In Vivo Studies and Flow Cytometric Investigation on Anticancer Potential of Selenium Nanoparticles Synthesized via Aqueous Extract of Clerodendron phlomidis
作者机构：National Centre for Nanoscience and NanotechnologyUniversity of MadrasGuindy CampusChennai 600025Tamil NaduIndia Saveetha School of EngineeringSIMATSThandalamChennai 602107Tamil NaduIndia Department of BiotechnologyA.C.TechAnna UniversityChennai 600025Tamil NaduIndia
出 版 物：《Proceedings of Anticancer Research》 (抗癌研究)
年 卷 期：2024年第8卷第1期
页 面：71-81页
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
主 题：Selenium nanoparticles Green synthesis Liver cancer Clerodendron phlomidis Flow cytometry In vivo studies
摘 要：Nowadays,doctors and nutritionists recommend individuals incorporate selenium-rich foods such as nuts,cereals,and mushrooms into their regular diet to maintain fitness and overall *** nanoparticles(SeNPs)exhibit strong chemopreventive *** anticipations for SeNPs with enhanced and tunable bioactive activities have led to a keen interest in *** this study,the aqueous extract of Clerodendron phlomidis plant leaves was utilized for the synthesis of *** traditional Indian medicine,this plant extract is recognized as a significant anti-diabetic *** flavonoids tetrahydroxylflavone,7-hydroxyflavanone,and 6,4’-dimethyl-7-acetoxy-scutellarein present in this plant leaf extract demonstrate excellent anticancer *** secondary metabolites exhibit the ability to reduce sodium selenite into *** a concentration of 13μg/mL,the synthesized SeNPs effectively inhibited the proliferation of the HepG2 cell *** results suggest that the SeNPs possess promising anti-cancer potential against liver cancer and can be considered as a therapeutic agent for liver cancer ***,the cell cycle arrest induced by SeNPs was further confirmed by the fluorescence-activated cell sorting(FACS)method,indicating that SeNPs could efficiently differentiate cancer cells from normal ***,it showed a significant improvement in diethylnitrosamine(DEN)-induced Swiss Wistar rat *** scientific investigation highlights the high anti-cancer potential of SeNPs,positioning them as a promising therapeutic agent for liver cancer treatment.
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