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Human iPSC-derived iMSCs improve bone regeneration in mini-pigs

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Bone Research 2019年第4期7卷 399-409页

作者： Pascal Jungbluth Lucas-Sebastian Spitzhorn Jan Grassmann stephan Tanner David Latz md Shaifur Rahman Martina Bohndorf Wasco Wruck Martin Sager Vera Grotheer Patric Kropil Mohssen Hakimi Joachim Windolf Johannes Schneppendahl James Adjaye Department of Trauma and Hand Surgery Heinrich Heine University Hospital DüsseldorfMoorenstr.540225 DüsseldorfGermany Institute for Stem Cell Research and Regenerative Medicine Medical FacultyHeinrich Heine UniversityDüsseldorfMoorenstr.540225 DüsseldorfGermany Animal Research Institute Heinrich Heine UniversityDüsseldorfMoorenstr.540225 DüsseldorfGermany Department of Diagnostic and Interventional Radiology Medical FacultyHeinrich Heine UniversityDüsseldorfMoorenstr.540225 DüsseldorfGermany Vivantes Klinikum Am Urban Dieffenbachstraβe 110967 BerlinGermany

Autologous bone marrow concentrate(BMC)and mesenchymal stem cells(MSCs)have beneficial effects on the healing of bone *** address the shortcomings associated with the use of primary MSCs,induced pluripotent stem cell(iPSC)-derived MSCs(iMSCs)have been proposed as an *** aim of this study was to investigate the bone regeneration potential of human iMSCs combined with calcium phosphate granules(CPG)in critical-size defects in the proximal tibias of mini-pigs in the early phase of bone healing compared to that of a previously reported autograft treatment and treatment with a composite made of either a combination of autologous BMC and CPG or CPG *** were derived from iPSCs originating from human fetal foreskin fibroblasts(HFFs).They were able to differentiate into osteoblasts in vitro,express a plethora of bone morphogenic proteins(BMPs)and secrete paracrine signaling-associated cytokines such as PDGF-AA and *** and histomorphometrically,HFF-iMSC+CPG transplantation resulted in significantly better osseous consolidation than the transplantation of CPG alone and produced no significantly different outcomes compared to the transplantation of autologous BMC+CPG after 6 *** results of this translational study imply that iMSCs represent a valuable future treatment option for load-bearing bone defects in humans.

关键词： healing alone treatment

Milestones in Molecular Dynamics Simulations of Single-Walled Carbon Nanotube Formation: A Brief Critical Review

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Nano Research 2009年第10期2卷 755-767页

作者： stephan Irle Yasuhito Ohta Yoshiko Okamoto Alister JPage Ying Wang Keiji Morokuma Fukui Institute for Fundamental Chemistry Kyoto UniversityKyoto 606-8103Japan Institute for Advanced Research and Department of Chemistry Nagoya UniversityNagoya 464-8602Japan Cherry L.Emerson Center for Scientic Computation and Department of Chemistry Emory UniversityAtlantaGA 30322USA Department of Chemistry Nara Women’s UniversityNara 630-8506Japan

We present a brief review of the most important efforts aimed at simulating single-walled carbon nanotube(SWNT)nucleation and growth processes using molecular dynamics(md)techniques reported in the *** simulations allow the spatio-temporal movement of atoms during nonequilibrium growth to be ***,it is hoped that a successful md simulation of the entire SWNT formation process will assist in the design of chirality-specic SWNT synthesis *** give special consideration to the role of the metal catalyst particles assumed in standard theories of SWNT formation,and describe the actual metal behavior observed in the reported md simulations,including our own recent quantum chemical md *** is concluded that the use of a quantum potential is essential for a qualitatively correct description of the catalytic behavior of the metal cluster,and that carbide formation does not seem to be a necessary requirement for nucleation and growth of SWNTs according to our most recent quantum chemical md simulations.

关键词： Carbon nanotubes transition metal catalysis molecular dynamics reactive forceelds quantum chemistry

应用全血阻抗法和传统透光聚集度评估体外循环所致血小板聚集功能改变的试验性研究

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麻醉与镇痛 2011年第3期7卷 48-56页

作者： Corinna Velik-Salchner, md stephan Maier, md Petra Innerhofer, md Christian Kolbitsch, md Werner Streif, md Markus Mittermayr, md Michael Praxmarer, MSc Dietmar Fries, md 冯雪辛(译) Departments of Anesthesiology and Intensive Care Medicine Innsbrudk Medical University Innsbruck Austria Pediatrics Innsbruck Medical University Innsbrudk Medical University Innsbruck Austria Assign Data Management and Biostatistics lnnsbruck Austria Innsbrudk Medical University Innsbruck Austria Department of General and Surgical Critical Care Medicine Innsbrudk Medical University Innsbruck Austria 不详

