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Prophylactic effects of asiaticoside-based standardized extract of Centella asiatica(l.) Urban leaves on experimental migraine: Involvement of 5HT1A/1B receptors

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Chinese Journal of Natural Medicines 2015年第4期13卷 274-282页

作者： Vijeta Bobade subhash l.bodhankar Urmila Aswar Vishwaraman Mohan Prasad Thakurdesai Department of Pharmacology Poona College of Pharmacy Bharati Vidyapeeth Deemed University Department of Pharmacology Sinhgad Institute of Pharmacy Indus Biotech Private limited 1 Rahul residency Kondhwa Pune-411026 India

The present study aimed at evaluation of prophylactic efficacy and possible mechanisms of asiaticoside(AS) based standardized extract of Centella asiatica(l.) Urban leaves(INDCA) in animal models of migraine. The effects of oral and intranasal(i.n.) pretreatment of INDCA(acute and 7-days subacute) were evaluated against nitroglycerine(NTG, 10 mg·kg-1, i.p.) and bradykinin(BK, 10 μg, intra-arterial) induced hyperalgesia in rats. Tail flick latencies(from 0 to 240 min) post-NTG treatment and the number of vocalizations post-BK treatment were recorded as a measure of hyperalgesia. Separate groups of rats for negative(Normal) and positive(sumatriptan, 42 mg·kg-1, s.c.) controls were included. The interaction of INDCA with selective 5-HT1 A, 5-HT1 B, and 5-HT1 D receptor antagonists(NAN-190, Isamoltane hemifumarate, and BRl-15572 respectively) against NTG-induced hyperalgesia was also evaluated. Acute and sub-acute pre-treatment of INDCA [10 and 30 mg·kg-1(oral) and 100 μg/rat(i.n.) showed significant anti-nociception activity, and reversal of the NTG-induced hyperalgesia and brain 5-HT concentration decline. Oral pre-treatment with INDCA(30 mg·kg-1, 7 d) showed significant reduction in the number of vocalization. The anti-nociceptive effects of INDCA were blocked by 5-HT1 A and 5-HT1 B but not 5-HT1 D receptor antagonists. In conclusion, INDCA demonstrated promising anti-nociceptive effects in animal models of migraine, probably through 5-HT1A/1B medicated action.

关键词： Centella asiatica(l.) Urban Experimental migraine Anti-nociception Serotonin,5HT1A and 5HT1B receptors

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In vitro antioxidant and antimicrobial activity cycloart-23-ene-3β,25-diol(B2) isolated from Pongamia pinnata(***)

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Asian Pacific Journal of Tropical Medicine 2011年第11期4卷 910-916页

作者： Sachin l Badole Anand A Zanwar Abhijeet N Khopade subhash l bodhankar Department of Pharmacology Poona College of PharmacyBharati Vidyapeeth UniversityPaud RoadErandwanePuneMaharashtraIndia

Objective:To evaluate the in-vitro antioxidant and antimicrobial activity of cvcloart-23- ene-3β,25-diol(called as B2) isolated from stem bark of Pongamia ***:In vitro antioxidant activity of B2 was determined by methods for determination of Dl’PH radical scavenging,reducing power,superoxide anion radical scavenging,hydroxyl radical scavenging, hydrogen peroxide scavenging,metal chelating and nitric oxide radical scavenging at the doses of 20.***.60.80 and 100μg/ml,respectively.3 -tocopherol with same concentration was used as a standard *** vitro antimicrobial activity of B2 was determined by cup plate method in different concentration range of 10-100μg/***:The results indicated that dose dependent%reduction against DPPH radical,reducing power,superoxide anion radical scavenging,hydroxyl radical scavenging,metal chelating,hydrogen peroxide scavenging and nitric oxide radical scavenging by B2 andβ-***:It is concluded that cycloart 23-ene-3β,25 diol(B2) showed dose dependent antioxidant activity.B2 showed more DPPH radical scavenging,reducing power,superoxide scavenging,hydroxyl radical scavenging, metal chelating scavenging,hydrogen peroxide radical scavenging and nitric oxide radical scavenging activity thanβ-tocopherol and in case of antimicrobial activity B2 exhibited broad-spectrum activ ity against bacteria and strong activity against yeast type of fungi.

