Acupuncture in diabetic peripheral neuropathy-neurological outcomes of the randomized acupuncture in diabetic peripheral neuropathy trial

作     者：Sebastian Hoerder Isabel Valentina Habermann Katrin Hahn Gesa Meyer-Hamme Miriam Ortiz Weronika Grabowska Stephanie Roll Stefan N.Willich Sven Schroeder Benno Brinkhaus Joanna Dietzel 

作者机构：Institute of Social MedicineEpidemiology and Health EconomicsCharitéUniversitätsmedizinBerlin 10117Germany Department of NeurologyCharitéUniversitätsmedizinCharitéplatz 1Berlin 10117Germany HanseMerkur Center of Traditional Chinese Medicine at University Hospital EppendorffMartinistr 52Hamburg 20246Germany 

出 版 物：《World Journal of Diabetes》 (世界糖尿病杂志（英文版）（电子版）)

年 卷 期：2023年第14卷第12期

页      面：1813-1823页

核心收录：

学科分类：1006[医学-中西医结合] 1005[医学-中医学] 1002[医学-临床医学] 100502[医学-中医临床基础] 10[医学] 100602[医学-中西医结合临床] 

主　　题：Diabetic peripheral neuropathy Numbness Nerve conduction study Acupuncture 

摘      要：BACKGROUND Diabetic peripheral neuropathy(DPN)is a common complication of diabetes mellitus and can lead to serious *** strategies for pain control are available but there are few approaches that influence neurological deficits such as *** To investigate the effectiveness of acupuncture on improving neurological deficits in patients suffering from type 2 *** The acupuncture in DPN(ACUDPN)study was a two-armed,randomized,controlled,parallel group,open,multicenter clinical *** were randomized in a 1:1 ratio into two groups:The acupuncture group received 12 acupuncture treatments over 8 wk,and the control group was on a waiting list during the first 16 wk,before it received the same treatment as the other *** groups received routine *** parameters were evaluated after 8,16 and 24 wk and included neurological scores,such as an 11-point numeric rating scale(NRS)11 for hypesthesia,neuropathic pain symptom inventory(NPSI),neuropathy deficit score(NDS),neuropathy symptom score(NSS);nerve conduction studies(NCS)were assessed with a handheld point-of-care ***-two participants were *** NRS for numbness showed a difference of 2.3(P0.001)in favor of theacupuncture group,the effect persisted until week 16 with a difference of 2.2(P0.001)between groups and 1.8points at week 24 compared to *** NPSI was improved in the acupuncture group by 12.6 points(P0.001)at week 8,the NSS score at week 8 with a difference of 1.3(P0.001);the NDS and the TNSc score improvedfor the acupuncture group in week 8,with a difference of 2.0 points(P0.001)compared to the control *** were persistent in week 16 with a difference of 1.8 points(P0.05).The NCS showed no *** both groups only minor side effects were *** Study results suggest that acupuncture may be beneficial in type 2 diabetic DPN and seems to lead to a reductionin neurological *** serious a