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Interaction of repaglinide with bovine serum albumin:Spectroscopic and molecular docking approaches

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Journal of Pharmaceutical Analysis 2019年第4期9卷 274-283页

作者： suma K.Pawar Seetharamappa Jaldappagari Department of Chemistry Karnatak University

Repaglinide (RPG) regulates the amount of glucose by stimulating the pancreas to release insulin in the blood. In view of its biological importance, we have examined the interaction between RPG and a model protein, bovine serum albumin (BSA) employing various spectroscopic, electrochemical and molecular docking methods. Fluorescence spectra of BSA were recorded in the presence and absence of RPG in phosphate buffer of pH 7.4. Fluorescence intensity of BSA was decreased upon the addition of increased concentrations of RPG, indicating the interaction between RPG and BSA. Stern-Volmer quenching analysis results revealed that RPG quenched the intensity of BSA through dynamic quenching mechanism. This was further confirmed from the time-resolved fluorescence measurements. The binding constant as calculated from the spectroscopic and voltammetric results was observed to be in the order of 104M-1 at 298 K, suggesting the moderate binding affinity between RPG and BSA. Competitive experimental results revealed that the primary binding site for RPG on BSA was site II. Absorption and circular dichroism studies indicated the changes in the secondary structure of BSA upon its interaction with RPG. Molecular simulation studies pointed out that RPG was bound to BSA in the hydrophobic pocket of site II.

关键词： BSA-RPG interaction Spectroscopic investigation Molecular docking

Factors affecting residual exotropia after two muscle surgery for intermittent exotropia

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International Journal of Ophthalmology(English edition) 2017年第7期10卷 1120-1125页

作者： Shailja Tibrewal Nishtha Singh Marazul Islam Bhuiyan suma Ganesh Pediatric Ophthalmology and Strabismology Services Dr.Shroff's Charity Eye Hospital Chittagong Eye Infirmary & Training Complex Pahartali

AIM： To study the factors affecting residual exotropia（〉10 PD） at 4-6wk postoperative visit following two rectus muscle surgery for intermittent exotropia [bilateral lateral rectus（LR） recession or unilateral recess resect procedure].METHODS： A retrospective chart review of patients with intermittent exotropia ≤50 PD who underwent two rectus muscle surgery in between Jan. 2011 to Dec. 2013 was performed. Possible factors were compared between patients with residual exotropia（〉10 PD） and successful outcome（within 10 PD of orthotropia） at the 4-6wk postoperative visit. Effect/dose ratio was calculated by dividing the effect of surgery by the total amount（mm） of muscle surgery ***： One hundred and fifty-seven patients with mean age of 14y（range 3-53y） were included. Twentyseven patients（17.2%） had residual exotropia at 4-6wk postoperative follow up. Age at surgery（P=0.009） and preoperative deviation for distance（P≤0.001） and near（P=0.001） were identified as important predictors of unsuccessful outcome. The occurrence of residual exotropia was not affected by amblyopia, anisometropia, lateral incomitance, pattern deviation, vertical deviation, type of exotropia or type of surgery done（recess-resect or bilateral LR recession）. The effect/dose ratio was more in deviations 〉40 PD in the both recess-resect and bilateral LR recession type of surgery. The effect/dose ratio was less in patients with residual exotropia as compared to the successful outcome group（1.36 PD/mm vs 2.05 PD/mm in the bilateral LR recession surgery and 1.93 PD/mm vs 2.63 PD/mm in the unilateral recess-resect surgery）.CONCLUSION： Residual exotropia is seen in 17% of patients after two muscle surgery for intermittent exotropia. Patients with older age and larger preoperative deviation have greater chances of developing failure of two muscle strabismus surgery for intermittent exotropia.