关键词： Antibacterial activity Antifungal activity In vitro antioxidant Cycloart-23-ene-3β 25-diol(B2) Pongamia pinnata

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Ameliorative effects of standardized extract from Trigonella foenum-graecum *** on painful peripheral neuropathy in rats

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Asian Pacific Journal of Tropical Medicine 2012年第5期5卷 385-390页

作者： Aashish S Morani subhash l bodhankar V Mohan Prasad A Thakurdesai Department of Pharmacology Poona College of PharmacyBharati Vidyapeeth Deemed UniversityErandwanePaud Road.Pune-411038India

Objective:To evaluate the effects of the standardized extract of fenugreek(Trigonella foenumgraecum ***:leguminasae) seed(IND01) in animal models of peripheral neuropathy. Methods:IND01 was prepared from fenugreek seeds and standardized by high performance liquid chromatography to a marker compound,*** effects of daily oral administration of IND01(50,100 and 200 mg/kg) were studied in rats after partial sciatic nerve ligation(PSNl) and sciatic nerve crush injury(SNCI) during 30-days *** measurements on thermal hyperalgesia(TH),motor function test(MFT) score and motor nerve conduction velocity (MNCV) were ***:IND01 offered sustained protection against TH and deranged MFT scores in both models from 7-day *** days of daily oral administration of IND01 restored MNCV reduction in rats with SNCI but not with ***:IND01 was found to be effective in rat models of painful peripheral neuropathy.

关键词： Trigonella foenum-graecum l. Peripheral nervous system diseases Peripheral neuropathy Neuropathic pain Sciatic nerve lesions Rat

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Anti-epileptic effect of morin against experimental pentylenetetrazol-induced seizures via modulating brain monoamines and oxidative stress

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Asian Pacific Journal of Tropical Biomedicine 2018年第7期8卷 352-359页

作者： Amit D.Kandhare Anwesha A.Mukherjee subhash l.bodhankar Department of Pharmacology Poona College of Pharmacy Bharati Vidyapeeth Deemed University

Objective: To evaluate the protective effect of morin against pentylenetetrazol(PTZ)-induced tonic-clonic convulsions in mice. Methods: Swiss albino mice(18-22 g) was used to induce convulsions by intraperitoneal(i.p.) administration of PTZ(90 mg/kg). Mice were either pretreated with morin(10, 20 and 40 mg/kg) or vehicle(distilled water, 10 mg/kg) 45 min before PTZ administration. Various behavioral and biochemical parameters were assessed. Results: PTZ administration resulted in significant production(Plonic conclusion and mortality in mice. PTZ-induced increase in the duration of convulsion, onset of convulsion and mortality was inhibited significantly by morin(20 and 40 mg/kg) administration. The PTZinduced decrease in brain GABA, dopamine and Na+K+ATPase levels and increase in xanthine oxidase activity were inhibited significantly by morin(20 and 40 mg/kg) treatment. The increased levels of malondialdehyde and nitric oxide level were significantly decreased by morin(20 and 40 mg/kg) treatment. Also, reduced levels of superoxide dismutase and glutathione were increased significantly by morin treatment. Conclusions: Results of the present study indicate that morin showed its anti-convulsant effect via modulating the levels of brain GABA, Na^+K^+ATPase, and oxido-nitrosative stress. Thus, morin can be a potential candidate for further clinical evaluations as an anti-epileptic agent.

