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The Impact of a Bicuspid Aortic Valve on Aortic Geometry and Function in Patients with Aortic Coarctation:A Comprehensive CMr Study

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Congenital Heart Disease 2021年第6期16卷 551-560页

作者： Laura Schweikert Dominik Gabbert sylvia Krupickova Inga Voges Department of Congenital Heart Disease and Paediatric Cardiology University Hospital Schleswig-HolsteinKielGermany royal Brompton Hospital LondonUK

Background:An isolated bicuspid aortic valve(BAV)is associated with structural and functional abnormalities of the aorta and the left ventricle(LV).Although~50%of patients with aortic coarctation(CoA)have a BAV,less is known about its impact on LV function and aortic geometry and function in CoA *** this cardiovascular magnetic resonance imaging(CMr)study,we analysed markers of LV and aortic function as well as aortic geometry in a large cohort of CoA patients with a BAVand compared them with CoA patients with a tricuspid aortic valve(TAV).Methods:We included 48 patients with a BAV(18.4±9.3 years)and 45 patients with TAV(20.7±9.9 years).LV volumes,mass and ejection fraction as well as aortic distensibilty,pulse wave velocity(PWV)were measured from standard cine CMr and phase-contrast CMr images.2-dimensional CMr feature tracking(2DCMr-FT)was performed to measure longitudinal,circumferential and radial strain and strain rate of the *** arch geometry was classified as romanic,gothic and ***:LV volumes,mass and ejection fraction as well as aortic distensibility and PWV did not significantly differ between the BAV and the TAV *** was also no significant difference for LV global longitudinal,radial and circumferential strain and strain rate between both *** with a BAV had more commonly a gothic aortic arch compared to TAV patients,but this difference was not statistically significant(22 vs.14,p=0.2).Ascending and descending aortic distensibility correlated with LV mass in the entire patient group(pngitudinal,circumferential and radial strain(GLS,GCS,GrS)and global longitudinal and circumferential strain rate(GLSr,GCSr)correlated with LV ejection fraction(pnclusion:Our data suggest that the presence of a BAV does not adversely impact LV and aortic function in children and young adults with *** correlation of global circumferential,longitudinal and radial strain values with LV ejection fraction dem

关键词： Aortic coarctation bicuspid aortic valve cardiovascular magnetic resonance feature tracking

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r0 Liver resection should be a First-line Treatment for Selected Patients with Intermediate Hepatocellular Cancer

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Journal of Clinical and Translational Hepatology 2023年第4期11卷 757-760页

作者： Martin Janicko sylvia Drazilova Peter Jarcuska Second Department of Internal Medicine PJ Safarik UniversityFaculty of Medicine and Pasteur University HospitalKosiceSlovakia

Introduction Hepatocellular cancer(HCC)is the sixth most common malignancy worldwide and the second most common cause of mortality among all *** HCCs occur in cirrhotic livers,but an increasing proportion of cases occur in livers without cirrhosis,particularly in Hepatitis B virus infection or in nonalcoholic fatty liver disease patients.^(1) Liver resection(Lr)is the treatment of choice in most noncirrhotic patients,therefore most discussion is related to patients with *** survival(OS)depends on the stage at the time of *** Clinic Liver Cancer(BCLC)staging is the currently preferred staging system for HCC in Europe and north America^(2) Only a small proportion of patients with HCC are diagnosed at a very early or early stage(BCLC 0-A)when curative treatment,including Lr,is generally recommended.

关键词： Liver Cancer mortality

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Survey on gastrointestinal parasites and detection of Cryptosporidium spp. on cattle in West Java,Indonesia

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Asian Pacific Journal of Tropical Medicine 2014年第3期7卷 197-201页

作者： sylvia Maharani Ananta Suharno Adi Hidayat Makoto Matsubayashi Parasitology Laboratory Disease Investigation Center SubangWest JavaIndonesiaDirectorate General of Livestock and Animal Health ServicesJl.Terusan Garuda Blok WerasariRT.33/RW.11Subang.West Java.Indonesia.41212 Laboratory of Protozoan Diseases National Institute of Animal HealthNational Agricultural and Food Research Organization3-1-5KannondaiTsukuba.Ibaraki 305-0856Japan

Objective:To evaluate the presence of gastrointestinal parasites on cattle in Indonesia because the prevalence of parasites varies between counlries depending on the terrain surrounding livestock farms and investigations in Indonesia have never been ***:Fecal samples from cattle at 35 farms in 7 districts in West Java,Indonesia,has been examined using the floatation or sedimentation methods,and a immunofluorescence assay and experimentally inoculation to mice for Cryptosporidium or Giardia ***:153 of 394 examined cattle(38.8%)were infected with gastrointestinal *** prevalence of Eimeria spp.,nematoda spp.(including Oesophagustomum and Bunostomum-like),Fasciola gigantica and Paramphistomum *** 22.4%,11.2%,12.5%and 3.8%,*** andersoni(***)was also found in two *** isolate of this parasite was confirmed to be transmitted to mice,in contrast to the isolates from other ***:although this survey is preliminary,the results shows that the infection of gastrointestinal parasites in Indonesia was not high,but these infected cattle could be as a potential source leading to economic losses in livestock production.