关键词： residual exotropia intermittent exotropia strabismus exotropia rectus muscle

New Preamble Sequence for WiMAX System with Improved Synchronization Accuracy

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Intelligent Automation & Soft Computing 2023年第3期35卷 3187-3197页

作者： suma Sekhar Sakuntala S.Pillai S.Santhosh Kumar Department of Electronics and Communication Engineering LBS Institute of Technology for WomenThiruvananthapuramKeralaIndia Mar Baselios College of Engineering and Technology ThiruvananthapuramKeralaIndia Department of Electronics and Communication Govt.Engineering CollegeIdukkiKeralaIndia

Worldwide Interoperability for Microwave Access(WiMAX)trusts Multiple Input Multiple Output-Orthogonal Frequency Division Multiplexing(MIMO-OFDM)combination for the deployment of physical layer functions and for connecting the medium access control to the wireless *** though Orthogonal Frequency Division Multiplexing(OFDM)facilitates reliable digital broadband transmission in the fading wireless channels,the presence of synchro-nization errors in the form of Carrier Frequency Offset(CFO)and Time Offset(TO)adversely affect the performance of OFDM based physical *** objective of this work is to improve the accuracy of the frequency and the time offset estimation in the WiMAX physical layer.A method to enhance the synchro-nization accuracy byﬁne-tuning the merit factor of the preamble sequence is sug-gested in this ***,a new preamble with improved synchronization accuracy is proposed for the WiMAX *** performance of the proposed preamble is evaluated in a Rayleigh fading channel and the results of simulations show that the Mean Square Error(MSE)in offset estimation is signiﬁcantly reduced and it outperforms the standard WiMAX preamble.

关键词： WiMAX MIMO OFDM time offset carrier frequency offset preamble sequence integrated sidelobe level merit factor

Studies on thermoresponsive polymers:Phase behaviour,drug delivery and biomedical applications

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Asian Journal of Pharmaceutical Sciences 2015年第2期10卷 99-107页

作者： Arijit Gandhi Abhijit Paul suma Oommen Sen Kalyan Kumar Sen Department of Pharmaceutics Gupta College of Technological SciencesAshram MoreG.T.RoadAsansol 713301West BengalIndia

The present review aims to highlight the applications of thermoresponsive ***-responsive polymers show a sharp change in properties upon a small or modest change in *** behaviour can be utilized for the preparation of so-called‘smart’drug delivery systems,which mimic biological response behaviour to a certain *** materials are used in the development of several applications,such as drug delivery systems,tissue engineering scaffolds and gene *** in this field are particularly relevant to applications in the areas of regenerative medicine and drug *** review addresses summary of the main applications of thermoresponsive polymers which are categorized based on their 3-dimensional structure;hydrogels,interpenetrating networks,micelles,films and *** physico-chemical behaviour underlying the phase transition is also discussed in brief.

关键词： Thermoresponsive polymers Phase transition Drug delivery Tissue engineering

Synthesis and spectral characterization of lanthanide complexes with 1,2-diphenyl-4-butyl-3,5-pyrazolidinedione: Luminescent property of Tb(Ⅲ) complex

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Journal of Rare Earths 2012年第7期30卷 709-715页

作者： M.R.Anoop P.S.Binil S.suma M.R.Sudarsanakumar Department of Chemistry S.N. College Department of Chemistry S.N .College Depart-ment of Chemistry M.G. College

The complexes of rare earth elements with 1,2-diphenyl-4-butyl-3,5-Pyrazolidinedione （PBH, phenylbutazone） were synthesized and characterized by elemental analysis, molar conductance, IR, UV-Vis, EPR and magnetic moment measurements. Based on these studies the complexes were formulated as [Ln（PB）3（H2O）2].nH2O, where Ln=Eu（III）, Gd（III）, Tb（III）, Dy（III） and Er（III）. From IR spectra, it was found that PBH acted as a bidentate mono-ionic ligand coordinating through two carbonyl oxygen of the pyrazolidinedione ring. The thermal analysis of all the complexes was carried out at a heating rate of 10 oC/min. The kinetic aspects of the complexes were evaluated. The nega-tive entropy value of the complexes indicated a more ordered state for the activated complexes. The photoluminescence property of Tb（III） complex was investigated. It showed all the characteristic emission peaks of Tb^3＋ with a life time of 0.98914 ms.

