Synthesis and properties of poly(3-hydroxybutyrate-co-3-hydroxyvalerate)/chitin nanocrystals composite scaffolds for tissue engineering

作     者：Hu-Yan Li He Li Bing-jie Wang Qun Gu Zhi-Qiang Jiang Xue-Dong Wu 

作者机构：College of Material Science and Chemical Engineering.Ningbo University Key Laboratory of Marine New Materials and Related TechnologyZhejiang Key Laboratory of Marine Materials and Protection TechnologyNingbo Institute of Material Technology  EngineeringChinese Academy of Sciences Ningbo University of Technology 

出 版 物：《Chinese Chemical Letters》 (中国化学快报（英文版）)

年 卷 期：2014年第25卷第12期

页      面：1635-1638页

核心收录：

学科分类：081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070305[理学-高分子化学与物理] 080501[工学-材料物理与化学] 0805[工学-材料科学与工程（可授工学、理学学位）] 0703[理学-化学] 

基　　金：Ministry of Science and Technology of the People's Republic of China(No.1106) Ningbo Science Foundation (No.2011A610116) National Key Basic Research Program of China(973,No.2014CB643305) the China Postdoctoral Science Foundation Funded Project(No.2012T50564) for financial support 

主　　题：PHBV Chitin nanocrystals Composite scaffolds hADSCs 

摘      要：Poly（3-hydroxybutyrate-co-3-hydroxyvalerate）（PHBV）/chitin nanocrystals（CNC） composite scaffolds were synthesized by the salt leaching and thermally induced phase separation（TIPS） *** scaffolds have porous structures with macro-pores（100-300 μm in diameters） and micro-pores（10μm）.The surface characteristics of the scaffolds were characterized by X-ray photoelectron spectroscopy（XPS） and static water contact angle measurement,and the mechanical properties were investigated by a compression *** adipose-derived stem cells（hADSCs） were seeded onto the PHBV/CNC scaffolds and in vitro cell culture results showed that the composite scaffolds enhanced the hADSCs adhesion,which implies that the material may have potential application in tissue engineering.