关键词： Brain GABA Epilepsy Morin Nitric oxide Pentylenetetrazol Oxidative stress Xanthine oxidase

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Protective effect of aqueous extract of Feronia elephantum correa leaves on thioacetamide induced liver necrosis in diabetic rats

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Asian Pacific Journal of Tropical Biomedicine 2012年第9期2卷 691-695页

作者： Prashant Sharma subhash l bodhankar Prasad A Thakurdesai Department of Pharmacology Poona College of PharmacyBharati Deemed Vidyapeeth University

Objective:To evalueate hepatoprotective effects Feronia elephantum(***)correa against thioacctamide(TA)induced liver necrosis in diabetic ***:Male wistar rats were made diabetic with alloxan(160 mg/kg)on day 0 of the *** were intoxicated with hepatotoxicant(thioacetamide,300 mg/kg,ip)on day 9 of study to produce liver *** of 7 day daily once administration(day 2 to day 9)of EF(400 and 800 mg/kg,po)were evaluated on necorosis of liver in terms of mortality,liver volume,liver weight,serum aspartate aminotransferase(AST)and serum alanine transaminase(AlT),and histopathology of liver sections(for signs of necorosis and inflammation)on day-9 of the *** groups of rats with treated only with alloxan(DA control),thioacetamide(TA control)and both(TA+DA control)were ***:FE significantly lowered the mortality rate and showed improvement in liver function parameters in TA-induced diabetic rats without change in liver weight,volume and serum glucose ***:FE showed promising activity against TA-induced liver necorsis in diabetic rats and so might be useful for prevention of liver complications in DM.

关键词： Feronia elephantum correa Hepatic necrosis Diabetes mellitus Thioacetamide

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Anti-inflammatory and anti-arthritic activity of type-A procyanidine polyphenols from bark of Cinnamomum zeylanicum in rats

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Food Science and Human Wellness 2013年第2期2卷 59-67页

作者： Sachin Vetal subhash l.bodhankar Vishwaraman Mohan Prasad A.Thakurdesai Department of Pharmacology Poona College of PharmacyBharati Vidyapeeth Deemed UniversityErandwanePune 411038India Indus Biotech Private limited 1Rahul ResidencyOff Salunke Vihar RoadKondhwaPune 411048India

Type-A procyanidine polyphenols(TAPP)are reported to have immunomodulatory and anti-inflammatory potential in *** objective of present work is to evaluate potential of TAPP extracted from Cinnamon(Cinnamomum zeylanicum)bark in animal models of inflammation and rheumatoid arthritis in ***-induced rat paw edema(CPE)and adjuvant induced established arthritis(AIA),in rats were used as the experimental models for inflammation and arthritis *** activity was evaluated in Randall–Selitto assay in AIA *** showed significant anti-inflammatory effect at dose of 4,8 and 25 mg/kg,*** not at 2 mg/kg,*** in CPE *** dose of 8 mg/kg,*** selected for the evaluation of anti-arthritic activity in AIA ***(8 mg/kg,p.o.,daily from day-12 to day-21)treatment in established arthritic rats showed significant reversal of changes induced in AIA with respect to body weight drop(cachexia),ankle diameter,arthritic score,serum C-reactive protein(CRP)***,TAPP was found to be non-ulcerogenic as compared to AIA control ***,TAPP did not show analgesic effect on AIA-induced pain as seen in Randall–Selitto *** conclusion,TAPP showed disease-modifying potential in animal models of inflammation and arthritis in rats.©2013 Beijing Academy of Food *** and hosting by Elsevier *** rights reserved.

关键词： Type-A procyanidine polyphenols Cinnamon bark Anti-inflammatory Rheumatoid arthritis

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Protective role of concomitant administration of flax lignan concentrate and omega-3-fatty acid on myocardial damage in doxorubicin-induced cardiotoxicity

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Food Science and Human Wellness 2013年第1期2卷 29-38页

作者： Anand A.Zanwar Mahabaleshwar V.Hegde subhash l.bodhankar Department of Pharmacology Poona College of PharmacyBharati Vidyapeeth UniversityPaud RoadErandwanePune 411038MaharashtraIndia Interactive Research School for Health Affairs Medical College CampusBharati Vidyapeeth UniversityDhankawadiPune 411043India

