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N6-methyladenosine methylation regulates the tumor microenvironment of Epstein-Barr virus-associated gastric cancer

World Journal of Gastrointestinal Oncology 2024年第6期16卷 2555-2570页

作者： Yu Zhang Fang Zhou Ming-Yu Zhang Li-Na Feng jia-Lun Guan Ruo-Nan Dong Yu-Jie Huang su-hong xia.jia.zhi lia. Kai Zhao Department of Gastroenterology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030Hubei ProvinceChina Institute of Liver and Gastrointestinal Diseases Hubei Key Laboratory of Hepato-Pancreato-Biliary DiseasesTongji Hospital of Tongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030Hubei ProvinceChina Department of Pharmacy Wuhan Fourth HospitalWuhan 430030Hubei ProvinceChina

BACKGROUND N6-methyladenosine(m6A)methylation modification exists in Epstein-Barr virus(EBV)primary infection,latency,and lytic *** also modifies EBV latent genes and lytic ***-associated gastric cancer(EBVaGC)is a distinctive molecular subtype of *** hypothesized EBV and m6A methylation regulators interact with each other in EBVaGC to differentiate it from other types of *** To investigate the mechanisms of m6A methylation regulators in EBVaGC to determine the differentiating factors from other types of *** First,The Cancer Gene Atlas and Gene Expression Omnibus databases were used to analyze the expression pattern of m6A methylation regulators between EBVaGC and EBV-negative GC(EBVnGC).Second,we identified Gene Ontology(GO)and Kyoto Encyclopedia of Genes and Genomes(KEGG)functional enrichment of m6A-related differentially expressed *** quantified the relative abundance of immune cells and inflammatory factors in the tumor microenvironment(TME).Finally,cell counting kit-8 cell proliferation test,transwell test,and flow cytometry were used to verify the effect of insulin-like growth factor binding protein 1(IGFBP1)in EBVaGC cell *** m6A methylation regulators were involved in the occurrence and development of *** with EBVnGC,the expression levels of m6A methylation regulators Wilms tumor 1-associated protein,RNA binding motif protein 15B,CBL proto-oncogene like 1,leucine rich pentatricopeptide repeat containing,heterogeneous nuclear ribonucleoprotein A2B1,IGFBP1,and insulin-like growth factor 2 binding protein 1 were significantly downregulated in EBVaGC(Psurvival rate of EBVaGC patients with a lower expression level of IGFBP1 was significantly higher(P=0.046).GO and KEGG functional enrichment analyses showed that the immunity pathways were significantly activated and rich in immune cell infiltration in *** with EBVnGC,the infiltration of activated CD4+T cells,activated CD8+T cel

关键词： N6-methyladenosine methylation Tumor microenvironment Epstein-Barr virus Gastric cancer Insulin-like growth factor binding protein 1

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Genomic data and ecological niche modeling reveal an unusually slow rate of molecular evolution in the Cretaceous Eupteleaceae

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Science China(Life Sciences) 2024年第4期67卷 803-816页

作者： Kun-Li xiang Sheng-Dan Wu lia. lia. Wen-Chuang He Dan Peng Huan-Wen Peng xiao-Ni Zhang hong-Lei Li jia-Yu Xue hong-Yan Shan Gui-xia Xu Yang Liu zhi-Qiang Wu Wei Wang State Key Laboratory of Plant Diversity and Specialty Crops Institute of BotanyChinese Academy of SciencesBeijing 100093China Shenzhen Branch Guangdong Laboratory of Lingnan Modern AgricultureKey Laboratory of Synthetic BiologyLaboratory of the Ministry of Agriculture and Rural AffairsAgricultural Genomics Institute at ShenzhenChinese Academy of Agricultural SciencesShenzhen 518120China China National Botanical Garden Beijing 100093China State Key Laboratory of Grassland Agro-Ecosystems and College of Ecology Lanzhou UniversityLanzhou 730000China University of Chinese Academy of Sciences Beijing 100049China College of Landscape Architecture and Life Science/Institute of Special Plants Chongqing University of Arts and SciencesChongqing 402160China College of Horticulture Academy for Advanced Interdisciplinary StudiesNanjing Agricultural UniversityNanjing 210095China Fairylake Botanical Garden Shenzhen&Chinese Academy of SciencesShenzhen 518004China

