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Effectiveness and safety of traditional Chinese medical therapy for cancer-related fatigue: a systematic review and Meta-analysis of randomized controlled trials

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Journal of Traditional Chinese Medicine 2020年第5期40卷 738-748页

作者： Zhao Yueyang Wang Sumei Li Jinhua Zhou Yushu Wu Wanyin swei sunny hann Department of Hematology Department of Medical OncologyLaboratory of Tumor BiologyGuangdong Provincial Hospital of Chinese MedicineThe Second Clinical Medical CollegeGuangzhou University of Chinese MedicineGuangzhouGuangdong Province 510120China

OBJECTIVE:To assess the effectiveness and safety of traditional Chinese medical therapy for cancer-related ***:We systematically searched eight electronic databases up to June 2017 for randomized clinical trials of traditional Chinese medical therapy for cancer-related *** authors independently extracted data and assessed the risk bias of the included trials using the Cochrane *** were analyzed by Rev Man 5.2 ***:A total of 23 trials involving 1832 participants identified with cancer-related fatigue were *** trials reported a beneficial effect of traditional Chinese medical therapy on cancer-related *** pooling the data from Chinese herbal medicine therapy and acupuncture or moxibustion therapy,respectively,significant differences were found between experimental groups and control *** improvement rates showed significant differences between traditional Chinese medical therapy and control groups[odds ratio(OR),7.62;95%confidence interval(CI),3.75-15.49;P<0.00001;and OR,3.78;95%CI,2.29-6.23;P<0.00001).Fatigue change scores also showed significant differences between the two groups(mean difference,-0.91;95%CI,-1.16 to-0.65;P<0.00001).Eleven trials demonstrated that traditional Chinese medical therapy improved the quality of life of cancer *** severe adverse effects occurred in traditional Chinese medical therapy ***:Meta-analysis showed that Chinese medical therapy seems to be effective and safe in the treatment of cancer-related fatigue.

关键词： Neoplasms Fatigue Medicine,Chinese Traditional Quality of life Systematic review Randomized clinical trial

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Could traditional Chinese medical therapy be an efficacy and safety method for cancer-related fatigue? A Systematic Review and Metaanalysis of Randomized Controlled Trials

Could traditional Chinese medical therapy be an efficacy and...

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第十七届全国中西医结合肿瘤学术大会

作者： YueYang Zhao SuMei Wang JinHua Li YuShu Zhou WanYin Wu swei sunny hann Department of Medical Oncology Guangdong Provincial Hospital of Chinese Medicine The Second Clinical Medical Collage Guangzhou University of Chinese Medicine Laboratory of Tumor Biology Guangdong Provincial Hospital of Chinese Medicine The Second Clinical Medical Collage Guangzhou University of Chinese Medicine Guangdong Provincial Key Laboratory of Clinical Research on Traditional Chinese Medicine Syndrome Guangdong Provincial Hospital of Chinese Medicine The Second Clinical Medical Collage Guangzhou University of Chinese Medicine

Objective: To assess the efficacy and safety of traditional Chinese medical therapy for the treatment of cancer-related fatigue. Methods : We systematically searched eight electronic databases up to June 2017 for randomized clinical trials of traditional Chinese medical therapy for cancer-related fatigue. Two authors independently extracted data and assess the risk bias of the included trials using Cochrane Handbook. Data was analyzed by RevMan 5.2 software. Results : We included 23 trials involving 1832 participants identified cancer-related fatigue in the study. 20 trials reported traditional Chinese medical therapy brings beneficialeffect on the treatment of cancer-related fatigue. Pooling the data that used Chinese herbal medicine therapy and acupuncture or moxibustion therapy respectively, it was found significant differences between the experimental groups and control groups. Fatigue improvement rates were respectively showed significant differences between traditional Chinese medical therapy groups and control groups.(OR: 7.62;95%CI: 3.75-15.49;P<0.00001;and OR : 3.78;95%CI: 2.29-6.23;P<0.00001) The data of Fatigue change scores also showed significant difference between the two groups.(MD:-0.91;95%CI:-1.16--0.65;P<0.00001). 11 trials demonstrated traditional Chinese medical therapy improves the quality of life on cancer patients. There were no severe adverse effects occurred at traditional Chinese medical therapy group. Conclusion: we found traditional Chinese medical therapy seems to be effective and safe in the treatment of cancer-related fatigue.

关键词： cancer fatigue Chinese medical therapy Systematic review Randomized clinical trial

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