检索结果-南通市图书馆

Efficacy of Vaccine Protection Against COVID-19 Virus Infection in Patients with Chronic Liver Diseases

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Clinical and Translational Hepatology 2023年第3期11卷 718-735页

作者： Carmen Ka Man Cheung Kimmy Wan Tung Law Alvin Wing Hin Law Man Fai Law Rita Ho sunny hei wong Department of Medicine and Therapeutics Prince of Wales HospitalHong KongChina West Island School Hong KongChina Department of Medicine North District HospitalHong KongChina Institute of Digestive Disease and Department of Medicine and Therapeutics State Key Laboratory of Digestive DiseaseLi Ka Shing Institute of Health SciencesThe Chinese University of Hong KongHong KongChinaLee Kong Chian School of MedicineNanyang Technological UniversitySingapore

The outbreak of coronavirus disease 2019 (COVID-19) has resulted in significant morbidity and mortality worldwide. Vaccination against coronavirus disease 2019 is a use-ful weapon to combat the virus. Patients with chronic liver diseases (CLDs), including compensated or decompensated liver cirrhosis and noncirrhotic diseases, have a decreased immunologic response to coronavirus disease 2019 vaccines. At the same time, they have increased mortality if infected. Current data show a reduction in mortality when patients with chronic liver diseases are vaccinated. A suboptimal vac-cine response has been observed in liver transplant recipi-ents, especially those receiving immunosuppressive therapy, so an early booster dose is recommended to achieve a better protective effect. Currently, there are no clinical data com-paring the protective efficacy of different vaccines in patients with chronic liver diseases. Patient preference, availability of the vaccine in the country or area, and adverse effect profiles are factors to consider when choosing a vaccine. There have been reports of immune-mediated hepatitis after coronavi-rus disease 2019 vaccination, and clinicians should be aware of that potential side effect. Most patients who developed hepatitis after vaccination responded well to treatment with prednisolone, but an alternative type of vaccine should be considered for subsequent booster doses. Further prospec-tive studies are required to investigate the duration of immu-nity and protection against different viral variants in patients with chronic liver diseases or liver transplant recipients, as well as the effect of heterologous vaccination.

关键词： COVID-19 SARS-CoV-2 Chronic liver disease Liver transplanta-tion Vaccine mRNA.

Spontaneous type 1 pattern, ventricular arrhythmias and sudden cardiac death in Brugada Syndrome： an updated systematic review and meta-analysis

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Geriatric Cardiology 2017年第10期14卷 639-643页

作者： Ahmed Bayoumy Meng-Qi GONG Ka Hou Christien Li sunny hei wong William KK Wu Guang-Ping LI George Bazoukis Konstantinos P Letsas Wing Tak wong Yun-Long XIA Tong LIU Gary Tse Department of Medicine and Therapeutics Faculty of Medicine Chinese University of Hong Kong Hong Kong China Li Ka Shing Institute of Health Sciences Faculty of Medicine Chinese University of Hong Kong Hong Kong China Faculty of Medicine University of Amsterdam The Netherlands Tianjin Key Laboratory of Ionic-Molecular Function of Cardiovascular Disease Department of Cardiology Tianjin Institute of Cardiology Second Hospitalof Tianjin Medical University Tianjin China Faculty of Medicine Newcastle University United Kingdom Department of Anaesthesia and Intensive Care Faculty of Medicine Chinese University of Hong Kong Hong Kong China Second Department of Cardiology Evangelismos General Hospital of Athens Athens Greece School of Life Sciences Chinese University of Hong Kong Hong Kong China Department of Cardiology First Affiliated Hospital of Dalian Medical University Dalian China

Brugada syndrome (BrS) is primary electrical disorder characterized by ST segment elevation with right bundle branch block morphology in patients with apparent structurally normal hearts. It predisposes affected individuals to ventricular tachycardia/fibrillation (VT/VF) and sudden cardiac death (SCD). A number of studies have identified risk factors that are associated with a more malignant course of disease. These include male gender, syncope, a spontaneous type 1 ECG pattern, family history of SCD,family history of Brugada syndrome, loss-of-function mutations in the SCN5a gene, inducible VT/VF during programmed electrical stimulation. Of these risk factors, many studies have demonstrated that the presence of a spontaneous type 1 pattern is associated with a significantly higher risk of VT/VF or SCD, but other studies have demonstrated a lack of significant predictive value.

