Role of immune dysfunction in drug induced liver injury

作     者：Chandrashekaran Girish Sukumaran Sanjay 

作者机构：Department of PharmacologyJawaharlal Institute of Postgraduate Medical Education and ResearchPuducherry 605006India 

出 版 物：《World Journal of Hepatology》 (世界肝病学杂志（英文版）（电子版）)

年 卷 期：2021年第13卷第11期

页      面：1677-1687页

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

主　　题：Immune dysfunction Liver damage Hepatotoxic drugs Drug-induced liver injury High mobility group box 1 

摘      要：Drug-induced liver injury(DILI)is one of the leading causes of liver failure and withdrawal of drugs from the market.A poor understanding of the precipitating event aetiology and mechanisms of disease progression has rendered the prediction and subsequent treatment *** literature suggests that some drugs can alter the liver’s repair systems resulting in *** pathophysiology of DILI is complex,and immune dysfunction plays an important role in determining the course and severity of the *** dysfunction is influenced by the host response to drug toxicity.A deeper understanding of these processes may be beneficial in the management of DILI and aid in drug *** review provides a structured framework presenting DILI in three progressive stages that summarize the interplay between drugs and the host defence networks.