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Soleus arthrogenic muscle inhibition following acute lateral ankle sprain correlates with symptoms and ankle disability but not with postural control

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Journal of Sport and Health Science 2024年第4期13卷 559-568,F0003页

作者： Kyung-Min kim joo-sung kim Alan R.Needle Department of Sport Science Sungkyunkwan UniversitySuwon-si 16419Republic of Korea Department of Health and Human Performance Texas State UniversitySan MarcosTX 78666USA Department of Public Health&Exercise Science Appalachian State UniversityBooneNC 28608USA Department of Rehabilitation Science Appalachian State UniversityBooneNC 28608USA

Background:Acute lateral ankle sprains(ALAS)are associated with long-term impairments and instability tied to altered neural *** muscle inhibition(AMI)has been observed in this population;however,relationships with injury-related impairments are unclear,potentially due to the resting,prone position in which AMI is typically *** AMI during bipedal stance may provide a better understanding of this ***:AMI was assessed in 38 young adults(19 ALAS within 72 h of injury:10 males,21.4±2.7 years;19 healthy controls:10 males,21.9±2.2 years;mean±SD)using the Hoffmann reflex(H-reflex)during bipedal *** stimulation was administered to identify the _(max)imal H-reflex(H_(max))and _(max)imal motor response(M_(max))from the soleus,fibularis longus,and tibialis anterior *** primary outcome measure was the H_(max)/M_(max) *** outcomes included acute symptoms(pain and swelling),postural control during bipedal stance,and self-reported ***:No significant group-by-limb interactions were observed for any ***,a significant group main effect was observed in the soleus muscle(F(1,35)=6.82,p=0.013),indicating significantly lower H_(max)/M_(max) ratios following ALAS(0.38±0.20)compared to healthy controls(0.53±0.16).Furthermore,lower H_(max)/M_(max) ratios in the soleus significantly correlated with acute symptoms and self-reported function but not with postural ***:This study supports previous evidence of AMI in patients with ALAS,providing insight into neurophysiologic impacts of musculoskeletal *** results suggest that assessing AMI in a standing position following acute injury may provide valuable insight into how AMI develops and guide potential therapeutic options to curb and offset the formation of joint instability.

关键词： Acute injuries Balance Hoffmann reflex Neural excitability Patient-reported outcomes

Role of ascites adenosine deaminase in differentiating between tuberculous peritonitis and peritoneal carcinomatosis

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World Journal of Gastroenterology 2012年第22期18卷 2837-2843页

作者： Seung joo Kang Ji Won kim Jee Hyun Baek Se Hyung kim Byeong Gwan kim Kook Lae Lee Ji Bong Jeong Yong Jin Jung joo sung kim Hyun Chae Jung In sung Song Department of Internal Medicine and Liver Research Institute Seoul National University College of Medicine Department of Internal Medicine Seoul National University Boramae Hospital Department of Radiology Seoul National University College of Medicine

AIM： To investigate the usefulness of tumor markers and adenosine deaminase in differentiating between tuberculous peritonitis （TBP） and peritoneal carcinoma- tosis （PC）. METHODS： A retrospective analysis of data was per- formed on consecutive patients who underwent perito- neoscopic and abdominal computed tomography （CT） evaluations. Among 75 patients at the Seoul National University Hospital from January 2000 to June 2010 who underwent both tests, 27 patients （36.0%） and 25 patients （33.3%） were diagnosed with TBP and PC, re- spectively. Diagnosis was confirmed by peritoneoscopic biopsy. RESULTS： Serum c-reactive protein （7.88：1：6.62 mg/ dL vs 3.12 ＋ 2.69 mg/dL, P = 0.01）, ascites adenos- ine deaminase （66.76：1：32.09 IU/L vs 13.89 ：l： 8.95 IU/L, P 〈 0.01）, ascites lymphocyte proportion （67.77 ：1： 23.41% vs 48.36 ＋ 18.78%, P 〈 0.01）, and serum- ascites albumin gradient （0.72 ＋ 0.49 g/dL vs 1.05 ＋ 0.50 g/dL, P = 0.03） were significantly different be- tween the two groups. Among tumor markers, serum and ascites carcinoembryonic antigen, serum carbohy- drate antigen 19-9 showed significant difference be- tween two groups. Abdominal CT examinations showed that smooth involvement of the parietal peritoneum was more common in the TBP group （77.8% vs 40.7%） whereas nodular involvement was more common in the PC group （14.8% vs 40.7%, P = 0.04）. From receiver operating characteristic （ROC） curves ascites adeno- sines deaminase （ADA） showed better discriminative capability than tumor markers. An ADA cut-off level of 21 IU/L was found to yield the best results of differ- ential diagnosis; sensitivity, specificity, positive predic- tive value, and negative predictive value were 92.0%, 85.0%, 88.5% and 89.5%, respectively. CONCLUSION： Besides clinical and radiologic findings, ascitic fluid ADA measurement is helpful in the differen- tial diagnosis of TBP and PC.

