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Rumex dentatus could be a potent alternative to treatment of microbial infections and of breast cancer

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Journal of Traditional Chinese Medicine 2019年第6期39卷 772-779页

作者： Riffat batool Ejaz Aziz Hina Salahuddin Javed Iqbal Saira Tabassum Tariq Mahmood University Institute of Biochemistry and Biotechnology Pir Mehr Ali Shah Arid Agriculture University RawalpindiRawalpindiPunjab 46000Pakistan Department of Botany Government Degree College KhanpurHaripur 22650Pakistan Department of Zoology University of OkaraOkara 56300Pakistan National University of Technology School of Applied Sciences and HumanitiesNational University of TechnologyIslamabad 42000Pakistan Department of Plant Sciences Faculty of Biological SciencesQuaid-i-Azam UniversityIslamabad 45320Pakistan

OBJECTIVE:To investigate the phytochemicals and in vitro antioxidant,antimicrobial and cytotoxic potential of Rumex dentatus(***)leaf ***:The total phenolics and flavonoids content of *** extracts were evaluated by the Folin-Ciocalteu and aluminum chloride colorimetric methods *** potential of studied plant extracts was assessed through 2,2-diphenyl-1-picrylhydrazyl radical scavenging capacity,total reducing power and total antioxidant ***,antibacterial and antifungal capacity was also evaluated by disc diffusion method against six clinically isolated multi-drug resistant bacterial strains as well as six fungal ***,cell cytotoxicity was also evaluated through3-(4,5-dimethylthiazolyl-2)-2,5-diphenyltetrazolium bromide ***:Ethanol extract showed highest total phenolic[(38.9±1.5)μg gallic acid equivalent/mg]and total flavonoids[(17.2±1.9)μg quercetin equivalent/mg]*** assays indicated that ethanol and methanol extracts possess potent antioxidant ***,it was observed that ethanol and hexane extracts have the potential to inhibit most of the tested multi-drug resistant bacterial strains while methanol,chloroform and hexane extracts could inhibit the growth of pathogenic fungal strains *** all the studied extracts,ethanolic extract showed highest cytotoxicity against MCF-7 cell line then Hep-2 and DU-145 cell lines by MTT assay with lowest IC50 of 47.3μg/m ***:These results suggest that *** could be a potent alternative candidate for treatment of microbial infections and for breast cancer treatment.

关键词： Rumex Atioxidants Anti-infective agents Drug resistant,multiple Cytotoxins

A Query-Based Greedy Approach for Authentic Influencer Discovery in SIoT

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Computers, Materials & Continua 2023年第3期74卷 6535-6553页

作者： Farah batool Abdul Rehman Dongsun Kim Assad Abbas Raheel Nawaz Tahir Mustafa Madni COMSATS University Islamabad IslamabadPakistan School of Computer Science and Engineering Kyungpook National UniversityDaegu41566Korea Department of Operations TechnologyEvents and Hospitality ManagementManchester Metropolitan UniversityUnited Kingdom

The authors propose an informed search greedy approach that efficiently identifies the influencer nodes in the social Internet of Things with the ability to provide legitimate ***,the proposed approach minimizes the network size and eliminates undesirable *** that,the proposed approach ranks each of the nodes and prioritizes them to identify an authentic ***,the proposed approach discards the nodes having a rank(α)lesser than 0.5 to reduce the network complexity.αis the variable value represents the rank of each node that varies between 0 to *** with the higher value ofαgets the higher priority and vice *** threshold valueα=0.5 defined by the authors with respect to their network pruning requirements that can be vary with respect to other research ***,the algorithm in the proposed approach traverses the trimmed network to identify the authentic node to obtain the desired *** performance of the proposed method is evaluated in terms of time complexity and accuracy by executing the algorithm on both the original and pruned *** results show that the approach identifies authentic influencers on a resultant network in significantly less time than in the original ***,the accuracy of the proposed approach in identifying the influencer node is significantly higher than that of the original ***,the comparison of the proposed approach with the existing approaches demonstrates its efficiency in terms of time consumption and network traversal through the minimum number of hops.

