检索结果-南通市图书馆

Acupuncture in diabetic peripheral neuropathy-neurological outcomes of the randomized acupuncture in diabetic peripheral neuropathy trial

引用

World Journal of Diabetes 2023年第12期14卷 1813-1823页

作者： Sebastian Hoerder Isabel Valentina Habermann Katrin Hahn Gesa Meyer-Hamme Miriam Ortiz Weronika Grabowska Stephanie Roll stefan n.willich Sven Schroeder Benno Brinkhaus Joanna Dietzel Institute of Social Medicine Epidemiology and Health EconomicsCharitéUniversitätsmedizinBerlin 10117Germany Department of neurology CharitéUniversitätsmedizinCharitéplatz 1Berlin 10117Germany HanseMerkur Center of Traditional Chinese Medicine at University Hospital Eppendorff Martinistr 52Hamburg 20246Germany

BACKGROUnD Diabetic peripheral neuropathy(DPn)is a common complication of diabetes mellitus and can lead to serious *** strategies for pain control are available but there are few approaches that influence neurological deficits such as *** To investigate the effectiveness of acupuncture on improving neurological deficits in patients suffering from type 2 *** The acupuncture in DPn(ACUDPn)study was a two-armed,randomized,controlled,parallel group,open,multicenter clinical *** were randomized in a 1:1 ratio into two groups:The acupuncture group received 12 acupuncture treatments over 8 wk,and the control group was on a waiting list during the first 16 wk,before it received the same treatment as the other *** groups received routine *** parameters were evaluated after 8,16 and 24 wk and included neurological scores,such as an 11-point numeric rating scale(nRS)11 for hypesthesia,neuropathic pain symptom inventory(nPSI),neuropathy deficit score(nDS),neuropathy symptom score(nSS);nerve conduction studies(nCS)were assessed with a handheld point-of-care ***-two participants were *** nRS for numbness showed a difference of 2.3(Pn favor of theacupuncture group,the effect persisted until week 16 with a difference of 2.2(Pn groups and 1.8points at week 24 compared to *** nPSI was improved in the acupuncture group by 12.6 points(PnSS score at week 8 with a difference of 1.3(PnDS and the TnSc score improvedfor the acupuncture group in week 8,with a difference of 2.0 points(Pntrol *** were persistent in week 16 with a difference of 1.8 points(PnCS showed no *** both groups only minor side effects were *** Study results suggest that acupuncture may be beneficial in type 2 diabetic DPn and seems to lead to a reductionin neurological *** serious a

关键词： Diabetic peripheral neuropathy numbness nerve conduction study Acupuncture

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Gastro esophageal reflux disease is associated with absence from work: Results from a prospective cohort study

引用

World Journal of Gastroenterology 2005年第45期11卷 7148-7151页

作者： Andreas Leodolter Marc nocon Michael Kulig stefan n.willich Peter Malfertheiner Joachim Labenz Department of Gastroenterology Institute of Social Medicine Ev.Jung-Stilling-Krankenhaus

AIM： To study the association of gastro-esophageal reflux disease （GERD） with the absence from work and to estimate the extent of loss in gross domestic product due to inability to work. METHODS： Analysis was based on the prospectively gathered data of a large European cohort study involving 6 215 symptomatic GERD patients （ProGERD）. Among these patients, 2 871 were initially employed. The calculation of the loss of gross domestic product was based on the assumption that the prevalence of GERD was about 15% in Germany. According to the German Federal Statistical Office, the mean gross wage of employees was 150 E/d in 2002. RESULTS： The data of 2 078 employed patients who were prospectively followed up for over 2 years were analyzed. At study entry, the patients reported a mean of 1.8 d per year of inability to work. During the prospective follow-up under routine clinical care, the proportion of patients reporting days with inability to work decreased from 14% to 6% and the mean number of days per year with inability to work decreased to 0.9 d. Assuming a prevalence of troublesome GERD of 15% in the employed German population, the loss of gross domestic product amounted to 668 million E/year in Germany. COnCLUSIOn： GERD causes a relevant impairment on the national economics by absence from work. The presented data demonstrate the importance of GERD, not only for patients and health insurance companies, but also for the community at large.

