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ERβ-activated LINC01018 promotes endometriosis development by regulating the CDC25C/CDK1/CyclinB1 pathway

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Journal of Genetics and Genomics 2024年第6期51卷 617-629页

作者： Ruihui lu Jingwen Zhu Xin Li Cheng Zeng Yan Huang Chao peng Yingfang Zhou Qing Xue Department of Obstetrics and Gynecology Peking University First HospitalBeijing 100034China

Endometriosis refers to as an estrogen-dependent *** receptorβ(ERB),the main estrogen receptor subtype which is encoded by the estrogen receptor 2(ESR2)gene,can mediate the action of estrogen in *** selective estrogen receptor modulators can target the ERβ,they are not specific due to the wide distribution of ERβ.Recently,long noncoding RNAs have been implicated in ***,we aim to explore and validate the downstream regulatory mechanism of ERβ,and to investigate the potential role of long intergenic noncoding RNA 1018(LINC01018)as a nonhormonal treatment for *** study demonstrates that the expression levels of ESR2 and LINCo1018 are increased in ectopic endometrial tissues and reveals a significant positive correlation between the ESR2 and LINCo1018 ***,ERβdirectly binds to an estrogen response element located in the LINCO1018 promoter region and activates LINC01018 ***,ERβcan regulate the CDC25C/CDK1/CyclinB1 pathway and promote ectopic endometrial stromal cell proliferation via LINC01018 in *** with these findings,the knockdown of LINC01018 inhibits endometriotic lesion proliferation in *** summary,our study demonstrates that the ERβ/LINC01018/CDC25C/CDK1/CyclinB1 signaling axis regulates endometriosis progression.

关键词： Estrogen receptorβ Long intergenic noncoding RNA 1018 (LINC01018) Endometriosis Cell cycle Proliferation

Ligation-assisted endoscopic submucosal resection following unroofing technique for small esophageal subepithelial lesions originating from the muscularis propria

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World Journal of Gastroenterology 2024年第32期30卷 3748-3754页

作者： Quan lu Quan-Zhou peng Jun Yao Li-Sheng Wang De-Feng Li Department of Gastroenterology Shenzhen People’s HospitalShenzhen 518020Guangdong ProvinceChina Department of Pathology Shenzhen People’s HospitalShenzhen 518020Guangdong ProvinceChina Department of Gastroenterology Shenzhen People’s HospitalThe Second Clinical Medical CollegeJinan UniversityShenzhen 518020Guangdong ProvinceChina The First Affiliated Hospital Southern University of Science and TechnologyShenzhen 518020Guangdong ProvinceChina

BACKGROUND The majority of esophageal subepithelial lesions originating from the muscularis propria(SEL-MPs)are benign in nature,although a subset may exhibit malignant *** endoscopic resection techniques are time-consuming and lack efficacy for small *** To evaluate the efficacy and safety of ligation-assisted endoscopic submucosal resection(ESMR-L)following unroofing technique for small esophageal *** From January 2021 to September 2023,17 patients diagnosed with esophageal SEL-MPs underwent ESMR-L following unroofing technique at the endoscopy center of Shenzhen People’s *** of clinicopathological characteristics and clinical outcomes were collected and *** The mean age of the patients was 50.12±12.65 *** mean size of the tumors was 7.47±2.83 mm and all cases achieved en bloc resection *** average operation time was 12.2 minutes without any *** identified 2 Lesions(11.8%)as gastrointestinal stromal tumors at very low risk,12 Lesions(70.6%)as leiomyoma and 3 Lesions(17.6%)as smooth muscle *** recurrence was found during the mean follow-up duration of 14.18±9.62 *** ESMR-L following roofing technique is an effective and safe technique for management of esophageal SEL-MPs smaller than 20 mm,but it cannot ensure en bloc resection and may require further treatment.

关键词： subepithelial lesions Muscularis propria Esophagus Ligation Endoscopic submucosal resection

Two different mutational types of familial gastrointestinal stromal tumors:Two case reports

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World Journal of Gastrointestinal Oncology 2024年第9期16卷 4028-4036页

作者： Xiao-Ke Wang lu-Fan Shen Xin Yang He su Tao Wu peng-Xian Tao Hong-Ying Lv Tong-Han Yao Lin Yi Yuan-Hui Gu The First School of Clinical Medical Gansu University of Chinese MedicineLanzhou 730000Gansu ProvinceChina School of Traditional Chinese and Western Medicine Gansu University of Chinese MedicineLanzhou 730000Gansu ProvinceChina Department of General surgery Gansu Provincial HospitalLanzhou 730000Gansu ProvinceChina