关键词： Tuberculous peritonitis Peritoneal carcino-matosis, Adenosine deaminase, Peritoneoscopy

Restraint stress induces and exacerbates intestinal inflammation in interleukin-10 deficient mice

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World Journal of Gastroenterology 2015年第28期21卷 8580-8587页

作者： Seong-joon Koh Ji Won kim Byeong Gwan kim Kook Lae Lee joo sung kim Department of Internal Medicine Seoul National University Boramae Hospital Seoul National University College of Medicine Department of Internal Medicine and Liver Research Institute Seoul National University College of Medicine

AIM:To investigate the effects of restraint stress on chronic colitis in interleukin(IL)-10 deficient(IL-10^(-/-))***:The first experiment compared the effect of restraint stress on the development of intestinal inflammation in wild-type and IL-10^(-/-) *** wildtype and IL-10^(-/-) mice were physically restrained in a well-ventilated,50 cm3 conical polypropylene tube for2 h per day for three consecutive *** second experiment was performed to assess the effect of restraint stress on exacerbation of colitis induced by piroxicam in IL-10^(-/-) *** IL-10^(-/-) mice were exposed to restraint stress for 2 h per day for 3consecutive days,and then treated with piroxicam for4 d at a dose of 200 ppm administered in the rodent ***:In the first experiment,none of the wildtype mice with or without restraint stress showed clinical and histopathological abnormality in the ***,IL-10^(-/-) mice exposed to restraint stress exhibited histologically significant intestinal inflammation as compared to those without restraint *** the second experiment,restraint stress significantly reduced body weight and increased the severity of intestinal inflammation assessed by histopathologic grading in IL-10^(-/-) *** IL12p40 mRNA expression was strongly increased in mice exposed to restraint ***:This novel animal model could be useful in future study of psychological stress in the pathogenesis of inflammatory bowel disease.

关键词： Stress Colitis Interleukin-10 Inflammatorybowel disease Mouse model

Proton pump inhibitors as a risk factor for recurrence of Clostridium-difficile-associated diarrhea

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World Journal of Gastroenterology 2010年第28期16卷 3573-3577页

作者： Ji Won kim Kook Lae Lee Ji Bong Jeong Byeong Gwan kim Sue Shin joo sung kim Hyun Chae Jung In sung Song Division of Gastroenterology and Hepatology Department of Internal MedicineSeoul National University Boramae Hospital Seoul National University College of Medicine Seoul 156-707South Korea Department of Laboratory Medicine Seoul National University Boramae Hospital Division of Gastroenterology and Hepatology Department of Internal MedicineSeoul National University Hospital Seoul National University College of Medicine Seoul 110-744South Korea