关键词： Gastro-esophageal reflux Sick leave Medicale conomics

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Machine Learning for heat radiation modeling of bi-and polydisperse particle systems including walls

引用

Particuology 2023年第3期74卷 119-140页

作者： Josef Tausendschön Gero Stöckl stefan Radl Institute of Process and Particle Engineering Graz University of TechnologyInffeldgasse 13/III8010GrazAustria

We investigated the ability of four popular Machine Learning methods i.e.,Deep neural networks(Dnns),Random Forest-based regressors(RFRs),Extreme Gradient Boosting-based regressors(XGBs),and stacked ensembles of Dnns,to model the radiative heat transfer based on view factors in bi-and polydisperse particle beds including *** training and analyzing the predictive capability of each method,an adjustment of markers used in monodisperse systems,as well as an evaluation of new markers was *** the basis of our dataset that considers a wide range of particle radii ratios,system sizes,particle volume fractions,as well as different particle-species volume fractions,we found that(i)the addition of particle size information allows the transition from monodisperse to bi-and polydisperse beds,and(ii)the addition of particle volume fraction information as the fourth marker leads to very accurate *** terms of the overall performance,Dnns and RFRs should be preferred compared to the other two *** particle-particle view factors,Dnn and RFR are on par,while for particle-wall the RFR is *** demonstrate that Dnns and RFRs can be built to meet or even exceed the prediction quality standards achieved in a monodisperse system.

关键词： Discrete element method(DEM) Heat radiation modeling Machine learning View factors Wall radiation Polydisperse particles

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Compartmentalized immune responses and the local microbiota determine mucosal and systemic immunity against SARS-CoV-2

引用

Cellular & Molecular Immunology 2022年第2期19卷 130-132页

作者： Jonas Buttenschön stefan Vogt Jochen Mattner Mikrobiologisches Institut-Klinische Mikrobiologie Immunologie und HygieneUniversitätsklinikum Erlangen and Friedrich-Alexander-Universität(FAU)Erlangen-NürnbergErlangenGermany Medical Immunology Campus Erlangen FAU Erlangen-NürnbergErlangenGermany.

The clinical manifestations of SARS-CoV-2 infection,which is the cause of the coronavirus disease 2019(COVID-19)pandemic,are highly variable and range from asymptomatic carriage or mild symptoms to severe disease involving different organ ***,the specific factors influencing individual clinical outcomes remain ***,to characterize the versatile interplay of mucosal and systemic immune responses with the local microbiome and the viral load,as well as its impact on the course of the disease,Smith et *** integrated analyses of nasopharyngeal swabs and plasma samples from COVID-19 patients with varying degrees of illness *** observed that spike-specific neutralizing antibodies were heterogeneous between paired plasma samples and nasopharyngeal swabs from individual SARS-CoV-2 patients,suggesting a tissuedependent regulation of humoral immune responses.

关键词： immunity mucosal clinical

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Blood pressure-related white matter microstructural disintegrity and associated cognitive function impairment in asymptomatic adults

引用

Stroke & Vascular neurology 2023年第5期8卷 358-367页

作者： Julián n Acosta stefan P Haider Cyprien Rivier Audrey C Leasure Kevin n Sheth Guido J Falcone Seyedmehdi Payabvash Department of neurology Yale School of MedicineNew HavenConnecticutUSA Department of Radiology and Biomedical Imaging Yale School of MedicineNew HavenConnecticutUSA Department of Otorhinolaryngology Ludwig Maximilians University MunichMunchenGermany

