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ADAM10 facilitates rapid neural stem cell cycling and proper positioning within the subventricular zone niche via JAMC/RAP1Gap signaling

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Neural Regeneration Research 2022年第11期17卷 2472-2483页

作者： Nadia McMillan Gregory W.Kirschen Sanket Desai emma Xia stella e.tsirka Adan Aguirre Program in Neuroscience and Medical Scientist Training Program Renaissance School of Medicine at Stony Brook UniversityStony BrookNYUSA Department of Pharmacological Sciences Renaissance School of Medicine at Stony Brook UniversityStony BrookNYUSA Department of Neurology Beth Israel Deaconess Medical Center/Harvard Medical SchoolBostonMAUSA Department of Gynecology and Obstetrics Johns Hopkins HospitalBaltimoreMDUSA

The mechanisms that regulate neural stem cell(NSC)lineage progression and maintain NSCs within diffe rent domains of the adult neural stem cell niche,the subventricular zone are not well *** NSCs are arranged at the apical ventricular wall,while mitotically activated NSCs are found in the basal,vascular region of the subventricular ***,we found that ADAM 10(a disintegrin and metalloproteinase 10)is essential in NSC association with the ventricular wall,and via this adhesion to the apical domain,ADAM10 regulates the switch from quiescent and undiffe rentiated NSC to an actively prolife rative and differentiating cell *** of JAMC(junctional adhesion molecule C)by ADAM 10 increases Rap1 GAP *** molecular machinery promotes NSC transit from the apical to the basal compartment and subsequent lineage *** the molecular mechanisms responsible for regulating the proper positioning of NSCs within the subventricular zone niche and lineage progression of NSCs could provide new targets for drug development to enhance the regenerative prope rties of neural tissue.

关键词： ADAM10 adhesion junctional adhesion molecule C neural stem cells neurogenesis olfactory bulb Rap1Gap sub-ventricular zone

Microglial contributions to aberrant neurogenesis and pathophysiology of epilepsy

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Neuroimmunology and Neuroinflammation 2020年第3期7卷 234-247页

作者： Tanya R.Victor stella e.tsirka Department of Pharmacological Sciences Stony Brook UniversityStony BrookNY 11794USA

Microglia are dynamic cells that constitute the brain's innate immune ***,research has demonstrated microglial roles beyond immunity,which include homeostatic roles in the central nervous *** function of microglia is an active area of study,with insights into changes in neurogenesis and synaptic pruning being discovered in both health and *** epilepsy,activated microglia contribute to several changes that occur during *** this review,we focus on the effects of microglia on neurogenesis and synaptic pruning,and discuss the current state of anti-seizure drugs and how they affect microglia during these *** understanding of the role of microglia post-seizure is still limited and may be pivotal in recognizing new therapeutic targets for seizure intervention.

关键词： Microglia epilepsy neurogenesis neuroinflammation seizures

effects of nanopillars and surface coating on dynamic traction force

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Microsystems & Nanoengineering 2023年第1期9卷 177-190页

作者： Yijun Cheng stella W.Pang Department of electrical engineering City University of Hong KongKowloonHong KongChina Centre for Biosystems Neuroscienceand NanotechnologyCity University of Hong KongKowloonHong KongChina

The extracellular matrix serves as structural support for cells and provides biophysical and biochemical cues for cell ***,material,and surface energy can regulate cell migration ***,the responses of MC3T3-e1 cells,including migration speed,morphology,and spreading on various platform surfaces,were ***(PDMS)micropost sensing platforms with nanopillars,silicon oxide,and titanium oxide on top of the microposts were fabricated,and the dynamic cell traction force during migration was *** relationships between various platform surfaces,migration behaviors,and cell traction forces were *** with the flat PDMS surface,cells on silicon oxide and titanium oxide surfaces showed reduced mobility and less *** the other hand,cells on the nanopillar surface showed more elongation and a higher migration speed than cells on silicon oxide and titanium oxide ***3T3-e1 cells on microposts with nanopillars exerted a larger traction force than those on flat PDMS microposts and had more filopodia and long *** the relationships between platform surface condition,migration behavior,and cell traction force can potentially lead to better control of cell migration in biomaterials capable of promoting tissue repair and regeneration.

