Biosynthesis and Characterization of Silver Nanoparticles Coated with Metabolites Extracted from Clerodendron phlomoides with Its Biochemical Studies in Liver Tissue
作者机构：National Centre for Nanoscience and NanotechnologyUniversity of MadrasChennai 600025India Saveetha School of EngineeringSaveetha Institute of Medical and Technical Sciences(SIMATS)ThandalamChennai 602105India
出 版 物：《Proceedings of Anticancer Research》 (抗癌研究)
年 卷 期：2023年第7卷第4期
页 面：1-19页
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
主 题：Silver nanoparticles Clerodendron phlomoides Aqueous extract SEM TEM Liver cancer
摘 要：Silver nanoparticles(AgNPs)have been used as a potential nanomaterial-based drug delivery vehicle for liver cancer treatment,as it induces cell death and produces cytotoxicity against cancerous cells at a low *** biosynthesis of green metallic nanoparticles uses secondary metabolites in plant extracts instead of toxic chemicals for a reduction-oxidation(redox)*** biosynthesis of AgNPs with the aqueous extract of Clerodendron phlomoides was performed in this *** phytochemical analysis of *** extract using gas chromatography-mass spectrometry(GC-MS)confirmed the presence of redox *** peak at 489 nm in UV-visible spectra confirmed the formation of bioactive AgNPs reduced from silver nitrate solution,whereas the Fourier-transform infrared(FTIR)spectra indicated the bioactive molecules of plant extracts that are responsible for the *** electron microscope(SEM)micrograph revealed the formation of spherical and ovoid structures of AgNPs,whereas transmission electron microscope(TEM)micrograph confirmed the size of AgNPs,which varies from 25 nm to 100 nm.X-ray diffraction(XRD)spectra showed the crystalline nature of AgNPs,and the size of crystallite was 4 nm,while dynamic light scattering(DLS)analysis confirmed the average particle size of AgNPs to be around 125 *** vivo studies showed that bioactive AgNPs have a significant anticancer potential against liver cancer,whereas biochemical studies of rats’liver tissue samples confirmed that bioactive AgNPs produced a potential hepatoprotective effect against diethylnitrosamine-induced liver cancer.
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