BACKGROUND Gastrointestinal stromal tumors(GISTs)are the most common mesenchymal tumors of the gastrointestinal(GI)tract,and cases of GISTs tend to be of the disseminated type,with a global incidence of 10 to 15 cases/million each *** rarer familial GISTs,which often represent a population,differ in screening,diagnosis,and *** GISTs include primary familial GISTs with predominantly KIT/PDGFRA mutations and wild-type ***,whether the same genetic family has different phenotypes has not been *** suMMARY We report two cases of rare GISTs in the same family:A male patient with the V561D mutation in exon 12 of the PDGFRA gene,who has been taking the targeted drug imatinib since undergoing surgery,and a female patient diagnosed with wild-type GIST,who has been taking imatinib for 3 years since undergoing *** favorable prognosis of these patients during the 7-year follow-up period validates the accuracy of our treatment strategy,and we have refined the entire process of diagnosis and treatment of familial GISTs in order to better manage this rare familial *** Different mutation types of familial GISTs in the same family are very rare,thus it is very important to make the correct diagnosis and treatment strategies according to the results of molecular detection for the management of familial GISTs.

关键词： Gastrointestinal stromal tumor Familial gastrointestinal stromal tumor Wild-type gastrointestinal stromal tumors PDGFRA Imatinib Treatment Case report

Reliability evaluation of IGBT power module on electric vehicle using big data

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Journal of Semiconductors 2024年第5期45卷 50-60页

作者： Li Liu Lei Tang Huaping Jiang Fanyi Wei Zonghua Li Changhong Du Qianlei peng Guocheng lu The School of Electrical Engineering Chongqing UniversityChongqing 400044China The Deepal Automobile Technology Co. Ltd.Chongqing 400023China

There are challenges to the reliability evaluation for insulated gate bipolar transistors(IGBT)on electric vehicles,such as junction temperature measurement,computational and storage *** this paper,a junction temperature estimation approach based on neural network without additional cost is proposed and the lifetime calculation for IGBT using electric vehicle big data is *** direct current(DC)voltage,operation current,switching frequency,negative thermal coefficient thermistor(NTC)temperature and IGBT lifetime are *** the junction temperature(T_(j))is *** the rain flow counting method,the classified irregular temperatures are brought into the life model for the failure *** fatigue accumulation method is then used to calculate the IGBT *** solve the limited computational and storage resources of electric vehicle controllers,the operation of IGBT lifetime calculation is running on a big data *** lifetime is then transmitted wirelessly to electric vehicles as input for neural *** the junction temperature of IGBT under long-term operating conditions can be accurately estimated.A test platform of the motor controller combined with the vehicle big data server is built for the IGBT accelerated aging ***,the IGBT lifetime predictions are derived from the junction temperature estimation by the neural network method and the thermal network *** experiment shows that the lifetime prediction based on a neural network with big data demonstrates a higher accuracy than that of the thermal network,which improves the reliability evaluation of system.

关键词： IGBT junction temperature neural network electric vehicles big data

维普期刊数据库

Data Component:An Innovative Framework for Information Value Metrics in the Digital Economy

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China Communications 2024年第5期21卷 17-35页

作者： Tao Xiaoming Wang Yu peng Jieyang Zhao Yuelin Wang Yue Wang Youzheng Hu Chengsheng lu Zhipeng Department of Electronic Engineering Tsinghua UniversityBeijing 100084China Beijing National Research Center for Information Science and Technology Beijing 100084China China Electronics Corporation Beijing 100084China

The increasing dependence on data highlights the need for a detailed understanding of its behavior,encompassing the challenges involved in processing and evaluating ***,current research lacks a comprehensive structure for measuring the worth of data elements,hindering effective navigation of the changing digital *** paper aims to fill this research gap by introducing the innovative concept of“data components.”It proposes a graphtheoretic representation model that presents a clear mathematical definition and demonstrates the superiority of data components over traditional processing ***,the paper introduces an information measurement model that provides a way to calculate the information entropy of data components and establish their increased informational *** paper also assesses the value of information,suggesting a pricing mechanism based on its *** conclusion,this paper establishes a robust framework for understanding and quantifying the value of implicit information in data,laying the groundwork for future research and practical applications.