关键词： Brugada 症候群冒险层化自发的类型 1 突然的心脏的死亡室的心律不齐

A meta-analysis of soluble suppression of tumorigenicity 2 （sST2） and clinical outcomes in pulmonary hypertension

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Geriatric Cardiology 2017年第12期14卷 766-771页

作者： King Sum Luk Christina Ip Meng-Qi GONG sunny hei wong William KK Wu Mei DONG Guang-Ping LI Ka Pang Chan Yi-Mei DU Tong LIU Martin CS wong David Shu Cheong Hui Gary Tse Department of Medicine and Therapeutics Faculty of Medicine Chinese University ofHong Kong Hong Kong China Li Ka Shing Institute of Health Sciences Faculty of Medicine Chinese University ofHong Kong Hong Kong China Tianjin Key Laboratory of Ionic-Molecular Function of Cardiovascular disease Department of Cardiology Tianjin Institute of Cardiology Second Hospital of Tianjin Medical University Tianjin China Department of Anaesthesia and Intensive Care State Key Laboratory of Digestive Disease LKS Institute of Health Sciences The Chinese University of Hong Kong Hong Kong China The State and Shandong Province Joint Key Laboratory of Translational Cardiovascular Medicine Department of Cardiology Qilu Hospital Shandong University Jinan China Research Center of Ion Channelopathy Institute of Cardiology Union Hospital Tongii Medical College Huazhong University of Science and Technology Wuhan China JC School of Public Health and Primary Care The Chinese University ofHong Kong Hong Kong China State Key Laboratory of Digestive Disease LKS Institute of Health Sciences Chinese University ofHong Kong Hong Kong China

Suppression of Tumorigenicity 2 (ST2) is a member of the interleukin (IL)-1 receptor family. The ST2 receptor exists in two isoforms - ST2 ligand (ST2L) and soluble ST2 (sST2). ST2L is a membrane receptor and sST2 is a truncated receptor which is soluble in the blood, allowing it to be detected in serum. IL-33 is a member of the IL-1 family of ligand and is the functional ligand of ST2L receptor. It binds to the ST2L, thereby mediating its immune function.

关键词：高血压临床膜受体 ST2 IL-1 肺免疫力家庭

Meta-analysis of T-wave indices for risk stratification in myocardial infarction

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Geriatric Cardiology 2017年第12期14卷 776-779页

作者： Gary Tse Cheuk Wai wong Meng-Qi GONG Lei MENG Konstantinos P Letsas Guang-Ping LI Paula Whittaker Aishwarya Bhardwaj Abhishek C Sawant William KK Wu sunny hei wong Jayaprakash Shenthar Lap Ah Tse Martin CS wong Adrian Baranchuk Gan-Xin YAN Tong LIU Department of Medicine and Therapeutics Faculty of Medicine Chinese University ofHong Kong Hong Kong China Li Ka Shing Institute of Health Sciences Faculty of Medicine Chinese University ofHong Kong Hong Kong China Li Ka Shing Faculty of Medicine The University of Hong Kong Hong Kong China Tianjin Key Laboratory of Ionic-Molecular Function of Cardiovascular disease Department of Cardiology Tianjin Institute of Cardiology Second Hospital of Tianjin Medical University Tianjin China Second Department of Cardiology Laboratory of Cardiac Electrophysiology 'Evangelismos' General Hospital of Athens Athens Greece Division of Population Health Health Services Research and Primary Care School of Health Sciences University of Manchester United Kingdom Division of Cardiology Department of Internal Medicine State University of New York at Buffalo USA Department of Anaesthesia and Intensive Care State Key Laboratory of Digestive Disease LKS Institute of Health Sciences The Chinese University of Hong Kong Hong Kong China Electrophysiology Unit Sri Jayadeva Institute of Cardiovascular Sciences and Research B G Road 9th Block Jayanagar Bangalore India JC School of Public Health and Primary Care The Chinese University of Hong Kong Hong Kong China Division of Cardiology Kingston General Hospital Queen 's University Kingston Ontario Canada Lankenau Institute for Medical Research and Lankenau Medical Center Wynnewood Pennsylvania USA Beijing Anzhen Hospital Capital Medical University Beijing China