背景本研究分别采用全血阻抗法与传统透光聚集度（LTA）测定血小板聚集率，以探讨抗血小板治疗药物是否会降低心脏手术或体外循环（CPB）后的血小板聚集功能。方法选择70例拟行择期冠状动脉旁路移植术的患者，分别于麻醉诱导前、诱导中... 详细信息

背景本研究分别采用全血阻抗法与传统透光聚集度（LTA）测定血小板聚集率，以探讨抗血小板治疗药物是否会降低心脏手术或体外循环（CPB）后的血小板聚集功能。方法选择70例拟行择期冠状动脉旁路移植术的患者，分别于麻醉诱导前、诱导中和肝素化后15分钟及3小时采取动脉血，应用Multiplate（M）测定随时间变化的电阻值作为聚集单位，同时使用以胶原（COL）、二磷酸腺苷（ADP）或花生四烯酸（AA）为激活剂的LTA（％聚集率）法进行检测。A组（n=48）为对照组，手术前停用抗血小板药物至少7天，B组（n=11）和C组（n=11）患者分别服用阿司匹林100mg／d或阿司匹林100mg／d与氯吡格雷75mg／d（双重抗血小板治疗）至手术前一天。结果未行抗血小板治疗的患者，给予鱼精蛋白15分钟及3小时后，应用3种激活剂及两种聚集方法均可观察到血小板聚集率明显降低。单纯使用阿司匹林的患者，LTA—COL、LTA—ADP及M—ADP随时间发生显著改变；接受双重抗血小板治疗的患者，两种方法的ADP检测均提示给予鱼精蛋白15分钟后血小板聚集显著减弱。通过计算受试者工作特征曲线（receiver-operatingcharacteristiccurves，ROC曲线）下面积来区分抗血小板药物，LTA-COL可以在CPB后15分钟和3小时区分出对照组与阿司匹林组或双重抗血小板治疗组，M—ADP则可在鱼精蛋白拮抗后3小时区分对照组和双重抗血小板治疗组。结论对于未经抗血小板治疗的患者，全血电阻抗法及使用了常用激活剂的传统LTA法均可检测出CPB所致的血小板聚集功能改变。而对于接受了抗血小板治疗的患者，ADP激活的抗血小板检测方法能更好地检测出CPB所致的血小板聚集功能减退。

关键词：血小板聚集功能电阻抗法体外循环试验性研究全血应用抗血小板药物抗血小板治疗

开放式肩袖修复术后0．2％与0．3％的罗哌卡因行连续肌间沟镇痛对手术后镇痛和运动功能影响的比较

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麻醉与镇痛 2012年第3期8卷 18-22页

作者： Alain Borgeat, md Jose Aguirre, md Michael Marquardt, md Jelena Mrdjen, md stephan Blumenthal, md 马宵雯(译) 杭燕南(校) Department of Anesthesiology Orthopedic University Clinic Zurich Balgrist Switzerland 不详

背景肌间沟镇痛是一种公认的肩部大手术的术后镇痛方法，但最有效的局麻药浓度仍有争议。本研究比较术后48小时肌间沟导管连续输注0．2％和0．3％的罗哌卡因的镇痛效果及不良反应。方法80例择期开放肩袖修复术患者随机分入两组中，通过... 详细信息

背景肌间沟镇痛是一种公认的肩部大手术的术后镇痛方法，但最有效的局麻药浓度仍有争议。本研究比较术后48小时肌间沟导管连续输注0．2％和0．3％的罗哌卡因的镇痛效果及不良反应。方法80例择期开放肩袖修复术患者随机分入两组中，通过肌间沟导管以14ml／h速率连续输注0．2％或0．3％罗哌卡因，所有患者术前给予0．5％的罗哌卡因40ml作为负荷量。由对分组盲态的麻醉医师进行疼痛评分（视觉模拟评分0-100）、运动阻滞强度、术后首夜睡眠质量、吗啡用量和患者满意度等方面的评估。结果0．3％罗哌卡因组中吗啡用量明显减少（12mg和30mg）、睡眠质量更佳（术后首夜觉醒率4％和27％），握力、视觉模拟评分以及不良反应两组间相似。结论开放式肩袖手术术后48小时，通过肌间沟导管输注0．3％罗哌卡因不增加运动阻滞强度和不良反应，且吗啡用量明显减少，术后首夜睡眠质量改善。

