RNA ac^(4)C modification in cancer biology:from regulatory mechanisms to clinical applications

作     者：Lijun Tao Yunqing Lu Zhuojia Chen Lichen Ge Junming He Jianxin Peng Hongsheng Wang 

作者机构：School of Pharmaceutical SciencesSun Yat-sen UniversityGuangzhou 510006China Sun Yat-sen University Cancer CenterState Key Laboratory of Oncology in South ChinaCollaborative Innovation Center for Cancer MedicineGuangzhou 510060China Department of Hepatobiliary SurgeryGuangdong Province Traditional Chinese Medical HospitalGuangzhou 510120China 

出 版 物：《Science China(Life Sciences)》 (中国科学（生命科学英文版）)

年 卷 期：2024年第67卷第4期

页      面：832-835页

核心收录：

学科分类：0710[理学-生物学] 1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：supported by the National Key Research and Development Program of China(2022YFC2601800) the National Natural Science Foundation of China(32161143017,82173833,82173126,82372743,81973343) the Guangdong Basic and Applied Basic Research Foundation(2023B1515040006,2022A1515011632) Science and Technology Planning Project of Guangdong Province,China(2022A0505050065) the Open Program of Shenzhen Bay Laboratory(SZBL202009051006) the Guangdong Provincial Key Laboratory of Construction Foundation(2023B1212060022) 

主　　题：clinical (4) modification 

摘      要：RNA modifications are increasingly recognized for their significance in diverse physiological and pathological processes,with over 170 types of chemical modifications having been discovered since *** these modifications,N4-acetylcytidine(ac^(4)C)is the first acetylated modification identified on eukaryotic RNAs,previously reported in transfer RNA(t RNA)and ribosomal RNA(rRNA)。