关键词： coating traction surface

Insights into the effect of a Natural Arsenate Dose on Growth,Nodulation and Redox Metabolism of Soybean Plants

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Pedosphere 2019年第4期29卷 527-533页

作者： eliana BIANUCCI Ana FURLAN Luis e.HeRNáNDeZ stella CASTRO Instituto de Investigaciones Agrobiotecnológicas INIAB CONICET-UNRC Facultad de Ciencias ExactasFísico-Químicas y Naturales Universidad Nacional de Río Cuarto Laboratorio de Fisiología Vegetal Departamento de BiologíaUniversidad Autónoma de Madrid

Dear editor, Arsenic (As) is a harmful metalloid that occurs in soil and water;its concentration varies considerably among geographic regions, with groundwater being the principal source of human contamination (Smedley and Kinniburgh, 2002). Besides the direct contamination effect of drinking water that contains high As concentration, human poisoning may also occur after ingestion of contaminated food.

关键词： Natural Arsenate Soybean Plants Redox Metabolism

Syringoceles of Cowper’s ducts and glands in adult men

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Asian Journal of Andrology 2020年第2期22卷 129-133页

作者： Simon Bugeja Anastasia Frost stella Ivaz Mariya Dragova Daniela e Andrich Anthony R Mundy Reconstructive Urology Unit University College London Hospitals NHS Foundation TrustLondon NW12PGUK

Cowper’s syringoceles are uncommon,usually described in children and most commonly limited to the *** describe more complex variants in an adult population affecting with varying degrees of severity,the glands themselves,and the complications they may lead *** hundred consecutive urethrograms of patients with unreconstructed strictures were ***-six patients(mean age:41.1 years)with Cowper’s syringoceles who were managed between 2009 and 2016 were subsequently ***,radiological appearance,treatment(when indicated),and outcomes were *** 100 urethrograms in patients with strictures,33.0%demonstrated filling of Cowper’s ducts or glands,occurring predominantly in patients with bulbar *** 1 of 26 patients with non-bulbar strictures had a visible duct/*** 26 symptomatic patients,15 presented with poor *** four patients,a grossly dilated Cowper’s duct obstructed the *** the remaining 11 patients,a bulbar stricture caused the symptoms and the syringocele was identified *** patients presented with perineal *** six of them,fluoroscopy and magnetic resonance imaging(MRI)revealed complex multicystic lesions within the bulbourethral *** patients developed perineoscrotal *** the 11 patients with strictures,the syringocele was no longer visible after *** three of four patients with urethral obstruction secondary to a dilated Cowper’s duct,this resolved after transperineal excision(n=2)and endoscopic deroofing(n=1).Five of six patients with complex syringoceles involving Cowper’s glands were excised surgically with symptomatic relief in *** conclusion,Cowper’s syringocele in adults is more common than previously thought and may cause lower urinary tract symptoms or be associated with serious complications which usually require surgical treatment.

关键词： complications Cowper’s glands syringocele treatment urethral stricture

Funneling of the bladder neck - radiological appearance after radical retropubic prostatectomy and clinical relevance

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Asian Journal of Andrology 2020年第2期22卷 152-153页

作者： Simon Bugeja Anastasia Frost stella Ivaz Felix Campos Daniela e Andrich Anthony R Mundy University College London Hospitals NHS Foundation TrustReconstructive Urology UnitLondon NW12PGUK

Several authors have commented on the anatomical changes following radical prostatectomy(RP)for prostate cancer and their characteristic radiological appearances.1,2 Most of these relate to periurethral fibrosis and its clinical significance in patients with postprostatectomy sphincter weakness incontinence.3,4 On magnetic resonance imaging(MRI),this postsurgical fibrosis appears as a focus of low-signal intensity in the periurethral tissues at and around the level of the vesicourethral anastomosis(VUA)which is appreciable on both T1-and T2-weighted images.

关键词： bladder clinical radiological

Spectroscopic investigations on the effect of humic acid on the formation and solubility of secondary solid phases of Ln_2(CO_3)_3

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Journal of Rare earths 2011年第6期29卷 516-521页

作者： stella Antoniou Ioannis Pashalidis Andre Gessner Michael U Kumke Department of Chemistry University of Cyprus P.O. Box 20537 1678 Nicosia Cyprus Chemistry Department/Physical Chemistry University of Potsdam Karl- Liebknecht-Str. 24-25 14476 Potsdam-Golm Germany

