检索结果-南通市图书馆

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

基于课程论观点的远程教育课程界定及其特点

现代远程教育研究 2011年第5期23卷 28-33页

作者：穆肃华南师范大学教育信息技术学院

根据远程教育的特点和远程教育课程的现实情况,从课程论的角度全面认识远程教育课程是一项基础工作。远程教育课程与传统教育课程相比有其独特之处。从课程论的视角来看,远程教育课程在课程要素或属性层面上应以经验为主导,在课程功能... 详细信息

根据远程教育的特点和远程教育课程的现实情况,从课程论的角度全面认识远程教育课程是一项基础工作。远程教育课程与传统教育课程相比有其独特之处。从课程论的视角来看,远程教育课程在课程要素或属性层面上应以经验为主导,在课程功能或作用层面上应以活动和进程为特点,在课程层次或结构层面上应是一种运作的课程和经验的课程的结合。远程教育课程不应过分强调课程的学术性和知识的体系结构,不应由教育行政部门统一组织课程标准和纲要,而应由远程教育机构按照实际需求来合理设置,应强调学生经验的获取,重视课程的动态性和过程性。这些特征突出地体现在远程教育课程的价值取向、课程目标、课程内容和课程实施等方面。

关键词：远程教育课程课程界定课程特点课程论

Evaluation on the state of sand filling layer and the influence on segment deformation of immersed tunnels

在线全文

学校读者我要写书评

暂无评论

Underground Space 2024年第3期16卷 224-238页

作者： Ziyao Xu Ailan Che Chao su School of Naval Architecture Ocean and Civil EngineeringShanghai Jiao Tong UniversityShanghai 200240China CCCC Second Harbor Engineering Company Ltd. Wuhan 430040China

The immersed tunnel is considered an effective solution for traffic problems across rivers and *** sand filling layer,as an important part of immersed tunnel foundation treatments,directly affects segment attitude *** to difficulties in quality control of concealed construction and the complex hydrodynamic environment,the sand filling layer is prone to compaction defects,further leading to changes in segment ***,limited by structural concealment and state complexity,most studies consider the sand filling layer part of the foundation to study its impact on settlement while neglecting its influence on segment *** research proposes an evaluation method for the sand filling layer state based on elastic wave testing and the elastic wave characteristic parameters selected come from analysis of the time domain,frequency domain and time–frequency *** classifying the elastic wave characteristic parameters through the K-means clustering method,the relationship between the state of the sand filling layer and the elastic wave characteristic parameters is *** state of the sand filling layer is divided into dense,incompact,and void.A numerical model is established based on the Guangzhou BI-UT immersed tunnel with incompact and void sand filling layer states to simulate deformation and *** results indicate that the settlement of the tunnel segment is low in the eastern region and high in the western region due to the presence of a less dense sand filling layer,with a maximum differential settlement of 0.04 *** evaluation method plays a crucial role in guiding the construction of immersed tube tunnels.

关键词： Sand filling layer state Immersed tunnel Elastic wave test Clustering algorithm

An improved bound on accelerated light dark matter

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Science China(Physics,Mechanics & Astronomy) 2024年第2期67卷 105-118页

作者： Liangliang su Lei Wu Bin Zhu Department of Physics and Institute of Theoretical Physics Nanjing Normal UniversityNanjing 210023China School of Physics Yantai UniversityYantai 264005China

Light(sub-GeV)dark matter has gained increasing interest in terms of direct *** dark matter is a promising candidate that can generate detectable nuclear recoil energy within the sub-GeV *** of the large kinetic energy,its interactions with the nucleus are predominantly governed by inelastic scattering,including quasi-elastic and deep inelastic *** this work,we calculated the inelastic effects in dark matter-Earth scattering mediated by a vector *** analysis revealed that the impact of inelastic scattering relies on the mediator mass and the kinetic energy spectrum of dark *** results exhibited considerable disparity:the upper bounds of the exclusion limit for the spin-independent cross-section between accelerated dark matter and nuclei via a heavy mediator differ by several tens of times when inelastic scattering is considered.

