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An herbal formula,CGX,exerts hepatotherapeutic effects on dimethylnitrosamine-induced chronic liver injury model in rats

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World Journal of Gastroenterology 2006年第38期12卷 6142-6148页

作者： Jang-Woo Shin Jin-Young son Se-Mi Oh Seung-Hyun Han Jing-Hua Wang Jung-Hyo Cho Chong-Kwan Cho Hwa-Seung Yoo Yeon-Weol Lee Myong-min Lee Xiao Ping Hu Chang-Gue son East-West Cancer Center Dunsan Oriental Hospitalof Orientai medical College of Daejeon University 1136 Dunsan-dong Seo-gu Daejeon 302-122 South Korea Department of Oromaxillofacial Infection and Immunity and Dental Research Institute School of Dentistry Seoul National University 28 Yongon-Dong Chongno-Gu Seoul 110-749 South Korea

AIM： To evaluate the therapeutic effect of Chunggan extract （CGX）, a modified traditional Chinese hepatotherapeutic herbal, on the dimethylnitrosamine （DMN）-induced chronic liver injury model in rats. METHODS： Liver injuries were induced in Wistar rats by injection of DMN （ip, 10 mg/mL per kg） for 3 consecutive days per week for 4 wk. The rats were administered with CGX Coo, 100 or 200 mg/kg per day） or distilled water as a control daily for 4 wk starting from the 15^th d of the DMN treatment. Biochemical parameters （serum albumin, bilirubin, ALP, AST and ALT）, lipid peroxides, hydroxyproline, as well as histological changes in liver tissues were analyzed. In addition, gene expression of TNF-α, TGF-β, TIMP-1, TIMP-2, PDGF-β, and MMP-2, all of which are known to be associated with liver fibrosis, were analyzed using real-time PCR. RESULTS： CGX administration restored the spleen weight to normal alter having been increased by DMN treatment. Biochemical analysis of the serum demonstrated that CGX significantly decreased the serum level of ALP （P 〈 0.05）, ALT （P 〈 0.02）, and AST （P 〈 0.02） that had been elevated by DMN treatment. CGX administration moderately lowered lipid peroxide production and markedly lowered hydroxyproline generation caused by DMN treatment in accordance with histopathological examination. DMN treatment induced a highly upregulated expression of TNF-α, TGF-β,TIMP-1, TIMP-2, PDGF-β, and MMP-2. Of these, the gene expression encoding PDGF-β and MMP-2 was still further enhanced 2 wk after secession of the 4-wk DMN treatment, and was remarkably ameliorated by CGX administration. CONCLUSION： CGX exhibits hepatotherapeutic properties against chronic hepatocellular destruction and consequential liver fibrosis.

关键词： Dimethylnitrosamine Hepatotherapeutic Herbal medicine PDGF-β Chunggan extract

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Fluorescent nanoswitch for monitoring specific pluripotency-related microRNAs of induced pluripotent stem cells： Development of polyethyleneimine- oligonucleotide hybridization probes

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Nano Research 2017年第8期10卷 2545-2559页

作者： Seungmin Han Hye Young son Byunghoon Kang Eunji Jang Jisun Ki Na Geum Lee Jongjin Park Moo-Kwang Shin Byeonggeol Mun Jeong-Ki min Seungjoo Haam Department of Chemical and Biomolecular Engineering College of Engineering Yonsei University Seou1120-749 Republic of Korea Department of Radiology College of Medicine Yonsei University Seou1120-752 Republic of Korea Severance Biomedical Science Institute College of Medicine Yonsei University Seou1120-752 Republic of Korea Biotherapeutics Translational Research Center Korea Research Institute of Bioscience and Biotechnology Daejeon 34141 Republic of Korea Department of Biomolecular Science University of Science & Technology Daejeon 34113 Republic of Korea

