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Role of dental plaque,saliva and periodontal disease in Helicobacter pylori infection

World Journal of Gastroenterology 2014年第19期20卷 5639-5653页

作者： Pradeep S Anand Kavitha P Kamath sukumaran anil Department of Periodontics People’s College of Dental Sciences and Research CentreBhopalMadhya Pradesh 462037India Department of Oral Pathology People’s Dental AcademyBhopalMadhya Pradesh 462037India Department of Periodontics and Community Dentistry College of DentistryKing Saud UniversityRiyadh 11545Saudi Arabia

Helicobacter pylori (H. pylori) infection is one of the most common bacterial infections in humans. Although H. pylori may be detected in the stomach of approximately half of the world’s population, the mechanisms of transmission of the microorganism from individual to individual are not yet clear. Transmission of H. pylori could occur through iatrogenic, fecal-oral, and oral-oral routes, and through food and water. The microorganism may be transmitted orally and has been detected in dental plaque and saliva. However, the role of the oral cavity in the transmission and recurrence of H. pylori infection has been the subject of debate. A large number of studies investigating the role of oral hygiene and periodontal disease in H. pylori infection have varied significantly in terms of their methodology and sample population, resulting in a wide variation in the reported results. Nevertheless, recent studies have not only shown that the microorganism can be detected fairly consistently from the oral cavity but also demonstrated that the chances of recurrence of H. pylori infection is more likely among patients who harbor the organism in the oral cavity. Furthermore, initial results from clinical trials have shown that H. pylori-positive dyspeptic patients may benefit from periodontal therapy. This paper attempts to review the current body of evidence regarding the role of dental plaque, saliva, and periodontal disease in H. pylori infection.

关键词： Helicobacter pylori Dental plaque Saliva Oral cavity Periodontitis Periodontal therapy

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Dental pulp stem cells and banking of teeth as a lifesaving therapeutic vista

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BIOCELL 2023年第1期47卷 71-80页

作者： sukumaran anil RAMYA RAMADOSS NEBU GTHOMAS JASMIN MGEORGE VISHNUPRIYA KSWEETY Oral Health Institute Department of DentistryHamad Medical CorporationDohaQatar College of Dental Medicine Qatar UniversityDohaQatar Saveetha Dental College Saveetha Institute of Medical and Technical Sciences(SIMATS)ChennaiIndia Pushpagiri College of Dental Sciences MedicityPerumthuruthyIndia

Exfoliated deciduous or an extracted healthy adult tooth can be used to harvest,process,and cryogenically preserve dental pulp stem *** stem cell-based regenerative medicine methods could benefit significantly from these mesenchymal stem *** serve as a substantial source of mesenchymal stem cells,otherwise disposed of as medical *** should be taken to store this treasure trove of stem *** responsibility of patients,dentists,and physicians is necessary to ensure that this valuable resource is not wasted and that every possible dental pulp stem cell is available for use in the *** dental pulp stem cells(DPSC)inside teeth represent a significant future source of stem cells for regenerative medicine *** review describes the ontogeny,the laboratory processing and collection,and isolation methods of *** review also discusses currently available stem cell banking facilities and their potential use in regenerative medicine procedures in dental and general medical applications in the future.

关键词： Dental stem cell Stem cell therapy Differentiation Regeneration Tissue engineering Tooth banking

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母猪蹄损伤和舍饲系统

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国外畜牧学（猪与禽） 2009年第1期29卷 26-27页

作者：罗何峰 sukumaran S.anil John Deen Marrina Schuttert

由于使用群体舍饲，特别是在条板式水泥地面上进行群体舍饲，我们发现母猪的跛行发生率以及随之而来的蹄损伤发病率上升了。

关键词：舍饲损伤猪蹄系统水泥地面发病率发生率群体

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Nature-inspired hybrid deep learning for race detection by face shape features

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International Journal of Intelligent Computing and Cybernetics 2020年第3期13卷 365-388页