关键词： Cattle Cryptosporidium andersoni Gastrointestinal parasites West Java

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Tourist Satisfaction: Based on the China Market in Fiji

Tourist Satisfaction: Based on the China Market in Fiji

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作者： sylvia Luisa ramanu Waqabaca 河北大学

学位级别：硕士

Tourism in Fiji is the main economic distributer and the fastest growing industry. This isbecause of the influx in tourism growth. This trend is evident in the increase in tourists’arrivals on a yearly basis from all markets specifically the China Market. Since2009, theChina Market has continued to boost the tourism industry. For example, the tourist arrivalnumbers from the China Market has increased from2009to2013（Fiji Bureau of Statistics2013）. recent studies on the tourism industry focused on the characteristics of tourists whovisited Fiji. This study will observe the tourists’ satisfaction of the China Market with analysisof the demographic and travel behavior characteristics. The expectancy–disconfirmation theory provided a conceptual framework for the *** theory can be defined as a theory for measuring customer satisfaction from perceivedquality of products or services. The consumer compares the performance prior to theexpectations. nadi Town, Fiji was the selected study area for this study. It is the main port of entry forall International Tourists as it is where the nadi International Airport is located. research wasconducted in the form of questionnaires handed out to the Chinese tourists on holiday in Fijiin December,2013. There were a total of300questionnaires handed out but there were only251that were able to be used. Therefore, the251respondents were analyzed. Appropriate statistical analyses were used according to the respective objectives anddescriptors. A list of25attractions that was used in this study resulted to four dimensions:General Attractions, Personal Attractions, Hotel related Attractions and Cultural *** data were coded and with the use of SPSS, the variables were analyzed and thehypotheses were tested. According to the results of this study, there are several recommendations that could bemade to increase tourists’ satisfaction in Fiji. Firstly, grasping what tourists’ seek atdestinations will help tourism organizat

关键词：出境旅游市场分析综合竞争力消费者满意度

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The corner that held them

The corner that held them

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作者： sylvia Townsend Warner

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A theory of carbon currency

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Fundamental research 2022年第3期2卷 375-383页

作者： Qiao Liu Zefeng Chen sylvia Xiaolin Xiao Guanghua School of Management Peking UniversityBeijing100871China

We propose a new international monetary system based on carbon currency(the carbon standard)to tackle two pressing externalities in today’s global economic and political context:the dangerous and irreversible effects caused by unconstrained green-house gas emissions and the cost to the rest of the world as a result of the *** being the dominated global currency and the *** reserve increasingly implementing monetary policies not aligned with the global common *** define carbon currency as standardized carbon-related securities backed up by the right of one unit of carbon *** can be used as a new global reserve currency and functions as an international unit of *** the trading of carbon currency,efficient carbon prices are *** incorporating the cost of carbon emissions into decision making,carbon pricing provides incentives for countries to pursue low-carbon growth,which helps achieve the net zero emissions global goal set under the 2015 Paris *** the carbon standard,the external shocks to the international financial system would come from variations of carbon emissions rather than the *** *** such,monetary authorities’commitment to maintaining stable exchange rates comes together with monetary policies aiming at pursuing low-carbon *** new system potentially poses a plausible solution to the classical Mundellian Trilemma because the objectives of maintaining fixed exchange rate and implementing monetary policy become *** several hurdles are constraining the launch of carbon currency immediately,the carbon standard poses a feasible international monetary system as the world-wide campaign to achieve carbon neutrality progresses.

关键词： Two externalities net zero carbon emissions Carbon currency Global reserve currency Mundellian Trilemma

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Pleiotropic effects of statins in the diseases of the liver

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World Journal of Gastroenterology 2016年第27期22卷 6201-6213页

作者： Martin Janicko sylvia Drazilova Daniel Pella Jan Fedacko Peter Jarcuska 1~(st) Department of Internal medicine Pavol Jozef Safarik University in Kosice Louis Pasteur University hospital Department of Internal Medicine Hospital Poprad

