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Molecular Plant 2017年第10期10卷 1349-1352页

作者： Justyna Kowalczyk Malgorzata Palusinska Agata Wroblewska-Swiniarska Zbigniew Pietras Lukasz Szewc Jakub Dolata Artur Jarmolowski szymon Swiezewski Department of Protein Biosynthesis Institute of Biochemistry of Biophysics Polish Academy of Sciences Warsaw Poland Department of Gone Expression Institute of Molecular Biology and Biotechnology Adam Mickiewicz University Poznan Poland

Dear Editor,Seed dormancy is adopted by plants to optimize their reproductive strategy. The DOG 1 （DELAY OF GERMINATION 1） gene is the main QTL controlling this trait in Arabidopsis （Bentsink et al., 2006） and therefore is extensively regulated. This includes the alternative polyadenylation （APA） of DOG1 mRNA （Cyrek et al., 2016） and an antisense transcript, asDOGl, which in cis suppresses DOG1 expression during seed maturation （Fedak et al., 2016）. As with many antisense transcripts （Mellor et al., 2016; Rosa et al., 2016）, asDOG1 originates from close to the transcription termination site of the sense gene. This raises the question of how this proximity affects antisense promoter activity.

关键词： the Sense Transcript Controls Transcription

De Sitter Space as a Computational Tool for Surfaces and Foliations

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American Journal of Computational Mathematics 2013年第1期3卷 1-5页

作者： Maciej Czarnecki szymon Walczak Katedra Geometrii WydziaiMatematyki i InformatykiUniwersytetLodzkiLodzPoland Katedra Metodyki Nauczania Matematyki WydziaiMatematyki i InformatykiUniwersytetLodzkiLodzPoland

The set of all spheres and hyperplanes in the Euclidean space Rn+1 could be identified with the Sitter space Λn+1. All the conformal properties are invariant by the Lorentz form which is natural pseudo-Riemannian metric on Λn+1. We shall study behaviour of some surfaces and foliations as their families using computation in the de Sitter space.

关键词： De Sitter Space Folation Conformal Geometry

Dormancy heterogeneity among Arabidopsis thaliana seeds is linked to individual seed size

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Plant Communications 2024年第2期5卷 215-227页

作者： Michal Krzyszton Sebastian P.Sacharowski Veena Halale Manjunath Katarzyna Muter Grzegorz Bokota Ce Wang Dariusz Plewczynski Tereza Dobisova szymon Swiezewski Laboratory of Seeds Molecular Biology Institute of Biochemistry and BiophysicsPAS02-106 WarsawPoland Laboratory of Functional and Structural Genomics Centre of New TechnologiesUniversity of WarsawWarsawPoland Laboratory of Bioinformatics and Computational Genomics Faculty of Mathematics and Information ScienceWarsaw University of TechnologyWarsawPoland Labdeers Ltd. 680-01 BoskoviceCzech Republic

Production of morphologically and physiologically variable seeds is an important strategy that helps plants to survive in unpredictable natural ***,the model plant Arabidopsis thaliana and most agronomically essential crops produce visually homogenous *** automated phenotype analysis,we observed that small seeds in Arabidopsis tend to have higher primary and secondary dormancy levels than large *** analysis revealed distinct gene expression profiles between large and small *** seeds have higher expression of translation-related genes implicated in germination *** contrast,small seeds have elevated expression of many positive regulators of dormancy,including a key regulator of this process,the DOG1 *** in DOG1 expression are associated with differential production of its alternative cleavage and polyadenylation isoforms;in small seeds,the proximal poly(A)site is selected,resulting in a short mRNA ***,single-seed RNA sequencing analysis demonstrated that large seeds resemble DOG1 knockout mutant ***,on the single-seed level,expression of genes affected by seed size is correlated with expression of genes that position seeds on the path toward *** results demonstrate an unexpected link between seed size and dormancy phenotypes in a species that produces highly homogenous seed pools,suggesting that the correlation between seed morphology and physiology is more widespread than initially assumed.