Background and objectives We aimed to investigate the white matter(WM)microstructural/cytostructural disintegrity patterns related to higher systolic blood pressure(SBP),and whether they mediate SBP effects on cognitive performance in middle-aged *** Using the UK Biobank study of community-dwelling volunteers aged 40-69 years,we included participants without a history of stroke,dementia,demyelinating disease or traumatic brain *** investigated the association of SBP with MRI diffusion metrics:fractional anisotropy(FA),mean diffusivity(MD),intracellular volume fraction(a measure of neurite density),isotropic(free)water volume fraction(ISOVF)and orientation dispersion across WM ***,we determined whether WM diffusion metrics mediated the effects of SBP on cognitive *** We analysed 31363 participants-mean age of 63.8 years(SD:7.7),and 16523(53%)*** SBP was associated with lower FA and neurite density,but higher MD and *** different WM tracts,diffusion metrics of the internal capsule anterior limb,external capsule,superior and posterior corona radiata were most affected by higher *** seven cognitive metrics,SBP levels were only associated with‘fluid intelligence’(adjusted pn mediation analysis,the averaged FA of external capsule,internal capsule anterior limb and superior cerebellar peduncle mediated 13%,9%and 13%of SBP effects on fluid intelligence,while the averaged MD of external capsule,internal capsule anterior and posterior limbs,and superior corona radiata mediated 5%,7%,7%and 6%of SBP effects on fluid intelligence,*** Among asymptomatic adults,higher SBP is associated with pervasive WM microstructure disintegrity,partially due to reduced neuronal count,which appears to mediate SBP adverse effects on fluid *** metrics of select WM tracts,which are most reflective of SBP-related parenchymal damage and cognitive impairment,may serve as imaging biomarkers to

关键词： capsule Blood impairment

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

nanocrystalline rare earth fluorides doped with Pr^(3+) ions

引用

Journal of Rare Earths 2016年第8期34卷 802-807页

作者： Marcin Runowski stefan Lis Department of Rare Earths Faculty of Chemistry Adam Mickiewicz University

Praseodymium（III） doped CeF3, CeF3：Gd, LaF3, GdF3 and YF3 inorganic fluorides were precipitated in an aqueous, sur- factant-free solution, using nH4F as a source of fluoride ions. The as-prepared products were subjected to a hydrothermal treatment, which led to the formation of crystalline nanoluminophores, composed of spherical （30 nm） and elongated （40-200 nm） nanos- tructures. Due to the presence of Pr3＋ ions, the synthesized nanomaterials showed yellow luminescence under a blue light irradiation. The nanoluminophore based on the YF3 host revealed the most promising spectroscopic properties, i.e., bright and intensive emission, hence it was investigated in detail. The photophysical properties of the nanomaterials obtained were studied by powder X-ray diffrac- tion （XRD）, transmission electron microscopy （TEM） and spectrofluorometry, i.e., measurements of excitation/emission spectra and luminescence decay curves.

关键词： yellow luminescence lanthanide fluorides Pr3+ doping nanocrystals hydrothermal post-treatment Ce3+ quenching rare earths

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Cancer Cell：癌细胞如何在没有葡萄糖的条件下继续增殖扩张？

引用

现代生物医学进展 2017年第2期17卷 I0001-I0002页

作者： stefan Burén Structural Biology and Biocomputing Programme Spectroscopy and Nuclear Magnetic Resonance Unit Centro Nacional de Investigaciones Oncológicas CNIO Madrid 28029 Spain

肿瘤细胞最主要的目标就是生存，其甚至不惜破坏其所依附的有机体的健康也要达到生存的目的；为了生存肿瘤细胞会练就许多健康细胞没有的本领，包括在葡萄糖水平极低的情况下继续保持生长势头，而这或许就是常用的抗血管生成因子难以消... 详细信息

肿瘤细胞最主要的目标就是生存，其甚至不惜破坏其所依附的有机体的健康也要达到生存的目的；为了生存肿瘤细胞会练就许多健康细胞没有的本领，包括在葡萄糖水平极低的情况下继续保持生长势头，而这或许就是常用的抗血管生成因子难以消除癌症的主要原因，肿瘤细胞通常会通过妨碍提供常规的营养物质和葡萄糖的血管的发育来影响机体健康，

关键词：葡萄糖水癌细胞 Cell 血管生成因子增殖肿瘤细胞机体健康营养物质

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Enhanced photodegradation activity of ZnO:Eu3+and ZnO:Eu3+@Au 3D hierarchical structures

引用

Journal of Rare Earths 2020年第1期38卷 21-28页

作者： nataliya Babayevska Igor Iatsunskyi Patryk Florczak Marcin Jarek Barbara Peplińska stefan Jurga nanoBioMedical Centre Adam Mickiewicz University