The isolation of high-grade （i.e. high-pluripotency） human induced pluripotent stem cells （hiPSCs） is a decisive factor for enhancing the purity of hiPSC populations or differentiation efficiency. A non-invasive imaging system that can monitor microRNA （miRNA） expression provides a useful tool to identify and analyze specific cell populations. However, previous studies on the monitoring/isolation of hiPSCs by miRNA expression have limited hiPSCs＇ differentiation system owing to long-term incubation with miRNA imaging probe-nanocarriers. Therefore, we focused on monitoring high-grade hiPSCs without influencing the pluripotency of hiPSCs. We reduced nanoparticle transfection time, because hiPSCs are prone to spontaneous differentiation under external factors during incubation. The fluorescent nanoswitch （＂ON＂ with target miRNA）, which can be applied for either imaging or sorting specific cells by fluorescence signals, contains an miRNA imaging probe （miP） and a PEI-PEG nanoparticle （miP-P）. Consequently, this nanoswitch can sense various endogenous target miRNAs within 30 min in vitro, and demonstrates strong potential for not only imaging but also sorting pluripotent hiPSCs without affecting pluripotency. Moreover, miP-P-treated hiPSCs differentiate well into endothelial cells, indicating that miP-P does not alter the pluripotency of hiPSCs. We envisage that this miRNA imaging system could be valuable for identifying and sorting high-grade hiPSCs for improved practical applications.

关键词： induced pluripotent stem cells (iPSCs) pluripotency microRNA (miRNA) fluorescence imaging nanoparticle

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Length of negative resection margin does not affect local recurrence and survival in the patients with gastric cancer

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World Journal of Gastroenterology 2014年第30期20卷 10518-10524页

作者： Chang min Lee Ye Seob Jee Ju-Hee Lee Sang-Yong son Sang-Hoon Ahn Do Joong Park Hyung-Ho Kim Department of Surgery Seoul National University Bundang HospitalSeongnam 463-707South Korea Department of Surgery Dankook University HospitalCheonan 330-715South Korea Colledge of Medicine Dankook UniversityCheonan 330-715South Korea Department of Surgery Hanyang University Medical CenterSeoul 133-792South Korea Colledge of Medicine Seoul National UniversitySeoul 110-799South Korea

AIM: To investigate the influence of the resection margin on local recurrence and survival in gastric cancer patients.

关键词： Gastric cancer Survival Recurrence Resection Margin

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World Journal of Gastroenterology 2008年第27期14卷 4359-4364页

作者： Young Hye Byun Jun Haeng Lee Moon Kyung Park Ji Hyun song Byung-Hoon min Dong Kyung Chang Young- Ho Kim Hee Jung son Poong-Lyul Rhee Jae J Kim Jong Chul Rhee Ji Hye Hwang Dong Il Park Sang Goon Shim In Kyung sung Department of Medicine Sungkyunkwan University School of Medicine Samsung Medical Center Department of Physical Medicine and Rehabilitation Sungkyunkwan University School of Medicine Samsung Medical Center Department of Medicine Sungkyunkwan University School of Medicine Kangbuk Samsung Hospital Department of Medicine Sungkyunkwan University School of Medicine Masan Samsung Hospital Department of Internal Medicine Konkuk University College of Medicine

AIM: To determine the prevalence and risk factors of work-related musculoskeletal disorders in gastrointestinal endoscopists in Korea. METHODS: A survey of musculoskeletal symptoms, using a self-administered questionnaire, was conducted on 55 endoscopists practicing in general hospitals or health promotion centers. RESULTS: Forty-nine (89.1%) endoscopists reported musculoskeletal pain on at least one anatomic location and 37 (67.3%) endoscopists complained of pain at rest. Twenty-six (47.3%) endoscopists had severe musculoskeletal pain defined as a visual analogue score greater than 5.5. Factors related to the development of severe pain were (1) standing position during upper endoscopy, (2) specific posture/ habit during endoscopic procedures, and (3) multiple symptomatic areas. Finger pain was more common in beginners, whereas shoulder pain was more common in experienced endoscopists. Sixteen percent of symptomatic endoscopists have modified their practice or reduced the number of endoscopic examinations. Only a few symptomatic endoscopists had sought professional consultation with related specialists. CONCLUSION: The prevalence of musculoskeletal pain in endoscopists is very high. The location of pain was different between beginners and experienced endoscopists. Measures for the prevention and adequate management of endoscopy-related musculoskeletal symptoms are necessary.

