Interaction of microglia and T cells: a deadly duo behind Taumediated neurodegeneration

作     者：Bilge Askin Susanne Wegmann Bilge Askin;Susanne Wegmann

作者机构：German Center for Neurodegenerative DiseasesCharitéplatz 110117 BerlinGermany Einstein Center for Neurosciences BerlinCharité-Universitätsmedizin BerlinBerlinGermany 

出 版 物：《Signal Transduction and Targeted Therapy》 (信号转导与靶向治疗(英文))

年 卷 期：2023年第8卷第9期

页      面：3894-3895页

核心收录：

学科分类：1002[医学-临床医学] 100204[医学-神经病学] 10[医学] 

基　　金：This work was funded by the DZNE in the Helmholtz Society and the Einstein Foundation Berlin 

主　　题：pathology amyloid inflammation 

摘      要：A recent study by Chen et *** in Nature reported the presence of activated T cells in the brains of transgenic mice with frontotemporal dementia(FTD)-like Tau protein pathology and in postmortem Alzheimer’s disease(AD)brains.1 The infiltration of T cells correlated with the degree of Tau pathology and microglia activation,and appeared to promote *** progressive aggregation of amyloid-β in extracellular amyloid plaques and of Tau in neurofibrillary tangles are the two main protein pathological hallmarks of *** are accompanied by synaptic loss,neuroinflammation,and neuronal death,and com-promise the blood-brain barrier,allowing immune cells to infiltrate the brain parenchyma and interact with glial cells and neurons;all of these factors contribute to disease progression.2 Activated T cells can be found in postmortem brains of different neurological disorders,in AD,particularly in areas with neuronal loss and Tau pathology,i.e.,the hippocampus and limbic structures.