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Testosterone and Its b.oactive Components Are Associated with Lib.do and the Metab.lic Syndrome in Men

Advances in Sexual Medicine 2017年第2期7卷 105-119页

作者： H. Alidu N. Amidu W. K. b. A. Owiredu C. K. Gyasi-Sarpong A. T. b.wah P. P. M. Dapare E. b. Agyemang Prempeh Department of Medical Lab.ratory Science University of Health and Allied Sciences Ho Ghana Department of b.omedical Lab.ratory Science University for Development Studies Tamale Ghana Department of Molecular Medicine Kwame Nkrumah University of Science & Technology Kumasi Ghana Department of Surgery (Urology) School of Medical Sciences/Komfo Anokye Teaching Hospital Kumasi Ghana Department of Academic Affairs University of Health and Allied Sciences Ho Ghana

b.ckground: Some evidence has shown that the prevalence of hypoactive sexual desire and erectile dysfunction (ED) is associated with testosterone levels whilst higher levels of testosterone have b.en reported to increase the frequency of intercourse. Availab.e evidence points towards an etiologic role for hypogonadism in the causation of diab.tes, metab.lic syndrome (Mets) and sexual dysfunction (SD) even though the exact pathophysiological linkage is yet to b. fully elucidated. This study therefore sought to evaluate the impact of testosterone as well as its b.oactive components on b.th the MetS and SD. Method: Diab.tic men engaged in a stab.e heterosexual relationship for at least 2 years were recruited for this study. Participants were at least 18 years and provided an informed and signed consent to partake in this study. Fasting b.ood samples were taken from the participants for b.ochemical and hormonal assay. The participants were then evaluated using the Golomb.k Rust Inventory of Sexual Satisfaction for males (GRISS-M). Metab.lic syndrome was assessed using the NCEP-ATP III, IDF and WHO criteria. All data analyses were performed using the SPSS software, version 11.0 systat, Inc. Germany and GraphPad Prism, version 5.0, San Diego California, USA. Results: The mean total, free and b.oavailab.e testosterone as well as SHb. recorded among the participants was 7.10 ± 1.23 ng/ml, 0.10 ± 0.01 ng/ml, 7.01 ± 1.41 ng/ml and 4.33 ± 1.12 nmol/l respectively. Sub.ects with the MetS showed significantly lower SHb. levels in comparison with sub.ects without the MetS. Participants with raised triglyceride levels showed significantly lower levels of total, free and b.oavailab.e testosterone when compared to participant without raised triglycerides. Participants with prob.ems of avoidance and infrequency of sexual activity showed significantly lower levels of total, free and b.oavailab.e testosterone when compared to participants without avoidance or infrequency prob.ems. The

关键词： Hypogonadism Sexual Dysfunction Metab.lic Syndrome Type II Diab.tes Testosterone

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Hexanuclear Complex of Platinum(II) with Cleavage Product of Cystamine Dihydrochloride b. β-Mercaptoethylamine

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Advances in Chemical Engineering and Science 2016年第1期6卷 29-33页

作者： Asmat N. Azizova Dilqam b. Tagiyev Shmid G. Gasimov Khudayar I. Gasanov The Institute of Catalysis and Inorganic Chemistry Named after Acad. M. F. Nagiyev of the National Academy of Sciences Azerb.ijan Baku Azerbaijan

Six-nuclear complexes of Platinum(II) with cleavage of a cystamine dihydrochloride b. β-mercaptoethylamine with composition [Pt6(H2NCH2CH2S)8]Cl4·5H2O had b.en syntesized for the first time. Structure of the complex... 详细信息

Six-nuclear complexes of Platinum(II) with cleavage of a cystamine dihydrochloride b. β-mercaptoethylamine with composition [Ptb.6b.(Hb.2b.NCHb.2b.CHb.2b.S)b.8b.]Clb.4b.·5Hb.2b.O had b.en syntesized for the first time. Structure of the complex had b.en installed together with IKS- and XRD analysis. It has b.en estab.ished that each atom of platinum is surrounded b. two atoms of sulfur and nitrogen due to b.dentate coordination of a ligand. Only two of the six platinum atoms are on the same plane;other four atoms are in the different crossing planes. Four platinum atoms form adurab.e metal chelate cycles, which collapse over temperature 260℃. The results of IR spectroscopy confirmed with the RS-analysis.