关键词： Endoscopy Endoscopist Musculoskeletal symptom

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Significance of vulnerability assessment in establishment of Hainan provincal disaster medical system

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亚太热带医药杂志：英文版 2011年第8期4卷 594-596页

作者： min Li Chuanzhu Lu Wei son Junhong Miao Yipeng Ding Longhe Li Leilei Zhang Nin Zhao Bijiang Hu Yunjun Zhang Hainan People's Hospital Hainan Medical College Hainan Normal University

Hainan is an island province in south China with a high frequency of unconventional emergencies due to its special geographic location and national military defense *** the limited transportation route from Hainan to the outside world,self-rescue is more important to Hainan Province than other provinces in China and it is therefore imperative to establish an independent, scientific as well as efficient provincal disaster medical system in *** regulatory role for vulnerability analysis/assessment has been demonstrated in establisment of disaster medical system in varoius countries and or *** this paper,we attempt to describe/propose how to adopt vulnerability assessment through mathematical modeling of major biophysical social vulnerability factors to establish an independent,scientific,effieicnt and comprehensive provincial disaster medical system in Hainan.

关键词： Vunlerability analysis Disasters medical Emergency medical rescue

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Difficulty of falling asleep and non-high-density lipoprotein cholesterol level among Canadian older adults:a cross-sectional analysis of the Canadian Longitudinal Study for Aging baseline data

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Journal of Geriatric Cardiology 2021年第8期18卷 597-608页

作者： Jian LIU Surim son Mike Giancaterino Miya Narushima Department of Health Sciences Brock UniversitySt.CatharinesOntarioCanada

OBJECTIVE To examine whether difficulty of falling asleep(DoFA)is associated with non-high-density lipoprotein cholesterol(non-HDL-C)level among Canadian older *** 26,954 individuals aged 45-85 years from the baseline data of the Canadian Longitudinal Study for Aging were in-cluded in this *** was categorized into five groups by answer to the question“Over the last month,how often did it take you more than 30 min to fall asleep?”Response options are“Never,<1 time/week,1−2 times/week,3−5 times/week,or 6−7 times/week”.Non-HDL-C,the difference of total cholesterol and HDL-C,were categorized into five categories based on these cut-offs(<2.6 mmol/L,2.6−3.7 mmol/L,3.7−4.8 mmol/L,4.8−5.7 mmol/L,and≥5.7 mmol/L).Ordinal logistic regression(logit link)continuation ratio models were used to estimate the odds of higher non-HDL-C levels for DoFA *** means of non-HDL-C by DoFA status were estimated by general linear *** analyses were sex separately using analytic weights to en-sure *** The proportions of DoFA in five categories were 41.6%,25.7%,13.6%,9.4%,9.7%for females and 52.9%,24.9%,10.5%,6.1%,5.6%for males,*** adjustment of demographical and other covariates(such as depression,comorbidity,sleeping hour,etc.)compared to those who reported never having DoFA,the ORs(95%CIs)of higher levels of non-HDL-C for those whose DoFA status in<1 time/week,1−2 times/week,3−5 times/week,and 6−7 times/week were 1.12(1.05−1.21),1.09(0.99−1.18),1.20(1.09−1.33),1.29(1.17−1.43)in females and 1.05(0.98−1.13),0.95(0.87−1.05),1.21(1.08−1.37),0.97(0.85−1.09)in males,*** adjusted means of non-HDL-C among the five DoFA status were 3.68 mmol/L,3.73 mmol/L,3.74 mmol/L,3.82 mmol/L,3.84 mmol/L for females and 3.54 mmol/L,3.58 mmol/L,3.51 mmol/L,3.69 mmol/L,3.54 mmol/L for males,*** The results of this study have identified a risk association pattern between DoFA status and non-HDL-C levels in females