关键词： seed size dormancy DOG1 Arabidopsis

Dynamics of vehicles with high gravity centre

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Theoretical & Applied Mechanics Letters 2012年第4期2卷 75-78页

作者： szymon Tengler Andrzei Harlecki University of Bielsko-Biala Department of MechanicsWillowa 243-309 Bielsko-BialaPoland

The vehicles with high gravity centre are more prone to roll over. The paper deals with a method of dynamics analysis of fire engines which is an example of these types of vehicle. Algorithms for generating the equations of motion have been formulated by homogenous transformations and Lagrange＇s equation. The model presented in this article consists of a system of rigid bodies connected one with another forming an open kinematic chain. Road maneuvers such as a lane change and negotiating a circular track have been presented as the main simulations when a car loses its stability. The method has been verified by comparing numerical results with results obtained by experimental measurements performed during road tests.

关键词： dynamics vehicles high gravity center Lagrange's equation

VprBP mitigates TGF-β and Activin signaling by promoting Smurf1-mediated type Ⅰ receptor degradation

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Journal of Molecular Cell Biology 2020年第2期12卷 138-151页

作者： Yihao Li Chao Cui Feng Xie szymon Kietbasa Hailiang Mei Maarten van Dinther Hans van Dam Andreas Bauer Long Zhang Peterten Dijke Department of Cell and Chemical Biology and Oncode Institute Leiden University Medical Center2300RC LeidenThe Netherlands MOE Laboratory of Biosystems Homeostasis and Protection and Innovation Center for Cell Signaling Network Life Sciences InstituteZhejiang UniversityHangzhou 310058China Department of Human Genetics Leiden Genome Technology CentreLeiden University Medical Center2300RC LeidenThe Netherlands Sequence Analysis Support Core Leiden University Medical Center2300RC LeidenThe Netherlands Novartis Institutes for BioMedical Research Inc.Novartis CampusForum 2.5.01.30CH-4056BaselSwitzerland

The transforming growth factor-β(TGF-β)family controls embryogenesis,stem cell differentiation,and tissue ***,how post-translation modifications contribute to fine-tuning of TGF-βfamily signaling responses is not well ***(I)-Smads can antagonize TGF-β/Smad signaling by recruiting Smurf E3 ubiquitin ligases to target the active TGF-βreceptor for proteasomal degradation.A proteomic interaction screen identified Vpr binding protein(VprBP)as novel binding partner of ***-expression studies revealed that VprBP negatively controls Smad2 phosphorylation,Smad2–Smad4 interaction,as well as TGF-βtarget gene *** was found to promote Smad7–Smurf1–TβRI complex formation and induce proteasomal degradation of TGF-βtype I receptor(TβRI).Moreover,VprBP appears to stabilize Smurf1 by suppressing Smurf1 *** multiple adult and mouse embryonic stem cells,depletion of VprBP promotes TGF-βor Activin-induced *** the mouse embryo VprBP expression negatively correlates with mesoderm marker expression,and VprBP attenuated mesoderm induction during zebrafish *** findings thereby uncover a novel regulatory mechanism by which Smurf1 controls the TGF-βand Activin cascade and identify VprBP as a critical determinant of embryonic mesoderm induction.

关键词： Smurfl TGF-βtype I receptor ubiquitination Activin mesoderm induction

InAlGaN superluminescent diodes fabricated on patterned substrates: an alternative semiconductor broadband emitter

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Photonics Research 2017年第2期5卷 30-34页

作者： ANNA KAFAR szymon STANCZYK MARCIN SARZYNSKI szymon GRZANKA JAKUB GOSS IRINA MAKAROWA ANNA NOWAKOWSKA-SIWINSKA TADEK SUSKI PIOTR PERLIN Institute of High Pressure Physics Polish Academy of Sciences TopGaN Ltd.