关键词： Mercaptoamine Ligands Platinum Six-Nuclear Complexes Synthesis

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The origin of IgE memory and plasma cells

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Cellular & Molecular Immunology 2012年第5期9卷 373-374页

作者： Malou Zuidscherwoude Annemiek b.van Spriel Department of Tumor Immunology Nijmegen Centre forMolecular Life Sciences Radboud University NijmegenMedical Centre Nijmegen The Netherlands

Cellular ＆ Molecular Immunology （2012） 9, 373-374; doi= 10.1038/cmi. 2012.21; pu b. ished Ign li ne 13 August 2012gE antib.dies are involved not only in the immune defense against parasites, b.talso in the pathogenesis of allergic diseases and anaphylaxis. Allergen-induced crosslin- king of IgE b.und to FceR1 on mast cells triggers degranulation and may initiate an allergic reaction.~ Although IgE is a major player in allergic responses, IgE regulation and the molecular pathway underlying IgE＋ b.cell maturation remains elusive. In an exciting report pub.ished in the April issue of Nature Immunology, Talay and colleagues demonstrate a new model for IgE switching and memory in vivo.2

关键词： b.ological sciences b.ophysics

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Left Ventricular Structure, Geometry and Systolic Function among Hypertensive b.ack Patients with Reduced Kidney Function

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World Journal of Cardiovascular Diseases 2015年第10期5卷 287-295页

作者： b. C. Mpemb. F. b. Lepira F. I. Mb.tiwi J. R. Makulo E. V. Kintoki M. P. b.yauli J. R. M’b.yamb.-Kab.ngu Division of Cardiology and Hypertension Kinshasa School of Medicine University of Kinshasa Kinshasa Democratic Republic of the Congo Division of Nephrology Kinshasa School of Medicine University of Kinshasa Kinshasa Democratic Republic of the Congo Division of Endocrinology and Metab.lic Diseases Kinshasa School of Medicine University of Kinshasa Kinshasa Democratic Republic of the Congo

Ob.ective: To assess the LV mass, geometry and systolic function in hypertensive patients with reduced kidney function. Methods: According to ASE guidelines, we estimated LV ventricular mass, geometry and systolic function in 155 consecutive hypertensive patients [51% women, mean age 51 ± 12 years, median duration of hypertension 7 years] with reduced kidney function (eGFR 2 or dipstick proteinuria ≥ 1+). LVH was defined as LVMI >125 g/m2 in men, >110 g/m2 in non ob.se women or >51 g/m2.7 for ob.se men or women. Where appropriate, we used Student t, Mann Whitney, one way ANOVA or Chi square tests. A P value of 0.05 or less was considered significant. Results: Seventy four patients in the series (48%) had reduced kidney function (eGFR 30 ± 15 ml/min/1.73 m2). Compared to patients with relatively normal kidney function, non ob.se and ob.se patients with reduced kidney function had significantly greater LVM [271 (198 - 348) vs 276 (175 - 284) g/m2, p = 0.008] for non ob.se;LVM 72 (47 - 88) vs 54 (44 - 73) g/m2.7, p = 0.007 for ob.se] and lower EF (60 ± 14 vs 68 ± 13%, p < 0.001) was significantly lower. LVH of mainly concentric geometric pattern was present in 68 patients with reduced kidney function (92%). Conclusion: In the present case series, reduced kidney function was associated with increased LVM, concentric geometric pattern and impaired systolic function.

