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Brainstem folding in an influenza child with Dandy-Walker variant

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World Journal of Clinical Cases 2020年第2期8卷 382-389页

作者： su-yun li Pei-Qing li Wei-Qiang Xiao Hong-Sheng liu Si-Da Yang Department of Pediatric Emergency Medicine Guangzhou Women and Children’s Medical CenterGuangzhou Medical UniversityGuangzhou 510623Guangdong ProvinceChina Department of Radiology Guangzhou Women and Children’s Medical CenterGuangzhou Medical UniversityGuangzhou 510623Guangdong ProvinceChina Department of Pediatric Neurology Guangzhou Women and Children’s Medical CenterGuangzhou Medical UniversityGuangzhou 510623Guangdong ProvinceChina

BACKGROUND Influenza in children is a major cause of morbidity and mortality *** system diseases are a factor relating to increased mortality ***, reports of how these underlying diseases contribute to the death of children with influenza are *** suMMARY A 4-year-old-girl developed type A influenza-related encephalopathy(IAE) with seizures, acute disorder of consciousness, and intracranial hypertension(cerebrospinal fluid pressure: 250 mm H2O), and the Dandy-Walker variant was found by her first magnetic resonance imaging(MRI) when admission. Three days later, she suddenly presented anisocoria, acute pulmonary edema, and coma, and the later MRI found that she had compressed brainstem, oblongata "Zlike folding", and swelling bilateral basal ganglia. After admission, the patient were tested for routine and special biomarkers and underwent neuroimaging and neuroelectrophysiology examinations as well as Oseltamivir and intravenous immunogloblin treatments. When predicting that unstable intracranial structures detected by MRI might have disastrous consequences in the progression of IAE,she was transferred into the pediatric intensive care unit and underwent continuous assessment of clinical condition while she did not have instability of basic vital signs;at the same time, her parents were fully informed about the risk and prognosis. Although she was ultimately dead from brain stem failure, the parents expressed understanding and did not trigger a doctor-patient *** In case of finding an unstable intracranial structure, intensive care should be given to IAE patient and their clinical condition should be monitored continuously.

关键词： Influenza-associated encephalopathy Dandy-Walker variant Predictive intensive care Case report

Altered profiles of fecal metabolites correlate with visceral hypersensitivity and may contribute to symptom severity of diarrhea-predominant irritable bowel syndrome

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World Journal of Gastroenterology 2019年第43期25卷 6416-6429页

作者： Wen-Xue Zhang Yu Zhang Geng Qin Kai-Min li Wei Wei su-yun li Shu-Kun Yao Graduate School Peking Union Medical College and Chinese Academy of Medical SciencesBeijing 100730China Department of Gastroenterology China-Japan Friendship HospitalBeijing 100029China School of Biological Science and Medical Engineering Beihang UniversityBeijing 100191China Department of Epidemiology and Health Statistics School of Public HealthQingdao UniversityQingdao 266071Shandong ProvinceChina

BACKGROUND Fecal metabolites are associated with gut visceral sensitivity,mucosal immune function and intestinal barrier function,all of which have critical roles in the pathogenesis of irritable bowel syndrome(IBS).However,the metabolic profile and pathophysiology of IBS are still *** hypothesized that altered profiles of fecal metabolites might be involved in the pathogenesis of IBS with predominant diarrhea(IBS-D).AIM To investigate the fecal metabolite composition and the role of metabolites in IBSD *** Thirty IBS-D patients and 15 age-and sex-matched healthy controls(HCs)underwent clinical and psychological assessments,including the IBS Symptom Severity System(IBS-SSS),an Italian modified version of the Bowel Disease Questionnaire,the Bristol Stool Form Scale(BSFS),the Hospital Anxiety and Depression Scale,and the Visceral Sensitivity *** sensitivity to rectal distension was tested using high-resolution manometry system by the same *** metabolites,including amino acids and organic acids,were measured by targeted metabolomics *** analyses between these parameters were *** The patients presented with increased stool water content,more psychological symptoms and increased visceral hypersensitivity compared with the *** fecal metabolites,His[IBS-D:0.0642(0.0388,0.1484),HC:0.2636(0.0780,0.3966),P=0.012],Ala[IBS-D:0.5095(0.2826,0.9183),HC:1.0118(0.6135,1.4335),P=0.041],Tyr[IBS-D:0.1024(0.0173,0.4527),HC:0.5665(0.2436,1.3447),P=0.018],Phe[IBS-D:0.1511(0.0775,0.3248),HC:0.3967(0.1388,0.7550),P=0.028],and Trp[IBS-D:0.0323(0.0001,0.0826),HC:0.0834(0.0170,0.1759),P=0.046]were decreased in IBS-D patients,but isohexanoate[IBS-D:0.0127(0.0060,0.0246),HC:0.0070(0.0023,0.0106),P=0.028]was significantly *** Tyr was mildly correlated with BSFS scores in all subjects(r=-0.347,P=0.019).A possible potential biomarker panel was identified to correlate with IBS-SSS score(R2 Adjust