关键词：手术后镇痛罗哌卡因修复术后肌间沟开放式运动功能肩袖视觉模拟评分

TiNiHf/SiO_(2)/Si shape memory film composites for bidirectional micro actuation

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International Journal of Smart and Nano Materials 2022年第2期13卷 293-314页

作者： Sabrina M.Curtis Marian Sielenkamper Gowtham Arivanandhan Duygu Dengiz Zixiong Li Justin Jetter Lisa Hanke Lars Bumke Eckhard Quandt stephan Wulfinghoff Manfred Kohl Institute for Materials Science Kiel University(CAU)KielGermany Materials Science and Engineering University of MarylandCollege ParkMDUnited States Institute of Microstructure Technology Karlsruhe Institute of Technology(KIT)KarlsruheGermany

The martensitic phase transformation in Ti_(40.4)Ni_(48)Hf_(11.6) shape memory alloys is leveraged for bi-directional actuation with TiNiHf/SiO_(2)/Si *** shape memory properties of magnetron sputtered Ti_(40.4)Ni_(48)Hf_(11.6) films annealed at 635℃-5 min are influenced by film thickness and the underlying *** TiNiHf film thick-ness from 21μm to 110 nm results in the reduction of all characteristic transformation temperatures until a critical thickness is ***,Ti_(40.4)Ni_(48)Hf_(11.6) thin films as low as 220 nm show transfor-mations above room temperature when deposited on SiO_(2) buffer layer,which is of great interest in *** comparison,220 nm films on Si substrates are austenitic at room temperature,and thus not suitable for *** fatigue tests on TiNiHf/SiO_(2)/Si bimorphs demonstrate better functional fatigue characteristics than freestanding films,with an average reduction of 15℃ after 125 cycles,with tempera-ture stabilization *** bi-directional actuation results are promising in the development of bistable actuators within a PMMA/TiNiHf/Si trimorph composite,whereby the additional PMMA layer undergoes a glass transition at 105℃.With the aid of constitutive modeling,a route is elaborated on how bistable actuation can be achieved at micro-to nanoscales by showing favorable thickness combinations of PMMA/TiNiHf/Si composite.

关键词： Bimorph microactuator NiTiHf bistable actuator shape memory alloy thin films

肺泡复张策略复合高水平呼气末正压通气不影响血容量充足的病态肥胖患者的血流动力学

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麻醉与镇痛 2011年第3期7卷 66-69页

作者： stephan H. Bohm, md Oliver C. Thamm, md Alexandra von Sandersleben, md Katrin Bangert, md Thomas E. Langwieler, md Gerardo Tusman, md Tim G. Strate, md, PhD Thomas G. Standl, md, PhD 邓希锦(译) Clinics of Anesthesiology Hospital Privado de Comunidad Mar del Plata Argentina General Visceral and Thoracic Surgery University Hospital Hamburg-Eppendorf Germany Hospital Privado de Comunidad Mar del Plata Argentina Department of Anesthesiology Hospital Privado de Comunidad Mar del Plata Argentina 不详

我们观察了20例血容量充足，准备行腹腔镜手术的病态肥胖（体重指数为50±9kg/m^2）患者，评估肺泡复张策略复合高水平呼气末正压通气（posidveend-expiratorypressure，PEEP）对其血流动力学的影响。肺泡复张策略是在有气腹和无气腹的... 详细信息

我们观察了20例血容量充足，准备行腹腔镜手术的病态肥胖（体重指数为50±9kg/m^2）患者，评估肺泡复张策略复合高水平呼气末正压通气（posidveend-expiratorypressure，PEEP）对其血流动力学的影响。肺泡复张策略是在有气腹和无气腹的情况下序贯进行，将PEEP水平逐渐升高，使平台压达到50—60cmH2O，呼吸10次／分，然后将PEEP水平逐渐降低。通过体循环和肺动脉导管的监测，没有发现肺泡复张及高水平PEEP对血流动力学产生显著的影响。经食管超声心动图显示左室舒张末期面积未发生变化，也无局部室壁运动异常的迹象。

关键词：呼气末正压通气血流动力学肥胖患者病态肥胖 P水平血容量肺泡复合

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麻醉与镇痛 2011年第4期7卷 46-55页

作者： Matthias Haenggi, md Heidi Ypparila-Wolters, PhD Sarah Buerki, cand. med Rebekka Schlauri, cand. med Ilkka Korhonen, PhD Jukka Takala, md, PhD stephan M. Jakob, md, PhD 马競(译) 王焱林(校) Department of Intensive Care Medicine Bern University Hospital and University of Bern Bern Switzerland VTF Technical Research Centre of Finland Tampere Finland 不详

