The origin of IgE memory and plasma cells

作     者：Malou Zuidscherwoude Annemiek B van Spriel 

作者机构：Department of Tumor Immunology Nijmegen Centre forMolecular Life Sciences Radboud University NijmegenMedical Centre Nijmegen The Netherlands 

出 版 物：《Cellular & Molecular Immunology》 (中国免疫学杂志（英文版）)

年 卷 期：2012年第9卷第5期

页      面：373-374页

核心收录：

学科分类：090603[农学-临床兽医学] 1001[医学-基础医学(可授医学、理学学位)] 08[工学] 09[农学] 0906[农学-兽医学] 081201[工学-计算机系统结构] 0812[工学-计算机科学与技术（可授工学、理学学位）] 

主　　题：Biological sciences Biophysics 

摘      要：Cellular ＆ Molecular Immunology （2012） 9, 373-374; doi= 10.1038/cmi. 2012.21; pu bl ished Ign li ne 13 August 2012 gE antibodies are involved not only in the immune defense against parasites, butalso in the pathogenesis of allergic diseases and anaphylaxis. Allergen-induced crosslin- king of IgE bound to FceR1 on mast cells triggers degranulation and may initiate an allergic reaction.~ Although IgE is a major player in allergic responses, IgE regulation and the molecular pathway underlying IgE＋ B-cell maturation remains elusive. In an exciting report published in the April issue of Nature Immunology, Talay and colleagues demonstrate a new model for IgE switching and memory in vivo.2