The severe cardiotoxicity incurred due to doxorubicin limits the use of their therapeutic *** current study aims to investigate the cardioprotective effect of concomitant administration of flax lignan concentrate(FlC)and omega-3-fatty acid(ω-3-FA)on myocardial damage in doxorubicin-induced cardiotoxicity in Wistar *** was induced by intraperitoneal injection of doxorubicin(4 mg/kg)on day 7th,14th,21st and 28th day in normal *** administration of FlC(500 mg/kg)andω-3-FA(1 ml/kg)lowered TNF-αlevel,normalized ST,QT and mean arterial blood pressure,elevation in endogenous enzymes levels such as glutathione and lowering in malondialdehyde,super oxide dismutase followed by normalized lipid profile and reduced the mortality *** treatment had antiapoptotic potential at cellular level also histopathology of heart tissue(light and electron microscopical).Thus concomitant action of FlC andω-3-FA may be antioxidant,antihyperlipidemic,anti-inflammatory and anti-apoptotic actions seem to the probable mechanisms in doxorubicin induced *** can be concluded that FlC andω-3-FA both have distinct mechanism for cardioprotection and hence the additive effect was observed in the present study due to concomitant administration of FlC andω-3-FA.©2013 Beijing Academy of Food *** and hosting by Elsevier *** rights reserved.

关键词： Apoptosis Cardiotoxicity Doxorubicin Flax lignan concentrate Poly unsaturated fatty acid TNF-α

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Effect of newly synthesized 1,2,4-triazino[5,6-b]indole-3-thione derivatives on olfactory bulbectomy induced depression in rats

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Asian Pacific Journal of Tropical Biomedicine 2012年第12期2卷 992-998页

作者： Urmila M Aswar Padmaja P Kalshetti Suhas M Shelke Sharad H Bhosale subhash l bodhankar Department of Pharmacology STES's Sinhgad Institute of Pharmacy Department of Pharmacology Maharashtra Institute of Pharmacy Department of Pharmacology Poona College of PharmacyBharati Vidyapeeth Deemed University

Objective:To study the derivatives of 1,2,4-triazino[5,6-b]indole-3-thione for antidepressant activity in olfactory bulbectomized(OBX)*** of various derivatives tested for acute tail suspension test,the two derivatives showiug prominent action *** for bilateral olfactory bulbeetomy rsodel of ehronic depression in ***:The sub aeute effects of 14-day oral pretreatment of two derivatives labeled as 3a(70 mg/kg)and 3r(70 mg/kg),imipramine(20 mg/kg),fluoxetiue(30 mg/kg)and moclobemide(15 mg/kg)were evaluated on bilateral bulbectomy induced rise in body weight,hyperphagia,hyperactivity,and on sexual *** serum sodium concentration,body temperature,and heart rate were also ***:The derivatives3a and 3r showed reversal of drop in body weight,reversed OBX indueed hyperactivity,normalized body temperature,heart rate,and serum sodium *** elevated maze test,moclobemide,3a,3r treatment significantly redueed time spent in open arm as compared to OBX rats.3a and 3r also irsproved sexual behavior ***:The present study shows promising antidepressant action and provides a proof of concept for the chronic treatrsent of 3a,3r to treat depression.

关键词： 1,2,4-triazino-[5,6-b]indole-3-thione Olfactory bulbectomy Antidepressant activity

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Effect of hydroalcoholic extract of Hibiscus rosa sinensis *** in experimental colitis in rats

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Asian Pacific Journal of Tropical Biomedicine 2012年第5期2卷 337-344页

作者： Amit D Kandhare Kiran S Raygude Pinaki Ghosh Arvindkumar E Ghule Tejas P Gosavi Sachin l Badole subhash l bodhankar Department of Pharmacology Poona College of PharmacyBharati Vidyapeeth Deemed University Department of Homeopathic Pharmacy Homeopathic Medical CollegeBharati Vidyapeeth Deemed University

