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Altered profiles of fecal metabolites correlate with visceral hypersensitivity and may contribute to symptom severity of diarrhea-predominant irritable bowel syndrome

Altered profiles of fecal metabolites correlate with visceral hypersensitivity and may contribute to symptom severity of diarrhea-predominant irritable bowel syndrome

作     者:Wen-Xue Zhang Yu Zhang Geng Qin Kai-Min Li Wei Wei Su-Yun Li Shu-Kun Yao 

作者机构:Graduate SchoolPeking Union Medical College and Chinese Academy of Medical SciencesBeijing 100730China Department of GastroenterologyChina-Japan Friendship HospitalBeijing 100029China School of Biological Science and Medical EngineeringBeihang UniversityBeijing 100191China Department of Epidemiology and Health StatisticsSchool of Public HealthQingdao UniversityQingdao 266071Shandong ProvinceChina 

出 版 物:《World Journal of Gastroenterology》 (世界胃肠病学杂志(英文版))

年 卷 期:2019年第25卷第43期

页      面:6416-6429页

核心收录:

学科分类:1002[医学-临床医学] 100201[医学-内科学(含:心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基  金:the National Key Technology Support Program for the “12th Five-Year Plan” of China,No.2014BAI08B00 the Research Projects on Biomedical Transformation of China-Japan Friendship Hospital,No.PYBZ1815 

主  题:Fecal metabolite Irritable bowel syndrome Amino acids Organic acids Short chain fatty acids Visceral hypersensitivity 

摘      要:BACKGROUND Fecal metabolites are associated with gut visceral sensitivity,mucosal immune function and intestinal barrier function,all of which have critical roles in the pathogenesis of irritable bowel syndrome(IBS).However,the metabolic profile and pathophysiology of IBS are still *** hypothesized that altered profiles of fecal metabolites might be involved in the pathogenesis of IBS with predominant diarrhea(IBS-D).AIM To investigate the fecal metabolite composition and the role of metabolites in IBSD *** Thirty IBS-D patients and 15 age-and sex-matched healthy controls(HCs)underwent clinical and psychological assessments,including the IBS Symptom Severity System(IBS-SSS),an Italian modified version of the Bowel Disease Questionnaire,the Bristol Stool Form Scale(BSFS),the Hospital Anxiety and Depression Scale,and the Visceral Sensitivity *** sensitivity to rectal distension was tested using high-resolution manometry system by the same *** metabolites,including amino acids and organic acids,were measured by targeted metabolomics *** analyses between these parameters were *** The patients presented with increased stool water content,more psychological symptoms and increased visceral hypersensitivity compared with the *** fecal metabolites,His[IBS-D:0.0642(0.0388,0.1484),HC:0.2636(0.0780,0.3966),P=0.012],Ala[IBS-D:0.5095(0.2826,0.9183),HC:1.0118(0.6135,1.4335),P=0.041],Tyr[IBS-D:0.1024(0.0173,0.4527),HC:0.5665(0.2436,1.3447),P=0.018],Phe[IBS-D:0.1511(0.0775,0.3248),HC:0.3967(0.1388,0.7550),P=0.028],and Trp[IBS-D:0.0323(0.0001,0.0826),HC:0.0834(0.0170,0.1759),P=0.046]were decreased in IBS-D patients,but isohexanoate[IBS-D:0.0127(0.0060,0.0246),HC:0.0070(0.0023,0.0106),P=0.028]was significantly *** Tyr was mildly correlated with BSFS scores in all subjects(r=-0.347,P=0.019).A possible potential biomarker panel was identified to correlate with IBS-SSS score(R2 Adjust

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