We demonstrate InGaN violet light-emitting superluminescent diodes with large spectral width suitable for applications in optical coherence *** was achieved using the concept of nonlinear indium content profile along the superluminescent diode waveguide.A specially designed 3D substrate surface shape leads to a step-like indium content profile,with the indium concentration in the InGaN/GaN quantum wells ranging approximately between 6% and 10%.Thanks to this approach,we were able to increase the width of the spectrum in processed devices from 2.6 nm(reference diode)to 15.5 nm.

关键词： InGaN InAlGaN superluminescent diodes fabricated on patterned substrates an alternative semiconductor broadband emitter

商业环境中企业员工感知的文化差异：一项实证研究

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商业环境中企业员工感知的文化差异：一项实证研究

作者： szymon Bieniek 华东理工大学

学位级别：硕士

本文探讨商业环境中的文化差异。这种文化差异被认为是在国际团队合作中不协调的根结。本实证研究基于多种文化背景下的被调查对象的意见进行统计数据分析。本文的文献综述介绍了文化差异和跨文化沟通的理论基础及最新研究,针对该问题... 详细信息

本文探讨商业环境中的文化差异。这种文化差异被认为是在国际团队合作中不协调的根结。本实证研究基于多种文化背景下的被调查对象的意见进行统计数据分析。本文的文献综述介绍了文化差异和跨文化沟通的理论基础及最新研究,针对该问题的不同意见,结合实例详细讨论。文献综述开始于用不同文化方式进行的讨论和研究人员之间的了解认知,并根据一些关于文化和文化差异的主要理论进行述评。主要的观点基于霍夫斯泰德的文化模式研究。文化冲击的情况介绍和讨论是在有关沟通（口头和非语言）的概述之后。本研究运用被调查者提供的定量数据进行分析,包括人口学统计数据、一般的经验和国际合作评估以及有关行为的评价,涉及多元文化合作中产生的许多问题,并结合定性分析进行讨论。最后,本文对这些问题做出结论,并指出无论是在多元文化环境中工作的人还是雇主将在本研究领域的未来可能方向。

关键词：员工认知文化差异工作环境

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墓地作为城市空间中的记忆和反思场所

墓地作为城市空间中的记忆和反思场所

作者： Krawiec szymon Krzysztof 湖南农业大学

学位级别：硕士

这项工作的目的是在封闭的市政游泳池和华沙市中心废弃的Skra体育场的场地上为记忆公园创建概念设计。记忆公园是当代版的墓地,响应社会和生态的需求。这项工作的范围分为两部分:·分析-我在其中介绍了我对研究区域、其周围环境、与路... 详细信息

这项工作的目的是在封闭的市政游泳池和华沙市中心废弃的Skra体育场的场地上为记忆公园创建概念设计。记忆公园是当代版的墓地,响应社会和生态的需求。这项工作的范围分为两部分:·分析-我在其中介绍了我对研究区域、其周围环境、与路人的交谈以及我对改变传统波兰墓地外观可能遇到的困难和可能性的考虑的分析结果。每个分析都以项目的结论和指南结束。·设计-我首先提出项目的主要思想和假设,解释其象征意义和行动,然后在24块板上展示其概念执行。记忆公园项目的主要目的是在华沙市中心创造一个有利于所有死者的反思和回忆的地方,特别是那些被埋葬在其土地上的提议的生态墓葬形式之一。通过唤起替代的埋葬形式,我还想提请注意60多年来没有进行任何改革的不变且因此过时的埋葬法中的一个问题。因此,它目前不受现代社会或环境的青睐。在我创建记忆公园的工作中,我使用了许多讨论埋葬历史和传统的资料,但也提出了对上述法律发展的建议。作品内容以照片、表格和手绘图的形式,帮助读者理解和想象记忆公园的概念。在工作结束时所附的图表中更详细地介绍了技术方面,这使得项目的可能实施成为可能。

关键词：公墓公园遗体堆肥生态葬礼

Cardiac implications of thrombotic thrombocytopenic purpura

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World Journal of Cardiology 2018年第12期10卷 254-266页

