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First-line anti-VEGF plus EGFR-TKI in EGFR-mutant NSCLC: adding the ARTEMIS trial to the puzzle of current evidence

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Signal Transduction and Targeted Therapy 2022年第1期7卷 4-6页

作者： susanne Hafner Institute of Pharmacology of Natural Products and Clinical Pharmacology Ulm UniversityD-89081 UlmGermany

In the ARTEMIS-CTONG1509 multicenter phase 3 study recently published in Cancer Cell,Zhou et *** the combination of the EGFR tyrosine kinase inhibitor(TKI)erlotinib and anti-angiogenic bevacizumab in treatmentnaive Chinese patients with advanced EGFR-mutant non-small cell lung cancer(NSCLC).^(1) The primary endpoint of progression-free survival(PFS)was significantly exte nded from 11.2 months with erloti nib mono therapy to 17.9 mon ths with the combination.

关键词： NSCLC TKI EGFR

Between fighting and tolerance： reproductive biology of wingless males in the ant Cardiocondyla venustula

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Insect Science 2017年第5期24卷 818-828页

作者： susanne Jacobs Jurgen Heinze LS ZoologielEvolutionsbiologie Universitat Regensburg Regensburg Germany

Male reproductive tactics vary widely across the species of the ant genus Cardiocondyla, from obligatory lethal combat among co-occurring males to complete mutual tolerance. The African species C. venustula Wheeler, 1908 has an intermediate phylogenetic position between taxa with fighting males and taxa with tolerant males and also shows an intermediate male behavior. Males from 2 native populations in South Africa and a population introduced to Puerto Rico attacked and killed freshly eclosing rivals but rarely engaged in deadly fights with adult competitors, Instead, several males per colony established small ＂territories＂ in their natal nests and defended them against other males. Males with a stable territory had more contact with female sexuals than nonterritorial males and more frequently engaged in mating attempts. In controlled choice experiments, female sexuals did not show any preference for particular males. We suggest that male territoriality in C. venustula is an adaptation to the seasonal production of large numbers of female sexuals by multiple mothers.

关键词： Cardiocondyla ergatoid males Formicidae male competition sexual selection territoriality

Quantitative data graphics in 3D desktop-based virtual environments-an evaluation

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International Journal of Digital Earth 2015年第8期8卷 623-639页

作者： susanne Bleisch Jason Dykes Geomatics Engineering FHNW University of Applied Sciences and Arts Northwestern SwitzerlandMuttenzSwitzerland giCentre City University LondonLondonUK

3D desktop-based virtual environments provide a means for displaying quantitative data in *** that are inherently spatial in three dimensions may benefit from visual exploration and analysis in relation to the environment in which they were collected and to which they *** empirically evaluate how effectively and efficiently such data can be visually analyzed in relation to location and landform in 3D versus 2D *** two experiments,participants performed visual analysis tasks in 2D and 3D visualizations and reported insights and their confidence in *** results showed only small differences between the 2D and 3D visualizations in the performance measures that we evaluated:task completion time,confidence,complexity,and insight ***,we found differences for different datasets and settings suggesting that 3D visualizations or 2D representations,respectively,may be more or less useful for particular datasets and contexts.

关键词： 3D geovisualization quantitative data graphics visual data analysis empirical evaluation

Beyond Membranes:The Evolution of Plant Lipid Signaling

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Molecular Plant 2020年第7期13卷 952-954页

作者： susanne Hoffmann-Benning Department of Biochemistry and Molecular Biology Michigan State UniversityEast LansingMIUSA

Lipids have many essential functions in plants:They are membrane components and as such play an important role in compartmentation of the cell,membrane curvature,and formation of lipid rafts/microdomains;they participate in vesicle formation and trafficking,and act as a barrier to unrestricted trafficking of *** are also important intermediates in the biosynthesis of secondary metabolites and storage *** more interesting is their role in signaling.