Ventricular tachy-arrhythmias are the commonest cause of sudden cardiac death in patients with ischemic heart disease. It is estimated that up to 20% patients with acute myocardial infarction suffer from these arrhythmias. There is a growing need for developing tools for risk assessment for sudden cardiac death (SCD) in this population. Several ECG indices have been proposed for risk stratification and for prognostication after myocardial infarction (MI). These can divided broadly into those based on repolarization, conduction or both, as reviewed recently. Repolarization indices include QT interval, QT dispersion, T_(peak)-T_(end) interval, T_(peak)-T_(end)/QT ratio, JT_(peak)/JT, (T_(peak)-T_(end))/JT_(peak) and T_(peak)/JT ratios. Conduction indices include QRS duration and QRS dispersion. Conduction-repolarization indices are exemplified by index of Cardiac Electrophysiological Balance (iCEB: QT/QRS), and QRS-T angle, amongst others.

关键词：风险梗塞心肌索引波浪开发工具死亡心脏

Dual ultra-wideband(UWB)radar-based sleep posture recognition system:Towards ubiquitous sleep monitoring

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

再生工程(英文) 2023年第1期4卷 36-43页

作者： Derek Ka-hei Lai Li-Wen Zha Tommy Yau-Nam Leung Andy Yiu-Chau Tam Bryan Pak-hei So Hyo-Jung Lim Daphne Sze Ki Cheung Duo Wai-Chi wong James Chung-Wai Cheung Department of Biomedical Engineering Faculty of EngineeringThe Hong Kong Polytechnic UniversityHong Kong 999077China Department of Bioengineering Imperial CollegeLondon SW72AZUnited Kingdom Research Institute of Smart Ageing The Hong Kong Polytechnic UniversityHong KongChina School of Nursing The Hong Kong Polytechnic UniversityHong KongChina

Sleep posture monitoring is an essential assessment for obstructive sleep apnea(OSA)*** objective of this study is to develop a machine learning-based sleep posture recognition system using a dual ultra-wideband radar *** collected radiofrequency data from two radars positioned over and at the side of the bed for 16 patients performing four sleep postures(supine,left and right lateral,and prone).We proposed and evaluated deep learning approaches that streamlined feature extraction and classification,and the traditional machine learning approaches that involved different combinations of feature extractors and *** results showed that the dual radar system performed better than either single *** statistical features with random forest classifier yielded the best accuracy(0.887),which could be further improved via an ablation study(0.938).Deep learning approach using transformer yielded accuracy of 0.713.

关键词： Obstructive sleep apnea Deep learning Sleep monitoring Feature extraction Ablation study

In vivo genome editing thrives with diversified CRISPR technologies

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Zoological Research 2018年第2期39卷 58-71页

作者： Xun Ma Avery Sum-Yu wong hei-Yin Tam Samuel Yung-Kin Tsui Dittman Lai-Shun Chung Bo Feng Key Laboratory for Regenerative Medicine in Ministry of Education School of Biomedical Sciences Faculty of Medicine The Chinese University of Hong Kong Guangzhou Institute of Biomedicine and Health Chinese Academy of Sciences SBS Core Laboratory CUHK Shenzhen Research Institute

Prokaryotic type II adaptive immune systems have been developed into the versatile CRISPR technology, which has been widely applied in site- specific genome editing and has revolutionized biomedical research due to its superior efficiency and flexibility. Recent studies have greatly diversified CRISPR technologies by coupling it with various DNA repair mechanisms and targeting strategies. These new advances have significantly expanded the generation of genetically modified animal models, either by including species in which targeted genetic modification could not be achieved previously, or through introducing complex genetic modifications that take multiple steps and cost years to achieve using traditional methods. Herein, we review the recent developments and applications of CRISPR-based technology in generating various animal models, and discuss the everlasting impact of this new progress on biomedical research.