Living fossils are evidence of long-term sustained ecological ***,whether living fossils have little molecular changes remains poorly known,particularly in ***,we have introduced a novel method that integrates phylogenomic,comparative genomic,and ecological niche modeling analyses to investigate the rate of molecular evolution of Eupteleaceae,a Cretaceous relict angiosperm family endemic to East *** assembled a high-quality chromosome-level nuclear genome,and the chloroplast and mitochondrial genomes of a member of Eupteleaceae(Euptelea pleiosperma).Our results show that Eupteleaceae is most basal in Ranunculales,the earliest-diverging order in eudicots,and shares an ancient whole-genome duplication event with the other *** document that Eupteleaceae has the slowest rate of molecular changes in the observed *** unusually low rate of molecular evolution of Eupteleaceae across all three independent inherited genomes and genes within each of the three genomes is in association with its conserved genome architecture,ancestral woody habit,and conserved niche *** findings reveal the evolution and adaptation of living fossil plants through large-scale environmental change and also provide new insights into early eudicot diversification.

关键词： conservation genomics eudicots evolutionary rates niche conservatism phylogenomics

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Analyzing the surface passivity effect of germanium oxynitride:a comprehensive approach through first principles simulation and interface state density

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Nuclear Science and Techniques 2024年第5期35卷 74-84页

作者： Sheng-Jie Du Xiu-xia Li Yang Tian Yuan-Yuan Liu Ke jia Zhong-Zheng Tang jian-Ping Cheng zhi Deng Yu-Lan Li Zheng-Cao Li Sha-Sha Lv College of Nuclear Science and Technology Joint Laboratory of Jinping Ultra‑Low Radiation Background Measurement of Ministry of Ecology and Environment Key Laboratory of Beam Technology of Ministry of Education Beijing Normal UniversityBeijing Normal UniversityBeijing 100875China Joint Research Center Nuctech Company LimitedBeijing 100084China Department of Engineering Physics Key Laboratory of Particle&Radiation Imaging of Ministry of EducationTsinghua UniversityBeijing 100084China Key Laboratory of Advanced Materials(MOE) School of Materials Science and EngineeringTsinghua UniversityBeijing 100084China

High-purity germanium(HPGe)detectors,which are used for direct dark matter detection,have the advantages of a low threshold and excellent energy *** surface passivation of HPGe has become crucial for achieving an extremely low energy *** this study,first-principles simulations,passivation film preparation,and metal oxide semiconductor(MOS)capacitor characterization were combined to study surface *** calculations of the energy band structure of the -H,-OH,and -NH_(2) passivation groups on the surface of Ge were performed,and the interface state density and potential with five different passivation groups with N/O atomic ratios were accurately analyzed to obtain a stable surface *** on the theoretical calculation results,the surface passivation layers of the Ge_(2)ON_(2) film were prepared via magnetron sputtering in accordance with the optimum atomic ratio *** microstructure,C-V,and I-V electrical properties of the layers,and the passivation effect of the Al/Ge_(2)ON_(2)/Ge MOS were characterized to test the interface state *** mean interface state density obtained by the Terman method was 8.4×10^(11) cm^(-2) eV^(-1).The processing of germanium oxynitrogen passivation films is expected to be used in direct dark matter detection of the HPGe detector surface passivation technology to reduce the detector leakage currents.

关键词： surface passivation High purity germanium detector Germanium nitrogen oxide Interface state density

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低速船舶微气泡减阻数值研究

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船舶力学 2024年第3期28卷 368-378页

作者：赵晓杰宗智王加夏洪智超胡俊明江苏科技大学船舶与海洋工程学院江苏镇江212000 大连理工大学船舶工程学院辽宁大连116024 工业装备结构分析国家重点实验室辽宁大连116024 江苏省船舶与海洋工程装备技术创新中心江苏南通226100

为了研究船舶微气泡减阻规律,本文基于OpenFOAM中两相欧拉数值模型,对低速散货船进行微气泡减阻数值研究。对气液两相分别建立控制方程,考虑五种相间作用力及气泡聚合和破碎,采用考虑气泡影响的改进k-ε湍流模型,忽略自由面影响,采用叠... 详细信息

为了研究船舶微气泡减阻规律,本文基于OpenFOAM中两相欧拉数值模型,对低速散货船进行微气泡减阻数值研究。对气液两相分别建立控制方程,考虑五种相间作用力及气泡聚合和破碎,采用考虑气泡影响的改进k-ε湍流模型,忽略自由面影响,采用叠模模型研究喷气量、气泡直径、航速及吃水等因素对船舶微气泡减阻的影响,分析气体体积分数、湍流粘度和气泡直径分布等。结果表明:微气泡可以同时减少船舶摩擦阻力、粘压阻力和总阻力;喷气量直接影响减阻率,喷气量越大,减阻率越高;较小气泡的平均气体体积分数较大且气体分布更均匀,同时湍流运动粘度较小,可以更有效减阻;气泡沿着流向会聚并,气泡越小聚并越剧烈;较高航速和小吃水更有利于减阻。