关键词： lanthanide complexes IR thermal analysis luminescent properties rare earths

Synthesis, spectral characterization, thermal and biological studies of lanthanide(Ⅲ) complexes of oxyphenbutazone

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Journal of Rare Earths 2014年第1期32卷 43-51页

作者： P.S.Binil M.R.Anoop K.R.Jisha S.suma M.R.Sudarsanakumar Department of Chemistry S.N.College Department of Chemistry M.G.College

Lanthanide（III） complexes of 4-butyl-1-（4-hydroxyphenyl）-2-phenyl-3,5-pyrazolidinedione （OPB） were prepared by ho-mogeneous precipitation. The solid complexes were characterized by elemental analysis, magnetic susceptibility data, molar conduc-tivity measurements and IR, UV-Vis, mass, 1H NMR and 13C NMR spectral methods. The thermal decomposition of the complexes under static air atmosphere was investigated by simultaneous TG/DTG at a heating rate of 10 °C/min. The final decomposition prod-ucts were found to be metal oxides. The spectroscopic data suggested that OPB acted as a bidentate, mono-ionic ligand coordinating through two carbonyl oxygens of the pyrazolidinedione ring. The kinetic and thermodynamic parameters such as activation energy, pre-exponential factor and entropy of activation for each step of the decomposition reactions were evaluated using Coats-Redfern and MacCallum-Tanner equations. The negative entropy values of the complexes indicated that the activated complexes had a more or-dered structure than the reactant and that the reactions were slower than normal. Investigations of antimicrobial activity of the com-pounds were carried out by the disk diffusion technique.

关键词： oxyphenbutazone lanthanide(III) complexes thermal study antimicrobial activity rare earths

Optimal Load Forecasting Model for Peer-to-Peer Energy Trading in Smart Grids

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Computers, Materials & Continua 2022年第1期70卷 1053-1067页

作者： Lijo Jacob Varghese K.Dhayalini suma Sira Jacob Ihsan Ali Abdelzahir Abdelmaboud Taiseer Abdalla Elfadil Eisa Department of Electrical and Electronics Engineering Christian College of Engineering and TechnologyOddanchatram624619India Department of Electrical and Electronics Engineering K.Ramakrishnan College of EngineeringTiruchirappalli621112India Department of Computer Science and Engineering Christian College of Engineering and TechnologyOddanchatram624619India Department of Computer System and Technology Faculty of Computer Science and Information TechnologyUniversity of Malaya50603Kuala LumpurMalaysia Department of Information Systems King Khalid UniversityMuhayel Aseer62529Saudi Arabia Department of Information Systems-Girls Section King Khalid UniversityMahayil62529Saudi Arabia

Peer-to-Peer(P2P)electricity trading is a significant research area that offers maximum fulfilment for both prosumer and *** also decreases the quantity of line loss incurred in Smart Grid(SG).But,uncertainities in demand and supply of the electricity might lead to instability in P2P market for both prosumer and *** recent times,numerous Machine Learning(ML)-enabled load predictive techniques have been developed,while most of the existing studies did not consider its implicit features,optimal parameter selection,and prediction *** order to overcome fulfill this research gap,the current research paper presents a new Multi-Objective Grasshopper Optimisation Algorithm(MOGOA)with Deep Extreme Learning Machine(DELM)-based short-term load predictive technique i.e.,MOGOA-DELM model for P2P Energy Trading(ET)in *** proposed MOGOA-DELM model involves four distinct stages of operations namely,data cleaning,Feature Selection(FS),prediction,and parameter *** addition,MOGOA-based FS technique is utilized in the selection of optimum subset of ***,DELM-based predictive model is also applied in forecasting the load *** proposed MOGOA model is also applied in FS and the selection of optimalDELM parameters to improve the predictive *** inspect the effectual outcome of the proposed MOGOA-DELM model,a series of simulations was performed using UK Smart Meter *** the experimentation procedure,the proposed model achieved the highest accuracy of 85.80%and the results established the superiority of the proposed model in predicting the testing data.

