Effects of nanopillars and surface coating on dynamic traction force
作者机构：Department of Electrical EngineeringCity University of Hong KongKowloonHong KongChina Centre for BiosystemsNeuroscienceand NanotechnologyCity University of Hong KongKowloonHong KongChina
出 版 物：《Microsystems & Nanoengineering》 (微系统与纳米工程（英文）)
年 卷 期：2023年第9卷第1期
页 面：177-190页
核心收录：
学科分类：0808[工学-电气工程] 0809[工学-电子科学与技术（可授工学、理学学位）] 07[理学] 0817[工学-化学工程与技术] 070205[理学-凝聚态物理] 08[工学] 0807[工学-动力工程及工程热物理] 080501[工学-材料物理与化学] 0805[工学-材料科学与工程（可授工学、理学学位）] 0802[工学-机械工程] 0811[工学-控制科学与工程] 0702[理学-物理学]
基 金：supported by the Center for Biosystems,Neuroscience,and Nanotechnology (CBNN) of the City University of Hong Kong (9360148,9380062) the University Grants Council of Hong Kong (GRF Projects:11212519,11207620,and 11207821)
摘 要：The extracellular matrix serves as structural support for cells and provides biophysical and biochemical cues for cell ***,material,and surface energy can regulate cell migration ***,the responses of MC3T3-E1 cells,including migration speed,morphology,and spreading on various platform surfaces,were ***(PDMS)micropost sensing platforms with nanopillars,silicon oxide,and titanium oxide on top of the microposts were fabricated,and the dynamic cell traction force during migration was *** relationships between various platform surfaces,migration behaviors,and cell traction forces were *** with the flat PDMS surface,cells on silicon oxide and titanium oxide surfaces showed reduced mobility and less *** the other hand,cells on the nanopillar surface showed more elongation and a higher migration speed than cells on silicon oxide and titanium oxide ***3T3-E1 cells on microposts with nanopillars exerted a larger traction force than those on flat PDMS microposts and had more filopodia and long *** the relationships between platform surface condition,migration behavior,and cell traction force can potentially lead to better control of cell migration in biomaterials capable of promoting tissue repair and regeneration.
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