关键词： Fecal metabolite Irritable bowel syndrome Amino acids Organic acids Short chain fatty acids Visceral hypersensitivity

Prevalence and Influencing Factors on Fatigue of First-line Nurses Combating with COVID-19 in China:A Descriptive Cross-Sectional Study

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Current Medical Science 2020年第4期40卷 625-635页

作者： Yu-xin ZHAN Shi-yu ZHAO Jiao YUAN Huan liU yun-fang liU ling-li GUI Hong ZHENG Ya-min ZHOU li-hua QIU Jiao-hong CHEN Jiao-hua YU su-yun li Deparment of Nursing Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China Deparment of Operating Room Union HospialTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China Department ofAcademic Research Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China Deparment of Nursing Yijishan Hospital Affiliated to Wannan Medical CollegeWuhu 241001China Department of Radiation and Medical Oncology Zhongnan HospitalWuhan UniversityWuhan 430071China Department of Urology Renmin Hospital of Wuhan UniversityWuhan 430060China Depariment of Operating Room Affiliated Hospital of Jianghan UniversityWuhan 430015China Department of Nursing Union Jiangbei HospitalWuhan 430100China Department of Neurosurgery Hubei Provincial Hospital of Integrated Chinese&Western MedicineWuhan 430015China

summary:Nurses'work-related fatigue has been recognized as a threat to nurse health and patient *** aim of this study was to assess the prevalence of fatigue among first-line nurses combating with COVID-19 in Wuhan,China,and to analyze its influencing factors on fatigue.A multi-center,descriptive,cross-sectional design with a convenience sample was *** statistical population consisted of the first-line nurses in 7 tertiary general hospitals from March 3,2020 to March 10,2020 in Wuhan of China.A total of 2667 samples from 2768 contacted participants completed the investgation,with a response rate of 96.35%.Social-demographic questionnaire,work-related questionnaire,Fatigue Scale-14,Generalized Anxiety Disorder-7,Patient Health Questionnaire-9,and Chinese Perceived Stress Scale were used to conduct online *** descriptive statistic of nurses'social-demographic characteristics was conducted,and the related variables of work,anxiety,depression,perceived stress and fatigue were analyzed by Z-tests,nonparametric test and Pearson's correlation *** significant factors which resulted in nurses'fatigue were further analyzed by multiple linear regression *** median score for the first-line nurses'fatigue in Wuhan was 4(2,8).The median score of physical and mental fatigue of them was 3(1,6)and 1(0,3)*** to the scoring criteria,35.06%nurses(w=935)of all participants were in the fatigue status,their median score of fatigue was 10(8,11),and the median score of physical and mental fatigue of them was 7(5,8)and 3(2,4)*** linear regression analysis revealed the participants in the risk groups of anxiety,depression and perceived stress had higher scores on physical and mental fatigue and the statistically significant positive correlation was observed between the variables and nurses'fatigue,the frequency of exercise and nurses'fatigue had a statistically significant negative correlation,and average daily working

关键词： COVID-19 pandemic Chinese nurses fatigue anxiety depression perceived stress cross-sectional study

Associations between the use of red yeast rice preparations and adverse health outcomes:An umbrella review of meta-analyses of randomized controlled trials

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Journal of Integrative Medicine 2024年第2期22卷 126-136页

作者： Zhen-yu Ma Shu-ping Yang Ying li Tian-tian Xu Ya-lin Yang Hui-yong Yang Heng-bing li Le-jin Zhou Yong Diao su-yun li School of Medicine Huaqiao UniversityQuanzhou 362021Fujian ProvinceChina College of Traditional Chinese Medicine Shandong University of Traditional Chinese MedicineJinan 250355Shandong ProvinceChina Second Clinical Medical College Nanjing Medical UniversityNanjing 211166Jiangsu ProvinceChina

