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Protective effect of aqueous extract of Feronia elephantum correa leaves on thioacetamide induced liver necrosis in diabetic rats

Protective effect of aqueous extract of Feronia elephantum correa leaves on thioacetamide induced liver necrosis in diabetic rats

作     者:Prashant Sharma Subhash L Bodhankar Prasad A Thakurdesai 

作者机构:Department of PharmacologyPoona College of PharmacyBharati Deemed Vidyapeeth University 

出 版 物:《Asian Pacific Journal of Tropical Biomedicine》 (亚太热带生物医学杂志(英文版))

年 卷 期:2012年第2卷第9期

页      面:691-695页

学科分类:1008[医学-中药学(可授医学、理学学位)] 1006[医学-中西医结合] 100602[医学-中西医结合临床] 10[医学] 

主  题:Feronia elephantum correa Hepatic necrosis Diabetes mellitus Thioacetamide 

摘      要:Objective:To evalueate hepatoprotective effects Feronia elephantum(***)correa against thioacctamide(TA)induced liver necrosis in diabetic ***:Male wistar rats were made diabetic with alloxan(160 mg/kg)on day 0 of the *** were intoxicated with hepatotoxicant(thioacetamide,300 mg/kg,ip)on day 9 of study to produce liver *** of 7 day daily once administration(day 2 to day 9)of EF(400 and 800 mg/kg,po)were evaluated on necorosis of liver in terms of mortality,liver volume,liver weight,serum aspartate aminotransferase(AST)and serum alanine transaminase(ALT),and histopathology of liver sections(for signs of necorosis and inflammation)on day-9 of the *** groups of rats with treated only with alloxan(DA control),thioacetamide(TA control)and both(TA+DA control)were ***:FE significantly lowered the mortality rate and showed improvement in liver function parameters in TA-induced diabetic rats without change in liver weight,volume and serum glucose ***:FE showed promising activity against TA-induced liver necorsis in diabetic rats and so might be useful for prevention of liver complications in DM.

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