关键词： Peer to Peer energy trade smart grid load forecasting machine learning feature selection

AModified Search and Rescue Optimization Based Node Localization Technique inWSN

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Computers, Materials & Continua 2022年第1期70卷 1229-1245页

作者： suma Sira Jacob K.Muthumayil M.Kavitha Lijo Jacob Varghese M.Ilayaraja Irina V.Pustokhina Denis A.Pustokhin Department of Computer Science and Engineering Christian College of Engineering and TechnologyOddanchatram624619India Department of Information Technology PSNA College of Engineering and TechnologyDindigul624622India Department of Electronics and Communication Engineering K.Ramakrishnan College of TechnologyTiruchirappalli621112India Department of Electrical and Electronics Engineering Christian College of Engineering and TechnologyOddanchatram624619India School of Computing Kalasalingam Academy of Research and EducationKrishnankoil626128India Department of Entrepreneurship and Logistics Plekhanov Russian University of EconomicsMoscow117997Russia Department of Logistics State University of ManagementMoscow109542Russia

Wireless sensor network(WSN)is an emerging technology which find useful in several application areas such as healthcare,environmentalmonitoring,border surveillance,*** issues that exist in the designing of WSN are node localization,coverage,energy efficiency,security,and so *** spite of the issues,node localization is considered an important issue,which intends to calculate the coordinate points of unknown nodes with the assistance of *** efficiency of the WSN can be considerably influenced by the node localization ***,this paper presents a modified search and rescue optimization based node localization technique(MSRONLT)*** major aim of theMSRO-NLT technique is to determine the positioning of the unknown nodes in *** the traditional search and rescue optimization(SRO)algorithm suffers from the local optima problemwith an increase in number of iterations,MSRO algorithm is developed by the incorporation of chaotic maps to improvise the diversity of the *** application of the concept of chaotic map to the characteristics of the traditional SRO algorithm helps to achieve better exploration ability of the MSRO *** order to validate the effective node localization performance of the MSRO-NLT algorithm,a set of simulations were performed to highlight the supremacy of the presented model.A detailed comparative results analysis showcased the betterment of the MSRO-NLT technique over the other compared methods in terms of different measures.

关键词： Node localization WSN chaotic map search and rescue optimization algorithm localization error

Influence of Processing on Dietary Fiber, Tannin and <i>in Vitro</i>Protein Digestibility of Pearl Millet

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Food and Nutrition Sciences 2011年第8期2卷 895-900页

作者： Florence suma Pushparaj Asna Urooj 不详

From the nutritional point of view, data on dietary fiber content, tannin and in vitro protein digestibility of processed millet is of importance, because millets are never eaten raw. Effects of commonly used traditional methods on dietary fiber, tannin content and %IVPD of two locally available pearl millet varieties (Kalukombu and Maharashtra Rabi Bajra) were investigated. The millet was subjected to various processing methods like milling (whole flour, semi refined flour and bran rich fraction) roasting, boiling, pressure cooking & germination respectively. Processing had little effect on the total dietary fiber (TDF) content in both varieties;however the bran rich fraction showed highest TDF content of around 29%. Tannins effectively lowered upon boiling and pressure cooking respectively, but significantly increased (P ≥ 0.05) upon germination. Although the % IVPD of the millet (45.5 – 49.3 g/100g) was low, it significantly increased upon milling (bran rich fraction), roasting and germination respectively.

关键词： Knowledge Attitudes Practices Food handlers Ghana