Background:Red yeast rice(RYR),a natural lipid-lowering agent,is widely used in clinical ***,the existing meta-analyses concerning the safety of RYR preparations have yielded inconsistent results,and the credibility of the evidence has not been ***:This study was designed to evaluate the existing evidence and offer a comprehensive understanding of the associations between the use of RYR preparations and various adverse health *** strategy:Seven literature databases were searched from inception to May 5,2023,using medical subject headings and free-text terms(e.g.,“red yeast rice,”“Xuezhikang,”and“Zhibitai”).Inclusion criteria:Meta-analyses that investigated and quantitatively estimated associations between the use of RYR preparations and adverse health outcomes were included in this *** extraction and analysis:Two researchers independently extracted data using a standardized data collection table;any disagreements were resolved by consulting a third *** on the participant,intervention,comparator and outcome(PICO)framework in each eligible meta-analysis,a series of unique associations between the use of RYR preparations and adverse health outcomes were *** associations’effect estimates were re-evaluated using random-effect ***:Fifteen meta-analyses,comprising 186(164 unique)randomized controlled trials,were *** on A Mea surement Tool to Assess Systematic Reviews version 2,3(20%)and 12(80%)of these meta-analyses had low and critically low confidence,respectively.A total of 61 unique associations between the use of RYR preparations and adverse health outcomes were extracted from eligible *** on the random-effect models,10(16.4%)associations indicated a significant protective effect of RYR preparations against adverse health outcomes,while 5(8.2%)indicated an increased risk of adverse health outcomes related to uric acid,alanine transaminase and aspartate trans

关键词： Red yeast rice Safety Adverse health outcomes Umbrella review Meta-analysis Systematic review

Efficacy and safety of Qingfei Huatan formula in the treatment of acute exacerbation of chronic obstructive pulmonary disease:A multi-centre,randomised,double-blind,placebo-controlled trial

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Journal of Integrative Medicine 2024年第5期22卷 561-569页

作者： Hui-zhi Zhu Cheng-yi li liang-ji liu Jia-bing Tong Zhi-hui Lan Shu-guang Tian Qiao li Xiang-li Tong Ji-feng Wu Zhen-gang Zhu su-yun li Jian-sheng li Department of Respiratory Medicine the First Affiliated Hospital of Anhui University of Traditional Chinese MedicineHefei 230031Anhui ProvinceChina Graduate School Anhui University of Traditional Chinese MedicineHefei 230012Anhui ProvinceChina Department of Respiratory Medicine Affiliated Hospital of Jiangxi University of Traditional Chinese MedicineNanchang 330006Jiangxi ProvinceChina Department of Respiratory Diseases the First Affiliated Hospital of Henan University of Traditional Chinese MedicineZhengzhou 450000Henan ProvinceChina Department of Pulmonary Diseases Taihe Hospital of Traditional Chinese Medicine Affiliated to Anhui University of Traditional Chinese MedicineFuyang 236600Anhui ProvinceChina Department of Respiratory and Critical Care Medicine Jiangxi Province Hospital of Integrated Chinese and Western MedicineNanchang 330002Jiangxi ProvinceChina Department of Respiratory Medicine the First Affiliated Hospital of Tianjin University of Traditional Chinese MedicineTianjin 300381China Collaborative Innovation Center for Respiratory Disease Diagnosis and Treatment and Chinese Medicine Development of Henan Province Zhengzhou 450046Henan ProvinceChina

Background Chronic obstructive pulmonary disease(COPD),a common respiratory disease,can be effectively treated by traditional Chinese medicine(TCM).Qingfei Huatan,a TCM formula,has been reported to effectively alleviate the clinical symptoms of COPD ***,there is a lack of multi-centre,randomised,double-blind,controlled clinical trials documenting the clinical efficacy and safety of this formula in the treatment of acute exacerbation of COPD(AECOPD).Objective This study evaluated the efficacy and safety of Qingfei Huatan formula in the treatment of AECOPD,thereby providing high-quality clinical ***,setting,participants and interventions A total of 276 patients with AECOPD were included in this multi-centre,randomised,double-blind,placebo-controlled trial and were randomised into treatment and control groups at a ratio of 1:*** in the treatment and control groups took Qingfei Huatan granules or simulated Qingfei Huatan granules twice a day,for 14 days,in addition to Western medicine *** patients were followed up for 3 *** outcome measures The primary outcome was time taken to symptom *** secondary outcomes included duration of antibiotic use,clinical symptom and sign score,TCM syndrome score,dyspnoea score,and quality of life(QOL)***,the safety of the formula was assessed through routine urine and stool tests,electrocardiograms,liver and kidney function tests,and the observation of adverse events throughout the *** The time taken for effective stabilisation(Plisation(Plinical symptom and sign score decreased in both groups,particularly in the treatment group(P<0.01).On days 9,12 and 14 of treatment,the TCM syndrome scores of both groups were reduced(P<0.01),with more significant reductions in the treatm