AIM:To investigate the risk factors for Clostridiumdifficile-associated diarrhea(CDAD)recurrence,and its relationship with proton pump inhibitors(PPIs). METHODS:Retrospective data of 125 consecutive hospitalized patients diagnosed with CDAD between January 2006 and December 2007 were collected by medical chart *** data included patient characteristics at baseline,underlying medical disease, antibiotic history before receiving a diagnosis of CDAD, duration of hospital stay,severity of CDAD,concurrenttreatment with PPIs,laboratory parameters,response to CDAD therapy,and recurrence of disease within 90 d of successful *** clinical and laboratory parameters were compared in patients in whom CDAD did or did not recur. RESULTS:Of the 125 patients(mean age,67.6± 13.9 years)that developed CDAD,98(78.4%)did not experience recurrence(non-recurrent group)and 27 (21.6%)experienced one or more recurrences(recurrent group).Prior to the development of CDAD,96% of the 125 patients were prescribed antibiotics,and 56(44.8%)of the patients received *** older than 65 years(P=0.021),feeding via nasogastric tube(NGT)(P=0.045),low serum albumin level(P =0.025),and concurrent use of PPIs(P=0.014) were found to be risk factors for CDAD recurrence by univariate ***,sex,length of hospital stay,duration and type of antibiotics used,severity of disease,leukocyte count and C-reactive protein(CRP) were not associated with risk of CDAD *** multivariate analysis,the important risk factors were advanced age(>65 years,adjusted OR:1.32,95% CI:1.12-3.87,P=0.031),low serum albumin level(< 2.5 g/dL,adjusted OR:1.85,95%CI:1.35-4.91,P= 0.028),and concurrent use of PPIs(adjusted OR:3.48, 95%CI:1.64-7.69,P=0.016). CONCLUSION:Advanced age,serum albumin level< 2.5 g/dL,and concomitant use of PPIs were found to be significant risk factors for CDAD recurrence.

关键词： Clostridium difficile Diarrhea Recurrence Risk factors Proton pump inhibitors

Clostridium difficile infection aggravates colitis in interleukin 10-deficient mice

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World Journal of Gastroenterology 2014年第45期20卷 17084-17091页

作者： Mi Na kim Seong-joon Koh Jung Mogg kim Jong Pil Im Hyun Chae Jung joo sung kim Seoul National University Healthcare System Gangnam Center Seoul National University Hospital Department of Internal Medicine Seoul National University Boramae Hospital Seoul National University College of Medicine Department of Microbiology Hanyang University College of Medicine Department of Internal Medicine Liver Research Institute Seoul National University College of Medicine

AIM: To investigate the effect of Clostridium difficile (C. difficile) infection in an interleukin 10-deficient (IL-10-/-) mouse model of inflammatory bowel disease.

关键词： Clostridium difficile Inflammatory bowel disease Interleukin 10-deficient mice Interferon-γ Colitis

Long-term outcome in patients with obscure gastrointestinal bleeding after negative capsule endoscopy

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World Journal of Gastroenterology 2013年第10期19卷 1632-1638页

作者： Seong-joon Koh Jong Pil Im Ji Won kim Byeong Gwan kim Kook Lae Lee Sang Gyun kim joo sung kim Hyun Chae Jung Department of Internal Medicine Seoul National University Boramae HospitalSeoul National University College of MedicineSeoul 110-744South Korea Department of Internal Medicine and Liver Research Institute Seoul National University College of MedicineSeoul 110-744South Korea

AIM:To investigate long-term outcome in obscure gastrointestinal bleeding(OGIB) after negative capsule endoscopy(CE) and identify risk factors for ***:A total of 113 consecutive patients underwent CE for OGIB from May 2003 to June 2010 at Seoul National University ***-five patients(84.1%) with a subsequent follow-up after CE of at least 6 mo were enrolled in this ***-up data were obtained from the patients' medical *** CE images were reviewed by two board-certified gastroenterologists and consensus diagnosis was used in all *** primary outcome measure was the detection of rebleeding after CE,and factors associated with rebleeding were evaluated using multivariate ***:Of the 95 enrolled patients(median age 61 years,range 17-85 years),62 patients(65.3%) were *** median duration of follow-up was 23.7 mo(range 6.0-89.4 mo).Seventy-three patients(76.8%) underwent CE for obscure-overt *** examination of the small bowel was achieved in 77 cases(81.1%).Significant lesions were found in 38 patients(40.0%).The overall rebleeding rate was 28.4%.The rebleeding rate was higher in patients with positive CE(36.8%) than in those with negative CE(22.8%).However,there was no significant difference in cumulative rebleeding rates between the two groups(log rank test;P = 0.205).Anticoagulation after CE examination was an independent risk factor for rebleeding(hazard ratio,5.019;95%CI,1.560-16.145;P = 0.007),regardless of CE ***:Patients with OGIB and negative CE have a potential risk of ***,close observation is required and alternative modalities should be considered in suspicious cases.