关键词： data component data element data governance data science information theory

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Design and experimental investigation of potential low-thermalconductivity high-entropy rare-earth zirconates

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Journal of Advanced Ceramics 2024年第8期13卷 1132-1142页

作者： lu Liu Hongying Dong peng Zhang Shaokun Wang Haolei Qil Mengyu Ding Zhefeng Li Yu Bai Wen Ma School of Chemical Engineering Inner Mongolia University of TechnologyHohhot 010051China Inner Mongolia Key Laboratory of Thin Film and Coatings School of Materials Science and EngineeringInner Mongolia University of TechnologyHohhot 010051China

Developing new high-entropy rare-earth zirconate(HE-RE_(2)Zr_(2)O_(7))ceramics with low thermal conductivity is essential for thermal barrier coating *** this work,the average atomic spacings,interatomic forces,and average atomic masses of 16 rare-earth elements occupying the A site of the cubic A_(2)B_(2)O_(7) crystal structure were calculated by density functional *** three physical qualities,as vectors,characterize the corresponding rare-earth *** distance between two vectors quantitatively describes the difference between two rare-earth *** greater differences between two rare-earth elements,the disorder degree of HE-RE_(2)Zr_(2)O_(7)is greater,and therefore,the thermal conductivity is *** to the theoretical calculations,the thermal conductivity of the ceramics gradually increases in the order of(SC_(0.2)Y_(0.2)La_(0.2)Ho_(0.2)Yb_(0.2))_(2)Zr_(2)0_(7),(SC_(0.2)Ce_(0.2)Nd_(0.2)Eu_(0.2)Gd_(0.2))_(2)Zr_(2)0_(7),(SC_(0.2)Y_(0.2)Tm_(0.2)Yb_(0.2)lu_(0.2))_(2)Zr_(2)0_(7),and(Sc_(0.2)Er_(0.2)Tm_(0.2)Yb_(0.2)lu_(0.2))_(2)Zr_(2)O_(7).Using the solution precursor plasma spray method and pressureless sintering method,four types of HE-RE2Zr2Oz powder and bulk samples were *** samples all showed a single defective fluorite structure with a uniform distribution of the elements and a stable phase *** thermal conductivities of the sintered HE-RE_(2)Zr_(2)0_(7) bulk samples ranged from 1.30 to 1.45 Wm^(-1).K^(-1) at 1400℃,and their differences were consistent with the theoretical calculation *** the ceramics,(Sc_(0.2)Y_(0.2)La_(0.2)Ho_(0.2)Yb_(0.2))_(2)Zr_(2)O_(7) had the lowest thermal conductivity(1.30 W·m^(-1)·K^(-1),1400℃),highest thermal expansion coefficient(10.19×10^(-6) K^(-1),200-1400℃),highest fracture toughness(1.69±0.28 MPa·m^(1/2)),and smallest brttleness index(3.03μm^(1/2)).Therefore,(Sc_(0.2)Y_(0.2)La_(0.2)Ho_(0.2)Yb_(0.2))_(2)Zr_(2)0_(7)is considered to be an ideal candidate material for

关键词： high-entropy ceramics rare-earth zirconate(HE-RE_(2)Zr_(2)O_(7)) composition design thermal conductivity thermal barriercoatings(TBCs)

Efficacy and safety of carrimycin in ten patients with severe pneumonia following solid organ transplantation

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World Journal of Clinical Cases 2024年第15期12卷 2542-2550页

作者： Xian-Quan Cui lu-Wei Zhang peng Zhao Jing-Jing Feng Department of Organ Transplantation Qilu Hospital of Shandong UniversityJinan 250012Shandong ProvinceChina Department of Blood Purification Qilu Hospital of Shandong UniversityJinan 250012Shandong ProvinceChina

BACKGROUND The number of patients undergoing solid organ transplantation has increased ***,infections in solid organ transplant recipients can have a severe effect on patient survival owing to the continued use of *** is a novel macrolide antibiotic produced by genetically engineered streptomyces spiramyceticus harboring a 4’’-O-isovaleryltransferase gene(ist)from streptomyces *** has good antibacterial and antiviral ***,no relevant studies have been conducted on the efficacy and safety of carrimycin in patients with severe pneumonia(SP)after solid organ *** To explore the efficacy and safety of carrimycin in patients with SP after solid organ transplantation to provide a medication reference for clinical *** In March 2022,ten patients with SP following solid-organ transplantation were treated at our hospital between January 2021 and March *** the condition was critical and difficult to control with other drugs,carrimycin was *** ten patients'clinical features and treatment protocols were retrospectively analyzed,and the efficacy and safety of carrimycin for treating SP following solid organ transplantation were *** All ten patients were included in the *** etiological agent detection,there were three cases of fungal pneumonia,two cases of bacterial pneumonia,two cases of Pneumocystis pneumonia,and three cases of mixed *** treatment with carrimycin,the disease in seven patients significantly improved,the course of the disease was significantly shortened,fever was quickly controlled,chest computed tomography was significantly improved,and oxygenation was significantly ***,the patients were discharged after *** patient died of acute respiratory distress syndrome,and two patients discontinued *** Carrimycin is a safe and effective treatment modality for SP following soli