作者： Asha sukumaran Thomas Brindha Department of Computer Science and Engineering Noorul Islam Centre for Higher EducationKumaracoilIndia Department of Information Technology Noorul Islam Centre for Higher EducationKumaracoilIndia

Purpose-The humans are gifted with the potential of recognizing others by their uniqueness,in addition with more other demographic characteristics such as ethnicity(or race),gender and age,*** the decades,a vast count of researchers had undergone in the field of psychological,biological and cognitive sciences to explore how the human brain characterizes,perceives and memorizes ***,certain computational advancements have been developed to accomplish several insights into this ***/methodology/approach-This paper intends to propose a new race detection model using face shape *** proposed model includes two key phases,namely.(a)feature extraction(b)*** feature extraction is the initial stage,where the face color and shape based features get ***,maximally stable extremal regions(MSER)and speeded-up robust transform(SURF)are extracted under shape features and dense color feature are extracted as color ***,the extracted features are huge in dimensions;they are alleviated under principle component analysis(PCA)approach,which is the strongest model for solving“curse of dimensionality”.Then,the dimensional reduced features are subjected to deep belief neural network(DBN),where the race gets ***,to make the proposed framework more effective with respect to prediction,the weight of DBNis fine tuned with a new hybrid algorithm referred as lion mutated and updated dragon algorithm(LMUDA),which is the conceptual hybridization of lion algorithm(LA)and dragonfly algorithm(DA).Findings-The performance of proposed work is compared over other state-of-the-art models in terms of accuracy and error ***,LMUDA attains high accuracy at 100th iteration with 90%of training,which is 11.1,8.8,5.5 and 3.3%better than the performance when learning percentage(LP)550%,60%,70%,and 80%,*** particularly,the performance of proposed DBNþLMUDAis 22.2,12.5 and 33.3%better than the trad

关键词： Facial race detection Color dense features DBN Optimization LMUDA

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Corrosion,mechanical and microstructural properties of aluminum 7075-carbon nanotube nanocomposites for robots in corrosive environments

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International Journal of Minerals,Metallurgy and Materials 2023年第6期30卷 1140-1151页

作者： Arun David Satheesh Kumar Gopal Poovazhagan Lakshmanan Amith sukumaran Chenbagam Sri Sivasubramaniya Nadar College of Engineering KalavakkamChennai-603110India

The introduction of in-pipe robots for sewage cleaning provides researchers with new options for pipe inspection,such as leakage,crack,gas,and corrosion detection,which are standard applications common in the current industrial *** question that is frequently overlooked in all these cases is the inherent resistance of the robots to *** mechanical,microstructural,and corrosion properties of aluminum 7075 incorporated with various weight percentages(0,0.5wt%,1wt%,and 1.5wt%)of carbon nanotubes(CNTs)are *** is fabricated using a rotational ultrasonication with mechanical stirring(RUMS)-based casting method for improved corrosion resistance without compromising the mechanical properties of the robot.1wt%CNTs-aluminum nanocomposite shows good corrosion and mechanical properties,meeting the requirements imposed by the sewage environment of the robot.

关键词： aluminum 7075 carbon nanotubes rotational ultrasonication with mechanical stirring mechanical characterization microstructure robot

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Gender plasticity uncovers multiple sexual morphs in natural populations of Cedrus deodara (Roxb.) G. Don

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Ecological Processes 2021年第1期10卷 459-469页

作者： Vinod Prasad Khanduri Arun sukumaran Chandra Mohan Sharma Department of Forestry College of ForestryVCSG Uttarakhand University of Horticulture and ForestryRanichauriTehri GarhwalUttarakhand 249199India Present Address:State Farming Corporation of Kerala Chithalvetty EstateKalanjoor KollamKeralaIndia.

