Compartmentalized immune responses and the local microbiota determine mucosal and systemic immunity against SARS-CoV-2
作者机构：Mikrobiologisches Institut-Klinische MikrobiologieImmunologie und HygieneUniversitätsklinikum Erlangen and Friedrich-Alexander-Universität(FAU)Erlangen-NürnbergErlangenGermany Medical Immunology Campus ErlangenFAU Erlangen-NürnbergErlangenGermany.
出 版 物：《Cellular & Molecular Immunology》 (中国免疫学杂志（英文版）)
年 卷 期：2022年第19卷第2期
页 面：130-132页
核心收录：
学科分类：1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 100102[医学-免疫学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学]
基 金：Open Access funding enabled and organized by Projekt DEAL
摘 要：The clinical manifestations of SARS-CoV-2 infection,which is the cause of the coronavirus disease 2019(COVID-19)pandemic,are highly variable and range from asymptomatic carriage or mild symptoms to severe disease involving different organ ***,the specific factors influencing individual clinical outcomes remain ***,to characterize the versatile interplay of mucosal and systemic immune responses with the local microbiome and the viral load,as well as its impact on the course of the disease,Smith et *** integrated analyses of nasopharyngeal swabs and plasma samples from COVID-19 patients with varying degrees of illness *** observed that spike-specific neutralizing antibodies were heterogeneous between paired plasma samples and nasopharyngeal swabs from individual SARS-CoV-2 patients,suggesting a tissuedependent regulation of humoral immune responses.
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