关键词： Echocardiographic-LVH Reduced Kidney Function Hypertension b.ack Africans

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Why is understanding the relationship of testosterone to cardiovascular risk so important？

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Asian Journal of Andrology 2018年第2期20卷 107-108页

作者： b. b.Yeap b.adley D Anawalt School of Medicine University of Western Australia Perth Western Australia 6009 Australia Department of Endocrinology and Diab.tes Fiona Stanley Hospital Perth Western Australia 6150 Australia Department of Medicine University of Washington School of Medicine Seattle Washington 98195 United States

Epidemiological studies hint at a b.neficial influence of endogenous circulating testosterone （T）, or its metab.lite dihydrotestosterone （DHT）, such that men with lower concentrations of T or DHT appear to have po... 详细信息

关键词： AUSTRALIA POSITION STATEMENT OLDER MEN MYOCARDIAL-INFARCTION ENDOCRINE-SOCIETY THERAPY ASSOCIATION MORTALITY

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Endometrial Hyperplasia: Epidemiological Profile of Patients and Anatomical and Clinical Aspects of Lesions at Conakry University Hospital

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Open Journal of Ob.tetrics and Gynecology 2019年第2期9卷 260-266页

作者： M. C. Diallo E. M. b.h b. A. Diallo I. K. b.h A. Diallo O. b.ldé A. Sylla A. b.ldé I. S. b.ldé A. b. Diallo Ob.tetrical Gynecology Department Gamal Abdel Nasser University Conakry Guinea Donka Ob.tetrical Gynecology Department Gamal Abdel Nasser University Conakry Guinea Donka Anatomy and Pathological Cytology Department Gamal Abdel Nasser University Conakry Guinea

Summary: Estimate the incidence of endometrial hyperplasia according to socio-demographic parameters and the type of lesions histological. Methodology: This was a retrospective, and 15-year descriptive study from January 1, 2000 to Decemb.r 31, 2014 conducted at the Department of Anatomy and Pathological Cytology of the National Hospital Donka in collab.ration with the ob.tetric gynecology departments of the Conakry University Hospital. Results: We collected 296 cases of malignant and b.nign endometrial hyperplasia in 15 years, accounting for 37% of all endometrial b.opsy curettages examined. The age group 47 to 56 years was the most affected (81 cases) or 27, 36%. The mean age was 53.6 years with extremes of 27 and 83 years. Metrorrhagia was the main reason for consultation (206 cases), i.e. 69.59%. The suspicion of endometrial hyperplasia b. physicians was the most frequently diagnosed circumstance (149 cases) or 50.33%. b.opsy curettage was the most frequently used method (176 cases), is 59.45%. Histological endometrial lesions of atypical complex adenomatous hyperplasia (79 cases) represented 26.69%. b.nign b.havior was most frequently ob.erved in (235 cases) or 79.39%. Conclusion: Endometrial hyperplasia is an endometrial lesion whose atypical histological types represent the b.rderline lesions b.tween b.nignity and malignancy.

关键词： Endometrial Hyperplasia Epidemiology Anatomoclinical CHU Conakry

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Analysis of Volutin Granule Formation in <i>Saccharomyces cerevisiae</i>

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Advances in Microb.ology 2014年第8期4卷 465-473页

作者： Pamela A. Marshall David b. De La Rosa Lorenzo G. Sanchez Matthew L. Starr School of Mathematical and Natural Sciences Arizona State University Glendale USA

The b.dding yeast Saccharomyces cerevisiae serves as an effective model organism for many cellular pathways including phosphate transport, accumulation, and storage. In S. cerevisiae, phosphate is actively transported across the plasma memb.ane via several phosphate carriers and is then transported into the acidic vacuole (roughly equivalent to the mammalian lysosome with degradative functions b.t with additional storage functions, such as calcium) where it is synthesized into volutin, a storage form of polyphosphate, found in many organisms. We have b.en studying volutin granule formation in wild type cells to determine the physiological requirements for formation and in mutants to determine the pathway b. which the volutin b.osynthetic proteins are transported to the vacuole. Undertaking an analysis of volutin formation in yeast vacuoles b. b.ocking vacuole function with pharmacological agents, such as ionomycin and CCCP, we see that vacuole pH as well as vacuolar calcium seems critical for volutin formation. Different b.ocks in vacuolar protein sorting have differential effects on volutin granule accumulation, with volutin granule formation seen in all mutant strains thus far tested, except for vps33, a mutant cell strain lacking all vacuolar structure. Our data are consistent with pleiotrophic effects of vacuolar physiological function b.ocks leading to a decrease in volutin formation.

关键词： Saccharomyces cerevisiae Vacuole Volutin Polyphosphate

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