Background:The expression of gender in gymnosperms is challenging because the extent of variability in gender segregations in tree crowns and selection pressure of nature can modify the gender through ***:An in-depth investigation on spatial segregation of genders in tree crowns and sex expression of a total of 500 trees in five different natural populations of Cedrus deodara was carried out and verified the occurrence of subdioecious(co-existence of male,female,and monoecious)genders in ***:Five different sexual morphs were apparent among the 500 selected individuals as(1)pure male(M):bearing only male strobili in the whole crown with 22.2%;(2)pure female(F):bearing only female strobili in the whole crown with 12.4%;(3)mixed-monoecious(MM):bearing both male and female strobili with 13.6%;(4)predominantly female(PF)with 25.6%;and(5)predominantly male(PM)with 26.2%.The occurrence of multiple sexual morphs resulted from the complex selection pressure,which increased the stability of the *** segregation of genders in crown layers deemed to increase the fitness that may be a mechanism for accelerating *** results of the study suggest that the subdioecious gender expression in *** is evolved through the monoecy–paradioecy *** production of male strobili revealed non-significant effect of tree sizes whereas a significant effect was observed for the production of female *** study established that the total pollen and seed outputs in *** changed frequently according to gender ***:The size of the tree,resource availability,sex allocation,plant architecture,gender segregation in crowns,and habitat conditions are the prominent causes for gender plasticity.

关键词： Gender Sex expression Gender segregation Strobili Pre-fertilisation Monoecy Dioecy

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Reproductive biology of Cornus capitata Wall. ex Roxb.: a native species in East Asia

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Journal of Forestry Research 2019年第6期30卷 2039-2050页

作者： Vinod Prasad Khanduri Arun sukumaran Chandra Mohan Sharma College of Forestry VCSG Uttarakhand University of Horticulture and Forestry

The reproductive biology of Cornus capitata was studied in detail from June 2014 to October 2015 in Tehri Garhwal, Uttarakhand, western Himalaya, India and elucidated floral morphology, confirming autogamy, geitonogamy, and xenogamy. A new inflorescence ball formed each year with developing fruits that were initiated the previous year; thus reproduction is a continuous cycle. The total pollen production within a tree ranged between 4.0 × 10~7 and 9.3 × 10~7. Anthesis peaked between 08:00 and 10:00. There was significant effect of micro-environmental condition on anthesis(F = 243.8, p = 3.01). A significant positive relationship between the number of lateral shoots and total inflorescence showed that the inflorescence production in C. capitate depends largely on the number of lateral shoots. Time and concentration of various solutions significantly affected pollen germination(time: F = 5.39, p = 0.002; concentration: F = 1.40,p = 0.234). Anthophora bees and thrips were observed as the main pollinators. There was a significant difference in seed set between natural and obligate self-pollination(t = 11.84, p = 1.99). Significant effect was also observed on fruit size(t = 8.88, p = 2.09) between open and shaded conditions. SEM micrographs of pollen grains showed that the shape of dehydrated pollen grains differed greatly due to variations in the rate of dehydration among pollen grains within the anther. Seed germination was observed only in quality seed derived from open pollination, supporting xenogamy in C. capitata. Findings of the present study will be of immense value in formulating effective conservation measures for the species in wild habitats.

关键词： Floral development Pollen production Pollination Pollinators Reproductive success SEM analysis

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Pollinator-mediated self-pollination and reproductive assurance in an isolated tree of Magnolia grandiflora L.

