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青藏东缘新生代两类高钾岩浆活动的热年代学研究

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中国科学（D辑） 2002年第7期32卷 529-537页

作者：王江海周江羽张玉泉解广轰尹安 t.m.Harrison m.Grove 中国科学院广州地球化学研究所广州510640 Department of Earth & Space Sciences and Institute of Geophysics & Planetary Physics

40Ar/39Ar年龄数据表明,青藏东缘和印支块体上出露两期新生代具有不同地球化学特征的岩浆活动,它们的时代分别为40～28和16～0ma.早期高钾岩石沿主走滑断裂如金沙江-红河断裂断续分布,是在转换压缩过程中产生的.晚期高钾岩石广泛分布于... 详细信息

40Ar/39Ar年龄数据表明,青藏东缘和印支块体上出露两期新生代具有不同地球化学特征的岩浆活动,它们的时代分别为40～28和16～0ma.早期高钾岩石沿主走滑断裂如金沙江-红河断裂断续分布,是在转换压缩过程中产生的.晚期高钾岩石广泛分布于裂谷盆地中,它与青藏和东亚地区出现的东-西向伸展有关.结合地球化学示踪结果可知,早期岩浆活动是在陆内俯冲过程中形成的,而晚期岩浆活动则起源于一个新近交代富集的亏损地幔.岩浆间歇期则代表在印度-亚洲东碰撞带一次重要的地球动力学转变,即从由地壳变形控制的过程向由地幔构造占主导的过程转变.

关键词：青藏东缘新生代高钾岩浆活动热年化学地球动力学高钾岩石

Efficacy of aqueous extract of flower of Edgeworthia gardneri(Wall.)meisn on glucose and lipid metabolism in KK/Upj-Ay/J mice

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Journal of traditional Chinese medicine 2022年第2期42卷 187-193页

作者： ZHANG Chengfei QIN Lingling wang Haiyan SUN Boju ZHAO Dan ZHANG Qiue ZHONG Fengying WU Lili LIU tonghua School of Life Sciences Beijing University of Chinese MedicineBeijing 102488China technology Department Beijing University of Chinese MedicineBeijing 100029China Dongfang Hospital of Beijing University of Chinese medicine Beijing 100029China Key Laboratory of tCm Health Cultivation of Beijing Beijing University of Chinese MedicineBeijing 102488China the First Clinical medical College of Shaanxi University of traditional Chinese medicine Shaanxi 712000China

OBJECtIVE:to observe the effects of the flower of Edgeworthia gardneri(Wall.)meisn(EWm)on glucose and lipid metabolism in KK/upj-Ay/J(KKAy)mice and investigate the possible mechanism of EWm in the liver of KKAy mice by transcriptome ***:Forty KKAy mice were fed a high-sugar and high-fat diet for 3 weeks to establish the animal model of metabolic *** 5 weeks of continuous administration of EWm,serum high-density lipoprotein(HDL),low-density lipoprotein(LDL),triglycerides(tG),total cholesterol(tC),and free fatty acids(FFA)were detected by *** fasting insulin(Fins)and adiponectin levels were measured by enzymelinked immunosorbent *** tissue fixed with paraformaldehyde was stained with hematoxylineosin and oil red *** analysis was used to evaluate the liver *** expressions of lipoprotein lipase(LPL),peroxisome proliferator-activated receptor-γ(PPARγ),adenosine 5‘-monophosphate-activated protein kinase(AmPK),sterol regulatory element binding protein1c(SREBP-1c),and fatty acid synthase(Fas)mRNA and protein in liver tissue were detected by reverse transcription-polymerase chain reaction(Rt-PCR)and Western blot ***:EWm slightly reduced FBG and Fins in KKAy ***,EWm was able to downregulate serum LDL,tG,tC,and FFA and upregulate the expression of serum HDL and *** analysis revealed the following differential pathways:the peroxisome proliferator-activated receptor(PPAR)signaling pathway and the AmPK signaling ***-PCR and western blot analysis detected the associated genes and *** addition,EWm was able to upregulate the expression of AmPK and downregulate the expression of PPARγ,SREBP1c,and Fas mRNA and protein and upregulate the expression of LPL ***:EWm can alleviate lipid metabolism disorders and to some extent improve glucose metabolism disorders in KKAy *** effects may be related to regulating PPARγ/LPL and activating the

关键词： transcriptome PPAR gamma AmP-activated protein kinases Edgeworthia gardneri(Wall.)meisn flower

A Fourth-Order modified method for the Cauchy Problem of the modified Helmholtz Equation

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Numerical mathematics(theory,methods and Applications) 2009年第3期2卷 326-340页

作者： R. Shi t. Wei H. H. Qin School of mathematics and Statistics Lanzhou University Lanzhou 730000 China.

this paper is concerned with the Cauchy problem for the modified Helmholtz equation in an infinite strip domain 0ta at x = 0 is given and the solution is then sought for the interval 0 详细信息

this paper is concerned with the Cauchy problem for the modified Helmholtz equation in an infinite strip domain 0ta at x = 0 is given and the solution is then sought for the interval 0m is highly ill-posed and the solution(if it exists) does not depend continuously on the given data. In this paper,we propose a fourth-order modified method to solve the Cauchy problem. Convergence estimates are presented under the suitable choices of regularization parameters and the a priori assumption on the bounds of the exact *** implementation is considered and the numerical examples show that our proposed method is effective and stable.