关键词： Capsule endoscopy Gastrointestinal hemorrhage Risk factors Prognosis Enteroscopy

Risk of inflammatory bowel disease in patients with chronic obstructive pulmonary disease: A nationwide, population-based study

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World Journal of Gastroenterology 2019年第42期25卷 6354-6364页

作者： jooyoung Lee Jong Pil Im Kyungdo Han Seona Park Hosim Soh Kukhwan Choi Jihye kim Jaeyoung Chun joo sung kim Department of Internal Medicine and Healthcare Research Institute Healthcare System Gangnam CenterSeoul National University HospitalSeoul 06236South Korea Department of Internal Medicine and Liver Research Institute Seoul National University College of MedicineSeoul 03080South Korea Department of Biostatics College of MedicineCatholic University of KoreaSeoul 06591South Korea Department of Internal Medicine CHA Gangnam Medical CenterCHA UniversitySeoul 06135South Korea Department of Internal Medicine Gangnam Severance HospitalYonsei University College of MedicineSeoul 06273South Korea

BACKGROUND There is a growing evidence regarding an increased risk of inflammatory bowel disease(IBD)among patients with airway *** To investigate the influence of chronic obstructive pulmonary disease(COPD)on the risk of *** A nationwide,population-based study was conducted using data from the National Health Insurance Service database.A total of 1303021 patients with COPD and 6515105 non-COPD controls were *** COPD group was divided into the severe and the mild COPD group according to diagnostic *** risk of IBD in patients with COPD compared to controls was analyzed by Cox proportional hazard regression *** cumulative incidences of IBD were compared between the *** The COPD group had higher incidences of IBD compared to non-COPD controls(incidence rate,9.98 vs 7.18 per 100000 person-years,P<0.001).The risk of IBD in the COPD group was increased by 1.38(adjusted hazard ratio(HR);95%CI:1.25-1.52).The incidence rate of IBD was higher in the severe COPD group than in the mild COPD group(12.39 vs 9.77 per 100000 person-year,P<0.001).The severity of COPD was associated with an increased risk of IBD(adjusted HR 1.70 in severe COPD,95%CI:1.27-2.21 and adjusted HR 1.35 in mild COPD,95%CI:1.22-1.49)CONCLUSION The incidences of IBD were significantly increased in COPD patients in South Korea and the risk of developing IBD also increased as the severity of COPD increased.

关键词： Claim data Inflammatory bowel disease Chronic obstructive pulmonary disease Crohn’s disease Ulcerative colitis

Gastrointestinal tuberculosis is not associated with proton pump inhibitors:A retrospective cohort study

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World Journal of Gastroenterology 2013年第2期19卷 258-264页

作者： Kyoung Sup Hong Seung joo Kang Jong Kyoung Choi Ju Han kim Heewon Seo Suehyun Lee Jae-Woo Jung Hye-Ryun Kang Sang-Heon Cho joo sung kim Department of Internal Medicine Drug Safety Monitoring CenterSeoul National University HospitalSeoul National University College of MedicineSeoul 110799South Korea Department of Internal Medicine Seoul National University HospitalSeoul National University College of MedicineSeoul 110799South Korea Division of Biomedical Informatics Systems Biomedical Informatics Research CenterSeoul National University College of MedicineSeoul 110799South Korea