背景包括镇静评分和常规镇静暂停在内的镇静方案，有助干减少机械通气时间和重症监护病房（ICU）入住时间。因临床上对于镇静深度的评估工作量大、仅能间断进行且干扰镇静和睡眠，所以通过脑电生理信号评估镇静深度的替代方法已经开始... 详细信息

背景包括镇静评分和常规镇静暂停在内的镇静方案，有助干减少机械通气时间和重症监护病房（ICU）入住时间。因临床上对于镇静深度的评估工作量大、仅能间断进行且干扰镇静和睡眠，所以通过脑电生理信号评估镇静深度的替代方法已经开始倍受青睐：我们想明确听觉诱发相关电位（ERPs）、脑电双频指数（BIS）和墒（Entropy）是否也能够评估临床镇静深度。方法选择10例择期全麻下行胸部或腹部手术的患者。手术后进入ICU，逐渐减少丙泊酚和瑞芬太尼靶控镇静程度[采用Rickmond Agitation镇静评分（RASS），-5分极深镇静，-4分深度镇静，-3～-1分中度镇静，0分清醒]期间，记录脑电图、BIS、状态熵（SE）、反应墒（RE）和ERPs。手术前或手术后数天测量指标的相关基础水平。结果基线、PASS-5分、RASS-4分、RASS-3至-1分和PASS-0分，对应的BIS值分别是94[4]（中位数，四分位数间距）、47[15]、68[9]、75[10]和88[6]；对应的SE值分别是87[3]、46[10]、60[22]、74[21]和87[5]；对应的RE值分别是97[4]、48[9]、71[25]、81[8]和96[3]（P〈0．05，Friedman检验）。BIS和墒都有高变异度。当单独考虑ERP振幅100时，各个镇静水平的ERPs值差异无显著性：但是、复括双参数主要变量分析的ERP辨别分析显示区别深度镇静、中度镇静和清醒状态的推算概率PK大约是0．89。与PK对应的RE，SE和BIS值分别是0．88、0．89和0．85。结论ERPs、BIS和熵均不能替代基于标准评分系统的临床镇静评估。全麻后对于极深镇静、深度到中度镇静和清醒的辨别，ERPs和脑电图仅能提供相似的PK值。BIS和熵存在较高的个体间和个体自身变异度，使其难以确定预测镇静水平的目标值范围，因而在危重患者中的使用受到限制。ERPs的变异度还不清楚。

关键词：脑电双频指数重症监护病房镇静评分危重患者相关电位听觉诱发状态熵 Friedman

新型神经肌肉阻滞评价系统改善肌肉松弛效果的随机对照临床研究

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麻醉与镇痛 2010年第2期6卷 75-82页

作者： Terence J. Gilhuly, MASc Bernard A. MacLeod, md, FRCPC Guy A. Dumont, PhD Alex M. Bouzane, MSc, md stephan K. W. Schwarz 宋宗斌(译) 郭曲练(校) Department of Anesthesiology Pharmacology & Therapeutics Hugill Anesthesia Research Centre Department of Electrical and Computer Engineering Department of Anesthesia St. Paul's Hospital The University of British Columbia Vancouver B.C. Canada 不详

背景传统的单次推注肌肉松弛药的给药方式存在着手术中可控性有限、潜在的苏醒延迟和麻醉恢复期残余阻滞等问题。为此，我们开发了一种新的自适应电脑程序，即神经肌肉阻滞评价系^（NMBAS）。该程序以六阶拉盖尔模型及患者的肌电反应记... 详细信息

背景传统的单次推注肌肉松弛药的给药方式存在着手术中可控性有限、潜在的苏醒延迟和麻醉恢复期残余阻滞等问题。为此，我们开发了一种新的自适应电脑程序，即神经肌肉阻滞评价系^（NMBAS）。该程序以六阶拉盖尔模型及患者的肌电反应记录为基础，向麻醉医师提供肌肉松弛药的时效及剂量的建议。本研究中，我们对使用NMBAS后的神经肌肉阻滞是否优于常规治疗方法进行了探讨。方法这是一项随机、双盲、平行对照的前瞻性临床研究。73例接受腹部手术的患者（ASAI～Ⅲ级），使用罗库溴铵为肌肉松弛剂，全身麻醉时间≥1．5小时。患者分别按常规方式或NMBAS指导下给予罗库溴铵。主要结果变量为反映肌肉松弛不完善的围手术期事件发生率。次级变量包括手术后拮抗前4个成串刺激（TOF）比值，罗库溴铵总量，拮抗剂、麻醉药物及其他药物的用量，手术后不良事件的发生率以及麻醉医师不依从NMBAS建议的发生率。结果73例患者中，每组有30例符合统计分析的要求。两组问患者一般资料具有可比性。与常规组相比，NMBAS组患者围手术期肌肉松弛不完善相关事件的发生率明显降低（19／30VS8／30；P=0．004），NMBAS组平均TOF比值明显增高（0.59[95％CI：0．48～0．69]vs0．14[95％CI：0．04～0．24]；P〈0．0001）。罗库澳铵总量、拮抗剂、其他药物应用及手术后不良事件的发生率无差异。结论与常规方法相比，NMBAS指导的肌肉松弛方案可改善肌肉松弛质量，提高手术后TOF比值，减少肌肉松弛残余的危险性，提高患者围手术期的安全。

