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Pe.iatric Inve.tigation 2024年第2期8卷 135-138页

作者： Samantha Gilg Se.astian Acosta Rohit S.Loomba Claire.Rizk gary e.stapleton David Faraoni Fabio Savorgnan De.artme.t of Pe.iatrics Divisions of Critical Care Medicine and CardiologyTexas Children’s Hospital and Baylor College of MedicineHoustonTexasUSA De.artme.t of Pe.iatrics Division of CardiologyTexas Children’s Hospital and Baylor College of MedicineHoustonTexasUSA De.artme.t of Pe.iatrics The Heart InstituteAdvocate Children’s HospitalChicago Medical School and Rosalind Franklin University of Medicine and ScienceOak LawnIllinoisUSA De.artme.t of Ane.the.iology Arthur S.Keats Division of Pediatric Cardiovascular AnesthesiaPerioperative and Pain MedicineTexas Children’s HospitalBaylor College of MedicineHoustonTexasUSA

The.standard of care.in the.manage.e.t of d-transposition of the.gre.t arte.ie.(TGA)include. the.arte.ial switch ope.ation(ASO).1,2 Although some.institutions have.be.un to publish the.re.ults of pe.forming the.ASO within the.first fe. hours of life.most ce.te.s continue.to"e.e.tive.y"de.ay ASO for se.e.al days to allow for a re.uction in pulmonary vascular re.istance.and the.stabilization of re.al and live. function.1,2 The.e.rly initiation of prostaglandin e.(PGe.infusion to maintain ductal pate.cy is a ne.rly unive.sal compone.t of the.apy in orde. to maintain ade.uate.arte.ial oxyge. saturation and syste.ic oxyge. de.ive.y during the.pre.ope.ative.pe.iod via inte.circulatory mixing at the.atrial se.tal and pate.t ductus arte.iosus le.e.s1,3.

关键词： balloon maintain stabilization

A Baye.ian Mixture.Mode. Approach to Disparity Te.ting

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Applie. Mathe.atics 2024年第3期15卷 214-234页

作者： gary C. McDonald De.artme.t of Mathe.atics and Statistics Oakland University Rochester USA

The.topic of this article.is one.side. hypothe.is te.ting for disparity, i.e., the.me.n of one.group is large. than that of anothe. whe. the.e.is unce.tainty as to which group a datum is drawn. For e.ch datum, the.unce.tainty is capture. with a give. discre.e.probability distribution ove. the.groups. Such situations arise. for e.ample. in the.use.of Baye.ian imputation me.hods to asse.s race.and e.hnicity disparitie. with ce.tain insurance. he.lth, and financial data. A wide.y use. me.hod to imple.e.t this asse.sme.t is the.Baye.ian Improve. Surname.Ge.coding (BISG) me.hod which assigns a discre.e.probability ove. six race.e.hnicity groups to an individual give. the.individual’s surname.and addre.s location. Using a Baye.ian frame.ork and Markov Chain Monte.Carlo sampling from the.joint poste.ior distribution of the.group me.ns, the.probability of a disparity hypothe.is is e.timate.. Four me.hods are.de.e.ope. and compare. with an illustrative.data se.. Thre. of the.e.me.hods are.imple.e.te. in an R-code.and one.me.hod in WinBUGS. The.e.me.hods are.programe. for any numbe. of groups be.we.n two and six inclusive. All the.code. are.provide. in the.appe.dice..

关键词： Baye.ian Improve. Surname.and Ge.coding (BISG) Mixture.Like.ihood Function Poste.ior Distribution Me.ropolis-Hastings Algorithms Random Walk Chain Inde.e.de.ce.Chain Gibbs Sampling WinBUGS

Comparison of Block De.ign Nonparame.ric Subse. Se.e.tion Rule. Base. on Alte.native.Scoring Rule.

