保护作用慢性肾功能衰竭临床研究受体抑制剂