关键词： Online social network influencer search query-based approach greedy search social internet of things(siot)

Umbilical cord-derived mesenchymal stem cells preconditioned with isorhamnetin:potential therapy for burn wounds

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World Journal of Stem Cells 2020年第12期12卷 1652-1666页

作者： Shazmeen Aslam Irfan Khan Fatima Jameel Midhat batool Zaidi Asmat Salim Stem Cell Laboratory Dr.Panjwani Center for Molecular Medicine and Drug ResearchInternational Center for Chemical and Biological SciencesUniversity of KarachiKarachi 74700SindhPakistan

BACKGROUND Impaired wound healing can be associated with different pathological *** wounds are the most common and detrimental injuries and remain a major health issue *** stem cells(MSCs)possess the ability to regenerate tissues by secreting factors involved in promoting cell migration,proliferation and differentiation,while suppressing immune *** of MSCs with small molecules having cytoprotective properties can enhance the potential of these cells for their use in cell-based *** To enhance the therapeutic potential of MSCs by preconditioning them with isorhamnetin for second degree burn wounds in *** Human umbilical cord MSCs(hU-MSCs)were isolated and characterized by surface markers,CD105,vimentin and *** preconditioning,hU-MSCs were treated with isorhamnetin after selection of the optimized concentration(5μmol/L)by cytotoxicity *** migration potential of these MSCs was analyzed by the in vitro scratch *** healing potential of normal,and preconditioned hU-MSCs was compared by transplanting these MSCs in a rat model of a second degree burn ***,and preconditioned MSCs(IH+MSCs)were transplanted after 72 h of burn injury and observed for 2 *** and gene expression analyses were performed on day 7 and 14 after cell transplantation to determine complete wound *** The scratch assay analysis showed a significant reduction in the scratch area in the case of IH+MSCs compared to the normal untreated MSCs at 24 h,while complete closure of the scratch area was observed at 48 *** analysis showed reduced inflammation,completely remodeled epidermis and dermis without scar formation and regeneration of hair follicles in the group that received IH+*** expression analysis was time dependent and more pronounced in the case of IH+***(IL)-1β,IL-6 and Bcl-2 associated X genes showed significant downregulation,while transforming growth f

关键词： Burn wound Isorhamnetin Mesenchymal stem cells Preconditioning Wound healing Small molecule

Inhibitory activities of extracts of Rumex dentatus, Commelina benghalensis, Ajuga bracteosa, Ziziphus mauritiana as well as their compounds of gallic acid and emodin against dengue virus

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Asian Pacific Journal of Tropical Medicine 2018年第4期11卷 265-271页

作者： Riffat batool Ejaz Aziz Tariq Mahmood Benny KH Tan Vincent TK Chow Department of Plant Sciences Faculty of Biological Sciences Quaid-i-Azam University Department of Pharmacology Yong Loo Lin School of Medicine National University of Singapore Department of Microbiology and Immunology Yong Loo Lin School of Medicine National University of Singapore

Objective: To investigate the inhibitory effects against dengue virus serotype 2(DENV-2) by five different fractions(extracted by methanol, ethanol, benzene, chloroform and n-hexane) of Rumex dentatus, Commelina benghalensis, Ajuga bracteosa and Ziziphus mauritiana, as well as their constituents(gallic acid, emodin, and isovanillic acid). Methods: All the samples were tested for cytotoxicity on baby hamster kidney cells by MTT assay and for anti-DENV-2 activity by plaque reduction neutralization assay using two DENV-2 doses(45 and 90 plaqueforming units or PFU). Results: All the samples except isovanillic acid exhibited significant prophylactic effects against DENV-2 infectivity(without cytotoxicity) when administered to cells before infection, but were not effective when given 6 h post-infection. The methanol extract of Rumex dentatus demonstrated the highest antiviral efficacy by inhibiting DENV-2 replication, with IC_(50) of 0.154 μg/mL and 0.234 μg/mL, when added before infection with 45 and 90 PFU of virus, respectively. Gallic acid also exhibited significant antiviral effects by prophylactic treatment prior to virus adsorption on cells, with IC_(50) of 0.191 μg/mL and 0.522 μg/mL at 45 and 90 PFU of DENV-2 infection, respectively. Conclusions: The highly potent activities of the extracts and constituent compounds of these plants against DENV-2 infectivity highlight their potential as targets for further research to identify novel antiviral agents against dengue.

关键词： Dengue virus Rumex dentatus Commelina benghalensis Ajuga bracteosa Ziziphus mauritiana Gallic acid

Biological evaluation of some important medicinal plants from Poonch valley, Azad Kashmir, Pakistan

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Journal of Traditional Chinese Medicine 2019年第6期39卷 753-763页

作者： Farmeen Kiran Muhammad Azam Khan Riffat batool Sobia Kanwal Syed Lal Shah Tariq Mahmood Department of Plant Sciences Quaid-i-Azam University IslamabadIslamabad 45320Pakistan Department of Botany Government Boys Degree College HajiraHajira 12160Pakistan Department of Zoology University of Gujrat Sub-Campus RawalpindiRawalpindi 46000Pakistan Pakistan Museum of National History Pakistan Science FoundationIslamabadIslamabad 44000Pakistan