关键词： Cauchy problem for the modified Helmholtz equation ill-posed problem fourth-ordermodified method.

EmDEN-FOWLER tYPE SYStEm:NOEtHER SYmmEtRIES AND FIRSt INtEGRALS

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Acta mathematica Scientia 2012年第5期32卷 1959-1966页

作者： B.muatjetjeja C.m.Khalique International Institute for Symmetry Analysis and mathematical modelling Department of Mathematical SciencesNorth-West UniversityMafikeng CampusPrivate Bag X 2046Mmabatho 2735Republic of South Africa

We classify a generalized coupled singular Emden-Fowler type system ＋a（t）vn=0,v＋b（t）um=0 with respect to the standard first-order Lagrangian according to the Noether point symmetries which it *** integrals of the various cases which admit Noether point symmetries are then *** system was discussed in the literature from the view-point of existence and uniqueness of positive solutions.

关键词： Lagrangian Noether symmetry first integrals Emden-Fowler type system Gauge function

Synthesis and properties of poly(3-hydroxybutyrate-co-3-hydroxyvalerate)/chitin nanocrystals composite scaffolds for tissue engineering

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Chinese Chemical Letters 2014年第12期25卷 1635-1638页

作者： Hu-Yan Li He Li Bing-jie wang Qun Gu Zhi-Qiang Jiang Xue-Dong Wu College of material Science and Chemical Engineering.Ningbo University Key Laboratory of marine New materials and Related technology Zhejiang Key Laboratory of Marine Materials and Protection TechnologyNingbo Institute of Material Technology  EngineeringChinese Academy of Sciences Ningbo University of technology

Poly（3-hydroxybutyrate-co-3-hydroxyvalerate）（PHBV）/chitin nanocrystals（CNC） composite scaffolds were synthesized by the salt leaching and thermally induced phase separation（tIPS） *** scaffolds have porous structures with macro-pores（100-300 μm in diameters） and micro-pores（10μm）.the surface characteristics of the scaffolds were characterized by X-ray photoelectron spectroscopy（XPS） and static water contact angle measurement,and the mechanical properties were investigated by a compression *** adipose-derived stem cells（hADSCs） were seeded onto the PHBV/CNC scaffolds and in vitro cell culture results showed that the composite scaffolds enhanced the hADSCs adhesion,which implies that the material may have potential application in tissue engineering.

关键词： PHBV Chitin nanocrystals Composite scaffolds hADSCs

On Skew triangular matrix Rings

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Algebra Colloquium 2015年第2期22卷 271-280页

作者： m. Habibi A. moussavi A. Alhevaz Department of Pure mathematics Faculty of Mathematical Sciences Tarbiat Modares University P.O. Box 14115-134 Tehran Iran

Let R be a ring with an endomorphism a. We show that the clean property and various Armendariz-type properties of R are inherited by the skew matrix rings S（R, n, σ） and t（R, n,σ）. they allow the construction of rings with a non-zero nilpotent ideal of arbitrary index of nilpotency which inherit various interesting properties of rings.

关键词： quasi-Armendariz ring clean ring triangular matrix ring

Intracellular accumulation of tau inhibits autophagosome formation by activating tIA1-amino acid-mtORC1 signaling

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military medical Research 2023年第2期10卷 175-190页

作者： meng-Zhu Li En-Jie Liu Qiu-Zhi Zhou Shi-Hong Li Shi-Jie Liu Hai-tao Yu Qi-Hang Pan Fei Sun ting He Wei-Jin wang Dan Ke Yu-Qi Feng Jun Li Jian-Zhi wang Department of Pathophysiology School of Basic MedicineKey Laboratory of Education Ministry of China/Hubei Province for Neurological DisordersTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Department of Neurosurgery the Central Hospital of WuhanTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430014China Department of Pathology the First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052China Department of Chemistry Wuhan UniversityWuhan 430072China Co-Innovation Center of Neuroregeneration Nantong UniversityNantong 226000JiangsuChina.