关键词： accelerated dark matter inelastic scattering direct detection experiment

Divergent responses of runoff to climate change in the upper basins of the Third Pole dominated by westerlies and monsoon

在线全文

学校读者我要写书评

暂无评论

Science China Earth Sciences 2024年第8期67卷 2592-2614页

作者： Qikai suN Fengge su He suN State Key Laboratory of Tibetan Plateau Earth System Environment and Resources(TPESER)Institute of Tibetan Plateau ResearchChinese Academy of SciencesBeijing 100101China University of Chinese Academy of Sciences Beijing 100101China

The diverse climates,distribution of snow and glaciers,and geographic locations directly affect the runoff response to climate change in the upper basins of the Third *** present,a comprehensive analysis of runoff variations and their distinct responses to climate change in the westerlies-and monsoon-dominated upper basins is still *** study comprehensively analyzed annual runoff variations in westerlies-dominated basins(the upper basins of the Aksu(UAKS),Syr Darya(USRD),Yarkant(UYK),Hotan(UHT),Amu Darya(UAMD),and Indus(UI))and monsoon-dominated basins(the upper basins of the Yangtze(UYA),Yellow(UYE),Lancang(ULC),Nujiang(UNJ),and Yarlung Zangbo(UYZ))of the Third Pole from 1961 *** multi-source meteorological data and large-scale circulation factors,this study investigated the divergent responses of runoff in the upper basins to climate change,and explored the large-scale circulation mechanisms underlying runoff variations in these upper *** results showed that:(1)The annual runoff in the majority of upper basins(except for the UYE and UYZ)exhibited an increasing trend,and the annual runoff in the UAKS,UYK,and UI showed a significant increasing trend from1961 to *** annual runoff in the upper basins of the Third Pole changed abruptly from decreasing to increasing between the 1980s and 2000s,with the exception of the UYE.(2)The runoff in the monsoon-dominated upper basins has been controlled primarily by changes in precipitation over the past 55 *** contrast,the runoff in the westerlies-dominated upper basins exhibited three distinct long-term responses to climate change:temperature-dominated(UYK and UHT),precipitation-dominated(USRD and UAMD),and the combined influence of precipitation and temperature(UAKS and UI).Since the 1960s,the sensitivity of runoff to warm season temperature changes in the most westerlies-dominated upper basins has decreased,while the response of runoff to precipitation changes has intensified.(3)The stud

关键词： Upper basins of the Third Pole Climate change Westerlies and monsoon Runoff variations Large-scale circulation factors

multi-Period Resilient Model for VSC-Based AC-DC HDS Considering Public-Safety Power Shutoff to Mitigate Wildfires

在线全文

学校读者我要写书评

暂无评论

CSEE Journal of Power and Energy Systems 2024年第2期10卷 821-833页

作者： Zekai Wang Tao Ding Xiaosheng Zhang Chenggang mu Pengwei Du Fangxing Li School of Electrical Engineering Xi'an Jiaotong UniversityXi'an 710049China Electric Reliability Council of Texas AustinTX76574 USA Department of Electrical Engineering and Computer Science The University of TennesseeKnoxville(UTK)TN37996USA

This paper proposes a voltage source converter (VSC) -based AC-DC hybrid distribution system (HDS) resilient model to mitigate power outages caused by wildfires. Before a wildfire happens, the public-safety power shutoff (PSPS) strategy is applied to actively cut some vulnerable lines which may easily cause wildfires, and reinforce some lines that are connected to critical loads. To mitigate load shedding caused by active line disconnection in the PSPS strategy, network reconfiguration is applied before the wildfire occurrence. During the restoration period, repair crews (RCs) repair faulted lines, and network reconfiguration is also taken into consideration in the recovery strategy to pick up critical loads. Since there exists possible errors in the wildfire prediction, several different scenarios of wildfire occurrence have been taken into consideration, leading to the proposition of a stochastic multi-period resilient model for the VSC-based AC-DC HDS. To accelerate the computational performance, a progressive hedging algorithm has been applied to solve the stochastic model which can be written as a mixed-integer linear program. The proposed model is verified on a 106-bus AC-DC HDS under wildfire conditions, and the result shows the proposed model not only can improve the system resilience but also accelerate computational speed.