关键词： Acute exacerbation of chronic obstructive pulmonary disease Clinical trial Syndrome of phlegm-heat congesting lung Qingfei Huatan formula Traditional Chinese medicine

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关于训练理论研究中若干方法论问题的思考

北京体育大学学报 2017年第5期40卷 94-99页

作者：苏芸澐李少丹北京体育大学北京100084

我国训练理论研究水平仍处在经验阶段,训练理论的治理迫在眉睫。运用文献资料法、时序法等研究方法,以科学技术哲学与复杂性科学为研究视角,从方法论层面试厘清训练理论研究中所出现的问题,以及未来研究趋向等问题。研究认为复杂性是认... 详细信息

我国训练理论研究水平仍处在经验阶段,训练理论的治理迫在眉睫。运用文献资料法、时序法等研究方法,以科学技术哲学与复杂性科学为研究视角,从方法论层面试厘清训练理论研究中所出现的问题,以及未来研究趋向等问题。研究认为复杂性是认识训练规律的路径、科学理性是提升训练理论着眼点、学科交叉性是促进训练理论增长点、非线性是促使训练理论研究转型、整体性是表达训练理论的要义。通过提出超越传统意义上的方法论纲领,以期加快竞技体育治理体系和治理能力的现代化,适应国家竞技体育发展战略的需求;希冀训练理论对现代训练实践的要求做出科学地解释与说明,实现训练理论在实践中的应用性和操作性。

关键词：训练理论方法理论复杂性科学研究趋向战略需求

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电力线通信中子载波基的优化选取

重庆大学学报（自然科学版） 2011年第4期34卷 130-133页

作者：李姣军李恒苏理云李刚重庆理工大学电子信息与自动化学院重庆400050 重庆理工大学数理学院重庆400050

针对电力线信道中的频率弥散特性,研究了采用不同的子载波基对系统抗干扰性能的影响,提出以小波包函数替代正交频分复用(OFDM)中的正弦基作为子载波基进行传输的技术,利用其正交性来对抗电力线信道中的多径干扰与频率选择性衰落特性。... 详细信息

针对电力线信道中的频率弥散特性,研究了采用不同的子载波基对系统抗干扰性能的影响,提出以小波包函数替代正交频分复用(OFDM)中的正弦基作为子载波基进行传输的技术,利用其正交性来对抗电力线信道中的多径干扰与频率选择性衰落特性。通过仿真,分析了采用不同小波包基的小波包调制与OFDM的抗干扰性能,结果表明:在信噪比达到一定值时,正交小波包调制技术的抗干扰性能优于半正交小波包调制及OFDM技术。

关键词：电力线通信子载波基小波包调制(WPM) 正交频分复用

Applications of the Aversion Order of Risks in Reinsurance

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Chinese Quarterly Journal of Mathematics 2010年第2期25卷 267-275页

作者： ZHANG Rui ZANG Zhen-chun su Bai-yun li Hai-yin Department of Mathematics and Information Science Henan Institute of Finance and Economic Zhengzhou 450002 China

The aversion order is a way of ordering of risks. Is there the optimal in aversion order in reinsurance contracts of reinsurance？ This paper discusses these objects and gives some optimal reinsurance contracts in cer... 详细信息

关键词： risk aversion order reinsurance contract the optimal reinsurance contract

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混沌噪声背景下微弱脉冲信号的检测及恢复

物理学报 2017年第9期66卷 23-32页

作者：苏理云孙唤唤王杰阳黎明重庆理工大学理学院重庆400054

构建了一种在混沌噪声背景下检测并恢复微弱脉冲信号的模型.首先,基于混沌信号的短期可预测性及其对微小扰动的敏感性,对观测信号进行相空间重构、建立局域线性自回归模型进行单步预测,得到预测误差,并利用假设检验方法从预测误差中检... 详细信息

构建了一种在混沌噪声背景下检测并恢复微弱脉冲信号的模型.首先,基于混沌信号的短期可预测性及其对微小扰动的敏感性,对观测信号进行相空间重构、建立局域线性自回归模型进行单步预测,得到预测误差,并利用假设检验方法从预测误差中检测观测信号中是否含有微弱脉冲信号.然后,对微弱脉冲信号建立单点跳跃模型,并融合局域线性自回归模型,构成双局域线性(DLL)模型,以极小化DLL模型的均方预测误差为目标进行优化,采用向后拟合算法估计模型的参数,并最终恢复出混沌噪声背景下的微弱脉冲信号.仿真实验结果表明本文所建的模型能够有效地检测并恢复出混沌噪声背景中的微弱脉冲信号.

关键词：混沌噪声微弱脉冲信号检测局域线性自回归模型双局域线性模型