关键词： cholesterol sectional Canadian

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Field-effect transistor with a chemically synthesized MoS2 sensing channel for label-free and highly sensitive electrical detection of DNA hybridization

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Nano Research 2015年第7期8卷 2340-2350页

作者： Doo-Won Lee Jinhwan Lee II Yung Sohn Bo-Yeong Kim Young min son Hunyoung Bark JaehyuckJung minseok Choi Tae Hyeong Kim Changgu Lee Nae-Eung Lee Department of Advanced Materials Science & Engineering Sungkyunkwan University Suwon Gyunggi-do 440-746 Republic of Korea Department of Mechanical Engineering Sungkyunkwan University Suwon Gyunggi-do 440-746 Republic of Korea SKKU Advanced Institute of Nanotechnology (SAINT) Sungkyunkwan University Suwon Gyunggi-do 440-746 Republic of Korea Samsung Advanced Institute for Health Sciences & Technology (SAIHST) Sungkyunkwan University Suwon Gyeonggi-do 440-746 Republic of Korea New Materials Team Future Device R&D Department LG Electronics Advanced Research Institute Seou1137-724 Republic of Korea These authors contributed equally to this work.

A field-effect transistor （FET） with two-dimensional （2D） few-layer MoS2 as a sensing-channel material was investigated for label-free electrical detection of the hybridization of deoxyribonucleic acid （DNA） molecules. The high-quality MoS2-channel pattern was selectively formedthrough the chemical reaction of the Mo layer with H2S gas. The MoS2 FET was very stable in an electrolyte and inert to pH changes due to the lack of oxygen-containing functionalities on the MoS2 surface. Hybridization of single-stranded target DNA molecules with single-stranded probe DNA molecules physically adsorbed on the MoS2 channel resulted in a shift of the threshold voltage （Vt,） in the negative direction and an increase in the drain current. The negative shift in Vth is attributed to electrostatic gating effects induced by the detachment of negatively charged probe DNA molecules from the channel surface after hybridization. A detection limit of 10 fM, high sensitivity of 17 mWdec, and high dynamic range of 106 were achieved. The results showed that a bio-FET with an ultrathin 2D MoS2 channel can be used to detect very small concentrations of target DNA molecules specifically hybridized with the probe DNA molecules.

关键词： two-dimensional(2D)materials, MoS2,field-effect transistor, biosensor,deoxyribonucleic acid (DNA) hybridization

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A flexible electromagnetic interference shielding film coated with a hybrid solder-magnetic powder mixture on a PET substrate

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Journal of Materiomics 2018年第4期4卷 390-401页

作者： Jae Hyang Lee Dong Seok Kang Sang Hoon Kim min-Jung son Jae Won Choi Dae Keun Choi Joon-Phil Choi Clodualdo Aranas Jr Metal 3D Printing Convergence Research Team Korea Institute of Machinery and Materials156 Gajeongbuk-roYuseong-guDaejeon34103Republic of Korea Metal Powder Department Korea Institute of Materials Science797 Changwon-daeroSeongsan-guChangwon-siGyeongsangnam-do51508Republic of Korea Digital Manufacturing Process Group Korea Institute of Industrial Technology113e58 Seohaean-roSiheung-siGyeonggi-do15014Republic of Korea Department of Printed Electronics Korea Institute of Machinery and Materials156 Gajeongbuk-roYuseong-guDaejeon34103Republic of Korea Department of mining and Materials Engineering McGill University3610 University StreetMontrealQuebecH3A 0C5Canada Mechanical Engineering University of New Brunswick15 Dineen DriveFrederictonNew BrunswickE3B 5A3Canada