关键词： AC-DC hybrid distribution system restoration network reconfiguration progressive hedging public safety power shutoffs strategy resilience

Alternative splicing and related RNA binding proteins in human health and disease

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Signal Transduction and Targeted Therapy 2024年第3期9卷 839-871页

作者： Yining Tao Qi Zhang Haoyu Wang Xiyu Yang Haoran mu Department of Orthopedics Shanghai General HospitalShanghai Jiao Tong University School of Medicine200000 ShanghaiChina Shanghai Bone Tumor Institution 200000 ShanghaiChina Department of Biochemistry and Molecular Cell Biology Shanghai Key Laboratory for Tumor Microenvironment and InflammationShanghai Jiao Tong University School of Medicine200000 ShanghaiChina

Alternative splicing(AS)serves as a pivotal mechanism in transcriptional regulation,engendering transcript diversity,and modifications in protein structure and *** varying tissues,developmental stages,or under specific conditions,AS gives rise to distinct splice *** implies that these isoforms possess unique temporal and spatial roles,thereby associating AS with standard biological activities and *** these,AS-related RNA-binding proteins(RBPs)play an instrumental role in regulating alternative splicing *** physiological conditions,the diversity of proteins mediated by AS influences the structure,function,interaction,and localization of proteins,thereby participating in the differentiation and development of an array of tissues and *** pathological conditions,alterations in AS are linked with various diseases,particularly *** changes can lead to modifications in gene splicing patterns,culminating in changes or loss of protein *** instance,in cancer,abnormalities in AS and RBPs may result in aberrant expression of cancer-associated genes,thereby promoting the onset and progression of *** and RBPs are also associated with numerous neurodegenerative diseases and autoimmune ***,the study of AS across different tissues holds significant *** review provides a detailed account of the recent advancements in the study of alternative splicing and AS-related RNA-binding proteins in tissue development and diseases,which aids in deepening the understanding of gene expression complexity and offers new insights and methodologies for precision medicine.

关键词： organs alterations thereby

Food nutrition and toxicology targeting on specific organs in the era of single-cell sequencing

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Food Science and Human Wellness 2024年第1期13卷 75-89页

作者： Xiaofei Wang Xiaowen Cheng Huiling Liu Xiaohuan mu Hao Zheng National Engineering Technology Research Center for Fruit and Vegetable Processing Key Open Laboratory of Fruit and Vegetable ProcessingMinistry of Agriculture and Rural AffairsBeijing Key Laboratory of Food Non-Thermal ProcessingCollege of Food Science and Nutritional EngineeringChina Agricultural UniversityBeijing 100083China

Due to the complex natures of dietary food components,it is difficult to elucidate how the compounds affect host *** food often selectively presents its mechanism of action on different cell types,and participates in the modulation of targeted cells and their microenvironments within ***,the limitations of traditional in vitro assays or in vivo animal experiments cannot comprehensively examine cellular heterogeneity and the tissue-biased ***-cell RNA sequencing(sc RNA-seq)has emerged as an indispensable methodology to decompose tissues into different cell types for the demonstration of transcriptional profiles of individual *** RNA-seq applications has been summarized on three typical organs(brain,liver,kidney),and two representative immune-and tumor related health *** everincreasing role of sc RNA-seq in dietary food research with further improvement can provide sub-cellular information and the coupling between other cellular *** this review,we propose utilizing sc RNAseq to more effectively capture the subtle and complex effects of food chemicals,and how they may lead to health problems at single-cell *** novel technique will be valuable to elucidate the underlying mechanism of both the health benefits of food nutrients and the detrimental consequences food toxicants at the cellular level.

