Correlation between Combined Urinary Metal Exposure and Grip Strength under Three Statistical Models:A Cross-sectional Study in Rural Guangxi

作     者：LIANG Yu Jian RONG Jia Hui WANG Xue Xiu CAI Jian Sheng QIN Li Dong LIU Qiu Mei TANG Xu MO Xiao Ting WEI Yan Fei LIN Yin Xia HUANG Shen Xiang LUO Ting Yu GOU Ruo Yu CAO Jie Jing HUANG Chu Wu LU Yu Fu QIN Jian ZHANG Zhi Yong LIANG Yu Jian;RONG Jia Hui;WANG Xue Xiu;CAI Jian Sheng;QIN Li Dong;LIU Qiu Mei;TANG Xu;MO Xiao Ting;WEI Yan Fei;LIN Yin Xia;HUANG Shen Xiang;LUO Ting Yu;GOU Ruo Yu;CAO Jie Jing;HUANG Chu Wu;LU Yu Fu;QIN Jian;ZHANG Zhi Yong

作者机构：Department of Environmental and Occupational HealthSchool of Public HealthGuangxi Medical UniversityNanning 530021GuangxiChina Key Laboratory of Tumor Immunology and Microenvironmental RegulationGuilin Medical UniversityGuilin 541199GuangxiChina Department of Environmental Health and Occupational MedicineSchool of Public HealthGuilin Medical UniversityGuilin 541199GuangxiChina Guangxi Colleges and Universities Key Laboratory of Prevention and Control of Highly Prevalent DiseasesGuangxi Medical UniversityNanning 530021GuangxiChina Guangxi Key Laboratory of Environment and Health ResearchGuangxi Medical UniversityNanning 530021GuangxiChina Key Laboratory of Longevity and Aging-related Diseases of Chinese Ministry of EducationGuangxi Medical UniversityNanning 530021GuangxiChina Guangxi Health Commission Key Laboratory of Entire Lifecycle Health and CareGuilin Medical UniversityGuilin 541199GuangxiChina 

出 版 物：《Biomedical and Environmental Sciences》 (生物医学与环境科学（英文版）)

年 卷 期：2024年第37卷第1期

页      面：3-18页

核心收录：

学科分类：100405[医学-卫生毒理学] 1004[医学-公共卫生与预防医学(可授医学、理学学位)] 10[医学] 

基　　金：supported by the National Natural Science Foundation of China[rant Nos.81960583,81760577,81560523 and 82260629] Major Science and Technology Projects in Guangxi[GKAA22399 and AA22096026] the Guangxi Science and Technology Development Project[Grant Nos.AD 17129003 and 18050005] the Guangxi Natural Science Foundation for Innovation Research Team[2019GXNSFGA245002] the Innovation Platform and Talent Plan in Guilin[20220120-2] the Guangxi Scholarship Fund of Guangxi Education Department of China 

主　　题：Urinary metals Handgrip strength Quantile g-computation Bayesian kernel machine regression 

摘      要：Objective This study aimed to investigate the potential relationship between urinary metals copper(Cu),arsenic(As),strontium(Sr),barium(Ba),iron(Fe),lead(Pb)and manganese(Mn)and grip *** We used linear regression models,quantile g-computation and Bayesian kernel machine regression(BKMR)to assess the relationship between metals and grip *** In the multimetal linear regression,Cu(β=−2.119),As(β=−1.318),Sr(β=−2.480),Ba(β=0.781),Fe(β=1.130)and Mn(β=−0.404)were significantly correlated with grip strength(P0.05).The results of the quantile g-computation showed that the risk of occurrence of grip strength reduction was−1.007(95%confidence interval:−1.362,−0.652;P0.001)when each quartile of the mixture of the seven metals was *** kernel function regression model analysis showed that mixtures of the seven metals had a negative overall effect on grip strength,with Cu,As and Sr being negatively associated with grip strength *** the total population,potential interactions were observed between As and Mn and between Cu and Mn(P_(interactions) of 0.003 and 0.018,respectively).Conclusion In summary,this study suggests that combined exposure to metal mixtures is negatively associated with grip ***,Sr and As were negatively correlated with grip strength levels,and there were potential interactions between As and Mn and between Cu and Mn.