A flexible electromagnetic interference(EMI)shielding film was innovatively fabricated using both low melting temperature solder arrays and amorphous soft magnet particulates consolidated on a polyethylene terephthalate(PET)***,the IneSneBi solder arrays presented a low melting point of 99.4C,which enabled attachment to the heat-sensitive plastic substrate without any thermal damage,and a low electrical resistivity of 14.1 mU cm,making them very effective at interrupting EM ***,the solder arrays with a high thermal conductivity of 61.2 W/(m$K)at 298.15 K were also useful as a thermal conductor for a heat ***,the solder arrays provide efficient electrical and thermal channels for electron transport induced by abruptly or consistently created EM waves due to suddenly turning on and the long term operation of electronics,***,the Fe-based magnetic particulates were added and resulted in effective saturation magnetization of 161.1 emu/g,remanence of 2.9 emu/g,and coercivity of 12.5 G,thus were able to disturb the EM pathway because of their soft magnetic ***,the hybrid EMI shielding film with exceptionally high electrical and thermal conductivity and superior soft magnetic properties provided remarkable shielding effectiveness of 102.5 dB at 10.2 GHz.

关键词： Flexible EMI shielding film PET substrate Solder arrays Magnetic particulates

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Uniform assembly of gold nanoparticles on S-doped g-C3N4 nanocomposite for effective conversion of 4-nitrophenol by catalytic reduction

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Journal of Materials Science & Technology 2020年第5期40卷 176-184页

作者： Vellaichamy Balakumar Hyungjoo Kim Ji Won Ryu Ramalingam Manivannan Young-A son Department of Advanced Organic Materials Engineering Chungnam National University220 Gung-dongYuseong-guDaejeon305-764South Korea

In this work,a simple synthesis of sulfur doped graphitic carbon nitride(S-g-C3N4)act as a support cum stabilizers for gold nanoparticles(Au)and its was characterized by UV–vis and XRD to measure the absorbance and crystallinity,*** functional group and morphology of the samples were identified using FT-IR and ***,the Au@S-g-C3N4 nanocatalyst exhibits good catalytic performance and stability in the reduction of hazardous 4-nitrophenol(NP)compared to S-g-C3N4 using Na ***,the Au@S-g-C3N4 nanocomposite holds a good catalytic efficiency(near 100%)achieved by within 5 *** highest catalytic reduction of NP is due to the synergistic effect of Au nanoparticles decorated on *** fast electron transfer reduction mechanism was elucidated and *** reusability and stability of the developed nanocomposites were also observed in consecutive reduction *** filtering and catalyzing device was used for the direct conversion of NP polluted *** method can open a new avenue for the metal nanoparticles based carbon materials heterogeneous catalyst and its reduction of toxic contaminants.

关键词： Gold nanoparticles S-doped g-C3N4 Catalytic reduction 4-nitrophenol

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Design of a Stabilizing Controller using T-S Fuzzy model for a rotary inverted pendulum

Design of a Stabilizing Controller using T-S Fuzzy model for...

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第二届亚洲机械电子学学术会议

作者： Myung-Gong Sohn Cheon Don son Hyung Gi min sung-Ha Kwon Eun Tae Jeung Department of Control & Instrumentation Engineering Changwon National University Sarim-dong ChangwonKyungnamKorea

We design a stabilizing controller for a rotary inverted pendulum system using the conception of parallel distribution compensation(PDC)and linear matrix inequalities(LMIs)based on T-S fuzzy modeling *** we show the result of the simulation and experimentation of a rotary inverted pendulum system in comparison with LMIs base on linearized dynamics and state feedback control using LQR problem.

关键词： T-S Fuzzy inverted pendulum PDC LMI

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