关键词：随机对照临床研究神经肌肉阻滞肌肉松弛药评价系统前瞻性临床研究罗库溴铵围手术期麻醉药物

Panda X-III： Searching for neutrinoless double beta decay with high pressure ^(136)Xe gas time projection chambers

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Science China(Physics,Mechanics & Astronomy) 2017年第6期60卷 8-47页

作者： Xun Chen Chang Bo Fu Javier Galan Karl Giboni Franco Giuliani Ling Hui Gu Ke Han Xiang Dong Ji Heng Lin Jiang Lai Liu Kai Xiang Ni Hiroki Kusano Xiang Xiang Ren Shao Bo Wang Yong Yang Dan Zhang Tao Zhang Li Zhao Xiang Ming Sun Shou Yang Hu Si Yu Jian Xing Long Li Xiao Mei Li Hao Liang Huan Qiao Zhang Ming Rui Zhao Jing Zhou Ya Jun Mao Hao Qiao Si Guang Wang Ying Yuan Meng Wang Amir N.Khan Neill Raper Jian Tang Wei Wang Jia Ning Dong Chang Qing Feng Cheng Li Jian Bei Liu Shu Bin Liu Xiao Lian Wang Dan Yang Zhu Juan F.Castel Susana Cebri'an Theopisti Dafni Javier G.Garza Igor G.Irastorza Francisco J.Iguaz Gloria Luz ′on Hector Mirallas stephan Aune Eric Berthoumieux Yann Bedfer Denis Calvet Nicole d'Hose Alain Delbart Maria Diakaki Esther Ferrer-Ribas Andrea Ferrero Fabienne Kunne Damien Neyret Thomas Papaevangelou Franck Sabatie Maxence Vanderbroucke AnDi Tan Wick Haxton Yuan Mei Chinorat Kobdaj Yu-Peng Yan NPAC and Department of Physics and Astronomy Shanghai Jiao Tong University Shanghai Laboratory for Particle Physics and Cosmology Shanghai 200240 China College of Physical Science and Technology Central China Normal University Wuhan 430079 China China Institute of Atomic Energy Beijing 102413 China School of Physics Peking University Beijing 100871 China School of Physics and Key Laboratory of Particle Physics and Particle Irradiation (MOE) Shandong University Jinan 250100 China School of Physics and Engineering Sun Yat-Sen University Guangzhou 510275 China Department of Modern Physics University of Science and Technology of China Hefei 230026 China State Key Laboratory of Particle Detection and Electronics University of Science and Technology of China Hefei 230026 China University ofZaragoza C/P Cerbuna 12 50009 Zaragoza Spain IRFU CEA Universite Paris-Saclay F-91191 Gif-sur-Yvette France Department of Physics University of Maryland College Park MD 20742 USA Nuclear Science Division Lawrence Berkeley National Laboratory Berkeley CA 94720 USA Center for Excellence in High Energy Physics and Astrophysics Suranaree University of Technology Nakhon Ratchasima 30000 Thailand

Searching for the neutrinoless double beta decay(NLDBD)is now regarded as the topmost promising technique to explore the nature of neutrinos after the discovery of neutrino masses in oscillation *** X-III(particle and astrophysical xenon experiment III)will search for the NLDBD of136Xe at the China Jin Ping Underground Laboratory(CJPL).In the first phase of the experiment,a high pressure gas Time Projection Chamber(TPC)will contain 200 kg,90%136Xe enriched gas operated at10 *** pitch micro-pattern gas detector(Microbulk Micromegas)will be used at both ends of the TPC for the charge readout with a cathode in the *** signals can be used to reconstruct the electron tracks of the NLDBD events and provide good energy and spatial *** detector will be immersed in a large water tank to ensure～5 m of water shielding in all *** second phase,a ton-scale experiment,will consist of five TPCs in the same water tank,with improved energy resolution and better control over backgrounds.

关键词： neutrinoless double beta decay lepton number violation underground experiment TPC Micromegas