Background:Autophagy dysfunction plays a crucial role in tau accumulation and neurodegeneration in Alzheimer’s disease(AD).this study aimed to investigate whether and how the accumulating tau may in turn affect ***:the primary hippocampal neurons,N2a and HEK293t cells with tau overexpression were respectively starved and treated with vinblastine to study the effects of tau on the initiating steps of autophagy,which was analysed by Student’s two-tailed *** rapamycin and concanamycin A were employed to inhibit the mammalian target of rapamycin kinase complex 1(mtORC1)activity and the vacuolar H+-AtPase(v-AtPase)activity,respectively,which were analysed by One-way ANOVA with post hoc *** Western blotting,co-immunoprecipitation and immunofuorescence staining were conducted to gain insight into the mechanisms underlying the tau effects of mtORC1 signaling alterations,as analysed by Student’s two-tailed t-test or One-way ANOVA with post hoc *** autophagosome formation was detected by immunofuorescence staining and transmission electron *** amino acids(AA)levels were detected by high performance liquid chromatography(HPLC).Results:We observed that overexpressing human full-length wild-type tau to mimic AD-like tau accumulation induced autophagy *** studies revealed that the increased tau could bind to the prion-related domain of t cell intracellular antigen 1(PRD-tIA1)and this association significantly increased the intercellular level of amino acids(Leucine,P=0.0038;Glutamic acid,P=0.0348;Alanine,P=0.0037;Glycine,P=0.0104),with concordant upregulation of mtORC1 activity[phosphorylated eukaryotic translation initiation factor 4E-binding protein 1(p-4EBP1),Pted 70 kD ribosomal protein S6 kinase 1(p-p70S6K1),P=0.0001,phosphorylated unc-51-like autophagyactivating kinase 1(p-ULK1),P=0.0015]and inhibition of autophagosome formation[microtubuleassociated protein light chain 3 II(LC3 II),P=0.0073;LC3 pun

关键词： tau Autophagy Amino acid pathway mammalian target of rapamycin kinase complex 1(mtORC1) t cell intracellular antigen 1(tIA1)

Synthesis and characterization of La Ni_xCo_(1–x)O_3: Role of microstructure on magnetic properties

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Journal of Rare Earths 2015年第3期33卷 277-281页

作者： L.Chávez-Guerrero B.medina-Lott R.F.Cienfuegos m.A.Garza-Navarro R.N.Vannier A.Ringuedé m. Hinojosa m.Cassir Universidad Autónoma de Nuevo León FIME. Cd. Universitaria San Nicolás de los Garza México C.P. 66450 México Laboratoired’Electrochimie et de Chimie Analytique UMR 7575 CNRS Chimie Paris Tech ENSCP 11 rue Pierre et Marie Curie F-75231 Paris Cedex 05 France Centro de Innovación Investigación y Desarrollo en Ingeniería y Tecnología PIIT Monterrey México Unité de Catalyse et de Chimie du Solide UMR 8181 CNRS Villeneuve d’Ascq France

Perovskite-type structures with the composition La Ni x Co1–x O3（x=0.3, 0.5, 0.7） were synthesized by a modified sol-gel method. Using transitional metal elements on the lanthanum base perovskites, properties could be tuned by doping the structure. thermogravimetric analysis（tGA） evidenced a temperature of 350 °C as the start point of the perovskite-phase formation. Scanning electron microscopy（SEm） images showed the microstructure changes（grain size） of the cobalt-doped perovskite due to composition. In addition, it was shown that magnetic properties of the samples were dependent of cobalt content; experimental results pointed to the existence of disordered spins interactions, which were more evident with the decrease of cobalt content and the existence of ferromagnetic coupling among spins of the samples. these results showed the feasibility of producing a family of compounds with the desired properties, manipulating composition and therefore the microstructure.

关键词： Co-doped perovskite microstructural control modified sol-gel ferromagnetic rare earths

An Automated Brain Image Analysis System for Brain Cancer using Shearlets

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Computer Systems Science & Engineering 2022年第1期40卷 299-312页

作者： R.muthaiyan Dr m.malleswaran Department of Electronics and Communication Engineering University College of Engineering ThirukkuvalaiTamilnadu610204India Department of Electronics and Communication Engineering University College of Engineering KancheepuramKancheepuram631552India

In this paper,an Automated Brain Image Analysis(ABIA)system that classifies the magnetic Resonance Imaging(mRI)of human brain is *** classification of mRI images into normal or low grade or high grade plays a vital role for the early *** Non-Subsampled Shearlet transform(NSSt)that captures more visual information than conventional wavelet transforms is employed for feature *** the feature space of NSSt is very high,a statistical t-test is applied to select the dominant directional sub-bands at each level of NSSt decomposition based on sub-band energies.A combination of features that includes Gray Level Co-occurrence matrix(GLCm)based features,Histograms of Positive Shearlet Coefficients(HPSC),and Histograms of Negative Shearlet Coefficients(HNSC)are *** combined feature set is utilized in the classification phase where a hybrid approach is designed with three classifiers;k-Nearest Neighbor(kNN),Naive Bayes(NB)and Support Vector machine(SVm)*** output of individual trained classifiers for a testing input is hybridized to take a final *** quantitative results of ABIA system on Repository of molecular Brain Neoplasia Data(REmBRANDt)database show the overall improved performance in comparison with a single classifier model with accuracy of 99% for normal/abnormal classification and 98% for low and high risk classification.

关键词： Brain image analysis wavelets Shearlet multi-scale analysis hybrid classification