Vitamin D,calcium homeostasis and aging

作     者：Vaishali Veldurthy Ran Wei Leyla Oz Puneet Dhawan Yong Heui Jeon Sylvia Christakos 

作者机构：Department of MicrobiologyBiochemistry and Molecular GeneticsRutgersThe State University of New JerseyNew Jersey Medical School 

出 版 物：《Bone Research》 (骨研究（英文版）)

年 卷 期：2016年第4卷第3期

页      面：133-139页

核心收录：

学科分类：1002[医学-临床医学] 100210[医学-外科学(含：普外、骨外、泌尿外、胸心外、神外、整形、烧伤、野战外)] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：funding from the National Institute of Health Grants AG044552 supported by the Scientific and Technical Research Council of Turkey (TUBITAK) 

主　　题：BMD VDR Vitamin D,calcium homeostasis and aging 

摘      要：Osteoporosis is characterized by low bone mass and microarchitecture deterioration of bone tissue, leading to enhanced bone fragility and consequent increase in fracture risk. Evidence is accumulating for an important role of calcium deficiency as the process of aging is associated with disturbed calcium balance. Vitamin D is the principal factor that maintains calcium homeostasis. Increasing evidence indicates that the reason for disturbed calcium balance with age is inadequate vitamin D levels in the elderly. In this article, an overview of our current understanding of vitamin D, its metabolism, and mechanisms involved in vitamin D-mediated maintenance of calcium homeostasis is presented. In addition, mechanisms involved in age-related dysregulation of 1,25（OH）2D3 action, recommended daily doses of vitamin D and calcium, and the use of vitamin D analogs for the treatment of osteoporosis （which remains controversial） are reviewed. Elucidation of the molecular pathways of vitamin D action and modifications that occur with aging will be an active area of future research that has the potential to reveal new therapeutic strategies to maintain calcium balance.