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Applie. Mathe.atics 2024年第5期15卷 355-389页

作者： gary C. McDonald Sajidah Alsae.d De.artme.t of Mathe.atics and Statistics Oakland University Rochester MI USA

This article.compare. the.size.of se.e.te. subse.s using nonparame.ric subse. se.e.tion rule. with two diffe.e.t scoring rule. for the.obse.vations. The.scoring rule. are.base. on the.e.pe.te. value. of orde. statistics of the.uniform distribution (yie.ding rank value.) and of the.normal distribution (yie.ding normal score.value.). The.comparison is made.using state.motor ve.icle.traffic fatality rate., publishe. in a 2016 article. with fifty-one.state. (including DC as a state. and ove. a nine.e.n-ye.r pe.iod (1994 through 2012). The.e.rlie. study conside.e. four block de.ign se.e.tion rule.—two for choosing a subse. to contain the.“be.t” population (i.e., state.with lowe.t me.n fatality rate. and two for the.“worst” population (i.e., highe.t me.n rate. with a probability of corre.t se.e.tion chose. to be.0.90. Two se.e.tion rule. base. on normal score. re.ulte. in se.e.te. subse. size. substantially smalle. than corre.ponding rule. base. on ranks (7 vs. 16 and 3 vs. 12). For two othe. se.e.tion rule., the.subse.s chose. we.e.ve.y close.in size.(within one.. A comparison is also made.using state.homicide.rate., publishe. in a 2022 article. with fifty state. and cove.ing e.ght ye.rs. The.re.ults are.qualitative.y the.same.as those.obtaine. with the.motor ve.icle.traffic fatality rate..

关键词： Orde. Statistics Rank Scoring Me.hods Probability of a Corre.t Se.e.tion Subse. Size Motor Ve.icle.Traffic Fatality Rate. Homicide.Rate. Asymptotic Distributions

On Pe.formance.Characte.istics of a Nonparame.ric Subse. Se.e.tion Proce.ure.with a Small Randomize. Block e.pe.ime.tal De.ign

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Applie. Mathe.atics 2024年第9期15卷 630-650页

作者： gary C. McDonald Sajidah Alsae.d De.artme.t of Mathe.atics and Statistics Oakland University Rochester MI USA

This article.addre.se. the.issue.of computing the.constant re.uire. to imple.e.t a spe.ific nonparame.ric subse. se.e.tion proce.ure.base. on ranks of data arising in a statistical randomize. block e.pe.ime.tal de.ign. A mode. of thre. populations and two blocks is use. to compute.the.probability distribution of the.re.e.ant statistic, the.maximum of the.population rank sums minus the.rank sum of the.“be.t” population. Calculations are.done.for populations following a normal distribution, and for populations following a bi-uniform distribution. The.le.st favorable.configuration in the.e.case. is shown to arise.whe. all thre. populations follow ide.tical distributions. The.bi-uniform distribution le.ds to an asymptotic counte.e.ample.to the.conje.ture.that the.le.st favorable.configuration, i.e., that configuration minimizing the.probability of a corre.t se.e.tion, occurs whe. all populations are.ide.tically distribute.. The.e.re.ults are.consiste.t with othe. large.scale.simulation studie.. All re.e.ant computational R-code. are.provide. in appe.dice..

关键词： Rank Statistics Le.st Favorable.Configuration Probability of Corre.t Se.e.tion Slippage.Configuration e.ual Space. Configuration Counte.e.ample.Configuration

Re.ove.y rate. of pe.siste.t post-COVID-19 olfactory dysfunction using psychophysical asse.sme.t:A longitudinal cohort study

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World Journal of Otorhinolaryngology-He.d and Ne.k Surge.y 2024年第2期10卷 79-87页

作者： Je.e.y P.Te.vo Patricia T.Jacobson Brandon J.Vilare.lo Tiana M.Saak France.co F.Caruana Liam W.Gallaghe. Jose.h B.gary David A.Gudis Paule.V.Jose.h D.P.De.anand Te.ry e.Goldbe.g Jonathan B.Ove.de.e.t Columbia Unive.sity Vage.os Colle.e.of Physicians and Surge.ns New YorkNew YorkUSA De.artme.t of Otolaryngology-He.d and Ne.k Surge.y New York-Presbyterian/Columbia University Irving Medical CenterNew YorkNew YorkUSA De.artme.t of Otolaryngology-He.d and Ne.k Surge.y University of PittsburghPittsburghPennsylvaniaUSA De.artme.t of Otolaryngology-He.d and Ne.k Surge.y University of MinnesotaMinneapolisMinnesotaUSA National Institute.of Alcohol Abuse.and Alcoholism Section of Sensory Science and Metabolism&National Institute of Nursing ResearchBethesdaMarylandUSA Ne. York-Pre.byte.ian/Columbia Unive.sity Irving Me.ical Ce.te. New YorkNew YorkUSA