关键词：两相欧拉模型微气泡减阻船舶摩擦阻力数值模拟

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RGS22 maintains the physiological function of ependymal cells to prevent hydrocephalus

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Science China Life Sciences 2024年

作者： Xue Pang Lin Gu Qiu-Ying Han jia-Qing Xing Ming Zhao Shao-Yi Huang Jun-Xi Yi Jie Pan Hao hong Wen Xue Xue-Qing Zhou zhi-Hui su Xin-Ran Zhang Li-Ming sun Shao-Zhen jiang Dan Luo Ling Chen Zheng-Jie Wang Yu Yu Tian xia Xue-Min Zhang Ai-Ling Li Tao Zhou hong Cai Tao Li Nanhu Laboratory National Center of Biomedical Analysis School of Basic Medical Sciences Fudan University Department of Basic Medical Sciences School of Medicine Tsinghua University

Ependymal cells line the wall of cerebral ventricles and ensure the unidirectional cerebrospinal fluid （CSF） flow by beating their motile cilia.coordinately. The ependymal denudation or cilia.y dysfunction causes hydrocephalus. Here, we report that the deficiency of regulator of Gprotein signaling 22 （RGS22） results in severe congenital hydrocephalus in both mice and rats. Interestingly, RGS22 is specifically expressed in ependymal cells within the brain. Using conditional knock-out mice, we further demonstrate that the deletion of Rgs22 exclusively in nervous system is sufficient to induce hydrocephalus. Mechanistically, we show that Rgs22 deficiency leads to the ependymal denudation and impaired ciliogenesis. This phenomenon can be attributed to the excessive activation of lysophosphatidic acid receptor （LPAR） signaling under Rgs22–/–condition, as the LPAR blockade effectively alleviates hydrocephalus in Rgs22–/–rats. Therefore, our findings unveil a previously unrecognized role of RGS22 in the central nervous system, and present RGS22 as a potential diagnostic and therapeutic target for hydrocephalus.

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Risk factors for renal outcomes in children with antineutrophil cytoplasmic antibody-associated vasculitis:a nationwide retrospective study in China

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World Journal of Pediatrics 2024年第5期20卷 506-516页

作者： Li-Wen Tan Jun-Li Wan Chun-Hua Zhu hong Xu Zheng-Kun xia Li-zhi Chen xiao-Chuan Wu Fang Wang xiao-Rong Liu Cheng-Guang Zhao xiao-Zhong Li jian-Hua Mao xiao-Wen Wang Wen-Yan Huang Yu-hong Li jian-jiang Zhang Shi-Pin Feng Jun Yang jiao-jiao Liu Chun-Lin Gao Li-Ping Rong Lan-Jun Shuai Ke Xu He-jia Zhang Qiu Li Ai-Hua Zhang Mo Wang Department of Nephrology Children’s Hospital of Chongqing Medical UniversityZhongshan 2nd Rd.136Chongqing400014China Ministry of Education Key Laboratory of Child Development and Disorders National Clinical Research Center for Child Health and DisordersChina International Science and Technology Cooperation Base of Child Development and Critical DisordersChildren’s Hospital of Chongqing Medical UniversityChongqingChina Chongqing Key Laboratory of Pediatrics Children’s Hospital of Chongqing Medical UniversityChongqingChina Department of Nephrology Children’s Hospital of Nanjing Medical University72 Guangzhou RoadNanjing210008China Department of Nephrology Children’s Hospital of Fudan UniversityNational Paediatric Medical Center of ChinaShanghaiChina Department of Pediatrics Jinling HospitalNanjing Medical UniversityNanjingChina Department of Pediatrics Jinling HospitalThe First School of Clinical MedicineSouthern Medical UniversityNanjingChina Department of Pediatrics Jinling HospitalMedical School of Nanjing UniversityNanjingChina Department of Pediatric Nephrology and Rheumatology The First Affiliated Hospital of Sun Yat-Sen UniversityGuangzhouChina Department of Pediatrics The Second Xiangya Hospital of Central South UniversityChangshaChina Department of Pediatrics Peking University First HospitalBeijingChina Department of Nephrology Beijing Children’s HospitalCapital Medical UniversityBeijing100045China National Center for Children’s Health BeijingChina Department of Pediatrics Shengjing Hospital of China Medical UniversityShenyangChina Department of Nephrology and Immunology Children’s Hospital of Soochow UniversitySuzhouChina Department of Nephrology Children HospitalZhejiang University School of MedicineHangzhouChina Department of Nephrology Wuhan Children’s Hospital(Wuhan Maternal and Child Healthcare Hospital)Tongji Medical CollegeHuazhong University of Science&TechnologyWuhanChina Department of Nephrology and Rheumatology Shanghai Children’s HospitalSchool