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Ecological Processes 2020年第1期9卷 517-525页

作者： Arun sukumaran Vinod Prasad Khanduri Chandra Mohan Sharma College of Forestry VCSG Uttarakhand University of Horticulture and ForestryRanichauriTehri GarhwalUttarakhand 249199India

Background:The ability to produce seeds when pollinators or potential mates are scarce is one of the principal advantages of self-pollination in flowering ***,the role of pollinators mediating self-pollination to ensure seed set when pollen or potential mates are limited has received less *** study examined the reproductive consequences and involvement of pollinators in assuring seed set in an isolated tree of Magnolia grandiflora,a predominantly outcrossing ***:We tested various aspects of reproduction such as flower density,floral rewards,stigma receptivity,pollinator abundance and behaviour,fruit set and seed set,in two successive reproductive years(2015-2016).Results:Flowers of *** possess a suite of traits facilitating pollinator-mediated self-pollination(PMS),although the chances of autonomous self-pollination are reduced due to herkogamy,spatial separation of anther and *** mean pollen production/flower was 5,152,289±285,094 with a pollen-to-ovule ratio of 39430±*** found a significant positive correlation between number of visits and seed production for bees(r=0.5099,p=0.0007)and beetles(r=0.7159,p=0.00001),indicating these are effective at *** was a significant negative correlation for thrips(r=-0.3206,p=0.044)and no correlation for flies or *** percent fruit set was 100%and the seed set per ovule ranged between 19 and 20%.Conclusions:PMS will guarantee reproductive assurance and mitigate the effect of reduced mates or pollen limitation which is expected to increase the fecundity and establishment of individual trees in geographically isolated locations.

关键词： Pollinator-mediated self-pollination Magnolia grandiflora Autonomous self-pollination Pollinator behaviour Reproductive assurance

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Role of immune dysfunction in drug induced liver injury

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World Journal of Hepatology 2021年第11期13卷 1677-1687页

作者： Chandrashekaran Girish sukumaran Sanjay Department of Pharmacology Jawaharlal Institute of Postgraduate Medical Education and ResearchPuducherry 605006India

Drug-induced liver injury(DILI)is one of the leading causes of liver failure and withdrawal of drugs from the market.A poor understanding of the precipitating event aetiology and mechanisms of disease progression has rendered the prediction and subsequent treatment *** literature suggests that some drugs can alter the liver’s repair systems resulting in *** pathophysiology of DILI is complex,and immune dysfunction plays an important role in determining the course and severity of the *** dysfunction is influenced by the host response to drug toxicity.A deeper understanding of these processes may be beneficial in the management of DILI and aid in drug *** review provides a structured framework presenting DILI in three progressive stages that summarize the interplay between drugs and the host defence networks.

关键词： Immune dysfunction Liver damage Hepatotoxic drugs Drug-induced liver injury High mobility group box 1

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Rice Heat Tolerance Breeding: A Comprehensive Review and Forward Gaze

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Rice science 2024年第4期31卷 375-400,I0022页

作者： Ravindran Lalithambika VISAKH Sreekumar ANAND sukumaran Nair ARYA Behera SASMITA Uday Chand JHA Rameswar Prasad SAH Radha BEENA Department of Genetics and Plant Breeding College of AgricultureVellayaniKerala Agricultural UniversityThiruvananthapuramKerala 695522India Crop Improvement Division Indian Council of Agricultural Research-National Rice Research InstituteCuttackOdisha 7530006India Department of Plant Breeding and Genetics Indian Institute of Pulse ResearchKanpur 208024India Department of Plant Physiology College of AgricultureVellayaniKerala Agricultural UniversityThiruvananthapuramKerala 695522India

The yield potential of rice is seriously affected by heat stress due to climate change. Since rice is a staple food globally, it is imperative to develop heat-resistant rice varieties. Thus, a thorough understanding of the complex molecular mechanisms underlying heat tolerance and the impact of high temperatures on various critical stages of the crop is needed. Adoption of both conventional and innovative breeding strategies offers a long-term advantage over other methods, such as agronomic practices, to counter heat stress. In this review, we summarize the effects of heat stress, regulatory pathways for heat tolerance, phenotyping strategies, and various breeding methods available for developing heat-tolerant rice. We offer perspectives and knowledge to guide future research endeavors aimed at enhancing the ability of rice to withstand heat stress and ultimately benefit humanity.

关键词： genetic mechanism high-temperature stress molecular breeding genomics selection

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