Knockdown of Na,K-ATPase β-subunits in Oncopeltus fasciatus induces molting problems and alterations in tracheal morphology
作者机构：Division of Molecular Evolutionary BiologyDepartment of BiologyInstitute of Cell and Systems Biology of AnimalsUniversitat HamburgHamburg20146Germany Division of NeurophysiologyDepartment of BiologyInstitute of Cell and Systems Biology of AnimalsUniversitat HamburgHamburg20146Germany
出 版 物：《Insect Science》 (昆虫科学（英文版）)
年 卷 期：2023年第30卷第2期
页 面：375-397页
核心收录：
学科分类：07[理学] 0701[理学-数学] 070101[理学-基础数学]
基 金：Projekt DEAL
主 题：ecdysis insect Na^(+)/K^(+)-ATPase protein distribution RNAi septate junctions tissue-specific function
摘 要：The ubiquitously expressed transmembrane enzyme Na,K-ATPase(NKA)is vital in maintaining functionality of *** association of α-and β-subunits is believed to be essential for forming a functional *** the large milkweed bug Oncopeltus fasciatus fourα1-paralogs and four β-subunits exist that can associate into NKA *** diversity raises the question of possible tissue-specific distribution and *** the α1-subunits are known to modulate cardenolide-resistance and ion-transport efficiency,the functional importance of the β-subunits needed further *** here characterize all four different β-subunits at the cellular,tissue,and whole organismal scales.A knockdown of different β-subunits heavily interferes with molting success resulting in strongly hampered *** failure of ecdysis might be related to disrupted septate junction(SJ)formation,also reflected in β2-suppression-induced alteration in tracheal *** data further suggest the existence of isolated β-subunits forming homomeric or β-heteromeric *** possible standalone and structure-specific distribution of the β-subunits predicts further,yet unknown pump-independent *** different effects caused byβknockdowns highlight the importance of the various β-subunits to fulfill tissue-specific requirements.
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