AIM:To evaluate the effect of proton pump inhibitors(PPIs) on the development of gastrointestinal ***:All patients who were more than 20 years old and who had received a prescription for PPIs among those who visited Seoul National University Hospital from January 1,2005 to December 31,2009 were *** to the low sensitivity of the microbiologic test and the nonspecific pathologic findings,the diagnosis of gastrointestinal tuberculosis was confirmed through the presence of active ulcerations and the responses to anti-tuberculosis *** patients were divided into two groups according to treatment duration(group 1:≤ 3 mo;group 2:> 3 mo) and were followed up from the time they took the first prescription of PPIs until their last *** regression analysis was used to calculate the relative risks(RR) and 95%CI,adjusting for ***:Among the 61 834 patients exposed to PPIs(50 534 in group 1;11 300 in group 2),21 patients were diagnosed with PPI-associated gastrointestinal tuberculosis during 124 274 person-years of *** 21 patients,the 12 who revealed only scar changes in the colonoscopy were excluded from the statistical *** those who remained,2 were excluded because they underwent gastrointestinal endoscopy within 4 wk of the first prescription for *** exposure to PPI was associated with a higher mean age(55.0 ± 14.5 in group 1 vs 58.2 ± 13.3 in group 2,P < 0.001) and a higher Charlson co-morbidity index(0.50 ± 0.93 in group 1 vs 0.77 ± 1.14 in group 2,P < 0.001).The true incidence of active gastrointestinal tuberculosis was 0.65 per 1000 person-years in group 1 and 0.03 per 1 000 person-years in group *** the less-than-three-month PPI treatment period in group 1,the over-three-month PPI therapy period in group 2 was not associated with increased risk of acquiring gastrointestinal tuberculosis,after adjusting for age and co-morbidities,whereas the Charlson co-morbidity index was associated

关键词： Proton pump inhibitor Acid suppression Tuberculosis Gastrointestinal tuberculosis Tuberculous colitis

Inverse correlation between gastroesophageal reflux disease and atrophic gastritis assessed by endoscopy and serology

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World Journal of Gastroenterology 2022年第8期28卷 853-867页

作者： Yoo Min Han Su Jin Chung Seokha Yoo Jong In Yang Ji Min Choi jooyoung Lee joo sung kim Department of Internal Medicine and Healthcare Research Institute Seoul National University Hospital Healthcare System Gangnam CenterSeoul 06236South Korea Department of Anesthesiology and Pain Medicine Seoul National University College of MedicineSeoul 03080South Korea Department of Internal Medicine and Liver Research Institute Seoul National University College of MedicineSeoul 03080South Korea

BACKGROUND Helicobacter pylori(***)infection is known to prevent the occurrence of gastroesophageal reflux disease(GERD)by inducing gastric mucosal ***,little is known about the relationship between atrophic gastritis(AG)and *** To confirm the inverse correlation between AG and the occurrence and severity of *** Individuals receiving health checkups who underwent upper gastrointestinal endoscopy at Seoul National University Healthcare System Gangnam Center were *** grade of reflux esophagitis was evaluated according to the Los Angeles *** AG(EAG)was categorized into six *** AG(SAG)was defined as pepsinogen I≤70 ng/m L and pepsinogen I/II ratio≤*** association between the extent of EAG and SAG and the occurrence and severity of GERD was evaluated using multivariate logistic regression *** In total,4684 individuals with GERD were compared with 21901 healthy *** multivariate logistic regression analysis,advanced age,male sex,body mass index>23 kg/m2,presence of metabolic syndrome,current smoking,and alcohol consumption were associated with an increased risk of *** for *** immunoglobulin G antibodies was associated with a decreased risk of *** was an inverse correlation between the extent of EAG and occurrence of GERD:Odds ratio(OR),1.01[95%confidence interval(CI):0.90-1.14]in C1,0.87(0.78-0.97)in C2,0.71(0.62-0.80)in C3,0.52(0.44-0.61)in O1,0.37(0.29-0.48)in O2,and 0.28(0.18-0.43)in ***,the extent of EAG showed an inverse correlation with the severity of *** presence of SAG was correlated with a reduced risk of GERD(OR=0.49,95%CI:0.28-0.87,P=0.014).CONCLUSION The extent of EAG and SAG exhibited strong inverse relationships with the occurrence and severity of *** followed by *** infection may be independently protect against GERD.

关键词： Gastroesophageal reflux disease Reflux esophagitis Helicobacter pylori Atrophic gastritis Pepsinogen