关键词： Lipid Plant curvature

Interaction of microglia and T cells: a deadly duo behind Taumediated neurodegeneration

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Signal Transduction and Targeted Therapy 2023年第9期8卷 3894-3895页

作者： Bilge Askin susanne Wegmann German Center for Neurodegenerative Diseases Charitéplatz 110117 BerlinGermany Einstein Center for Neurosciences Berlin Charité-Universitätsmedizin BerlinBerlinGermany

A recent study by Chen et *** in Nature reported the presence of activated T cells in the brains of transgenic mice with frontotemporal dementia(FTD)-like Tau protein pathology and in postmortem Alzheimer’s disease(AD)brains.1 The infiltration of T cells correlated with the degree of Tau pathology and microglia activation,and appeared to promote *** progressive aggregation of amyloid-β in extracellular amyloid plaques and of Tau in neurofibrillary tangles are the two main protein pathological hallmarks of *** are accompanied by synaptic loss,neuroinflammation,and neuronal death,and com-promise the blood-brain barrier,allowing immune cells to infiltrate the brain parenchyma and interact with glial cells and neurons;all of these factors contribute to disease progression.2 Activated T cells can be found in postmortem brains of different neurological disorders,in AD,particularly in areas with neuronal loss and Tau pathology,i.e.,the hippocampus and limbic structures.

关键词： pathology amyloid inflammation

Transcriptional inhibition in Schwann cell development and nerve regeneration

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Neural Regeneration Research 2017年第8期12卷 1241-1246页

作者： susanne Quintes Bastian G.Brinkmann Max-Planck-Institute of Experimental Medicine Department of Neurogenetics Gottingen Germany Department of Clinical Neurophysiology University Medical Center Gotingen (UMG) Gottingen Germany

Schwann cells, the myelinating glial cells of the peripheral nervous system are remarkably plastic after nerve trauma. Their transdifferentiation into specialized repair cells after injury shares some features with their development from the neural crest. Both processes are governed by a tightly regulated balance between activators and inhibitors to ensure timely lineage progression and allow re-maturation after nerve injury. Functional recovery after injury is very successful in rodents, however, in humans, lack of regeneration after nerve trauma and loss of function as the result of peripheral neuropathies represents a significant problem. Our understanding of the basic molecular machinery underlying Schwann cell maturation and plasticity has made significant progress in recent years and novel players have been discovered. While the transcriptional activators of Schwann cell development and nerve repair have been well defined, the mechanisms counteracting negative regulation of（re-）myelination are less well understood. Recently, transcriptional inhibition has emerged as a new regulatory mechanism in Schwann cell development and nerve repair. This mini-review summarizes some of the regulatory mechanisms controlling both processes and the novel concept of ＂inhibiting the inhibitors＂ in the context of Schwann cell plasticity.

关键词： Schwann cell Zeb2 myelin transcription factors regeneration remyelination neuropathy

Knockdown of Na,K-ATPase β-subunits in Oncopeltus fasciatus induces molting problems and alterations in tracheal morphology

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Insect Science 2023年第2期30卷 375-397页

作者： Marlena Herbertz Jennifer Lohr Christian Lohr susanne Dobler Division of Molecular Evolutionary Biology Department of BiologyInstitute of Cell and Systems Biology of AnimalsUniversitat HamburgHamburg20146Germany Division of Neurophysiology Department of BiologyInstitute of Cell and Systems Biology of AnimalsUniversitat HamburgHamburg20146Germany

The ubiquitously expressed transmembrane enzyme Na,K-ATPase(NKA)is vital in maintaining functionality of *** association of α-and β-subunits is believed to be essential for forming a functional *** the large milkweed bug Oncopeltus fasciatus fourα1-paralogs and four β-subunits exist that can associate into NKA *** diversity raises the question of possible tissue-specific distribution and *** the α1-subunits are known to modulate cardenolide-resistance and ion-transport efficiency,the functional importance of the β-subunits needed further *** here characterize all four different β-subunits at the cellular,tissue,and whole organismal scales.A knockdown of different β-subunits heavily interferes with molting success resulting in strongly hampered *** failure of ecdysis might be related to disrupted septate junction(SJ)formation,also reflected in β2-suppression-induced alteration in tracheal *** data further suggest the existence of isolated β-subunits forming homomeric or β-heteromeric *** possible standalone and structure-specific distribution of the β-subunits predicts further,yet unknown pump-independent *** different effects caused byβknockdowns highlight the importance of the various β-subunits to fulfill tissue-specific requirements.