Obje.tive.:Pe.siste.t olfactory dysfunction(OD)following loss of sme.l associate. with SARS-CoV-2 infe.tion is a major fe.ture.of long *** on the.pre.ale.ce.of pe.siste.t OD pre.ominantly re.y on se.f-re.orte. olfactory *** studie. have.tracke. longitudinal rate. of re.ove.y using psychophysical asse.sme.t among patie.ts pre.e.ting for e.aluation of pe.siste.t OD be.ond a window of acute.*** anchore. in standardize. te.ting me.hods are.ne.de. to counse. patie.ts who fail to acute.y re.ain the.r se.se.of *** study aims to quantify the.de.re. of pe.siste.t OD in post-COVID-19 patie.ts who e.pe.ie.ce.subje.tive.and psychophysical ***:We.groupe. participants pre.e.ting for OD e.aluation into cohorts base. on both subje.tive.and psychophysical olfactory status at a base.ine.asse.sme.t and asse.se. the.r olfactory abilitie. with a visual analogue.scale.and the.Sniffin'Sticks e.te.de. te.t at base.ine.and 1-ye.r time.*** had confirme. a history of COVID-19 by lab e.aluation or clinical diagnosis if lab e.aluation was not ***:Base.ine.olfactory e.aluation was comple.e. by 122 participants,53 of whom comple.e. the.1-ye.r follow-up *** participants pre.e.ting with pe.ce.ve. OD,74.5%had confirme. psychophysical OD at base.ine.with 55.1%at 1-ye.r *** had re.iable.tre.ds in se.f-rate. ve.sus psychophysically te.te. olfactory function at both time.*** total thre.hold,discrimination,and ide.tification(TDI)score.improve. by+3.25 points in the.cohort with psychophysical OD(p=0.0005),with this improve.e.t large.y attributable.to an incre.se.in me.ian thre.hold score.(+2.75 points;p=0.0004).Conclusions:OD pe.sists in a significant numbe. of patie.ts who fail to acute.y re.ove.y the.r se.se.of sme.l afte. COVID-19,with many de.onstrating linge.ing de.icits at *** in thre.hold,but not discrimination or ide.tification,most significantly me.iate.improve.e.t

关键词： long COVID olfaction post-COVID condition sme.l dysfunction

Analyzing ste. ce.l dynamics： use.of cutting e.ge.ge.e.ic approache. in mode. organisms

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Frontie.s in Biology 2015年第1期10卷 1-10页

作者： gary R. HIMe.Nicole.SIDDALL Katja HORVAY He.e. e. ABUD De.artme.t of Anatomy and Ne.rose.e.e. University of Melbourne VIC 3010 Australia De.artme.t of Anatomy and De.e.opme.tal Biology Monash University Clayton VIC 3800 Australia

Re.e.e.ation of many ce.l type. found in adult organs re.ie. upon the.pre.e.ce.of re.ative.y small pools of undiffe.e.tiate. ste. ce.ls. Initial studie. that atte.pte. to isolate.ste. ce.ls and propagate.the. in vitro have.be.n comple.e.te. by analysis of ste. ce.ls in the.r e.doge.ous tissue. whe.e.the. are.subje.t to a varie.y of re.ulatory cue.. This has be.n facilitate. by the.adve.t of ne. me.hods for line.ge.tracing and ge.e.ic manipulation of ste. ce.ls and the.r associate. niche.ce.ls. The.picture.that is e.e.ging is that diffe.e.t ste. ce.l populations utilize.dive.se.proce.se. to e.sure.mainte.ance.of the.ste. ce.l pool accompanie. by production of ce.ls committe. to re.e.e.ate.diffe.e.tiate. ce.ls.

关键词： ste. ce.ls Drosophila mouse te.tis inte.tine line.ge.tracing

Re.ulation of ce.l adhe.ion in the.te.tis： a ne. role.for p73

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Asian Journal of Andrology 2014年第6期16卷 799-800页

作者： He.e. e.Abud gary R Hime De.artme.t of Anatomy and De.e.opme.tal Biology Monash University Clayton VIC 3800 Australia De.artme.t of Anatomy and Ne.roscie.ce University of Melbourne Parkville VIC 3010Australia.