OBJECTIVE:To estimate the phytochemical composition,antioxidant,antifungal,cytotoxic and phytotoxic activities of three important medicinal plants of Poonch valley,Azad Kashmir ***:Phytochemicals were investigated for both qualitative(phenols,flavonoids,alkaloids and saponins)and quantitative(total phenolic and flavonoid contents)analysis of plant extracts prepared in ethanol,ethyl acetate and ***,antioxidant potential was investigated by screening botanical extracts against 2,2-diphenyl-1-picrylhydrazyl scavenging assay,phosphomolybdenum and total reducing power ***,disc diffusion method was used for determination of antifungal potential of all extracts against four pathogenic ***,brine shrimp cytotoxicity assay was conducted for cytotoxic potential and radish seed germination assay was carried out for estimation of allelopathic potential of plant ***:Phytochemical evaluation showed the presence of phenolics,flavonoids,alkaloids and saponins in almost all *** addition to significant antioxidant potential,Rubia cordifolia(ethanolic extract)revealed highest amount of phenolics and *** said plant also exhibited good cytotoxic *** plant extracts highest antifungal activity and allelopathic potential was recorded by Oxalis latifolia(ethyl acetate extract).Ethanol and ethyl acetate were observed to be the best choice of *** best solvents-based results were obtained by Ethanol followed by Ethyl acetate and ***:For further studies,Rubia cordifolia and Oxalis latifolia are the most promising medicinal plants of Poonch valley,Azad Kashmir Pakistan at molecular level in order to isolate the compounds concerning with pronounced activities.

关键词： Melinis repens Oxalidaceae Rubia Cytotoxins Pakistan

Analysis and Power Quality Improvement in Hybrid Distributed Generation System with Utilization of Unified Power Quality Conditioner

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Computer Modeling in Engineering & Sciences 2023年第2期134卷 1105-1136页

作者： Noor Zanib Munira batool Saleem Riaz Farkhanda Afzal Sufian Munawar Ibtisam Daqqa Najma Saleem Department of Electrical Engineering University of Engineering and TechnologyTaxila47050Pakistan School of Automation Northwestern Polytechnical University170072Xi’anChina National University Science&Technology MCSIslamabad44000Pakistan Department of Quantitative Methods College of Business AdministrationImam Abdulrahman Bin Faisal UniversityDammam34212Saudi Arabia Department of Mathematics and Natural Sciences College of Sciences and Human StudiesPrince Mohammad Bin Fahd UniversityKhobar31952Saudi Arabia

This paper presents a comprehensive study that includes the sizing and power flow by series and parallel inverters in a distributed generation system(DGs)that integrates the system of hybrid wind photovoltaic with a unified power quality conditioner(UPQC).In addition to supplying active power to the utility grid,the system of hybrid wind photovoltaic functions as a UPQC,compensating reactive power and suppressing the harmonic load ***,the load is supplied with harmonic-free,balanced and regulated output *** PVWind-UPQC is established on a dual compensation scheme,the series inverter works like a sinusoidal current source,while the parallel inverter works like a sinusoidal voltage ***,a smooth alteration from interconnected operating modes to island operating modes and vice versa can be achieved without load voltage *** PV-Wind-UPQC inverters handle the energy generated through the hybrid wind photovoltaic system and the energy demanded through the load,the converters should be sized cautiously.A detailed study of the flow of power via the PV-Wind-UPQC is imperative to gain a complete understanding of the system operation and the proper design of the ***,curves that allow the sizing of the power converters according to the power flow via the converters are presented and *** results are presented to assess both steady state and dynamic performances of the grid connected hybrid system of *** investigation is verified by simulating and analyzing the results with Matlab/Simulink.

关键词： Photovoltaic wind turbine unified power quality conditioner power flow distributed generation system

Mutagenic and cytotoxic potential of Endosulfan and Lambda-cyhalothrin—In vitro study describing individual and combined effects of pesticides

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Journal of Environmental Sciences 2014年第7期26卷 1471-1479页

作者： Umber Saleem Sohail Ejaz Muhammad Ashraf Muhammad Ovais Omer Imran Iltaf Zainab batool Riffat Fatima Msbah Afzal Department of Pharmacology & Toxicology University of Veterinary and Animal Sciences Lahore 54000 Pakistan Department of Clinical Neurosciences Neurology Unit Addenbrooke's Hospital University of Cambridge Cambridge UK Microbiology Section Quality Operations Laboratory University of Veterinary and Animal Sciences Lahore Pakistan