Background Pediatric antineutrophil cytoplasmic antibody-associated vasculitis(AAV)is a life-threatening systemic vasculitis featured by lia.ility to renal ***,there are few studies on the risk factors and predictive models for renal outcomes of AAV in *** Data from 179 AAV children in multiple centers between January 2012 and March 2020 were collected *** risk factors and predictive model of end-stage renal disease(ESRD)in AAV were *** Renal involvement was the most typical manifestation(95.5%),and the crescent was the predominant pathological lesion(84.9%).The estimated glomerular filtration rate(eGFR)was evaluated in 114 patients,of whom 59.6%developed ESRD,and the median time to ESRD was 3.20 *** eGFR[P=0.006,odds ratio(OR)=0.955,95%confidence interval(CI)=0.924–0.987]and the percentages of global glomerulosclerosis(pGGS;P=0.018,OR=1.060,95%CI=1.010–1.112)were independent risk factors for ESRD of renal *** on the pGGS and eGFR at renal biopsy,we developed three risk grades of ESRD and one predictive *** Kaplan‒Meier curve indicated that renal outcomes were significantly different in different risk grades(Psus 0.58,Psus 0.92)in external *** Renal involvement is the most common manifestation of pediatric AAV in China,of which more than half deteriorates into *** predictive model based on eGFR at renal biopsy and the pGGS may be stable and accurate in speculating the risk of ESRD in AAV children.

关键词： Antineutrophil cytoplasmic antibody End-stage renal disease Glomerulonephritis Pediatric nephrology Vasculitis

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Correlation between Combined Urinary Metal Exposure and Grip Strength under Three Statistical Models:A Cross-sectional Study in Rural Guangxi

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Biomedical and Environmental Sciences 2024年第1期37卷 3-18页

作者： lia.G Yu jian RONG jia Hui WANG Xue Xiu CAI jian Sheng QIN Li Dong LIU Qiu Mei TANG Xu MO xiao Ting WEI Yan Fei LIN Yin xia HUANG Shen xiang LUO Ting Yu GOU Ruo Yu CAO Jie Jing HUANG Chu Wu LU Yu Fu QIN jian ZHANG zhi Yong Department of Environmental and Occupational Health School of Public HealthGuangxi Medical UniversityNanning 530021GuangxiChina Key Laboratory of Tumor Immunology and Microenvironmental Regulation Guilin Medical UniversityGuilin 541199GuangxiChina Department of Environmental Health and Occupational Medicine School of Public HealthGuilin Medical UniversityGuilin 541199GuangxiChina Guangxi Colleges and Universities Key Laboratory of Prevention and Control of Highly Prevalent Diseases Guangxi Medical UniversityNanning 530021GuangxiChina Guangxi Key Laboratory of Environment and Health Research Guangxi Medical UniversityNanning 530021GuangxiChina Key Laboratory of Longevity and Aging-related Diseases of Chinese Ministry of Education Guangxi Medical UniversityNanning 530021GuangxiChina Guangxi Health Commission Key Laboratory of Entire Lifecycle Health and Care Guilin Medical UniversityGuilin 541199GuangxiChina

Objective This study aimed to investigate the potential relationship between urinary metals copper(Cu),arsenic(As),strontium(Sr),barium(Ba),iron(Fe),lead(Pb)and manganese(Mn)and grip *** We used linear regression models,quantile g-computation and Bayesian kernel machine regression(BKMR)to assess the relationship between metals and grip *** In the multimetal linear regression,Cu(β=−2.119),As(β=−1.318),Sr(β=−2.480),Ba(β=0.781),Fe(β=1.130)and Mn(β=−0.404)were significantly correlated with grip strength(Psults of the quantile g-computation showed that the risk of occurrence of grip strength reduction was−1.007(95%confidence interval:−1.362,−0.652;Psummary,this study suggests that combined exposure to metal mixtures is negatively associated with grip ***,Sr and As were negatively correlated with grip strength levels,and there were potential interactions between As and Mn and between Cu and Mn.