关键词： ecdysis insect Na^(+)/K^(+)-ATPase protein distribution RNAi septate junctions tissue-specific function

Comparison of carotenoid,chlorophyll concentrations and their biosynthetic transcript levels in different coloured cauliflower

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Horticultural Plant Journal 2024年第3期10卷 743-754页

作者： Fatemeh Izadpanah Katja Frede Forouzandeh Soltani susanne Baldermann Food Chemistry and Human Nutrition Leibniz Institute of Vegetable and Ornamental CropsTheodor-Echtermeyer-Weg 114979 GroßbeerenGermany Department of Food Chemistry Institute of Nutritional SciencesUniversity of PotsdamArthur-Scheunert-Allee 114-11614558 NuthetalGermany Department of Horticultural Science University of TehranDaneshkade Ave31587-77871KarajIran Faculty of Life Sciences:Food Nutrition and HealthFood MetabolomeUniversity of BayreuthFritz-Hornschuch-Straße1395326 KulmbachGermany

Carotenoids and chlorophylls are among the most widely distributed pigments in nature that play essential roles in the photosynthetic apparatus and confer diverse colours in *** all vegetables,cauliflower(Brassica oleracea ***)is rich in phytochemicals and is an important crop grown all over the *** study investigates carotenoid and chlorophyll concentrations in differently pigmented cultivars and elucidates the role of transcriptional regulation of carotenoid accumulation including lutein andβ-***,we characterised changes in pigments by UHPLC-DAD-ToF-MS and changes in transcript levels of carotenoid metabolic genes by qRT-PCR in florets and leaves of orange(‘Jaffa'and‘Sunset'),purple(‘Di Sicilia Violetto'and‘Graffiti'),green(‘Trevi')and white(‘Clapton')*** levels of all carotenoid metabolic genes showed different transcript level patterns in the leaves and *** to the other cultivars,the orange cultivars had the highest levels ofβ-carotene in the florets and lutein in the leaves resulting in changes lutein/β-carotene *** the green cultivar,higher transcript levels were also found,especially for phytoene synthase and phytoene desaturase genes of the core biosynthesis ***,no increased carotenoid concentrations were observed,possibly due to a higher carotenoid turnover induced by the carotenoid cleavage dioxygenase 4 in the green *** the white(‘Clapton')and purple(‘Di Sicilia Violetto'and‘Graffiti')cultivars the phytoene desaturase transcript levels as well as carotenoid concentrations were *** concentrations changed in trend comparable to the carotenoid concentrations and were only significantly lower in the leaves of the orange cultivar‘Jaffa'.Also,the chlorophyll a/b ratio changed in‘Jaffa'.In florets the highest chlorophylls concentrations were observed for the green cultivar(‘Trevi')and the purple cultivar(‘Di Sicilia Violetto').Taken together,the study dem

关键词： Brassica oleracea L.var.botrytis Carotenoid Lutein β-Carotene Biosynthesis qRT-PCR

Additive effects of functionally dissimilar above- and belowground organisms on a grassland plant community

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Journal of Plant Ecology 2011年第4期4卷 221-227页

作者： susanne Wurst Matthias C.Rillig Plant Ecology/Functional Biodiversity Dahlem Centre of Plant SciencesInstitut für BiologieFreie Universität BerlinAltensteinstr.614195 BerlinGermany

In nature,plant communities are affected simultaneously by a variety of functionally dissimilar organisms both above and below the ***,there is a gap of knowledge on interactive effects of functionally dissimilar organisms on plant communities that is needed to be filled to better understand and predict the general impact of biotic factors on plant *** We conducted a full-factorial mesocosm study to investigate the individual and combined impacts of above-and belowground functionally dissimilar organisms on a grassland plant *** studied the effects of aboveground herbivores(Helix aspersa,Gastropoda),arbuscular mycorrhizal fungi(AMF;Glomus spp.,Glomeromycota)and endogeic earthworms(Aporrectodea spp.,Lumbricidae)on the diversity,structure and productivity of an experimental grassland plant community and each *** Findings Aboveground herbivory by snails decreased,AMF increased and earthworms had no effects on the diversity of the grassland plant community,while their combined effects were *** biomass of the plant community was negatively affected by snails and AMF,while no effects of earthworms or interaction effects were *** plant species were differently affected by snails and *** effects of the above-and belowground organisms on each other’s performance were *** the effects of the functionally dissimilar organisms on the grassland plant community were mainly independent,the results indicate that their combined effects may be predicted by knowing the individual effects,at least under the conditions used in the present mesocosm study.

关键词： aboveground–belowground interactions AMF earthworms snails