作者： szymon L Wiernek Bo Jiang Gregory M Gustafson Xuming Dai Division of Cardiology McAllister Heart Institute University of North Carolina at Chapel Hill Division of Cardiology Lang Research Center New York Presbyterian Medical Group–Queens Hospital

Thrombotic thrombocytopenic purpura(TTP) is a multisystem disorder that essentially can affect any organ in the human body. The hallmark of the pathogenesis in TTP is the large von Willebrand factor multimers on plateletmediated micro-thrombi formation, leading to microvascular *** studies showed that cardiac arrest and myocardial infarction are the most common immediate causes of death in these patients. Clinical manifestations of cardiac involvement in TTP vary dramatically, from asymptomatic elevation of cardiac biomarkers, to heart failure, MI and sudden cardiac death. There is limited knowledge about optimal cardiac evaluation and management in patients with TTP. The absence of typical cardiac symptoms,combined with complicated multi-organ involvement in TTP, may contribute to the under-utilization of cardiac evaluation and treatment. Prompt diagnosis and timely initiation of effective therapy could be critically important in selected cases. Based on our experience and this review of the literature, we developed several recommendations for focused cardiac evaluation for patients with acute TTP:(1) patients with suspected or confirmed TTP should be screened for the potential presence of cardiac involvement with detailed history and physical,electrocardiogram and cardiac enzymes;(2) clinical deterioration of TTP patients warrants immediate cardiac reevaluation;(3) TTP patients with clinical evidence of cardiac involvement should be monitored for telemetry, cardiac biomarkers and evaluated with transthoracic echocardiography. These patients require urgent targeted TTP treatment as well as cardiac-specific treatment. Aspirin therapy is indicated for all TTP patients. Since epicardial coronary artery involvement is rare, cardiac catheterization is usually not required, given the high risk for hemorrhage and kidney injury;(4) we recommend evidence-based medical therapy for ischemic symptoms and heart failure. TTP patients with evidence of cardiac invol

关键词： Thrombotic thrombocytopenic purpura Acute myocardial infarction Coronary artery disease Anti-platelet therapy von Willebrand factor ADAMTS13

Genetics of coronary artery disease and myocardial infarction

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World Journal of Cardiology 2016年第1期8卷 1-23页

作者： Xuming Dai szymon Wiernek James P Evans Marschall S Runge Division of Cardiology University of North Carolina at Chapel Hill Department of Genetics University of North Carolina at Chapel Hill

Atherosclerotic coronary artery disease(CAD) comprises a broad spectrum of clinical entities that include asymptomatic subclinical atherosclerosis and its clinical complications, such as angina pectoris, myocardial infarction(MI) and sudden cardiac death. CAD continues to be the leading cause of death in industrialized society. The long-recognized familial clustering of CAD suggests that genetics plays a central role in its development, with the heritability of CAD and MI estimated at approximately 50% to 60%. Understanding the genetic architecture of CAD and MI has proven to be difficult and costly due to the heterogeneity of clinical CAD and the underlying multi-decade complex pathophysiological processes that involve both genetic and environmental interactions. This review describes the clinical heterogeneity of CAD and MI to clarify the disease spectrum in genetic studies, provides a brief overview of the historical understanding and estimation of the heritability of CAD and MI, recounts major gene discoveries of potential causal mutations in familial CAD and MI, summarizes CAD and MIassociated genetic variants identified using candidate gene approaches and genome-wide association studies(GWAS), and summarizes the current status of the construction and validations of genetic risk scores for lifetime risk prediction and guidance for preventive strategies. Potential protective genetic factors against the development of CAD and MI are also discussed. Finally, GWAS have identified multiple genetic factors associated with an increased risk of in-stent restenosis following stent placement for obstructive CAD. This review will also address genetic factors associated with in-stent restenosis, which may ultimately guide clinical decision-making regarding revascularization strategies for patients with CAD and MI.

关键词： Coronary artery disease Myocardial infarction In-stent restenosis Genetics Heritability Genome-wide association study Atherosclerosis