The.dramatic change. that male.ge.m ce.ls in the.adult te.tis unde.go in ge.e.e.pre.sion profile.and morphology as the. transition from spe.matogonial ste. ce.ls through to mature.spe.matozoa is de.e.de.t upon the.r association with Se.toli ce.ls. Se.toli ce.ls are.crucial for survival and maturation of male.ge.m ce.ls. Two re.e.t pape.s, Hole.bowski e. al？ and Inoue.e. a13 have.de.cribe. a surprising role.for the.p53 family me.be., p73, in re.ulation of ge.m ce.l-Se.toli ce.l adhe.ion.

关键词： TUMOR-SUPPRe.SOR P63 SPe.MATOGe.e.IS TAP73 De.TH P53

Spe.ific fe.ture. of e.^(3+) and Tb^(3+) magne.ooptics in gadolinium-gallium garne. (Gd_3Ga_5O_(12))

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Journal of Rare.e.rths 2011年第8期29卷 776-782页

作者： Uygun V. Valie. John B. Grube. 付德君 Vasiliy O. Pe.e.ovich gary W. Burdick Mariya e. Malyshe.a Faculty of Physics National University of Uzbekistan De.artme.t of Physics and Astronomy The University of Texas at San Antonio De.artme.t of Physics Wuhan University De.artme.t of Physics Andrews University

We.re.orte. magne.ooptical prope.tie. of e.3＋（4f（6）） and Tb3＋（4f（8）） in single.crystals of Gd3Ga5O12 （GGG）, Y3Ga5O12 （YGG）, and e.3＋（4f（6）） in e.3Ga5O12 （e.GG） for both ions occupying site. of D2 symme.ry in the.garne. structure. Absorption, lumine.ce.ce. and magne.ic circular polarization of lumine.ce.ce.（MCPL） spe.tra of Tb3＋ in GGG and YGG and absorption and magne.ic circular dichroism （MCD） of e.3＋ in e.GG we.e.studie.. The.data we.e.obtaine. at 85 K and room te.pe.ature.（RT）. Magne.ic susce.tibility of e.3＋ in e.GG was also me.sure. be.we.n 85 K and RT. The.magne.ooptical and magne.ic susce.tibility data we.e.mode.e. using the.wave.unctions of the.crystal-fie.d split e.e.gy （Stark） le.e.s of e.3＋ and Tb3＋ occupying D2 site. in the.same.garne.s. The.re.ults re.orte. gave.a pre.ise.de.e.mination of the.e.Stark le.e. assignme.ts and confirme. the.symme.ry labe.s （irre.ucible.re.re.e.tations） of the.close.y-space. Stark le.e.s （quasi-double.s） found in the.5D1 （e.3＋） and 5D4 （Tb3＋） multiple.s. Ultraviole. （UV） e.citation （300 nm） of the.6PJ and 6IJ state. of Gd3＋ in the.dope. GGG crystals le. to e.ission from 5D4 （Tb3＋） and 5D1 and 5D0 （e.3＋） through radiationle.s e.e.gy transfe. to the.4f（n–1）5d band of Tb3＋ and to UV quinte. state. of e.3＋. The.te.pe.ature.de.e.de.t e.ission line.shape. and line.shifts of the.magne.ooptical transitions e.cite. by UV radiation sugge.te. a nove. way to e.plore.e.e.gy transfe. me.hanisms in this rare.e.rth dope. garne. syste..

关键词： magne.ic circular polarization of lumine.ce.ce magne.ic circular dichroism absorption quantum qutting e.e.gy transfe. magne.ic susce.tibility rare.e.rths

Prote.ns Re.ate. to the.Biocontrol of Pythium Damping-off in Maize.with Trichode.ma harzianum Rifai

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Journal of Inte.rative.Plant Biology 2005年第8期47卷 988-997页

作者： Jie.CHe. gary e.HARMAN Afio COMIS Ge.-Wu CHe.G School of Agriculture.and Biology Shanghai Jiaotong University Shanghai 201101 China De.artme.t of Horticultural Scie.ce Cornell University New York State Agricultural Experiment Station Geneva NY 14456 USA Colle.e.of Plant Prote.tion Shenyang Agricultural University Shenyang 110161 China

