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Journal of Clinical and Nursing Research 2024年第2期8卷 137-148页

作者： subha veeramani Kirubanandan Shanmugam National Centre for Nano science and Nanotechnology University of MadrasGuindy CampusChennai 600025.India. Saveetha School of Engineering SIMATSThandalamChennai 602105India

Copper nanoparticles(CuNPs)have emerged as a promising alternative due to their unique antimicrobial *** synthesis of CuNPs using Asparagus racemosus,commonly known as Shatavari,offers a sustainable and environmentally friendly approach to producing ***,the resulting CuNPs have been found to possess excellent antibacterial,and antioxidant properties,which further expands their potential applications in medicine and environmental *** this article,we discussed the in vitro characterization of the *** vitro studies revealed that CuNPs have the potential for biomedical applications and as a base nanomaterial for the construction of drug delivery and targeting vehicles.

关键词： Copper nanoparticles Green Synthesis Asparagus racemosus Antimicrobial and antioxidant activities

Biosynthesis of Silver Nanoparticles with Clerodendron phlomoides Leave Extract:Particle Morphology,Antimicrobial Potential and Application

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Journal of Clinical and Nursing Research 2024年第1期8卷 51-64页

作者： Kirubanandan Shanmugam subha veeramani Renganathan Sahadevan Saveetha School of Engineering SIMATSChennai 602105India National Centre for Nanoscience and Nanotechnology University of MadrasGuindy CampusChennai 600025India Centre for Biotechnology A.C.TechAnna UniversityChennai 600025India

Silver nanoparticles are versatile nanomaterials that have found numerous applications in various *** use of plant extract for the synthesis of silver is a green and sustainable *** phlomoides leaves extract has been found to contain various phytochemicals,such as phenols,flavonoids,tannins,and alkaloids,which possess reducing and stabilizing properties that can aid the production of silver *** this paper,morphological and topographical analyses were performed on silver *** biosynthesized silver nanoparticles showed antimicrobial potential against wound *** and TEM micrographs revealed that the particles were sphere and nanosized,which makes them suitable for various biomedical applications.

关键词： Silver nanoparticles Clerodendron phlomoides Biosynthesis Morphology SEM TEM FTIR Antimicrobial activity and wound pathogens

In Vivo Studies and Flow Cytometric Investigation on Anticancer Potential of Selenium Nanoparticles Synthesized via Aqueous Extract of Clerodendron phlomidis

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Proceedings of Anticancer Research 2024年第1期8卷 71-81页

作者： veeramani subha Kirubanandan Shanmugam Renganathan Sahadevan National Centre for Nanoscience and Nanotechnology University of MadrasGuindy CampusChennai 600025Tamil NaduIndia Saveetha School of Engineering SIMATSThandalamChennai 602107Tamil NaduIndia Department of Biotechnology A.C.TechAnna UniversityChennai 600025Tamil NaduIndia

Nowadays,doctors and nutritionists recommend individuals incorporate selenium-rich foods such as nuts,cereals,and mushrooms into their regular diet to maintain fitness and overall *** nanoparticles(SeNPs)exhibit strong chemopreventive *** anticipations for SeNPs with enhanced and tunable bioactive activities have led to a keen interest in *** this study,the aqueous extract of Clerodendron phlomidis plant leaves was utilized for the synthesis of *** traditional Indian medicine,this plant extract is recognized as a significant anti-diabetic *** flavonoids tetrahydroxylflavone,7-hydroxyflavanone,and 6,4’-dimethyl-7-acetoxy-scutellarein present in this plant leaf extract demonstrate excellent anticancer *** secondary metabolites exhibit the ability to reduce sodium selenite into *** a concentration of 13μg/mL,the synthesized SeNPs effectively inhibited the proliferation of the HepG2 cell *** results suggest that the SeNPs possess promising anti-cancer potential against liver cancer and can be considered as a therapeutic agent for liver cancer ***,the cell cycle arrest induced by SeNPs was further confirmed by the fluorescence-activated cell sorting(FACS)method,indicating that SeNPs could efficiently differentiate cancer cells from normal ***,it showed a significant improvement in diethylnitrosamine(DEN)-induced Swiss Wistar rat *** scientific investigation highlights the high anti-cancer potential of SeNPs,positioning them as a promising therapeutic agent for liver cancer treatment.

关键词： Selenium nanoparticles Green synthesis Liver cancer Clerodendron phlomidis Flow cytometry In vivo studies

Biosynthesis and Characterization of Silver Nanoparticles Coated with Metabolites Extracted from Clerodendron phlomoides with Its Biochemical Studies in Liver Tissue

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Proceedings of Anticancer Research 2023年第4期7卷 1-19页

作者： subha veeramani Kirubanandan Shanmugam National Centre for Nanoscience and Nanotechnology University of MadrasChennai 600025India Saveetha School of Engineering Saveetha Institute of Medical and Technical Sciences(SIMATS)ThandalamChennai 602105India

Silver nanoparticles(AgNPs)have been used as a potential nanomaterial-based drug delivery vehicle for liver cancer treatment,as it induces cell death and produces cytotoxicity against cancerous cells at a low *** biosynthesis of green metallic nanoparticles uses secondary metabolites in plant extracts instead of toxic chemicals for a reduction-oxidation(redox)*** biosynthesis of AgNPs with the aqueous extract of Clerodendron phlomoides was performed in this *** phytochemical analysis of *** extract using gas chromatography-mass spectrometry(GC-MS)confirmed the presence of redox *** peak at 489 nm in UV-visible spectra confirmed the formation of bioactive AgNPs reduced from silver nitrate solution,whereas the Fourier-transform infrared(FTIR)spectra indicated the bioactive molecules of plant extracts that are responsible for the *** electron microscope(SEM)micrograph revealed the formation of spherical and ovoid structures of AgNPs,whereas transmission electron microscope(TEM)micrograph confirmed the size of AgNPs,which varies from 25 nm to 100 nm.X-ray diffraction(XRD)spectra showed the crystalline nature of AgNPs,and the size of crystallite was 4 nm,while dynamic light scattering(DLS)analysis confirmed the average particle size of AgNPs to be around 125 *** vivo studies showed that bioactive AgNPs have a significant anticancer potential against liver cancer,whereas biochemical studies of rats’liver tissue samples confirmed that bioactive AgNPs produced a potential hepatoprotective effect against diethylnitrosamine-induced liver cancer.

关键词： Silver nanoparticles Clerodendron phlomoides Aqueous extract SEM TEM Liver cancer