关键词： Dietary food Cellular heterogeneity Single-cell RNA sequencing Food nutrients Food toxicants

Genome-wide association study identifies 12 new genetic loci associated with growth traits in pigs

在线全文

学校读者我要写书评

暂无评论

Journal of Integrative Agriculture 2024年第1期23卷 217-227页

作者： mu Zeng Binhu Wang Lei Liu Yalan Yang Zhonglin Tang Guangdong Provincial Key Laboratory of Animal Molecular Design and Precise Breeding/Key Laboratory of Animal Molecular Design and Precise Breeding of Guangdong Higher Education Institutes School of Life Science and EngineeringFoshan UniversityFoshan 528231China Kunpeng Institute of Modern Agriculture at Foshan Agricultural Genomics Institute at ShenzhenChinese Academy of Agricultural SciencesFoshan 528200China Shenzhen Branch Guangdong Laboratory of Lingnan Modern Agriculture/Key Laboratory of Livestock and Poultry Multi-omics of Ministry of Agriculture and Rural AffairsAgricultural Genomics Institute at ShenzhenChinese Academy of Agricultural SciencesShenzhen 518124China

Growth traits are among the most important economic traits in pigs and are regulated by polygenes with complex regulatory *** the major indicators of growth performance,the backfat thickness(BFT),loin eye area(LEA),and days to 100 kg(D100)traits are commonly used to the genetics improvement in ***,the available genetic markers for these traits are *** uncover novel loci and candidate genes associated with growth performance,we collected the phenotypic information of BFT,LEA,and D100 in 1,186 pigs and genotyped all these individuals using the Neogen GGP porcine 80K *** performed a genome-wide association study(GWAS)using 4 statistical models,including mixed linear models(MLM),fixed and random model circulating probability unification(FarmCPU),settlement of MLM under progressively exclusive relationships(suPER),Bayesian-information and linkage-disequilibrium Iteratively nested keyway(Blink),and identified 5,3,and 6 high-confidence single nucleotide polymorphisms(SNPs)associated with BFT,LEA,and D100,*** annotation and quantitative trait locus(QTL)mapping analysis suggested that6 genes(SKAP2,SATB1,PDE7B,PPP1R16B,WNT3,and WNT9B)were potentially associated with growth performance in *** analysis suggested that the expression of Src Kinase Associated Phosphoprotein 2(SKAP2)was higher in prenatal muscles than in postnatal muscles,and the expression of Phosphodiesterase 7B(PDE7B)continuously increased during the prenatal stages and gradually decreased after birth,implying their potential roles in prenatal skeletal muscle ***,this study provides new candidate loci and genes for the genetic improvement of pigs.

关键词： GWAS pig growth trait QTL mapping skeletal muscle

The journey towards physiology and pathology: Tracing the path of neuregulin 4

在线全文

学校读者我要写书评

暂无评论

Genes & Diseases 2024年第2期11卷 687-700页

作者： Min Chen Jieying Zhu Hongyang Luo Wangjing mu Liang Guo School of Exercise and Health and Shanghai Frontiers Science Research Base of Exercise and Metabolic Health Shanghai University of SportShanghai 200438China

Neuregulin 4 (Nrg4),an epidermal growth factor (EGF) family member,can bind to and activate the ErbB4 receptor tyrosine ***4 has five different isoforms by alternative splicing and performs a wide variety of ***4 is involved in a spectrum of physiological processes including neurobiogenesis,lipid metabolism,glucose metabolism,thermogenesis,and *** pathological processes,Nrg4 inhibits inflammatory factor levels and suppresses apoptosis in inflammatory *** addition,Nrg4 could ameliorate obesity,insulin resistance,and cardiovascular ***,Nrg4 improves non-alcoholic fatty liver disease (NAFLD) by promoting autophagy,improving lipid metabolism,and inhibiting cell death of ***,Nrg4 is closely related to the development of cancer,hyperthyroidism,and some other ***,elucidation of the functional role and mechanisms of Nrg4 will provide a clearer view of the therapeutic potential and possible risks of Nrg4.

关键词： Angiogenesis Cardiovascular diseases Inflammation Insulin resistance Lipid and glucose metabolism NAFLD Neurobiogenesis Obesity