The formation of secondary Ln（III） solid phases （e.g., Nd2（CO3）3 and Sm2（CO3）3） was studied as a function of the humic acid concentration in 0.1 mol/L NaClO4 aqueous solution in the neutral pH range （5–6.5）. The solid phases under investigation were prepared by alkaline precipitation under 100% CO2 atmosphere and characterized by attenuated total reflectance Fourier transform infrared spectroscopy （ATR-FTIR）, X-ray diffraction （XRD）, time-resolved laser fluorescence spectroscopy （TRLFS）, diffuse reflectance ultraviolet-visible （DR-UV-Vis）, Raman spectroscopy, and solubility measurements. The spectroscopic data obtained indicated that Nd2（CO3）3 and Sm2（CO3）3 were stable and remained the solubility limiting solid phases even in the presence of increased humic acid concentration （0.5 g/L） in solution. Upon base addition in the Ln（III）-HA system, decomplexation of the previously formed Ln（III）-humate complexes and precipitation of two distinct phases occurred, the inorganic （Ln2（CO3）3） and the organic phase （HA）, which was adsorbed on the particle surface of the former. Nevertheless, humic acid affected the particle size of the solid phases. Increasing humic acid concentration resulted in decreasing crystallite size of the Nd2（CO3）3 and increasing crystallite size of the Sm2（CO3）3 solid phase, and affected inversely the solubility of the solid phases. However, this impact on the solid phase properties was expected to be of minor relevance regarding the chemical behavior and migration of trivalent lanthanides and actinides in the geosphere.

关键词： lanthanide ions humic acid solid phase solubility Raman TRLFS DR-UV-Vis rare earths

Single-stage tubular urethral reconstruction using oral grafts is an alternative to classical staged approach for selected penile urethral strictures

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Asian Journal of Andrology 2020年第2期22卷 134-139页

作者： Felix Campos-Juanatey Simon Bugeja Mariya Dragova Anastasia V Frost stella L Ivaz Daniela e Andrich Anthony R Mundy Reconstructive Urology Unit Institute of UrologyUniversity College London HospitalsLondon W1G 8PHUK Department of Urology Marques de Valdecilla University HospitalInstitute of Investigation Valdecilla(IDIVAL)Santander 39008Spain Urology Unit Mater Dei HospitalMsida MSD 2090Malta

Penile urethral strictures have been managed by a staged surgical *** selected cases,spongiofibrosis can be excised,a neo-urethral plate created using buccal mucosa graft(BMG)and tubularized during the same procedure,performing a“twoin-one”stage *** aim to identify stricture factors which indicate suitability for this two-in-one stage *** assess surgical outcome and compare with staged *** conducted an observational descriptive *** data were prospectively collected from two-in-one stage and staged penile urethroplasties using BMG in a single center between 2007 and *** minimum follow-up was 6 *** were assessed clinically,radiologically,and by flow-rate *** was defined as recurrent stricture or any subsequent surgical or endoscopic *** analysis of stricture characteristics and statistical comparison was made between *** 425 penile urethroplasties,139 met the inclusion criteria:59 two-in-one stage and 80 *** mean stricture length was 2.8 cm(single stage)and 4.5 cm(staged).etiology was lichen sclerosus(LS)52.5%(single stage)and 73.8%hypospadias related(staged).40.7%of patients had previous failed urethroplasties in the single-stage group and 81.2%in the *** most common stricture locations were navicular fossa(39.0%)and distal penile urethra(59.3%)in the single-stage group and mid or proximal penile urethra(58.7%)in the staged *** rates were 89.8%(single stage)and 81.3%(staged).A trend toward a single-stage approach for select penile urethral strictures was *** conclude that a single-stage substitution penile urethroplasty using BMG as a“two-in-one”approach is associated with excellent functional *** most suitable strictures for this approach are distal,primary,and LS-related strictures.

关键词： anterior urethral stricture hypospadias lichen sclerosus oral mucosa reconstructive surgical procedures tissue transplants

Association of rs1568885, rs1813443 and rs4411591 polymorphisms with anti-TNF medication response in Greek patients with Crohn's disease

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World Journal of Gastroenterology 2014年第13期20卷 3609-3614页

作者： Diamantis Thomas Maria Gazouli Theodoros Karantanos stella Rigoglou Georgios Karamanolis Konstantinos Bramis George Zografos George e Theodoropoulos Colorectal Unit 1st Department of Propaedeutic Surgery"Hippokrateio" HospitalSchool of MedicineUniversity of Athens11527 AthensGreece Department of Basic Medical Science Laboratory of BiologySchool of MedicineUniversity of Athens11527 AthensGreece Gastroenterology Unit 2nd Department of Surgery"Aretaieio" HospitalUniversity of AthensAthens 11527Greece

AIM: To investigate the correlation between rs1568885, rs1813443 and rs4411591 polymorphisms and response to infliximab in a cohort of Greek patients with Crohn’s disease (CD).

关键词： Crohn’ s disease, Treatment response, Infliximab, Polymorphisms