关键词： Carrimycin Organ transplantation Severe pneumonia Immunosuppressant Infection Antiviral drugs

Layer Hall effect induced by hidden Berry curvature in antiferromagnetic insulators

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National Science Review 2024年第2期11卷 15-23页

作者： Rui Chen Hai-peng sun Mingqiang Gu Chun-Bo Hua Qihang Liu Hai-Zhou lu X.C.Xie Shenzhen Institute for Quantum Science and Engineering and Department of Physics Southern University of Science and Technology(SUSTech) International Quantum Academy Institute for Theoretical Physics and Astrophysics University of Würzburg School of Electronic and Information Engineering Hubei University of Science and Technology Guangdong Provincial Key Laboratory of Computational Science and Material Design Southern University of Science and Technology Shenzhen Key Laboratory of Quantum Science and Engineering International Center for Quantum Materials School of PhysicsPeking University Collaborative Innovation Center of Quantum Matter CAS Center for Excellence in Topological Quantum Computation University of Chinese Academy of Sciences

The layer Hall effect describes electrons spontaneously deflected to opposite sides at different layers, which has been experimentally reported in the MnBi2Te4thin films under perpendicular electric fields. Here, we reveal a universal origin of the layer Hall effect in terms of the so-called hidden Berry curvature, as well as material design principles. Hence, it gives rise to zero Berry curvature in momentum space but non-zero layer-locked hidden Berry curvature in real space. We show that, compared to that of a trivial insulator, the layer Hall effect is significantly enhanced in antiferromagnetic topological insulators. Our universal picture provides a paradigm for revealing the hidden physics as a result of the interplay between the global and local symmetries, and can be generalized in various scenarios.

关键词： layerHall effect hidden Berry curvature antiferromagnetic insulator axion insulator, quantum transport

Ultra-high-temperature application of MXene: Stabilization of 2D Ti_(3)C_(2)T_(x) for cross-scale strengthening and toughening of 3D TiC

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Journal of Advanced Ceramics 2024年第1期13卷 1-10页

作者： lu Liu Guobing Ying Quanguo Jiang Dong Wen peng Wang Meng Wu Ziying Ji Yongting Zheng Xiang Wang Department of Materials Science and Engineering College of Mechanics and MaterialsHohai UniversityNanjing 211100China Key Laboratory of superlight Materials&surface Technology Ministry of EducationHarbin Engineering UniversityHarbin 150001China Shenzhen Key Laboratory for Advanced Materials School of Materials Science and EngineeringHarbin Institute of Technology(Shenzhen)Shenzhen 518055China Center for Composite Materials and Structures Harbin Institute of TechnologyHarbin 150001China

Transition metal carbide/nitride cores within MXenes make them considerably useful for ultra-high-temperature ***,extensive research on Ti_(3)C_(2)T_(x) MXene has revealed its tendency to undergo a phase transition to TiCy at temperatures above 800℃due to high activity of a superficial Ti atomic ***,spark plasma sintering of Ti_(3)C_(2)T_(x) and TiC is performed to prevent the Ti_(3)C_(2)T_(x) phase transition at temperatures up to 1900℃through the fabrication of composites at a pressure of 50 *** a focused ion beam scanning electron microscope to separate layered substances in the composites and examining selected area diffraction spots in a transmission electron microscope enabled identification of non-phase-transitioned ***-principles calculations based on density functional theory indicated the formation of strong chemical bonding interfaces between Ti_(3)C_(2)T_(x) and TiC,which imposed a stability constraint on the Ti atomic layer at the Ti_(3)C_(2)T_(x) *** performance tests,such as three-point bending and fracture toughness analysis,demonstrated that the addition of Ti_(3)C_(2)T_(x) can effectively improve the cross-scale strengthening and toughening of the TiC matrix,providing a new path for designing and developing two-dimensional(2D)carbides cross-scale-enhanced three-dimensional(3D)carbides with the same elements relying on a wide variety of MXenes.

关键词： MXene ultra-high-temperature phase stability interface bonding cross-scale strengthening and toughening structural ceramic composites