关键词： CRISPR/Cas9 Genome editing Animal models

Parallelized volumetric fluorescence microscopy with a reconfigurable coded incoherent light-sheet array

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Light(Science & Applications) 2020年第1期9卷 1914-1924页

作者： Yu-Xuan Ren Jianglai Wu Queenie T.K.Lai hei Ming Lai Dickson M.D.Siu Wutian Wu Kenneth K.Y.wong Kevin K.Tsia Department of Electrical and Electronic Engineering The University of Hong KongPokfulam RoadHong KongSAR 999077China Department of Physics University of CaliforniaBerkeleyCA 94720USA School of Biomedical Sciences Li Ka Shing Faculty of MedicineThe University of Hong KongHong KongSAR 999077China Department of Psychiatry Faculty of MedicineThe Chinese University of Hong KongHong KongSAR 999077China GHM Institute of CNS Regeneration Jinan University601 Huangpu Avenue WestGuangzhou 510632China Re-Stem Biotechnology Suzhou 215007China

Parallelized fluorescence imaging has been a long-standing pursuit that can address the unmet need for a comprehensive three-dimensional(3D)visualization of dynamical biological processes with minimal ***,the available approaches are limited to incomplete parallelization in only two dimensions or sparse sampling in three *** hereby develop a novel fluorescence imaging approach,called coded light-sheet array microscopy(CLAM),which allows complete parallelized 3D imaging without mechanical *** the concept of an“infinity mirror”,CLAM generates a light-sheet array with controllable sheet density and degree of ***,CLAM circumvents the common complications of multiple coherent light-sheet generation in terms of dedicated wavefront engineering and mechanical dithering/***,the encoding of multiplexed optical sections in CLAM allows the synchronous capture of all sectioned images within the imaged *** demonstrate the utility of CLAM in different imaging scenarios,including a light-scattering medium,an optically cleared tissue,and microparticles in fluidic *** can maximize the signal-to-noise ratio and the spatial duty cycle,and also provides a further reduction in photobleaching compared to the major scanning-based 3D imaging *** flexible implementation of CLAM regarding both hardware and software ensures compatibility with any light-sheet imaging modality and could thus be instrumental in a multitude of areas in biological research.

关键词： scattering light mirror

Unidirectional p-GaN gate HEMT with composite source-drain field plates

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Science China(Information Sciences) 2022年第2期65卷 265-266页

作者： Haiyong WANG Wei MAO Shenglei ZHAO Yuanhao HE Jiabo CHEN Ming DU Xuefeng ZHENG Chong WANG Chunfu ZHANG Jincheng ZHANG Yue HAO Key Lab of Ministry of Education for Wide Band-Gap Semiconductor Materials and Devices School of Microelectronics Xidian University

Dear editor,Ga N-on-Si high electron mobility transistors (HEMTs) have attracted attention for power device applications due to their low cost and large-area availability[1].Recently,bidirectional switches are highly desirable in many industrial bidirectional power conversion applications,such as rolling mills,elevators,and wind power *** addition,normally-off unidirectional HEMTs can be valuable devices to implement the high-performance bidirectional switches[2,3].

关键词： Nano CMOS ESD Reliability Hot-carrier Charge trapping

Lues Maligna in an Immune-Reconstituted Patient with Retroviral Infection: A Case Report

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

International Journal of Dermatology and Venereology 2020年第2期3卷 118-120页

作者： Tee Louis Y. Tan Chee Hian Chan Michelle M.F. wong hei Man Pang Shiu Ming Yeo Yi Wei Department of Dermatology Singapore General HospitalSingapore National Skin Centre Singapore Department of Anatomical Pathology Singapore General HospitalSingapore Department of Infectious Diseases Singapore General HospitalSingapore

The coronavirus disease 2019(COVID-19)outbreak affects the use of biologics for psoriatic patients,in the way that the consequential immunosuppression potentially alters a patient's susceptibility to the virus or deteriorate the condition if the patient is infected or even change the prognosis of ***,authors reviewed currently available recommendations from international psoriasis academic organizations and specialists,and summarized them with the specific situation in *** are trying to provide guidance to the use of biologics for psoriatic patients in the following contexts:patients on biologic therapy,patients being considered for biologic therapy initiation,patients with low-risk or high-risk of SARS-CoV-2 coronavirus infection,patients tested negative or positive for the nucleic acid testing of virus.

关键词： Immune constitute summarized