In this work the flower-like hierarchical structures(HS) based on 3 D pristine ZnO,ZnO:Eu^3+ and ZnO:Eu^3+ @Au were successfully obtained by a template-free solvothermal and deposition-precipitation *** decolorization/photodegradation of these structures towards model organic dye(rhodamine 6 G) was *** synthesized ZnO-based HS were characterized by X-ray diffraction(XRD),scanning electron microscopy(SEM),UV-vis and photoluminescence(PL) *** proposed synthesis approaches allow to obtain highly crystalline 3 D ZnO,ZnO:Eu^3+ and ZnO:Eu^3+ @Au *** of scanning microscopy show that ZnO flower-like HS are assemblies from smaller components,forming larger ones,the whole ZnO structure was approximately 3 μ*** nanoparticles(size^10 nm)are successfully deposited on ZnO HS *** studies show that ZnO is an ideal matrix for incorporation of Eu^3+ ions in broad concentration range(Eu^3+=1.0 at%-5.0 at%) with an efficient red *** strong UV emission in ZnO,as well as ZnO;Eu^3+HS is observed under 325 nm *** of ZnO HS matrix by Eu^3+ions leads to the red shift of deep level emission peak(DLE).The PL intensity reaches the maximum up to 5 at% Eu^3+.The photocatalytic properties of ZnO and ZnO:Eu^3+ @Au HS were investigated under UV-Vis light irradiation towards rhodamine 6 *** obtained results demonstrate the synergetic effect of the deposited gold nanoparticles and Eu3^+ doping on photocatalytic activity of ZnO:Eu^3+@Au HS in comparison to pristine ZnO and ZnO:Eu^3+ HS.

关键词： Zinc oxide Hierarchical structures Europium Gold Photocatalysis Rhodamine 6G

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Toward room-temperature nanoscale skyrmions in ultrathin films

引用

npj Computational Materials 2020年第1期6卷 58-68页

作者： Anastasiia SVarentcova Stephan von Malottki Maria n.Potkina Grzegorz Kwiatkowski stefan Heinze Pavel F.Bessarab ITMO University St.Petersburg 197101Russia Science Institute University of IcelandReykjavík 107Iceland Kavli Institute of nanoscience Delft University of TechnologyP.O.Box 4056Delft 2600 GAThe Netherlands Institute of Theoretical Physics and Astrophysics University of KielLeibnizstrasse 15Kiel 24098Germany St.Petersburg State University St.Petersburg 198504Russia Peter Grünberg Institute and Institute for Advanced Simulation Forschungszentrum JülichJülich 52425Germany

Breaking the dilemma between small size and room-temperature stability is a necessary prerequisite for skyrmion-based information *** we demonstrate by means of rate theory and an atomistic spin Hamiltonian that the stability of isolated skyrmions in ultrathin ferromagnetic films can be enhanced by the concerted variation of magnetic interactions while keeping the skyrmion size *** predict film systems where the lifetime of sub-10 nm skyrmions can reach years at ambient conditions.

关键词： conditions stability films

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Synthesis of luminescent KY_3F_(10) nanopowder multi-doped with lanthanide ions by a co-precipitation method

引用

Journal of Rare Earths 2016年第8期34卷 808-813页

作者： Szymon Goderski Marcin Runowski stefan Lis Department of Rare Earths Faculty of Chemistry Adam Mickiewicz University

A series of KY3F10 nanophosphors doped with Gd3＋, Ce3＋ and Eu3＋ ions were obtained with the use of a co-precipitation method. The resulting products were white precipitates, consisting of spherical particles with diameter about 150-200 nm, which was confirmed using transmission electron microscopy （TEM） technique. Powder X-ray diffraction （XRD） and energy dispersive X-ray analysis （EDX） measurements confirmed appropriate structures of the nanoparticles obtained. Spectroscopic properties of the prod- ucts were examined on the basis of the measured excitation/emission spectra and luminescence decay curves. The synthesized sam- ples showed orange-red luminescence, characteristic for Eu3＋ ions. The reaction process was performed in required alkaline pH ad- justed with the use of ethylenediaminetetraacetic acid （EDTA） and potassium hydroxide. The samples containing large amounts of Gd3＋ dooant ions exhibited a tendencv to form nroducts with different momhologies.

关键词： : fluorides co-precipitation nanophosphors luminescence nanopowders Ce3+/Gd3+/Eu3+ doping rare earths

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：