Excessive use of pesticides poses increased risks to non target species including humans. In the developing countries, lack of proper awareness about the toxic potential of pesticides makes the farmer more vulnerable to pesticide linked toxicities, which could lead to diverse pathological conditions. The toxic potential of a pesticide could be determined by their ability to induce genetic mutations and cytotoxicity. Hence, determination of genetic mutation and cytotoxicity of each pesticide is unavoidable to legislate health and safety appraisal about pesticides. The objective of current investigation was to determine the genotoxic and cytotoxic potential of Endosulfan（EN） and Lambda-cyhalothrin（LC）; individually and in combination. 3-（4,5-Dimethylthiazol-2-yl）-2,5-Diphenyltetrazolium Bromide（MTT） assay was utilized to determine cytotoxicity, while two mutant histidine dependent Salmonella strains（TA98, TA100） were used to determine the mutagenicity of EN and ***, mutagenicity assay was conducted with and without S9 to evaluate the effects of metabolic activation on mutagenicity. Even though a dose dependent increase in the number of revertant colonies was detected with EN against both bacterial strains, a highly significant（p 〈 0.05） increase in the mutagenicity was detected in TA98 with S9. In comparison, data obtained from LC revealed less mutagenic potential than EN. Surprisingly,the non-mutagenic individual-concentrations of EN and LC showed dose dependent mutagenicity when combined. Combination of EN and LC synergistically induced mutagenicity both in TA98 and TA100. MTT assay spotlighted comparable dose dependent cytotoxicity effects of both pesticides. Interestingly, the combination of EN and LC produced increased reversion and cytotoxicity at lower doses as compared to each pesticide, concluding that pesticide exposure even at sub-lethal doses can produce cytotoxicity and genetic mutations, which could lead to carcinogenicity.

关键词： Endosulfan Lambda-cyhalothrin Mutagenicity Cytotoxicity

Self-Care Assessment for Daily Living Using Machine Learning Mechanism

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Computers, Materials & Continua 2022年第7期72卷 1747-1764页

作者： Mouazma batool Yazeed Yasin Ghadi Suliman A.Alsuhibany Tamara al Shloul Ahmad Jalal Jeongmin Park Department of Computer Science Air UniversityIslamabad44000Pakistan Department of Computer Science and Software Engineering Al Ain UniversityAl Ain15551UAE Department of Computer Science College of ComputerQassim UniversityBuraydah51452Saudi Arabia Department of Humanities and Social Science Al Ain UniversityAl Ain15551UAE Department of Computer Engineering Korea Polytechnic University237 Sangidaehak-ro Siheung-siGyeonggi-do15073Korea

Nowadays,activities of daily living(ADL)recognition system has been considered an important field of computer *** and optical sensors are widely used to assess the daily living activities in healthy people and people with certain *** conventional ADL utilizes RGB optical sensors but an RGB-D camera with features of identifying depth(distance information)and visual cues has greatly enhanced the performance of activity *** this paper,an RGB-D-based ADL recognition system has been ***,human silhouette has been extracted from the noisy background of RGB and depth images to track human movement in a *** on these silhouettes,full body features and point based features have been extracted which are further optimized with probability based incremental learning(PBIL)***,random forest classifier has been used to classify activities into different *** n-fold crossvalidation scheme has been used to measure the viability of the proposed model on the RGBD-AC benchmark dataset and has achieved an accuracy of 92.71%over other state-of-the-art methodologies.

关键词： Angular geometric features decision tree classifier human activity recognition probability based incremental learning ridge detection

Smart Shoes Safety System for the Blind People Based on (IoT) Technology

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Computers, Materials & Continua 2023年第7期76卷 415-436页

作者： Ammar Almomani Mohammad Alauthman Amal Malkawi Hadeel Shwaihet batool Aldigide Donia Aldabeek Karmen Abu Hamoodeh Research and Innovation Department Skyline University CollegeP.O.Box 1797SharjahUAE. IT-Department-Al-Huson University College Al-Balqa Applied UniversityP.O.Box 50IrbidJordan Department of Information Security Faculty of Information TechnologyUniversity of PetraAmmanJordan

People’s lives have become easier and simpler as technology has *** is especially true with the Internet of Things(IoT).The biggest problem for blind people is figuring out how to get where they want to *** with good eyesight need to help these *** shoes are a technique that helps blind people find their way when they ***,a special shoe has been made to help blind people walk safely without worrying about running into other people or solid *** this research,we are making a new safety system and a smart shoe for blind *** system is based on Internet of Things(IoT)technology and uses three ultrasonic sensors to allow users to hear and react to *** has ultrasonic sensors and a microprocessor that can tell how far away something is and if there are any *** and flame sensors were used,and a sound was used to let the person know if an obstacle was near *** sensors use Global Positioning System(GPS)technology to detect motion from almost every side to keep an eye on them and ensure they are *** test our proposal,we gave a questionnaire to 100 *** questionnaire has eleven questions,and 99.1%of the people who filled it out said that the product meets their needs.

关键词： IoT smart shoe sensors GSM GPS Arduino blind people safety system