Statins are a class of molecules that inhibit HMG Co A reductase. They are usually prescribed as a lipid lowering medication. However, there is accumulating evidence that statins have multiple secondary effects both related and unrelated to their lipid-lowering effect. This narrative review of the literature aims to provide the reader with information from clinical studies related to the effect of statin and statins' potential use in patients with liver diseases. In patients with advanced liver disease due to any etiology, statins exhibit an antifibrotic effect possibly through the prevention of hepatic sinusoidal microthrombosis. Two randomized controlled trials confirmed that statins decrease hepatic vein pressure gradient in patients with portal hypertension and improve the survival of patients after variceal bleeding. Lower rates of infections were observed in patients with cirrhosis who received statin treatment. Statins decrease the risk of hepatocellular carcinoma(HCC) in patients with advanced liver disease in general but particularly in patients with chronic hepatitis B and C. Statins in patients with chronic hepatitis C likely increase the virological response to the treatment with pegylated interferon and ribavirin and have the potential to decrease the rate of fibrosis. Finally, data from randomized controlled trials also confirmed that the addition of statin prolongs the survival of patients with advanced HCC even more than sorafenib. Statins are a very promising group of drugs especially in patients with liver disease, where therapeutic options can often be limited. Some indications, such as the prevention of re-bleeding from esophageal varices and the palliative treatment of HCC have been proven through randomized controlled trials, while additional indications still need to be confirmed through prospective studies.

关键词： Statins Hepatitis Cirrhosis Esophageal varices Hepatocellular carcinoma

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Vitamin D,calcium homeostasis and aging

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Bone research 2016年第3期4卷 133-139页

作者： Vaishali Veldurthy ran Wei Leyla Oz Puneet Dhawan Yong Heui Jeon sylvia Christakos Department of Microbiology Biochemistry and Molecular GeneticsRutgersThe State University of New JerseyNew Jersey Medical School

Osteoporosis is characterized by low bone mass and microarchitecture deterioration of bone tissue, leading to enhanced bone fragility and consequent increase in fracture risk. Evidence is accumulating for an important role of calcium deficiency as the process of aging is associated with disturbed calcium balance. Vitamin D is the principal factor that maintains calcium homeostasis. Increasing evidence indicates that the reason for disturbed calcium balance with age is inadequate vitamin D levels in the elderly. In this article, an overview of our current understanding of vitamin D, its metabolism, and mechanisms involved in vitamin D-mediated maintenance of calcium homeostasis is presented. In addition, mechanisms involved in age-related dysregulation of 1,25（OH）2D3 action, recommended daily doses of vitamin D and calcium, and the use of vitamin D analogs for the treatment of osteoporosis （which remains controversial） are reviewed. Elucidation of the molecular pathways of vitamin D action and modifications that occur with aging will be an active area of future research that has the potential to reveal new therapeutic strategies to maintain calcium balance.

关键词： BMD VDr Vitamin D,calcium homeostasis and aging

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A Setup for a Scenario-Driven Water Balance at Landscape Scale—Assessment with AKWA-M~-Embedded in a Model Framework for Land-Use Planning’s Decision Support in Mountainous Southwest China

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Journal of Earth Science 2010年第6期21卷 974-978页

作者： Andreas Wahren Karin Berkhoff Albrecht Münch sylvia Herrmann Karl-Heinz Feger Insitute of Soil Science and Site Ecology Technische Universitt Dresden Dr. Dittrich & Partner Hydro-Consult GmbH Institute of Environmental Planning Leibniz University Hannover

Land-cover changes cause a loss of natural vegetation in many parts of the world. In the Xishuangbanna （西双版纳） district （Yunnan （云南） Province）, rubber plantations replace tropical rainforests covering already an area of about 10% of the study area （2007）. There, land-use allocation is mostly driven by economic considerations. Thus, local planning authorities need decision support for land-use planning issues, which integrate socio-economic and ecological aspects. Within the nabanFrame, an agro-economic, ecological and social model was applied, which, altogether, interacted with a land allocation model via defined interfaces. Effects on the water cycle, ecological conditions as well as socio-economic should be considered by integrating the spatially distributed rainfali-runoff and water balance model AKWA-M in the model setup.

关键词： land-use water balance model rubber integrated land-use planning land-use prognosis.

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Msx homeobox gene family and craniofacial development

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Cell research 2003年第6期13卷 429-442页

作者： sylvia ALAPPAT Division of Developmental Biology Department of Cell and Molecular Biology Tulane University new Orleans LA 70118 USA.

Vertebrate Msx genes are unlinked, homeobox-containing genes that bear homology to the Drosophila muscle segment homeobox gene. These genes are expressed at multiple sites of tissue-tissue interactions during vertebrate embryonic development. Inductive interactions mediated by the Msx genes are essential for normal craniofacial, limb and ectodermal organ morphogenesis, and are also essential to survival in mice, as manifested by the pheno typic abnormalities shown in knockout mice and in humans. This review summarizes studies on the expression, regulation, and functional analysis of Msx genes that bear relevance to craniofacial development in humans and mice.

关键词： Msx genes craniofacial tooth cleft palate suture development transcription factor signaling molecule.

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