Objective:To elucidate the ameliorative effect of liydrualcuholic extract of leaves of Hibiscus rosa sinensis(HRS) in acetic acid induced experimental colitis in male wistar ***: The animals were administered with 2 ml acetic acid(4%) via intra *** animals were divided into various treatment groups(n=6).Prednisolone was used as standard drug and HRS was administered at a dose of 50,100 and 200 mg/kg *** control group of animals received 1 ml of vehicle(distilled water).Ulcer area,ulcer index,spleen weight,colon weight to length ratio, macroscopic score,haemalological parameters,colonic superoxide dismutase(SOD),glutathione(GSH),myeloperoxidase(MPO),malondialdchyde(MDA),tumor necrosis factor-α(TNK- α), nitric oxide(NO) and histological changes were recorded after the treatment regimen of 11 days. Results:Intrarectal instillation of acetic acid caused enhanced ulcer area,ulcer index,spleen weight,colon weight to length ratio,colonic MPO,MDA,NO and TNF-α It caused significant decreased level of SOD and *** with HRS for 7 days exhibited significant effect in lowering of oxidative stress,colonic NO,TNF- α and elevation of SOD and GSH at a dose of 100 and 200 mg/kg in acetic acid induced ***:The present investigation demonstrates HRS is of potent therapeutic value in the amelioration of expcrimenlal colilis in laboralory animals by inhibiting the proinflammatory mediator like NO and TNK-α.

关键词： Acetic acid Hibiscus rosa sinensis Inflammatory bowel disease Inflammatory cytokine Nitrite/nitrate Oxidative stress Ulcerative colitis Prednisolone

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Association of smoking, alcohol and NSAIDs use with expression of cag A and cag T genes of Helicobacter pylori in salivary samples of asymptomatic subjects

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Asian Pacific Journal of Tropical Biomedicine 2012年第6期2卷 479-484页

作者： Pinaki Ghosh subhash laxmanrao bodhankar Department of Pharmacology Poona College of Pharmacy Bharati Vidyapeeth Deemed University

Objective:To determine the association of smoking, alcohol and nonsteroidal anti-inflammatory drugs(NSAIDs) use with presence and virulence of Helicobacter pylori(H. pylori) infection in a representative sample of a random adult population of asymptomatic ***:Non virulent 16S rRNA and virulent cag A and T genes from salivary samples of 854 asymptomatic subjects were determined using polymerase chain reaction. The presence and absence of virulent and non virulent infection was statistically compared with consumption of smoking, alcohol and NSAID ***:The prevalence of infection in male and female subjects was found to be 69.25% and 66.90%, respectively. The prevalence of infection in the population of asymptomaticsubjects with respect to consumption of alcohol was as follows: current(31.22%), former(52.20%) and never(43.58%). The prevalence of infection in the population of asymptomatic subjects withrespect to smoking of cigarettes was as follows: current(88.80%), former(57.14%) and never(33.33%).The prevalence of infection in the subject population consuming NSAIDs and not consuming NSAIDs frequently was found to be 82.75%and 21.16%, respectively. Virulence in male and femalesubjects was found to be 60.00%and 50.00%, respectively. The presence of virulent infection in the population of asymptomatic subjects with respect to consumption of alcohol was as follows:current(28.57%), former(40.15%) and never(50.00%). The prevalence of virulent infection in the population of asymptomatic subjects with respect to smoking of cigarettes was as follows: current(79.32%), former(75.00%) and never(50.00%). The prevalence of virulent infection in the subject population consuming NSAIDs and not consuming NSAIDs frequently was found to be 88.23% and 66.66%, ***:It can be concluded that smoking and NSAIDs consumption are aggravating factors for virulence ofH. pylori and alcohol can inhibitH. pyloriin fection in asymptomatic subjects.

关键词： Smoking Alcohol NSAIDs Helicobacter pylori Cag A Cag T 16S rRNA PCR Agarose gel electrophoresis Virulence Prevalence Infection Asymptomatic

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