Rumex dentatus could be a potent alternative to treatment of microbial infections and of breast cancer

作     者：Riffat Batool Ejaz Aziz Hina Salahuddin Javed Iqbal Saira Tabassum Tariq Mahmood 

作者机构：University Institute of Biochemistry and BiotechnologyPir Mehr Ali Shah Arid Agriculture University RawalpindiRawalpindiPunjab 46000Pakistan Department of BotanyGovernment Degree College KhanpurHaripur 22650Pakistan Department of ZoologyUniversity of OkaraOkara 56300Pakistan National University of TechnologySchool of Applied Sciences and HumanitiesNational University of TechnologyIslamabad 42000Pakistan Department of Plant SciencesFaculty of Biological SciencesQuaid-i-Azam UniversityIslamabad 45320Pakistan 

出 版 物：《Journal of Traditional Chinese Medicine》 (中医杂志（英文版）)

年 卷 期：2019年第39卷第6期

页      面：772-779页

核心收录：

学科分类：1008[医学-中药学(可授医学、理学学位)] 1007[医学-药学(可授医学、理学学位)] 1006[医学-中西医结合] 1005[医学-中医学] 1002[医学-临床医学] 100602[医学-中西医结合临床] 10[医学] 

主　　题：Rumex Atioxidants Anti-infective agents Drug resistant,multiple Cytotoxins 

摘      要：OBJECTIVE:To investigate the phytochemicals and in vitro antioxidant,antimicrobial and cytotoxic potential of Rumex dentatus(***)leaf ***:The total phenolics and flavonoids content of *** extracts were evaluated by the Folin-Ciocalteu and aluminum chloride colorimetric methods *** potential of studied plant extracts was assessed through 2,2-diphenyl-1-picrylhydrazyl radical scavenging capacity,total reducing power and total antioxidant ***,antibacterial and antifungal capacity was also evaluated by disc diffusion method against six clinically isolated multi-drug resistant bacterial strains as well as six fungal ***,cell cytotoxicity was also evaluated through3-(4,5-dimethylthiazolyl-2)-2,5-diphenyltetrazolium bromide ***:Ethanol extract showed highest total phenolic[(38.9±1.5)μg gallic acid equivalent/mg]and total flavonoids[(17.2±1.9)μg quercetin equivalent/mg]*** assays indicated that ethanol and methanol extracts possess potent antioxidant ***,it was observed that ethanol and hexane extracts have the potential to inhibit most of the tested multi-drug resistant bacterial strains while methanol,chloroform and hexane extracts could inhibit the growth of pathogenic fungal strains *** all the studied extracts,ethanolic extract showed highest cytotoxicity against MCF-7 cell line then Hep-2 and DU-145 cell lines by MTT assay with lowest IC50 of 47.3μg/m ***:These results suggest that *** could be a potent alternative candidate for treatment of microbial infections and for breast cancer treatment.