关键词： Urinary metals Handgrip strength Quantile g-computation Bayesian kernel machine regression

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基于分层卷积自编码器的钝体湍流流场降阶分析

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吉林大学学报（工学版） 2024年第4期54卷 874-882页

作者：夏超王梦佳朱剑月杨志刚同济大学汽车学院上海201804 同济大学上海地面交通工具风洞中心上海201804 同济大学铁道与城市轨道交通研究院上海201804 北京民用飞机技术研究中心北京102211

本文采用了一种非线性的分层卷积自编码器,类比于本征正交分解的方法,可以对提取到的低维特征进行能量排序,同时又能在一定范围内达到更高的降阶性能。文中以雷诺数为20000的三维圆柱钝体湍流尾迹流动为例,分析分层卷积自编码器对该流... 详细信息

本文采用了一种非线性的分层卷积自编码器,类比于本征正交分解的方法,可以对提取到的低维特征进行能量排序,同时又能在一定范围内达到更高的降阶性能。文中以雷诺数为20000的三维圆柱钝体湍流尾迹流动为例,分析分层卷积自编码器对该流场的降阶能力,并与本征正交分解的结果作对比。同时,在此基础上延伸出组合模态的概念,并增加每一组低维潜在向量数,观察重构流场与原始流场的均方误差变化。结果表明,在分层层数及每层潜在空间向量数较少时,非线性的分层卷积自编码器相对于本征正交分解的方法对流场有更强的还原能力,但是其优势会随着层数和潜在向量数的增加而减弱。

关键词：分层自编码器卷积神经网络钝体湍流尾迹降阶模型

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催化合成α-amyrin的氧化鲨烯环化酶基因克隆及功能表征

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中国中药杂志 2024年第12期49卷 3204-3211页

作者：梁志鹏于宛彤苏新堯侯红平薛建平刘佳王彩霞淮北师范大学生命科学学院安徽淮北235000 中国中医科学院中药研究所北京100700 安徽省特色资源植物利用工程实验室安徽淮北235000

熊果酸近年来由于其独特的药理活性以及宝贵的市场价值,逐渐引起人们的广泛关注。目前熊果酸大多从枇杷叶中提取,但植物提取法产率低,成本高,化学合成法又不易获得,因此生物合成法为熊果酸提供了一个新的来源。α-amyrin作为合成熊果酸... 详细信息

熊果酸近年来由于其独特的药理活性以及宝贵的市场价值,逐渐引起人们的广泛关注。目前熊果酸大多从枇杷叶中提取,但植物提取法产率低,成本高,化学合成法又不易获得,因此生物合成法为熊果酸提供了一个新的来源。α-amyrin作为合成熊果酸的主要前体物质,其产量与熊果酸产量呈正相关性。氧化鲨烯环化酶(OSC)属于多基因家族,可以催化常见的前体2,3-氧化鲨烯生成多种不同类型的三萜骨架,为三萜类物质的合成起决定性作用。但药用植物中催化合成α-amyrin的关键基因报道较少,且其催化产物中α-amyrin产量及占比一直是研究者们关注的重点。该文从鸢尾、苹果、青蒿和长春花中克隆出能够催化2,3-氧化鲨烯生成α-amyrin的4种环化酶ItOSC2、MdOSC1、AaOSC2和CrAS基因,系统地对4种环化酶进行序列比对以及进化树分析,并以质粒形式将其转化至酿酒酵母中进行异源表达。发酵7 d后测定其催化产物中α-amyrin、β-amyrin以及麦角固醇的产量及占比,筛选出一个催化生成α-amyrin能力最好的AaOSC2,为后期构建高产α-amyrin及熊果酸的工程酵母菌株提供关键基因元件。

关键词：氧化鲨烯环化酶 α-amyrin β-amyrin 酿酒酵母鲨烯

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航空发动机旋转盘腔内部流动换热特性研究进展综述

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风机技术 2024年第1期66卷 88-96页

作者： jia-yue xia Wen-chao sun Xue-zhi Dong Chun-qing Tan Nanjing University of Aeronautics and Astronautics Instituete for Aero Engine Tsinghua University

The rotating disk cavity is an important part of the cooling-air system of the aero engine,and it has obviously significance to study the internal flow and heat transfer characteristics of the disc cavity,which will be helpful to improve the efficiency of the aero *** paper summarizes the existing research results of domestic and *** present work considers the test methods and calculation methods of the flow and heat transfer characteristics of the rotating disc cavity of the aircraft *** points out that,the main factors which affect the heat transfer characteristics are the disc chamber speed,the intake volume,the design of the disc cavity pre-rotation/despin structure,and the type of disc cavity *** influence of these factors on the characteristics of flow heat transfer is *** on these factors,the disc cavity structure can be optimized and designed,which provides suggestions for reducing the weight of the turbine,improving the thrust-to-weight ratio of the aero engine,and improving the cooling efficiency.

关键词： Rotating Disk Cavity Test Method Calculation Method Flow Heat Transfer The Optimization Design

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