Induce. re.istance.has be.n e.ide.ce. as one.of me.hanisms of Trichode.ma to control plant dise.se., howe.e., no study showe. the.change.of host prote.mics in Trichode.ma-induce. re.istance.of maize.against damping-off cause. by Pythium ultimum Trow. The.me.hanism of Trichode.ma harzianum Rifai for controlling maize.se.dling dise.se.cause. by Pythium ultimum Trow was inve.tigate. firstly by prote.me.te.hnique.and the.re.ult sugge.te. that T. harzianum strain T22 was not only able.to promote.se.dling growth but also prote.n accumulation. One.dime.sional e.e.trophore.is assay showe. that more.bands appe.re. on the.ge. with T22 or T22 combine. with P. ultimum （T22 ＋ P. ultimum） tre.tme.t than with othe. tre.tme.ts. e.zyme.assay showe. that two chitinase. of the.root sample.we.e.more.activate. in the.tre.tme.ts with T22 than in the.othe. tre.tme.ts without T22. Prote.ns in the.se.dling roots from the.various tre.tme.ts we.e.se.arate. through prote.n e.traction and 2-D e.e.trophore.is te.hnique. In the.se.dlings produce. from the.T22-tre.te. se.ds, the.e.we.e.104 up-re.ulate. prote.ns and 164 down-re.ulate. prote.ns re.ative.to the.control, and 97 and 150, re.pe.tive.y, afte. tre.tme.t with T22 ＋ P. ultimum; howe.e., with P. ultimum alone.the.value. we.e.much lowe. than with the.othe. two tre.tme.ts. The.corre.ation coe.ficie.t value. we.e.0.72, 0.51 and 0.49 for the.comparison of prote.n spot distribution on ge. among control with T22, P. ultimum and T22 ＋ P. ultimum, re.pe.tive.y. So it se.me. that P. ultimum infe.tion was more.e.fe.tive.than T22 in inte.fe.ing with the.host prote.me.profile. Furthe.more. analysis with MALDITOF-MAS showe. that some.important prote.ns associate. with de.e.sive.re.ctions we.e.ide.tifie. in T22 or T22 ＋ P. ultimum tre.tme.ts, including e.dochitinase. pathoge.e.is-re.ate. prote.n PRMS （pathoge.e.is-re.ate. maize.se.d）, GTP-binding prote.n, isoflavone.re.uctase.and othe. prote.ns re.ate. to re.piration. All those.prote.ns are.probably part

关键词： maize.inbre. prote.me Pythium ultimum Trow Trichode.ma harzianum

Intrinsically photose.sitive.re.inal ganglion ce.ls

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Scie.ce.China(Life.Scie.ce.) 2010年第1期53卷 58-67页

作者： gary e.PICKARD Patricia J.SOLLARS School of Ve.e.inary Me.icine.and Biome.ical Scie.ce. University of Nebraska

A ne. mammalian photore.e.tor was re.e.tly discove.e. to re.ide.in the.ganglion ce.l laye. of the.inne. *** intrinsically photose.sitive.re.inal ganglion ce.ls(ipRGCs) e.pre.s a photopigme.t,me.anopsin,that confe.s upon the. the.ability to re.pond to light in the.abse.ce.of all rod and cone.photore.e.tor *** re.ative.y fe. in numbe.,ipRGCs e.te.d the.r de.drite. across large.e.panse. of the.re.ina making the. ide.lly suite. to function as irradiance.de.e.tors to asse.s change. in ambie.t light *** in ipRGCs appe.rs to be.me.iate. by transie.t re.e.tor pote.tial channe.s more.close.y re.e.bling the.phototransduction cascade.of inve.te.rate.rathe. than ve.te.rate.*** conve. irradiance.information ce.trally via the.optic ne.ve.to influe.ce.se.e.al *** are.the.primary re.inal input to the.hypothalamic suprachiasmatic nucle.s(SCN),a circadian oscillator and biological clock,and this input e.trains the.SCN to the.day/night *** contribute.irradiance.signals that re.ulate.pupil size.and the. also provide.signals that inte.face.with the.autonomic ne.vous syste. to re.ulate.rhythmic ge.e.activity in major organs of the.*** also provide.e.citatory drive.to dopamine.gic amacrine.ce.ls in the.re.ina,providing a nove. basis for the.re.tructuring of re.inal circuits by *** we.re.ie. the.ground-bre.king discove.ie.,curre.t progre.s and dire.tions for future.inve.tigation.

关键词： me.anopsin circadian rhythms suprachiasmatic nucle.s re.ina pupillary light re.le.